Abstract: A cushioning bumper assembly for a forklift includes one or more cushioning bumper members assembled from a belting material wrapped around a cylindrical compressible material. The cushioning bumper members are secured to a fastener, such as an elongated box tubing which may be secured to the shank of the forklift to position the bumper members at a desired height and position forward of the shank.

Abstract: A device assembly having a syndicated data service interface that is communicatively coupled to a vendor-specific syndicated data application platform and having an installed vendor specific syndicated data application, with the interface receiving point-to-multipoint non-addressed transport bearer channels of different syndicated data channel transport networks initially only including the monitoring of the syndicated data channels and not decoding the syndicated data messages or syndicated data informational data contained therein, identifying from the transport bearer channels a received syndicated data channel having an syndicated data channel identifier of the specific syndicated data device, and reading the syndicated data messages within the received syndicated data channel and extracting the syndicated data supplier-independent informational data from the syndicated data message and providing the extracted syndicated data informational data to at least one of the installed vendor specific syndicated d

Abstract: The various embodiments disclosed herein relate to surgical robot positioning systems and devices that aid in the gross positioning of surgical devices during surgical procedures. For example, a gross positioning system for use with a robotic surgical device may include a positioning body, a yaw mechanism operably coupled to the positioning body at a yaw rotational joint, a pitch mechanism operably coupled to the positioning body at a pitch rotational joint, and a plunge mechanism operably coupled to the pitch mechanism, where the plunge mechanism is configured to slide and to be coupleable to the robotic surgical device.

Abstract: The invention relates to a compound of formula (I) comprising a mitochondrial targeting group linked to a group capable of releasing hydrogen sulphide for use in the treatment of the human or animal body or tissues and cells derived therefrom and to the use in the treatment of plants and to novel related compounds.

Abstract: Drug delivery device, drug delivery system, and system components are provided including configuration of a container, reservoir or barrel for medium or fluid and a pump mechanism or driving components for advancing a plunger to dispense the medium or fluid from the reservoir or barrel, and/or for filling the reservoir or barrel with the medium or fluid, where the pumping mechanism or driving components are disposed such that individual and/or overall dimensions of the pump mechanism or the driving components can be reduced compared to conventional designs. A provided system can include a syringe-style drug container, reservoir, or barrel containing a medium or fluid which can be dispensed by a pumping mechanism configured to advance a plunger/stopper disposed inside the barrel via cable, or a ribbon, connected to the plunger/stopper.

Abstract: The present disclosure relates to systems and methods for providing cybersecurity functionality to computer implemented inventions such as Internet of Thing (IoT) systems and object devices, and more specifically, to an improved cybersecurity system, method and capabilities for the protecting IoT and similar devices through non-discriminatory vendor/supplier independent distribution of secure predetermined IoT syndication data to unidentified and non-registered IoT devices, through the use of a passive data distribution technology and out-of-band, system-to-device distribution channel and no peer-to-peer stateless relationship with the receiving device and using Quality of Service (QoS) and enabling the determination as to whether there is any suspicious activity occurring and prohibiting the IoT device from taking any customer-defined action without have a separately provided authentication.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger, and plunger driver assembly comprising double-acting, telescoping lead screws that is located behind and outside of the barrel. Simultaneously and counter-rotating sleeve screw and center screw telescope out of a nested configuration of the plunger driver assembly and into the reservoir at a rate of double their individual and equal pitch and lead parameters when the sleeve screw is rotated. A threaded nut and gear anchor disposed on an end of the barrel receive the sleeve screw and the threaded nut causes the sleeve screw to translate and rotate in response to motor operation. A distal end of the center screw can be keyed to a plunger pusher for anti-rotation constraint when the motor is imparting rotation on the threaded nut and sleeve screw.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger and plunger driver assembly comprising a spiral zipper-driven pump mechanism. A flexible band in the spiral zipper-driven pump mechanism is transformed from a collapsed, nested configuration to an extended configuration by controllably unfurling and recoiling the band into a spiral column of interlocking revolutions of the band. The column has sufficient stiffness to impart translational motion to a plunger along a longitudinal reservoir axis that is precisely controllable by rotation of gears by a motor. The collapsed, non-extended configuration of the spiral zipper-driven pump mechanism reduces reservoir and fluid delivery device length.

Abstract: Disclosed is a medication delivery system comprising: a container for a medium: a plunger disposed in the container; and a lead screw axially fixed with respect to the container and in threaded engagement with the plunger, where the lead screw is disposed inside of the container, and the rotation of the lead screw causes axial displacement of the plunger with respect to the container. A patch pump comprising the medication delivery system and a medicament delivery device comprising the medication delivery system are also disclosed.

