Abstract: Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

Abstract: Novel fused pyrazine compounds are disclosed that have a formula represented by the following: with Z, R1, R2, R8 and R9 as defined in the written description. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

Abstract: Novel fused pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammation, rheumatoid arthritis and others.

Abstract: An audio signal is conveyed more efficiently by transmitting or recording a baseband of the signal with an estimated spectral envelope and a noise-blending parameter derived from a measure of the signal's noise-like quality. The signal is reconstructed by translating spectral components of the baseband signal to frequencies outside the baseband, adjusting phase of the regenerated components to maintain phase coherency, adjusting spectral shape according to the estimated spectral envelope, and adding noise according to the noise-blending parameter. Preferably, the transmitted or recorded signal also includes an estimated temporal envelope that is used to adjust the temporal shape of the reconstructed signal.

Abstract: The device measuring a parameter p that depends on the real and/or imaginary parts of the permittivity of body tissue operates at a frequency f where a temperature change affects the permittivity of free water only weakly. If the parameter p depends on the real part of the permittivity only, the frequency f should be between 6.2 and 10.1 GHz. If the parameter p depends on the imaginary part of the permittivity only, the frequency f should be between 25.5 and 36 GHz. If parameter p depends on the real and imaginary parts of the permittivity, the derivative of the parameter in respect to the real and imaginary parts of permittivity can be used to calculate an optimum frequency range.

Abstract: A receiver in an audio coding system receives a signal conveying frequency subband signals representing an audio signal. The subband signals are examined to assess one or more characteristics of the audio signal including temporal shape. Spectral components are synthesized having the one or more assessed characteristics, integrated with the subband signals and passed through a synthesis filterbank to generate an output signal.

Abstract: An audio upmixer, such as a two-channel to three-channel upmixer, employs a difference in a measure of sound at the ears of a listener in accordance with first and second models, one based on a reproduction of the original channels and the other based on a reproduction of the upmixed channels. The difference is minimized while simultaneously causing a, portion of one or more of the stereophonic channels to be applied to the center loudspeaker under some conditions of the signals in the stereophonic channels, the portion being commensurate with the value of a weighting factor, such that the weighting factor controls a balance between two opposing conditions, one in which no signals are applied to the center loudspeaker and another in which no signals are applied to the left and right loudspeakers.

Abstract: A receiver in an audio coding system receives a signal conveying frequency subband signals representing an audio signal. The subband signals are examined to assess one or more characteristics of the audio signal including temporal shape. Spectral components are synthesized having the one or more assessed characteristics, integrated with the subband signals and passed through a synthesis filterbank to generate an output signal.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: Each of N audio signals are filtered with a unique decorrelating filter (38) characteristic, the characteristic being a causal linear time-invariant characteristic in the time domain or the equivalent thereof in the frequency domain, and, for each decorrelating filter characteristic, combining (40, 44, 46), in a time and frequency varying manner, its input (Zi) and output (Z-i) signals to provide a set of N processed signals (X i). The set of decorrelation filter characteristics are designed so that all of the input and output signals are approximately mutually decorrelated. The set of N audio signals may be synthesized from M audio signals by upmixing (36), where M is one or more and N is greater than M.

Abstract: Novel [1.2.4]triazolo[1,5-a]pyrazine and imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

Abstract: Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

Abstract: The invention provides a method for gassing an explosive to sensitise the explosive and/or modify the density of the explosive. The method comprises reacting at least one oxidiser with at least one nitrogen containing compound in the explosive to generate nitrogen gas. The explosive is formulated to effect diffusion of the oxidiser and/or the compound into contact with each other, the nitrogen gas being generated by oxidation of the compound by the oxidiser. The invention extends to the explosive compositions themselves.

Abstract: Certain types of parametric spatial coding encoders use interchannel amplitude differences, interchannel time differences, and interchannel coherence or correlation to build a parametric model of a multichannel soundfield that is used by a decoder to construct an approximation of the original soundfield. However, such a parametric model does not reconstruct the original temporal envelope of the soundfield's channels, which has been found to be extremely important for some audio signals. The present invention provides for the reshaping the temporal envelope of one or more of the decoded channels in a spatial coding system to better match one or more original temporal envelopes.

Abstract: The present invention provides a process for sanitizing an object. The process comprises: (i) placing the object to be sanitized in a substantially enclosed environment, the environment being at atmospheric pressure when the object is placed therein, (ii) providing a gaseous chlorine dioxide vapour in the environment, and (iii) exposing the gaseous chlorine dioxide vapour to the object to sanitize the object. The process includes maintaining a pressure in the environment at substantially atmospheric pressure.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: A method of conducting a seismic survey comprising using at least one seismic source operable to emit an acoustic signal comprises: —providing a first receiver line extending in a first direction across a region of the ground to be surveyed; —locating at least one seismic receiver at a point on the first receiver line, the seismic i receiver(s) being adapted to record reflected acoustic signals emitted by the seismic source(s); —providing a first pre-determined shot line having a plurality of shot points along its length, extending in a second direction and along which the seismic source(s) is movable; —operating the or one of the seismic source(s) to emit an acoustic signal at a first shot point on the pre-determined shot line, the reflection of the acoustic signal being recorded by the or one of the seismic receiver(s); and —operating the or one of the seismic source(s) to emit another acoustic signal at a second shot point on the pre-determined shot line, the reflection of the another acoustic signal being

Abstract: Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

Abstract: Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.

Abstract: A method for controlling the power consumption in a peer-to-peer (P2P) network of content delivery devices is provided. The method comprises the steps of: determining the capacity of the network to deliver each content unit stored on a device; determining the demand of the network for each content unit stored on the device; comparing the capacity with the demand for each content unit stored on the device; and controlling the power supplied to said device based on said comparison.