Patents by Inventor Mark Brown

Mark Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis
    Publication number: 20150034813
    Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
    Type: Application
    Filed: November 16, 2011
    Publication date: February 5, 2015
    Inventors: Jeffery Mark Brown, Steven Derek Pringle, Keith Richardson
  • Mass spectrometer with beam expander
    Patent number: 8916820
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: December 23, 2014
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Mass Spectrometer With Beam Expander
    Publication number: 20140346342
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
    Type: Application
    Filed: August 11, 2014
    Publication date: November 27, 2014
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Mass spectrometer with beam expander
    Patent number: 8895920
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: November 25, 2014
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Mass Spectrometer
    Publication number: 20140322817
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Inventors: Martin Raymond Green, Jason Lee Wildgoose, Jeffery Mark Brown
  • Wheel spindle drive element
    Patent number: 8869962
    Abstract: A wheel spindle drive element for a wheel disconnect system. The wheel spindle assembling onto an outer diameter of a spindle, displacing material to form a joint with high torque transmission characteristics.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: October 28, 2014
    Assignee: Schaeffler Technologies AG & Co. KG
    Inventor: Mark Brown
  • Multi Inlet For Solvent Assisted Inlet Ionisation
    Publication number: 20140291507
    Abstract: A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionisation (“SAII”) interface.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 2, 2014
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Jason Lee Wildgoose
  • Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer
    Publication number: 20140291501
    Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
    Type: Application
    Filed: July 6, 2012
    Publication date: October 2, 2014
    Applicant: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Kevin Giles, Daniel James Kenny, Paul Murray, Keith Richardson
  • Mass Spectrometers Comprising Accelerator Devices
    Publication number: 20140284471
    Abstract: A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device. The potential at which a first length of the flight region is maintained is then changed from a first potential to a second potential whilst at least some ions are travelling within the first length of flight region. The changed potential provides a first potential difference at an exit of the length of flight region, through which the ions are accelerated as they leave the length of flight region. This increases the kinetic energy of the ions prior to them reaching the detector or fragmentation cell.
    Type: Application
    Filed: November 5, 2012
    Publication date: September 25, 2014
    Inventors: Jeffery Mark Brown, Martin Raymond Green, David J. Langridge
  • Time of flight mass spectrometer with analog to digital converter and method of using
    Patent number: 8809767
    Abstract: A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: August 19, 2014
    Assignee: Micromass UK Limited
    Inventors: Robert Harold Bateman, Jeffery Mark Brown, Martin Green, Jason Lee Wildgoose, Anthony James Gilbert, Steven Derek Pringle
  • Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer
    Publication number: 20140224974
    Abstract: A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 14, 2014
    Applicant: MICROMASS UK LIMITED
    Inventors: Daniel James Kenny, Paul Murray, Keith Richardson, Kevin Giles, Jeffery Mark Brown
  • Mass spectrometer
    Patent number: 8779354
    Abstract: A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: July 15, 2014
    Assignee: Micromass UK Limited
    Inventors: Martin Green, Jason Lee Wildgoose, Jeffrey Mark Brown
  • Ion Guide Coupled to MALDI Ion Source
    Publication number: 20140191123
    Abstract: A pulsed ion source is disclosed wherein the ion source is energised one or more times to generate a first group of ions and a second group of ions. The first and second groups of ions are simultaneously transmitted through an ion guide whilst keeping the first and second groups of ions isolated from each other.
    Type: Application
    Filed: July 6, 2012
    Publication date: July 10, 2014
    Applicant: MICROMASS UK LIMITED
    Inventors: Jason Lee Wildgoose, Steven Derek Pringle, Kevil Giles, Jeffery Mark Brown, Paul Murray, Daniel James Kenny
  • Mass Spectrometer With Beam Expander
    Publication number: 20140124660
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyser. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyser.
    Type: Application
    Filed: October 24, 2013
    Publication date: May 8, 2014
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • COMPOSITIONS AND METHODS FOR CAPTURE AND ELUTION OF BIOLOGICAL MATERIALS VIA PARTICULATES
    Publication number: 20140127773
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Application
    Filed: January 14, 2014
    Publication date: May 8, 2014
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn
  • Method of Charge Reduction of Electron Transfer Dissociation Product Ions
    Publication number: 20140110576
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Application
    Filed: December 31, 2013
    Publication date: April 24, 2014
    Applicant: Micromass UK Limited
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • METHODS FOR THE ANALYSIS OF GLYCOPROTEINS OR GLYCOPEPTIDES BY MASS SPECTROMETRY
    Publication number: 20140099725
    Abstract: A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing said chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptide ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction data mass spectral data to provide structural information relating to the glycopeptide.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 10, 2014
    Applicant: MICROMASS UK LIMITED
    Inventors: Jonathan P. Williams, Jeffery Mark Brown
  • Stabilizer bar
    Patent number: 8690175
    Abstract: A disconnectible stabilizer bar assembly for a vehicle having first and second stabilizer bar halves, a housing fixed to an end portion of each stabilizer bar half, so as to align the two halves. The housing containing a stator with magnetic coil, a rotor with exterior magnets and threaded onto a hollow screw, with the stator selectively rotating the rotor and the rotation translated into axial movement of the screw. The screw having meshing means on an interior surface and an end face, the interior meshing means meshed with an exterior meshing means on one of the stabilizer bar halves, and the end face meshing means selectively coupled and decoupled with aligned mashing means on the other of the stabilizer bar halves.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: April 8, 2014
    Assignee: Schaeffler Technologies AG & Co. KG
    Inventor: Mark Brown
  • SWIRL INTERRUPTION SEAL TEETH FOR SEAL ASSEMBLY
    Publication number: 20140072415
    Abstract: A seal assembly for sealing between a rotating component and a stationary component in a turbomachine. The seal assembly includes a plurality of radially inwardly projecting, axially spaced teeth extending from the stationary component, wherein at least one of the plurality of teeth has at least one axially extending hole therethrough. Axial flow of an operating fluid through the holes acts as an air-curtain to interrupt swirl flow in a seal cavity, therefore reducing steam force that could act to destabilize rotordynamics.
    Type: Application
    Filed: September 11, 2012
    Publication date: March 13, 2014
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Xiaoqing Zheng, Daniel Mark Brown, Jason Winfred Jewett, Fred Thomas Willett, JR.
  • Compositions and methods for capture and elution of biological materials via particulates
    Patent number: 8663974
    Abstract: Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological material. Lysing material may include beads or other material which may be coated that facilitates binding. The medium may include a fluid with a high salt or low pH level. Binding of biological materials to solid surfaces may be induced by particular media. The biological material may be eluted by lowering a concentration of salt or increasing a pH level. Lysing materials with two or more different affinities may be employed. Lysing materials may include particles of different sizes. Heating may be used. Lysing may be performed in a flow through apparatus. Surfaces of solid materials may be modified to capture bacteria with high cell wall lipid content.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: March 4, 2014
    Assignee: Claremont BioSolutions LLC
    Inventors: Mark Brown, Robert Doebler, Bruce Irvine, Tanya Ferguson, Gary Blackburn