Abstract: A fluid delivery device (110) comprising an integrated vial connector system (180) disposed in a fluid path (124) between a reservoir (122) and an insertion mechanism (116). Additionally, a fluid delivery device (210) and an external fill device (294) wherein when the external fill device (294) engages the fluid delivery device (210), a main drive gear (234) is disengaged and a leadscrew (236) is engaged for filling the fluid delivery device (210) with the medicament. Also, a vial adapter (280) comprising an elastomer (282) that engages an outer diameter of a cannula (217) in an insertion mechanism (216) to provide a sealing surface, wherein the vial adapter (280) engages the fluid delivery device (210) and the vial (202) to fill the fluid delivery device (210) with medicament while maintaining a sealed interface. In addition, a vial adapter (380) for engaging a filling station (284) to fill a fluid delivery device (210).

Abstract: The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: A floating barrier system has a plurality of connected floating barrier units. Capture net segments are positioned on the floating barrier units by support post members, forming a barrier to vessel passage. Lanyards attach the ends of the capture net segments to the floating barrier units. Upon a vessel striking the capture net segments with sufficient force, the capture nets detach from the support post members and/or pull the support post members over, and the forces from the vessel are transferred via the lanyards to the floating barrier unit. The vessel is prevented from fully passing over the floating barrier unit, thus itself forming a barrier to passage by other vessels.

Abstract: A fluid delivery device has a syringe barrel-type reservoir with plunger, and plunger driver assembly comprising double-acting, telescoping lead screws that is located behind and outside of the barrel. Simultaneously and counter-rotating sleeve screw and center screw telescope out of a nested configuration of the plunger driver assembly and into the reservoir at a rate of double their individual and equal pitch and lead parameters when the sleeve screw is rotated. A threaded nut and gear anchor disposed on an end of the barrel receive the sleeve screw and the threaded nut causes the sleeve screw to translate and rotate in response to motor operation. A distal end of the center screw can be keyed to a plunger pusher for anti-rotation constraint when the motor is imparting rotation on the threaded nut and sleeve screw.

Abstract: The invention provides a compound of compound of formula (I): or a salt thereof, wherein R1, n, L, and X have any of the values described herein, as well as compositions and lipid nanoparticles comprising a compound of formula I, and their use for delivering therapeutic agents such as siRNA and mRNA.

Abstract: A hard seal, positive displacement pump is provided which may be included within a fluid delivery system. The pump includes a housing, a sleeve disposed radially within the housing, and a piston disposed radially within the sleeve. An outer shape of a first end of the sleeve contacts a correspondingly-shaped inner shape of a first end of the housing, thereby sealing the first end of the sleeve within the first end of the housing. The piston is radially and axially moveable within the sleeve, and an axially-reciprocating motion of the piston within the sleeve opens and closes a pump chamber defined between a first end of the piston and a first end of the sleeve.

Abstract: A fluid delivery device has a syringe barrel with reservoir chamber for fluid, a plunger that translates along a longitudinal axis to expel fluid, and a pusher dimensioned to translate within the barrel and coupled to a drive mechanism to controllably contact and move the plunger. The pusher contacts the plunger at its mechanical center to reduce tilt in the plunger. Contact faces of the pusher and plunger cooperate as a ball joint to minimize non-axial forces on the plunger face. The pusher can have a protrusion of various lengths extending toward and being at least partially received in a recess of various depths in the plunger. The pusher is rigidly connected to a drive mechanism for anti-rotation. The pusher can have scalloped edges for air venting, and apertures for cooperating with protrusions on the drive mechanism to prevent bottoming out the plunger when filling.

Abstract: The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: A collapsible protective helmet (10) comprises an impact-resistant base body (11) intended to encircle the head of a wearer and an impact-resistant crown (12) coupled to the base body by coupling means to be movable between a protective position in which the crown is supported by the base body in an orientation in which the crown covers the top of the head of the wearer and a stored position inverted relative to the protective position in which the crown is supported by, but nested in, the base body. The helmet further comprises releasable locking means for locking the base body (11) and crown (12) together in each of the two positions of the crown.

Abstract: A delivery device for delivering medicament, such as insulin, to a patient includes a housing and a base enclosing an inner cavity. Enclosed within the housing is a reservoir for containing a medicament, a delivery mechanism for delivering the medicament to the patient, and a pump in fluid communication with the reservoir and delivery mechanism. The base has an integrally formed fluid channel covered by a flexible membrane in fluid communication with the reservoir and the delivery mechanism. A peristaltic pump mechanism includes a cam assembly having a plurality of cams and cam follower assembly with a plurality of protrusions to sequentially engaging the flexible membrane to advance the fluid through fluid channel.