Abstract: Various examples are provided for securing deep brain stimulation (DBS) leads. In one example, among others, a DBS cap for securing a DBS lead includes a base ring adapted to be mounted within a counterbore opening formed in the skull, a lead securing element that mounts to the base ring, and. a top cover that mounts to the base ring. In another example, a method for securing a DBS lead includes forming a counterbore opening in the skull, securing a DBS cap within the counterbore opening, passing a DBS lead through the DBS cap and the counterbore opening and positioning a tip of the lead in brain tissue, and securing the DBS lead to the DBS cap using an adhesive. The skull opening includes a lower bore, a concentric upper bore, and a step positioned at the interface of the upper and lower bores.

Abstract: The present invention provides a compound of formula (I), having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: Ventilator management systems are provided. In one aspect, a ventilator management system includes a memory that includes an initial configuration profile configured to designate operating parameters for a ventilation device, and a processor. The processor is configured to receive ventilator data from the ventilation device, the ventilator data includes at least one of operating parameters of the ventilation device or physiological statistics of a patient associated with the ventilation device, and determine, based on the ventilator data, a modification to the initial configuration profile for the ventilation device. The processor is also configured to generate a modified configuration profile for the ventilation device based on the determined modification. Methods and machine-readable media are also provided.

Abstract: The present invention relates to a compound of formula (IA), wherein G1 is lower alkyl; lower alkyl substituted by one or more halogens; cycloalkyl; tetrahydropyran-4-yl; phenethyl; phenethyl substituted by one or more halogens; phenoxymethyl; phenoxymethyl substituted by one or more halogens; benzyloxyethyl; benzyloxy-ethyl substituted by one or more halogens; or is —NR2R3; R2 is hydrogen or lower alkyl; R3 is lower alkyl; tetrahydropyran-4-yl; —CH2-cycloalkyl; or cycloalkyl optionally substituted by lower alkyl substituted by one or more halogens; or R2 and R3 form together with the N-atom to which they are attached a heterocycloalkyl group with 4 or 5 carbon atoms, which is optionally substituted by one or more substituents selected from halogen; or lower alkyl substituted by one or more halogens; X is —CH2— or —(CH2)2—; Ar is phenyl or pyridinyl; R4 is halogen; lower alkyl; lower alkyl substituted by one or more halogens; or lower alkoxy; n is 1 or 2; or to a pharmaceutically active salt thereof, to a ste

Abstract: A motor vehicle steering wheel assembly may include a ring-shaped member comprising a slot and an internal recess, wherein the slot and internal recess extend circumferentially about the ring-shaped member, the slot being provided in a surface of the ring-shaped member and forming an aperture into the internal recess; a support portion configured to be coupled to a vehicle support structure, the support portion extending through the slot; and a guide portion coupled to the support portion, the guide portion being slidably disposed in the internal recess such that the ring-shaped member is rotatable.

Abstract: Ventilation systems are provided. In one aspect, a ventilation system includes system includes a ventilation device that is configured to provide breathable air or gas mixture to a patient according to certain operating parameters, a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive, over a network, at least one of patient data, order data, configuration data, user data, or rules or protocols, and provide a modification of operating parameters of the ventilation device based on the received patient data, order data, configuration data, user data, or rules or protocols. Methods and machine-readable media are also provided.

Abstract: Content maintained in a first repository of a first installation (which can optionally be an on-premise installation) of a content management system, as well as metadata associated with the content, can be shared via an approach in which content items maintained in the first repository are synchronized with a copy of the content items maintained in a second repository of a second installation (which can optionally be a cloud-based installation). The first installation can be optionally firewall protected. The copy of the content items can be accessed by collaborative users both within and external to a firewall. Related systems, methods, products, etc. are described.

Abstract: A labeling device for a syringe that includes a first labeling subsystem adapted to print a first label having machine readable information and a second labeling subsystem adapted to print a second label having human readable information is disclosed. The first labeling subsystem includes a label applicator adapted to automatically apply the first label to a portion of the syringe. The first labeling subsystem includes a syringe clamp assembly that securely holds the syringe while the label applicator automatically applies a first label to the syringe. The second labeling subsystem includes a removal device adapted to automatically remove a backing material from the second label.

