Abstract: The present invention provides devices comprising multimodal depth electrodes for real-time quantification of chemistry and electrophysiology of the body. The devices are useful in several applications, including monitoring primary and secondary brain injury. The multimodal depth electrodes electrically transduce signals from biological parameters of interest, including EEG, temperature, pressure, oxygen level, blood flow, and chemistry.

Abstract: A system and methods for context-aware and situation-aware secure, policy-based access control for computing devices. The invention enhances the previously disclosed policy-based control system by adding contextual information to the set of resources by which a policy decision point can adjudicate a query to execute a transaction or to access a secure resource. Policy information points are able to store information collected over time related to resources under the control of the system. The system can further include an analytical processing engine capable of inferring new information from existing information that also can be used by the decision points. The policy information points provide context to the decision. They are also able to consider and include information that is external to the system or detected outside the system itself.

Abstract: In general, among other things, compounds of Formula I are provided: in which R11 is e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N1,N1,N3-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; R13 is, e.g., phenyl optionally substituted with one or more substituents; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided.

Abstract: Policy-based client-server systems and methods for attestation in managing and securing mobile computing devices. Attestation provides the means to make efficient, secure, and reproducible use of knowledge possessed by trusted expert parties and authorities within the expression and enforcement of policies for controlling use of, and access to, onboard software and hardware, network capabilities, and remote assets and services. Aspects of secure attestation of applications that use shared and dynamically loaded libraries are presented, as well as potential business models for attestation used in such a policy-based system. The system of the present invention resolves attestation record conflicts using digital certificates and digital signatures.

Abstract: The present invention relates to a device and method for determining the presence of a specific compound in solution. The device includes a nanosensor having an electrically conducting pathway between at least a first and second contact. The device also includes a first receptor, suitable for binding a specific compound in the solution, attached to the nanosensor, and a second receptor also suitable for binding the specific compound while the specific compound is bound to the first receptor. The second receptor is attached to an enzyme added to the solution. When the solution having the second receptor is added to the device, and a second compound that is a substrate for the enzyme is subsequently added to the solution, a measured difference in an electrical property in the device before and after the application of the second compound is indicative of the presence of the specific compound in the solution.

Abstract: A fan containment system for fitment around an array of radially extending fan blades mounted on a hub in an axial gas turbine engine, including: a fan case having an annular casing element for encircling an array of fan blades and an annular fan track liner lining a radially inner side of the casing element, including a first fan track liner panel positioned circumferentially adjacent a second fan track liner panel. An engagement arrangement engages the first fan track liner panel to the second, extending along at least a portion of adjacent sides of the liner panels, and is configured and the liner panels are shaped such that axial movement of the first fan track liner panel by a distance less than the length of the engagement arrangement, being measured in a direction parallel to the adjacent sides of the liner panels, disengages the first liner panel from the second.

Abstract: The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance, Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.

Abstract: The present invention provides a microfluidic purification chip for capturing a biomarker from a physiological solution. The present invention also provides a method of capturing and releasing a biomarker, wherein the biomarker is originally in a physiological solution. The present invention further provides a method of pre-purifying and measuring the concentration of a biomarker in a physiological solution.

Abstract: In general, among other things, compounds of Formula I are provided: in which R11 is e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, N-methyl-3-(pyrrolidin-1-yl)propan-1-amino, N1,N1,N3-trimethylpropane-1,3-diamino, N,N-dimethylpiperidin-4-amino, 3-(pyrrolidin-1-ylmethyl)azetidin-1-yl, 3-(pyrrolidin-1-ylmethanon)azetidin-1-yl, or 3-(morpholin-1-ylmethyl)azetidin-1-yl; R13 is, e.g., phenyl optionally substituted with one or more substituents; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided.

Abstract: A fan containment system includes an annular casing element and a hook projecting in a generally radially inward direction from the annular casing element. A fan track liner is connected to the hook via a fastener. The fan track liner has a forward end proximal to the hook and a rearward end distal to the hook. A pivot member protrudes radially inward from the annular casing element and is arranged and positioned between the forward and rearward end of the fan track liner such that a forward portion of the fan track liner is pivotable about the pivot member, so that upon release of a fan blade the forward portion of the fan track liner pivots about the pivot member into a voidal region provided between the annular casing element and the forward portion of the fan track liner to encourage engagement of the hook with a released fan blade.

Abstract: The present invention relates to uniform nanostructure biosensors and methods of calibrating the response of nanostructure biosensors. The invention overcomes device to device variability that has made quantitative detection difficult. The described biosensors have uniform characteristics that allow for more reliable comparison across devices. The methods of the invention comprise normalizing the initial current rate, as measured by the nanostructure biosensor following the addition of an analyte, to device characteristics of the biosensor. The device characteristics of the biosensor which can be used to normalize the response include baseline current and transconductance. Calibration of responses allows for the generation of calibration curves for use in all devices to quantitatively detect an analyte, without the need for individual device calibration.

Abstract: Policy-based client-server systems and methods for attestation in managing and securing mobile computing devices. Attestation provides the means to make efficient, secure, and reproducible use of knowledge possessed by trusted expert parties and authorities within the expression and enforcement of policies for controlling use of, and access to, onboard software and hardware, network capabilities, and remote assets and services. Aspects of secure attestation of applications that use shared and dynamically loaded libraries are presented, as well as potential business models for attestation used in such a policy-based system. The system of the present invention resolves attestation record conflicts using digital certificates and digital signatures.

Abstract: An elbow prosthesis can include a humeral component having a yoke, an ulnar component having a head, a humeral bearing positionable in a base of the humeral component, an ulnar bearing assembly configured to engage with the head, and a pin extendable through the bearing assembly and the head. The pin can be extendable into first and second ears of the yoke to enable pivotable movement of the ulnar component relative to the humeral component. The elbow prosthesis can include a first fastener insertable through the first ear of the yoke and configured to engage with the pin, and a second fastener insertable through the second ear of the yoke and configured to engage with the pin.

Abstract: An elbow prosthesis can include a humeral component having a yoke, an ulnar component having a head, a humeral bearing positionable in a base of the humeral component, an ulnar bearing assembly configured to engage with the head, and a pin extendable through the bearing assembly and the head. The pin can be extendable into first and second ears of the yoke to enable pivotable movement of the ulnar component relative to the humeral component. The elbow prosthesis can include a first fastener insertable through the first ear of the yoke and configured to engage with the pin, and a second fastener insertable through the second ear of the yoke and configured to engage with the pin.

Abstract: In general, among other things, compounds of Formula I are provided: in which R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, etc.; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided.

Abstract: Policy-based client-server systems and methods for attestation in managing and securing mobile computing devices. Attestation provides the means to make efficient, secure, and reproducible use of knowledge possessed by trusted expert parties and authorities within the expression and enforcement of policies for controlling use of, and access to, onboard software and hardware, network capabilities, and remote assets and services. Aspects of secure attestation of applications that use shared and dynamically loaded libraries are presented, as well as potential business models for attestation used in such a policy-based system.

Abstract: In general, among other things, compounds of Formula I are provided: in which R11 is selected from the group consisting of benzylamino, N-methylbenzylamino, morpholino, thiomorpholino, pyrrolidino, etc.; R13 is selected from the group consisting of 3-(1-ethanol-2-yl)phenyl, 3-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, 2-(1-ol-2,2,2-trifluoroethan-2-yl)phenyl, etc.; and R12 and R14 are each independently hydrogen or alkyl. Methods of treatment are also provided.