Abstract: An apparatus and related methods for constructing articles with cured pressure-sensitive adhesives comprising (i) a coater that applies a curable adhesive to a membrane; (ii) a cross-linking apparatus adapted to receive said membrane with said curable adhesive, said cross-linking apparatus comprising a light source positioned a first predetermined height above an aperture plate having an aperture therethrough, wherein said aperture plate is positioned a second predetermined height, said first predetermined height and said second predetermined height selected to define an exposure area of light emitted from said light source on to said curable adhesive to form a composite product; and (iii) a roll adapted to receive said composite product, said roll adapted to control a speed at which said membrane with said curable adhesive is exposed to light from said light source.

Abstract: A modular animal pen system comprises front and rear panels and opposed side panels extending between the front and rear panels to form a primary enclosure. The front panel has adjacent doorway apertures formed therein to receive respective selectively closable gates, and a mullion is disposed between the doorway apertures. The mullion has a first slot, and a second slot in the rear panel is in registration with the first slot. The animal pen system further comprises a removable divider panel whose longitudinal ends are sized to fit removably within the respective slots so that the divider panel can divide the primary enclosure into two secondary enclosures. The side and divider panels may be formed by interchangeable profile panels, and the front and rear panels may be formed by interchangeable face panels connectable end-to-end to form a junction slot therebetween sized to receive the longitudinal ends of the profile panels.

Abstract: An electronic media platform and associated methods for navigating content from multiple users and for sharing information by a user in different forms, wherein the platform maybe used to select, filter, display, content from a plurality of sources and/or user and permit a user to navigate through the content in a logical and easy manner. A user interface includes an active area may be used to display content, summaries, links, navigation inputs, and other information to the user.

Abstract: Methods and systems for installing and verifying installation of a fastener assembly using predictive verification. A method includes receiving, at a processor, at least one fastener assembly hole characteristic of a fastener assembly hole. The method further includes determining, via the processor, whether the at least one fastener assembly hole characteristic is within a predetermined range of fastener assembly hole variable and, upon determining the at least one fastener assembly hole characteristic is within the predetermined range of fastener assembly hole variables, transmitting instructions, via the processor, to a fastening device to initiate installation of a fastener assembly in the fastener assembly hole. The processor then receives at least one installation value of the fastener assembly and determines via the processor, whether the installation value is within a predetermined range of fastener installation variables.

Abstract: Aspects of articulating devices and methods are disclosed. An exemplary articulating device may comprise an interior core with a reinforcing extending along a central axis, an exterior layer bonded to the interior core by an interface, and a lumen extending through the exterior layer, exterior of the reinforcing element, and parallel to the central axis. A steering wire may be moveable in the lumen to articulate a distal end of the device relative to the central axis in response to a force applied to the steering wire. Related methods of manufacturing an articulating device are also described.

Abstract: A device assembly having a syndicated data service interface that is communicatively coupled to a vendor-specific syndicated data application platform and having an installed vendor specific syndicated data application, with the interface receiving point-to-multipoint non-addressed transport bearer channels of different syndicated data channel transport networks initially only including the monitoring of the syndicated data channels and not decoding the syndicated data messages or syndicated data informational data contained therein, identifying from the transport bearer channels a received syndicated data channel having an syndicated data channel identifier of the specific syndicated data device, and reading the syndicated data messages within the received syndicated data channel and extracting the syndicated data supplier-independent informational data from the syndicated data message and providing the extracted syndicated data informational data to at least one of the installed vendor specific syndicated d

Abstract: An improved syndicated data system and method providing a plurality of intelligent devices with syndicated vendor-independent data from a syndication data server having informational data that is supplier-independent, formatting the received informational data into syndicated data messages, creating syndicated data channels, transmitting by broadcasting over a point-to-multipoint non-addressed transport bearer channel, with the devices monitoring the received point-to-multipoint non-addressed transport bearer channels of the different syndicated channel transport networks, identifying a received channel by comparing to the stored message or channel selection criteria to the received channel or IoT message contained therein, successful reading the syndicated data messages within the received syndicated channel, extracting the supplier-independent informational data from the syndicated data message and providing the extracted syndicated informational data to an installed vendor specific syndicated data applicat

Abstract: A method includes determining a first task requiring one of a plurality of machines to traverse along a first route and determining a second task requiring the one of the plurality of machines to traverse along a second route. The method also includes determining a first route score for the first route, the first route score being at least in part indicative of a difficulty of traversing along the first route, and determining a second route score for the second route, the second route score being at least in part indicative of a difficulty of traversing along the second route. The method may also include receiving sensor data generated by a sensor associated with a first machine of the plurality of machines and determining, based at least in part on the sensor data, an alertness metric associated with an operator of the first machine.

