Abstract: This invention is directed to a medical device having an elongate shaft having a distal end and a controller coupled to the shaft. A control member can extend through at least part of the elongate shaft and at least part of the controller, wherein the control member in a tensioned configuration can be moveable by the controller to control the distal end of the shaft and the control member can be slack in an untensioned configuration. A tensioning mechanism can be configured to move relative to at least one of the elongate shaft and the controller to tension the control member and automatically lock the control member in the tensioned configuration.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: The present invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel cationic lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo. The compositions of the present invention are highly potent, thereby allowing effective knock-down of a specific target protein at relatively low doses. In addition, the compositions and methods of the present invention are less toxic and provide a greater therapeutic index compared to compositions and methods previously known in the art.

Abstract: A process for forming a construction composite, the process comprising (i) providing a construction article having an adhesive coating layer of a curable pressure-sensitive adhesive; and (ii) subjecting the curable pressure-sensitive adhesive to UV radiation, where the amount of UV radiation imparted to the upper surface of the adhesive coating layer is from about 75 to about 125 millijoule/cm2, and where at least 60% of the radiation rays contributing to this power have an intensity of at least 200 milliWatts/cm2.

Abstract: A fastener insertion system, for use with an assembly stack-up, includes a fastener and an end effector. The end effector includes a drill bit for drilling a hole through the stack-up, a probe for determining a stack-up parameter, and a fastener feed head for installing the fastener into the hole and applying rotational torque to complete fastener installation. The fastener insertion system also includes a processing device and an angle sensor communicatively coupled to the processing device and to the end effector. The processing device is programmed to measure, with the rotation angle sensor, the angular displacement required to complete fastener installation and to transmit a signal representative of the measured angular displacement from the angle sensor to the processing device. The processing device is also programmed to compare the measurement of angular displacement required to complete fastener installation to a range of angular displacement indicative of correct fastener installation.

Abstract: The invention relates to a compound comprising a mitochondrial targeting group linked to group capable of releasing hydrogen sulfide, or a pharmaceutically acceptable salt thereof, for use in the treatment of the human or animal body by surgery or therapy. The invention also relates to the use of the compound in the treatment of a plant, and to certain forms of the compound.

Abstract: A system for managing a plurality of machines is provided that includes a plurality of machines, each having a control module and a tire sensor associated with a tire on the machine. The tire sensor is configured to measure tire data including at least one of tire temperature and tire pressure. A worksite controller is in communication with each control module, and is configured to generate new travel paths for the machines and selectively communicate the new travel path to each control module. A central processor in communication with the worksite controller receives the tire data and uses it to determine a tire load for each tire, comparing the tire load against a tire rating and determining whether the tire rating will be exceeded. The worksite controller is further configured to alter the current assignment of at least one machine in response to the tire load.

Abstract: A drywall compound storage system includes a ladder that has a topmost step. A drywall hawk is provided and drywall compound is positioned thereon. A support is provided and the support is selectively positioned on the ladder. The drywall hawk is selectively positioned on the support such that the drywall hawk is retained in a horizontal orientation. In this way the support inhibit the drywall compound from sliding off of the drywall hawk when the drywall hawk is set on the support.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: A modular animal pen system comprises front and rear panels and opposed side panels extending between the front and rear panels to form a primary enclosure. The front panel has adjacent doorway apertures formed therein to receive respective selectively closable gates, and a mullion is disposed between the doorway apertures. The mullion has a first slot, and a second slot in the rear panel is in registration with the first slot. The animal pen system further comprises a removable divider panel whose longitudinal ends are sized to fit removably within the respective slots so that the divider panel can divide the primary enclosure into two secondary enclosures. The side and divider panels may be formed by interchangeable profile panels, and the front and rear panels may be formed by interchangeable face panels connectable end-to-end to form a junction slot therebetween sized to receive the longitudinal ends of the profile panels.

