Abstract: An apparatus, method, and computer-readable medium, the apparatus including processing circuitry configured to determine a first validation based on a first activity performed at a first location, which is determined based on a sensor of an external device, determine a second validation based on a second activity performed at a second location, which is determined based on the sensor of the external device, the second location being different from the first location, compute a total validation by aggregating the first validation and the second validation, calculate a total measure by adjusting an initial measure by the total validation, the initial measure corresponding to an amount that fluctuates based on predetermined conditions associated with a time of day and total amount of time spent at a geographical location that includes the first location and the second location, and transmit, via a network, the calculated total measure to the external device.

Abstract: A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location.

Abstract: A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are analysed and a second mode in which parent ions are fragmented and their fragment ions are mass analysed. In the first mode the parent ions are charge reduced before being analysed, so as to simplify the parent ion spectral data obtained. In the second mode, the parent ions are not charge reduced prior to fragmentation, so that it remains relatively easy to induce the parent ions to fragment. The parent ions are then associated with their fragment ions using the mass spectral data obtained.

Abstract: A method of mass spectrometry is disclosed comprising alternating between a first mode in which parent ions are mass analyzed and a second mode in which the parent ions are subjected to Electron Capture Dissociation (“ECD”) at atmospheric pressure so as to produce fragment ions which are then mass analyzed. The parent ions are associated with their fragment ions based on the times at which they were detected. This method enables parent ions to be associated with their fragment ions, even when the ECD fragmentation is performed at atmospheric pressure.

Abstract: A method of mass spectrometry is disclosed having a mode comprising: providing a source of precursor ions and reagent ions for reacting with said precursor ions; providing a reaction region downstream of said source; providing an ion mobility separator between said source and said reaction region; providing a bypass cell between said source and said reaction region for guiding ions from said source to said reaction region without the ions passing through said ion mobility separator; guiding said precursor ions from said source, through said ion mobility separator so that said precursor ions separate according to their ion mobility and into said reaction region; and guiding said reagent ions from said source, through said bypass cell and into said reaction region; wherein the reagent ions react with the precursor ions within the reaction region to produce product ions.

Abstract: A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device. The potential at which a first length of the flight region is maintained is then changed from a first potential to a second potential while at least some ions are travelling within the first length of flight region. The changed potential provides a first potential difference at an exit of the length of flight region, through which the ions are accelerated as they leave the length of flight region. This increases the kinetic energy of the ions prior to them reaching the detector or fragmentation cell.

Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ?300 mm. The laser beam is directed onto the target substrate at an angle ? with respect to the perpendicular to the target substrate, wherein ??3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

Abstract: A method includes receiving, by a system on a chip (SoC) from a logically centralized controller, configuration information and reading, from a semantics aware storage module of the SoC, a data block in accordance with the configuration information. The method also includes performing scheduling to produce a schedule in accordance with the configuration information and writing the data block to an input data queue in accordance with the schedule to produce a stored data block. Additionally, the method includes writing a tag to an input tag queue to produce a stored tag, where the tag corresponds to the data block.

Abstract: A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analyzing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analyzing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analyzing the third ions.

Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length?300 mm. The laser beam is directed onto the target substrate at an angle ? with respect to the perpendicular to the target substrate, wherein ??3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

Abstract: A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.

Abstract: A mass spectrometer is disclosed comprising a cooling cell for cooling ions so as to reduce their kinetic energy. The cooling cell comprises: a chamber for receiving the ions or for generating the ions therein, wherein said chamber is formed from walls defining a substantially enclosed region; and a cooling jacket surrounding said chamber, wherein said cooling jacket is arranged and configured to contain a cooling fluid and so as to remove heat from one or more walls of the chamber. The mass spectrometer further comprises a mass analyzer for receiving ions from the cooling cell after they have been cooled. The present invention reduced the kinetic energy of the ions prior to mass analysis and hence improves the resolution of the mass analyzer. The mass analyzer is preferably a time of flight mass analyzer.

Abstract: A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location.

Abstract: A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing the chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptides ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction mass spectral data to provide structural information relating to the glycopeptide.

Abstract: A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionisation (“SAII”) interface.

Abstract: A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein said survey scan comprises analysing the ion mobilities of the ions and mass analysing the ions; determining the charge states of parent or precursor ions analysed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting said selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.

Abstract: A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionisation device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionisation device. A second portion of the sample is then analysed using the one or more optimum or preferred parameters.

Abstract: A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.

Abstract: A seal assembly for sealing between a rotating component and a stationary component in a turbomachine. The seal assembly includes a plurality of radially inwardly projecting, axially spaced teeth extending from the stationary component, wherein at least one of the plurality of teeth has at least one axially extending hole therethrough. Axial flow of an operating fluid through the holes acts as an air-curtain to interrupt swirl flow in a seal cavity, therefore reducing steam force that could act to destabilize rotordynamics.

Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.