Abstract: This application provides a process for mineral carbonation, which process comprises the steps of: providing a bed of hydroxylated magnesium silicate mineral particles in a heating vessel; agitating the bed of particles under conditions of a sub-atmospheric pressure and at a temperature of at least 600° C. to produce particles of dehydroxylated magnesium silicate mineral; and reacting the dehydroxylated magnesium silicate mineral with carbon dioxide, carbonate ions and/or bicarbonate ions to form magnesium carbonate. This application also provides a reactor system for carrying out the process, which includes (1) mineral from mine, (2) hydroxylated magnesium silicate mineral, (3) crushing, grinding, sizing, (4) agitated bed of particles, (5) external heating, (6) vacuum system, (7) from carbon source, (8) carbon dioxide or carbonate or bicarbonate ions in solution, (9) carbonation reactions, (10) carbonate product, (11) pre-heat, (12) heat recovery, and (13) magnetic fraction.

Abstract: The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABAA ?5) and act as GABAA ?5 negative allosteric modulators (GABAA ?5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABAA ?5 such as Alzheimer's disease.

Abstract: The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABAA ?5) and act as GABAA ?5 negative allosteric modulators (GABAA ?5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABAA ?5 such as Alzheimer's disease.

Abstract: A method of producing an explosive composition comprising a liquid energetic material and sensitizing voids, the sensitizing voids being present in the liquid energetic material with a non-random distribution, which method comprises: providing a flow of liquid energetic material; and delivering sensitizing voids into the flow of liquid energetic material in a series of pulses to provide regions in the liquid energetic material in which sensitizing voids are sufficiently concentrated to render those regions detonable and regions in the liquid energetic material in which the sensitizing voids are not so concentrated.

Abstract: The present invention relates to novel aminoindazolyl derivative compounds of Formula (I), the use of said compounds in treating diseases mediated by modulation of voltage-gated sodium channels in particular Nav1.7 AND to compositions containing said derivatives.

Abstract: A mobile manufacturing and delivery platform that is adapted to provide in a blasthole an explosive composition comprising a liquid energetic material and sensitizing voids, the sensitizing voids being present in the liquid energetic material with a non-random distribution. The platform comprises a storage tank for the liquid energetic material; at least two delivery lines for conveying respective streams of the liquid energetic material from the storage tank; a void delivery system for producing sensitizing voids in at least one of the streams of liquid energetic material; a mixer for mixing the streams of liquid energetic material to produce the explosive composition; and a blasthole loading hose. The mixer may be provided at the end of the loading hose. A blasting method employs the platform to manufacture and deliver the explosive composition into a blasthole, which composition is subsequently detonated.

Abstract: Methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro are provided. Compositions and systems of cell populations of TEP cells as well as cells formed during different stages of differentiation of PS cells into TEP cells are also disclosed. The methods, isolated in vitro cell populations, compositions, and systems disclosed provide functional TEP cells that mature into thymic epithelial cells in vivo.

Abstract: An apparatus is provided for mechanically loading a biological sample. The apparatus comprises: a container for housing the biological sample; a ferromagnetic element, for attachment to the biological sample within the container; and a solenoid for generating a magnetic field within the container, so as to apply a force to the ferromagnetic element. The solenoid is configured, when energised by a constant current, to produce a force on the ferromagnetic element that varies by less than a predetermined amount over a predetermined range of movement of the magnet within the container. A method of mechanically loading a biological sample is also disclosed.

Abstract: The apparatus for the non-invasive glucose detection comprises an electrical detection device (2) for measuring the response of the tissue or blood to an electric field at low frequencies below 1 MHz and at high frequencies above 10 MHz. The former is primarily dominated by skin hydration and sweat, while the latter contains contributions from the current glucose level. Combining the two signals allows an increased degree of accuracy. The apparatus further comprises a force or acceleration sensor (4, 5), which allows to detect the pressure of the apparatus against the skin and/or quick movements. Further sensor modules, such as a temperature sensor (6) or alternative perfusion sensor (7), improve the accuracy of the measured result.

Abstract: A parameter affecting the absorptivity or the concentration of blood in tissue is measured using a semiconductor light source (7) and a light detector (8). The semiconductor light source (7) is operated at several operating conditions, at which it has different temperatures and therefore different emission spectra. In particular, the operating conditions correspond to different time intervals after switching the light source (7) on, while the light source (7) has not yet reached thermal equilibrium. This allows to perform a spectroscopic measurement using one light source only, which increases accuracy and reduces device cost.

