Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: An optical-signal receiver comprises an optical sensor operable to receive an optical signal from an optical-signal emitter communicatively coupled to an electronic system and a processor operable to implement a performance characteristic value specified by the optical signal.

Abstract: Display of message flow interactions corresponding to service invocations in a computing environment based on a service-oriented distributed computing model. Aggregations are created, where multiple instances of a particular deployed service operation may be represented by a single node (even though those instances may be hosted on different application servers). Links are depicted between the nodes, where the links represent call paths or invocations among the service operations. A user obtains a high-level, in-context view of the as-observed interactions among service operation instances, and may drill down for further details. A presentation to the user can be automatically scoped to the set of services which are observed as interacting (i.e., via their call relationships), so that the user can be shown that part of the environment that is immediately relevant to a context in which the user launches the view.

Abstract: A method, system, and computer program product for identifying the relationships between managed resources and displaying these relationships and resources in an interactive computerized system. A Relationships Display and Highlight (RDH) utility provides both an interactive view of a primary relationship via a topological graph and an interactive associated view to highlight the secondary relationships between a set of managed resources. The RDH utility links the graphical view to the associated view by displaying and/or highlighting the resources in the graphical view when secondary relationships are interactively explored in the associated view. When a secondary relationship is selected via the associated view, each resource which participates directly in the selected secondary relationship is highlighted, within the topological graph. When a resource is selected via the primary view, the RDH utility identifies a set of relationships in the associated view in which the resource participates.

Abstract: A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions.

Abstract: Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed.

Abstract: A reader for electro-optically reading two-dimensional symbols of different heights, includes a scanner for scanning the symbols with light in a raster scan pattern of an adjustable height, and for detecting light scattered from the symbols to generate electrical signals indicative of the detected light. A controller not only decodes the electrical signals to read the symbols, but also controls the scanner to adjust the height of the raster scan pattern, and optionally the rate of height adjustment, upon a determination that a symbol being scanned is a two-dimensional symbol, and that the two-dimensional symbol has not been read after a predetermined time period has elapsed. The controller can also be programmed to read symbols only of a certain height.

Abstract: The present invention provides a method for treating structural heart disease in a subject, comprising administering an effective amount of an inhibitor of CaMKII to the subject, whereby the administration of the inhibitor treats the structural heart disease in the subject. Also provided are transgenic animal models for treating structural heart disease. Further provided is a means of screening for a compound that can treat structural heart disease.

Abstract: A method and the system perform geolocation activities relating to a network address. A query, including a network address, is received from an external entity at a geolocation system. Responsive to receipt of the query, geolocation activities are initiated at the geolocation system to map the network address to a geographic location.

Abstract: An imaging apparatus including a photo sensor array having an array of sensors is disclosed, each sensor having an active area and a support hardware area adjoining the active area. In the prior art, the support hardware area of each sensor adjoins the active area of the sensor in the same direction. In the present invention, a sensor array has an array of sensors where, for each sensor, the support hardware area adjoins the active area of the sensor in a direction that is radially away from center of the sensor array whereby at least one freed area is defined within the sensor array. One or more reference detectors can be fabricated in the freed areas. This design allows the imaging apparatus to gather better image statistics, overcome shortcomings of the prior art design, or both.

Abstract: A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions.

Abstract: A pharmaceutical composition includes, as an active ingredient, a compound according to formula 1436 as shown in FIG. 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient. Various pharmaceutical products may be produced including this pharmaceutical composition. Such pharmaceutical products may be used for the treatment of obesity or diabetes. Methods for using the pharmaceutical compositions also are described. In these methods, various diseases are treated or other body functions are activated or inhibited by administering an effective amount of the pharmaceutical composition. For example, diabetes and obesity may be treated by administering an effective amount of the pharmaceutical compositions. Weight gain, and growth factor production can be inhibited by administering an effective amount of these pharmaceutical compositions.

Abstract: A method for providing a graphical user interface (GUI), where the GUI allows a user to look ahead to object relationships at the additional navigational layers in a taxonomy, without navigating to other layers in the taxonomy, wherein the method includes: selecting an object on a display screen to view the objects context at another layer in the taxonomy; providing the user with a pop-up taxonomy menu; selecting from the pop-up taxonomy menu a layer within the taxonomy to see the selected object's context in relation to additional objects of the taxonomy; providing the user a window display in the area of the selected object; wherein the window displays the current object selected in relationship and in context to the additional objects at the selected layer in the taxonomy; and does not obscure or replace an original view or the selected object.

Abstract: A document product includes a web having a transverse splice therein. A mask is formed near the splice and is subsequently used for automatically rejecting a spliced document.

Abstract: A closed loop compensation system including a deformable mirror including an array of spaced actuators. An array of spaced sensors is mapped in optical space to reside between pairs of actuators. A lens system receives a wavefront from the deformable mirror and focuses sub-apertures of the wavefront onto individual ones of the spaced sensors. A sequencer addresses each actuator and associated sensor in the arrays. A compute unit is configured to respond to the sequencer to set a first actuator to an adjusted stroke position and then adjust the stroke of subsequent actuators to locate, to a pre-established position, the focused sub-aperture on a sensor in the pathway between each particular subsequent actuator and a neighboring previously adjusted portion of the mirror to compensate for sub-aperture tilt while maintaining relative phase between sub-apertures.

Abstract: An integrated circuit interconnect is fabricated by using a mask to form a via in an insulating layer for a conductive plug. After the plug is formed in the via, a thin (e.g., <100 nm) isolation layer is deposited over the resulting structure. An opening is created in the isolation layer by using the same mask at a different radiation exposure level to make the opening more narrow than the underlying plug. A conductive line is then formed which makes electrical contact with the plug through the opening in the isolation layer. By vertically separating and electrically isolating the conductive plug from adjacent conductive lines, the isolation layer advantageously reduces the likelihood of an undesired electrical short occurring between the conductive plug and a nearby conductive line.

Abstract: Compositions and methods for treatment of acute herpetic zoster and post herpetic neuralgia. The compositions comprise the combination of five or six components, namely, a carrier penetrator, an anti-inflammatory agent, a topical analgesic, a nonsteroidal anti-inflammatory penetrator, a direct-application anti-viral agent, and, optionally, an anti-convulsant and calcium-channel blocker. The compositions are formulated to be applied topically to the affected areas.

Abstract: Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to the use of these compounds in treating brain cancer.

Abstract: Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Abstract: A paint can holder has a paint can support and a rod-like projection projecting from the support away from any paint can supported by the paint can support. The rod-like projection has a free end remote from the support. The rod-like projection is configured such that the rod-like projection may be inserted into a rung of a ladder to support the paint can from the ladder.