Abstract: Data points, calendar entries, trends, behavioral patterns may be used to predict and pre-emptively build digital and printable products with selected collections of images without the user's active participation. The collections are selected from files on the user's device, cloud-based photo library, or other libraries shared among other individuals and grouped into thematic products. Based on analysis of the user's collections and on-line behaviors, the system may estimate types and volumes of potential media-centric products, and the resources needed for producing and distributing such media-centric products for a projected period of time. A user interface may take the form of a “virtual curator”, which is a graphical or animated persona for augmenting and managing interactions between the user and the system managing the user's stored media assets. The virtual curator can assume one of many personas, as appropriate, with each user.

Abstract: Aspects of articulating devices and methods are disclosed. An exemplary articulating device may comprise an interior core with a reinforcing extending along a central axis, an exterior layer bonded to the interior core by an interface, and a lumen extending through the exterior layer, exterior of the reinforcing element, and parallel to the central axis. A steering wire may be moveable in the lumen to articulate a distal end of the device relative to the central axis in response to a force applied to the steering wire. Related methods of manufacturing an articulating device are also described.

Abstract: Release mechanism for medical device includes a bushing having a proximal end, a distal end and a channel extending therethrough. Plurality of extend proximally from the distal end are biased toward a release configuration in which engagement surfaces at distal ends thereof retract radially into the channel. A core pin insertable through the channel applies a radially expansive pressure to move the arms radially outward to a locking configuration. Engagement surfaces of the first and second arms connect to a retaining surface of a tissue treatment device containing capsule, which extends at an angle relative to the engagement surfaces selected so that a first portion of a force transmitted along an axis of the bushing moves the arms radially inward toward the release configuration before a second portion of the force exceeds a threshold level associated with the removal of a tissue treatment device from gripped tissue.

Abstract: A one-sided fastener assembly for use in coupling an assembly stack-up includes a sleeve comprising an outer cylindrical surface and an inner tapered surface oriented at a first angle with respect to the outer surface. The inner tapered defines an opening extending through the sleeve. The fastener assembly also includes a core extending along an axis and configured for insertion into the opening. The core includes an outer tapered surface oriented at a second angle with respect to the axis configured for engagement with the sleeve inner tapered surface such that insertion of the core into the sleeve causes radial expansion of the sleeve creating an interference fit with the assembly stack-up to complete installation of the one-sided fastener assembly.

Abstract: Release mechanism for medical device includes a bushing having a proximal end, a distal end and a channel extending therethrough. Plurality of extend proximally from the distal end are biased toward a release configuration in which engagement surfaces at distal ends thereof retract radially into the channel. A core pin insertable through the channel applies a radially expansive pressure to move the arms radially outward to a locking configuration. Engagement surfaces of the first and second arms connect to a retaining surface of a tissue treatment device containing capsule, which extends at an angle relative to the engagement surfaces selected so that a first portion of a force transmitted along an axis of the bushing moves the arms radially inward toward the release configuration before a second portion of the force exceeds a threshold level associated with the removal of a tissue treatment device from gripped tissue.

Abstract: The application discloses integrated air suspension and platform lifting systems that utilize an existing air supply for lifting one or more platforms installed in a trailer or hauling vehicle. An apparatus for lifting a rear gate or platform of a trailer or a hauling vehicle is disclosed that includes an actuating mechanism operable to pivot the platform between a lowered position (e.g., where the end of the platform is in contact with the ground) and a range of raised positions (e.g., where the platform is raised to meet an elevated platform such as a loading dock). The lifting mechanisms for raising and lowering the platform(s) may utilize a pressurized gas supply from a compressor. In some embodiments, the lifting mechanism may be supplied with pressurized air from a compressor of a brake system of a tractor. In some embodiments a separate locking mechanism is provided to hold the platform in place after the lifting system has moved it into a desired position.

Abstract: The preferred embodiment of the present invention provides a system and method for programming and/or charging one or more audio/video devices such that the audio/video devices will be programmed and charged to receive transmitted audio and video signals associated with an event, allowing a user to use the audio/video device to observe the sights and sounds of the event. A preferred embodiment of the present invention includes a cart with a docking port for each of a plurality of personal audio/video devices, a charger configured to charge the power source of each personal audio/video display device, and programming logic configured to program each of the personal audio/video devices.