Abstract: A method and apparatus for processing object-based audio signals for reproduction through a playback system is provided. The apparatus receives a plurality of object-based audio signals in at least one audio frame. In addition, the apparatus receives at least one audio object command associated with at least one object-based audio signal of the plurality of object-based audio signals. In addition, the apparatus processes the at least one object-based audio signal based on the received at least one audio object command. Further, the apparatus renders a set of object-based audio signals of the plurality of object-based audio signals to a set of output signals based on the at least one audio object command. The at least one audio frame may be received from one of a set top box, an OD player, or a television. The apparatus may be an AV receiver or a television.

Abstract: A computing device may receive or otherwise access a base audio layer and one or more enhancement audio layers. The computing device can reconstruct the retrieved base layer and/or enhancement layers into a single data stream or audio file. The local computing device may process audio frames in a highest enhancement layer retrieved in which the data can be validated (or a lower layer if the data in audio frames in the enhancement layer(s) cannot be validated) and build a stream or audio file based on the audio frames in that layer.

Abstract: In one embodiment, the presence of anomalous material within tissue is detected by scanning a patient using magnetic resonance imaging (MRI) to obtain MRI data, identifying individual voxels of the MRI data, identifying multiple parameters of each voxel, and determining as to each voxel based upon the identified parameters the likelihood of tissue represented by the voxel containing anomalous material.

Abstract: An arrow or bolt comprising of an indicator that will chemically indicate the fluids that have come into contact with the arrow as it has passed through the animal. The indicator may comprise a treated substrate that chemically reacts with bodily fluids of the animal as the arrow or bolt passes through the animal to provide an indication of the acidity thereof. The chemical indicator may be attached to the arrow allowing a user to reuse the arrow by simply removing a used indicator and replacing with an unused chemical indicator. Alternatively, a portion of the arrow or bolt may be provided with an absorptive neutral substrate on which a reusable chemical indicator dye could be applied. The substrate could be cleaned following use and the indicator dye reapplied to enable reuse of the arrow or bolt.

Abstract: The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, Formula (I), wherein R1, R3, R4, L1, L2, L3, L4, and n, have the same meaning as that defined in the claims and the description. The present invention also relates to compositions, in particular pharmaceuticals, comprising such compounds, and to uses of such compounds and compositions for the prevention and/or treatment of metabolic disorders and/or neurodegenerative diseases, and/or protein misfolding disorders.

Abstract: The Invention is a system and method for adaptively attaching a work piece, especially an imprecise work piece, to a non-adaptive fixture that can be repeatably attached to one or more CNC machines. The Invention allows a work piece to be set up once for multiple machining operations. The Invention avoids the potential for errors and the cost and complexity inherent in adaptive machining and adaptive fixturing.

Abstract: A balance assembly for an engine is provided. The balance assembly includes a first electric motor coupled to the engine and configured to rotate a first eccentric mass relative to the engine, the first eccentric mass being coupled to a first shaft of the first electric motor, and a second electric motor coupled to the engine and configured to rotate a second eccentric mass relative to the engine, the second eccentric mass being coupled to a second shaft of the second electric motor. The first and second electric motors are configured to rotate the first and second eccentric masses in order to balance a vibration characteristic of the engine.

Abstract: Ventilation systems are provided. In one aspect, a ventilation system includes system includes a ventilation device that is configured to provide breathable air or gas mixture to a patient according to certain operating parameters, a memory that includes instructions, and a processor. The processor is configured to execute the instructions to receive, over a network, at least one of patient data, order data, configuration data, user data, or rules or protocols, and provide a modification of operating parameters of the ventilation device based on the received patient data, order data, configuration data, user data, or rules or protocols. Methods and machine-readable media are also provided.

Abstract: The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The invention relates to a compound of formula (I) wherein R1 to R4 and n are defined as in the description and in the claims. The compound of formula (I) can be for treating.

Abstract: The invention relates to a compound of formula (I) wherein A1 to A3 and R1 to R3 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: The systems and methods are directed towards object driven attributes for characters within a network-based game. More specifically, characters within a network-based game have various attributes that are influenced with the association and/or possession of objects provided by the user. These user-provided objects impact one or more attributes possessed by a character within the network-based game thereby influencing the character's actions, personality and motivations. In other embodiments, the characters within the network-based game communicate with players using a variety of methods such as social media, e-mail and text. The communications provide in-game updates for the player to view. The player can provide natural language commands or responses for the characters that may influence the character's actions within the game.