Abstract: The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Abstract: An enzymatic-based process of extracting value added products from oil seed and grain biomasses is described. The process comprises an alkaline pretreatment step followed by treatment with a proteolytic enzyme, and provides increased product yield and solubility. The products obtained can be soluble protein/peptide and purified dietary fiber. The use of such a process in the production of a food, drink, cosmetics, feed or feed additive product is also described.

Abstract: An improved Internet of Things (IoT) system and method providing a plurality of IoT devices with syndicated vendor-independent IoT data from a IoT syndication data server having informational data that is IoT supplier-independent, formatting the received IoT informational data into syndicated IoT data messages, creating syndicated IoT channels, transmitting by broadcasting over a point-to-multipoint non-addressed transport bearer channel, with the IoT devices monitoring the received point-to-multipoint non-addressed transport bearer channels of the different syndicated IoT channel transport networks, identifying a received IoT channel by comparing to the stored IoT message or channel selection criteria to the received IoT channel or IoT message contained therein, successful reading the IoT data messages within the received IoT channel, extracting the IoT supplier-independent informational data from the IoT data message and providing the extracted IoT informational data to an installed vendor specific IoT appl

Abstract: A modular animal pen system comprises front and rear panels and opposed side panels extending between the front and rear panels to form a primary enclosure. The front panel has adjacent doorway apertures formed therein to receive respective selectively closable gates, and a mullion is disposed between the doorway apertures. The mullion has a first slot, and a second slot in the rear panel is in registration with the first slot. The animal pen system further comprises a removable divider panel whose longitudinal ends are sized to fit removably within the respective slots so that the divider panel can divide the primary enclosure into two secondary enclosures. The side and divider panels may be formed by interchangeable profile panels, and the front and rear panels may be formed by interchangeable face panels connectable end-to-end to form a junction slot therebetween sized to receive the longitudinal ends of the profile panels.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel, trialkyl, cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses.

Abstract: The present invention provides compositions comprising mRNA molecules encapsulated within lipid particles. The lipid particles comprise a cationic lipid, a non-cationic lipid, and an mRNA molecule that is encapsulated within the lipid particle. The compositions are useful, for example, to introduce the mRNA molecules into a human subject where they are translated to produce a polypeptide that functions to ameliorate one or more symptoms of a disease. The invention also provides cationic lipids that are useful for preparing the compositions of the invention.

Abstract: An apparatus and related methods for constructing articles with cured pressure-sensitive adhesives comprising (i) a coater that applies a curable adhesive to a membrane; (ii) a cross-linking apparatus adapted to receive said membrane with said curable adhesive, said cross-linking apparatus comprising a light source positioned a first predetermined height above an aperture plate having an aperture therethrough, wherein said aperture plate is positioned a second predetermined height, said first predetermined height and said second predetermined height selected to define an exposure area of light emitted from said light source on to said curable adhesive to form a composite product; and (iii) a roll adapted to receive said composite product, said roll adapted to control a speed at which said membrane with said curable adhesive is exposed to light from said light source.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: Aspects of articulating devices and methods are disclosed. An exemplary articulating device may comprise an interior core with a reinforcing extending along a central axis, an exterior layer bonded to the interior core by an interface, and a lumen extending through the exterior layer, exterior of the reinforcing element, and parallel to the central axis. A steering wire may be moveable in the lumen to articulate a distal end of the device relative to the central axis in response to a force applied to the steering wire. Related methods of manufacturing an articulating device are also described.

Abstract: A modular animal pen system comprises front and rear panels and opposed side panels extending between the front and rear panels to form a primary enclosure. The front panel has adjacent doorway apertures formed therein to receive respective selectively closable gates, and a mullion is disposed between the doorway apertures. The mullion has a first slot, and a second slot in the rear panel is in registration with the first slot. The animal pen system further comprises a removable divider panel whose longitudinal ends are sized to fit removably within the respective slots so that the divider panel can divide the primary enclosure into two secondary enclosures. The side and divider panels may be formed by interchangeable profile panels, and the front and rear panels may be formed by interchangeable face panels connectable end-to-end to form a junction slot therebetween sized to receive the longitudinal ends of the profile panels.

Abstract: An exercise apparatus of the present technology may include a cylindrical shaped first frame member that defines a substantially cylindrical first frame portion. The cylindrical shaped first frame member/portion may have an exterior surface, an interior surface, a first radius between the interior surface and the center of the cylindrical shape, a second radius between the exterior surface and the center of the cylindrical shape, and a thickness as the difference between the first radius and the second radius. The exercise apparatus of the present technology that includes the cylindrical first frame member may include different sizes of frame members, for example cylindrical portions having a different length along the center axis of the cylinder, in order to achieve different weights for the exercise apparatus.