Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.

Abstract: Methods and apparatus are provided controlling aircraft cabin pressure, and more specifically engine bleed air manifold pressure, during aircraft descent. An aircraft engine bleed air manifold control pressure setpoint is to either a descent pressure setpoint or a cruise pressure setpoint by determining a rotational speed of an aircraft engine component, determining a component speed setpoint value, and determining aircraft vertical speed. The engine bleed air manifold control pressure setpoint is set to the descent pressure setpoint if either the determined rotational speed of the aircraft engine component is below the component speed setpoint value or the aircraft vertical speed is less than a predetermined vertical speed value.

Abstract: The invention relates to an authentication and/or energy auditing system for a plug-in electric drive vehicle. A first device connects to a first power apparatus and establishes an electrical power path between the first and a remote device. The latter is connectable to a second power apparatus. The authentication system preferably includes a powerline transceiver to receive a request containing an identifier from the remote device over the power path. Control means controls operation of the first device and responds to the request to initiate an authentication process to determine whether or not the remote device is authentic and authorised to exchange power with the first device, and to activate a control switch to electrically connect the first device to the first power apparatus only upon an authentic and authorised determination.

Abstract: A system and method for updating a filtering system which controls access to a website/page between a local area network (LAN) and an Internet. The LAN includes an Internet gateway system coupled to a workstation and configured to receive a URL request. The system controls access to the website/page associated with the URL based on one or more categories that are associated with the URL. The Internet gateway system can determine the category that is associated with the URL by referencing a master database or requesting the category from a database factory. The database factory can receive URLs from multiple Internet gateway systems. The database factory determines whether the identifier was previously categorized by the database factory and provides the category to the Internet gateway system. Once the Internet gateway system has the category, it applies rules associated with the category and user to filter access to the requested website/page.

Abstract: An aspiration and resuscitation system which is useable to perform aspiration and/or resuscitation procedures on living beings, particularly small animals, and most particularly newborn small animals such as puppies and kittens. The system includes an aspirator and a resuscitator. Each includes a separable pump and animal interface mask. Further disclosed are aspiration and resuscitation methods using the disclosed apparatus.

Abstract: A modular display booth system is disclosed. The booth comprises walls, inserts, and toolless fasteners. The system is configured for efficient assembly and disassembly. The modular display booth system may be stored entirely on a single dolly for ease of transportation, coordination, and in warehouse alterations.

Abstract: Methods and apparatus may augment the utility of an electrically powered vehicle. A first electric motor (110a or 110b) may be provided with a first effective gear ratio, a second electric motor (111a or 111b) may be provided with a second effective gear ratio, and additional electric motors may be provided additional effective gear ratios. An electrically powered vehicle may be differentially powered by said electric motors at said different effective gear ratios. A transdisciplinary electrical diagnostic processor (440) may process electrically recondite operation parameters of one or more electrical components to provide transdisciplinary diagnostic output to a user. A standardized modular interface (540) supported on a trailer chassis (510) may be configured to accept multipurposed modular interchangeable trailer tops (560) at an interchange position (550) of said trailer chassis (510). A hand actuated accessory mount may be provided with a quick release interface (322).

Abstract: The present invention describes oral care compositions comprising certain surface-coated inorganic oxides and their use for treating dentine hypersensitivity.

Abstract: A continuous sheet having a combination of acidic and basic water-absorbing resin particles that are essentially not neutralized and can be continuously manufactured on conventional papermaking apparatus, using a wet, dry, or wet-dry process to manufacture a water-absorbent sheet-like substrate containing 50%-100% by weight of the combination of acidic and basic water-absorbent particles is disclosed.

Abstract: A method and a system perform geolocation activities relating to a network address. A database of network addresses, and associated geographic locations, is maintained. A query, including a network address, is received against the database for a geographic location associated with the network address. Information, concerning the query received against the database, is logged. Geolocation activities relating to at least the network address are modified based on the logged information.

Abstract: The present disclosure relates to a combination of therapeutic agents for use in treating a patient a subject suffering from cancer. In addition, the present disclosure also relates to diagnostic assays useful in classification of patients for treatment with one or more therapeutic agents.

Abstract: A credential communication device and method adapted to transmit and receive data, including means to process said data in order to effect credential verification and trusted mutual recognition between the device and a second credential communication device, without reference to a third party, further including at least one proximity conductor adapted to transfer at least some data only when in such physical proximity to a second credential communication device as to effectively exclude the possibility of third party involvement in the transaction.

Abstract: An integrated circuit interconnect is fabricated by using a mask to form a via in an insulating layer for a conductive plug. After the plug is formed in the via, a thin (e.g., <100 nm) isolation layer is deposited over the resulting structure. An opening is created in the isolation layer by using the same mask at a different radiation exposure level to make the opening more narrow than the underlying plug. A conductive line is then formed which makes electrical contact with the plug through the opening in the isolation layer. By vertically separating and electrically isolating the conductive plug from adjacent conductive lines, the isolation layer advantageously reduces the likelihood of an undesired electrical short occurring between the conductive plug and a nearby conductive line.

Abstract: The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the administration of the inhibitor treats the structural heart disease in the subject. Also provided are transgenic animal models for treating structural heart disease. Further provided is a means of screening for a compound that can treat structural heart disease.

Abstract: Methods and apparatus are provided controlling aircraft cabin pressure, and more specifically engine bleed air manifold pressure, during aircraft descent. An aircraft engine bleed air manifold control pressure setpoint is to either a descent pressure setpoint or a cruise pressure setpoint by determining a rotational speed of an aircraft engine component, determining a component speed setpoint value, and determining aircraft vertical speed. The engine bleed air manifold control pressure setpoint is set to the descent pressure setpoint if either the determined rotational speed of the aircraft engine component is below the component speed setpoint value or the aircraft vertical speed is less than a predetermined vertical speed value.

Abstract: Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.

Abstract: Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host cells, compositions, formulations, devices, transgenic animals, transgenic plants, and methods of making and using thereof. The antibodies of the invention bind human tissue factor and demonstrate enhanced ADCC activity. Accordingly, the antibodies can be used in a variety of methods for diagnosing, treating, and/or preventing diseases involving tissue factor, where enhanced ADCC activity is desirable such as cancer.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.