Abstract: Ghost expressions with user-provided information may be provided in asynchronous gameplay. According to some implementations, ghost data associated with a first performance by a first user of a first task in a game may be obtained. The ghost data may be configured to allow generation of a ghost expression in the game corresponding to the first performance of the first task in the game by the first user. User-provided information associated with the first performance of the first task in the game may be obtained. The ghost data may be augmented with the user-provided information to obtain augmented ghost data. The augmented ghost data may be provided to effectuate presentation in the game of the ghost expression and at least some of the user-provided information via a client computing platform associated with the first user or a second user of the game.

Abstract: The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs thereof (wherein the characters are as defined in the description). The compounds represented by formula (I) have affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 (GABAA ?5) and act as GABAA ?5 negative allosteric modulators (GABAA ?5 NAM), so that they are useful in the prevention and/or treatment of diseases which are related to the GABAA ?5 such as Alzheimer's disease.

Abstract: A mobile manufacturing and delivery platform that is adapted to provide in a blasthole an explosive composition comprising a liquid energetic material and sensitizing voids, the sensitizing voids being present in the liquid energetic material with a non-random distribution. The platform comprises a storage tank for the liquid energetic material; at least two delivery lines for conveying respective streams of the liquid energetic material from the storage tank; a void delivery system for producing sensitizing voids in at least one of the streams of liquid energetic material; a mixer for mixing the streams of liquid energetic material to produce the explosive composition; and a blasthole loading hose. The mixer may be provided at the end of the loading hose. A blasting method employs the platform to manufacture and deliver the explosive composition into a blasthole, which composition is subsequently detonated.

Abstract: A method of producing an explosive composition comprising a liquid energetic material and sensitizing voids, the sensitizing voids being present in the liquid energetic material with a non-random distribution, which method comprises: providing a flow of liquid energetic material; and delivering sensitizing voids into the flow of liquid energetic material in a series of pulses to provide regions in the liquid energetic material in which sensitizing voids are sufficiently concentrated to render those regions detonable and regions in the liquid energetic material in which the sensitizing voids are not so concentrated.

Abstract: A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.

Abstract: Methods for generating thymic epithelial progenitor (TEP) cells from pluripotent stem (PS) cells in vitro are provided. Compositions and systems of cell populations of TEP cells as well as cells formed during different stages of differentiation of PS cells into TEP cells are also disclosed. The methods, isolated in vitro cell populations, compositions, and systems disclosed provide functional TEP cells that mature into thymic epithelial cells in vivo.

Abstract: A root guide for lengthening roots of a plant in a pot can include a track spiralling radially from a central axis. The track can spiral for at least two revolutions. In use, roots of the potted plant can spiral down the soil covered track as the plant grows.

Abstract: A device is described for measuring a parameter of living tissue, in particular a glucose level, which parameter affects a response of said tissue to an electric field. The device comprises a substrate (2), which carries a ground electrode (10) as well as a plurality of signal electrodes (12a, 12b, 13a-13c, 14). The gaps (15) between the ground electrode and the signal electrodes are filled with a solid filler material (16) in order to provide an even surface. Optical reflection detectors (23a, 23b, 23c) can also be located in these gaps in order to avoid field distortions and obtain a compact design. The backside of substrate (2) carries electronic high-frequency components for improving signal quality.

Abstract: Ambience signal components are obtained from source audio signals, matrix-decoded signal components are obtained from the source audio signals, and the ambience signal components are controllably combined with the matrix-decoded signal components. Obtaining ambience signal components may include applying at least one decorrelation filter sequence. The same decorrelation filter sequence may be applied to each of the input audio signals or, alternatively, a different decorrelation filter sequence may be applied to each of the input audio signals.

Abstract: An audio signal is conveyed more efficiently by transmitting or recording a baseband of the signal with an estimated spectral envelope and a noise-blending parameter derived from a measure of the signal's noise-like quality. The signal is reconstructed by translating spectral components of the baseband signal to frequencies outside the baseband, adjusting phase of the regenerated components to maintain phase coherency, adjusting spectral shape according to the estimated spectral envelope, and adding noise according to the noise-blending parameter. Preferably, the transmitted or recorded signal also includes an estimated temporal envelope that is used to adjust the temporal shape of the reconstructed signal.