Patents by Inventor Mark Brown

Mark Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Auxiliary gas inlet
    Patent number: 9881779
    Abstract: There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a continuous ionisation source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: January 30, 2018
    Assignee: MICROMASS UK LIMITED
    Inventor: Jeffery Mark Brown
  • Monitoring liquid chromatography elution to determine when to perform a lockmass calibration
    Patent number: 9881776
    Abstract: A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time T during the single experimental run or acquisition for calibrating the mass spectrometer. The step of determining the first time T further comprises determining a time when the mass spectral data being acquired during the single experimental run or acquisition is equal to or below a threshold. The mass spectrometer is then calibrated by introducing calibrant or lockmass ions at the first time T.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: January 30, 2018
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Paul Murray
  • Hybrid acquisition method incorporating multiple dissociation techniques
    Patent number: 9881778
    Abstract: A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragmentation or reaction. This enables a full un-biased MS/MS data set to be provided over a wide mass to charge ratio range with high-duty cycle, together with complementary detailed fragment data of interest, in a single experimental run or acquisition.
    Type: Grant
    Filed: April 17, 2015
    Date of Patent: January 30, 2018
    Assignee: MICROMASS UK LIMITED
    Inventor: Jeffery Mark Brown
  • METHODS AND COMPOSITIONS FOR UPREGULATING ENDOGENOUS ANTIOXIDANT SYSTEMS
    Publication number: 20180015070
    Abstract: A nutritional supplement for reducing free radical damage is disclosed. The nutritional supplement includes a first vehicle comprising an upregulating compound mixture configured to upregulate an endogenous antioxidant system and an exogenous antioxidant mixture and a second vehicle comprising a mineral mixture. The upregulating compound mixture is configured to upregulate an endogenous antioxidant system to protect against free radical damage. The upregulating compound mixture includes alpha lipoic acid, resveratrol, curcumin, EGCG, Olivol®, rutin, quercetin, and hesperetin. The endogenous antioxidant system includes transcription factors such as Nrf2, NF-?B, PPAR?, PPAR?/?, and PPAR? that promote transcription of antioxidant genes.
    Type: Application
    Filed: July 6, 2017
    Publication date: January 18, 2018
    Inventors: Mark Brown, John Cuomo, Jeremy Tian
  • Method of Charge Reduction of Electron Transfer Dissociation Product Ions
    Publication number: 20180012743
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Application
    Filed: September 11, 2017
    Publication date: January 11, 2018
    Inventors: Weibin CHEN, Asish B. CHAKRABORTY, John Charles GEBLER, Jeffery Mark BROWN
  • METHODS AND COMPOSITIONS FOR SUPPORTING ENDOGENOUS SYSTEMS RELATED TO LIFE SPAN
    Publication number: 20180007945
    Abstract: A composition for supporting endogenous systems related to life span, inhibiting mTOR, and reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes regulation of mitophagy through mTOR mediated regulation, and a Nrf2 transcription factors that promotes transcription of antioxidant genes.
    Type: Application
    Filed: July 6, 2017
    Publication date: January 11, 2018
    Inventors: Mark Brown, John Cuomo, Jeremy Tian
  • METHODS AND COMPOSITIONS FOR REDUCING DAMAGE ASSOCIATED WITH OXIDATIVE PHOSPHORYLATION
    Publication number: 20180008573
    Abstract: A composition for reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes a Nrf2 transcription factors that promotes transcription of antioxidant genes.
    Type: Application
    Filed: July 6, 2017
    Publication date: January 11, 2018
    Inventors: Mark Brown, John Cuomo, Jeremy Tian
  • Mass Spectrometry for Determining if a Mutated Variant of a Target Protein is Present in a Sample
    Publication number: 20170292960
    Abstract: A method of mass spectrometry is disclosed for determining if a mutated variant of a target protein is present in a sample. The method comprises subjecting the sample to fragmentation so as to cause said target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. The method determines if a mutated variant is present in the sample by determining that an ion in the spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if said target protein was a normal unmutated version of said target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of said target protein. This method of analysing second generation fragment ions if a rapid and efficiency method of analysing a sample.
    Type: Application
    Filed: October 1, 2015
    Publication date: October 12, 2017
    Inventors: Jeffery Mark BROWN, Michael Raymond MORRIS, Jonathan WILLIAMS, Brian GREEN
  • Scalable Autonomic Message-Transport with Synchronization
    Publication number: 20170293512
    Abstract: Methods and apparatus for inter-process communication are provided. A circuit may have a plurality of clusters, and at least one cluster may have a computation element (CE), a memory operatively coupled with the CE, and an autonomic transport system (ATS) block operatively coupled with the CE and the memory. The ATS block may be configured to perform inter-process communication (IPC) for the at least one cluster. In one embodiment, the ATS block may transfer a message to a different cluster based on a request from the CE. In another embodiment, the ATS block may receive a message by allocating a buffer in the memory and write the message into the buffer. The ATS block may also be configured to manage synchronization and schedule tasks for the CE.
    Type: Application
    Filed: April 12, 2016
    Publication date: October 12, 2017
    Inventors: Peter Yan, Alan Gatherer, Alex Elisa Chandra, Lee Dobson Mcfearin, Mark Brown, Debashis Bhattacharya, Fang Yu, Xingfeng Chen, Yan Bei, Ke Ning, Chushun Huang, Tong Sun, Xiaotao Chen
  • Method of charge reduction of electron transfer dissociation product ions
    Patent number: 9761425
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: September 12, 2017
    Assignee: Micromass UK Limited
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Multi inlet for solvent assisted inlet ionisation
    Patent number: 9761428
    Abstract: A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionization (“SAII”) interface.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: September 12, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Jason Lee Wildgoose
  • Method of Introducing Ions into a Vacuum Region of a Mass Spectrometer
    Publication number: 20170221690
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric pressure region and a sub-atmospheric pressure region of the spectrometer, wherein the sub-atmospheric pressure region comprises an ion guide or ion trap; providing a sample probe comprising a needle assembly on which a sample is deposited or that is supplied with a sample; inserting the needle assembly through the orifice and into the sub-atmospheric pressure region so that the sample is arranged within or adjacent to the ion guide or ion trap in the sub-atmospheric pressure region; and then desorbing the sample from the needle assembly within the sub-atmospheric pressure region and/or ionising the sample within the sub-atmospheric pressure region so as to generate ions that enter the ion guide or ion trap.
    Type: Application
    Filed: August 5, 2015
    Publication date: August 3, 2017
    Inventors: Jeffery Mark BROWN, Martin Raymond GREEN
  • Charging plate for enhancing multiply charged ions by laser desorption
    Patent number: 9721775
    Abstract: A sample plate for an ion source is disclosed comprising a plurality of ionization regions, each ionization region comprising a first electrode and a second separate electrode separated by an insulator.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: August 1, 2017
    Assignee: Micromass UK Limited
    Inventor: Jeffery Mark Brown
  • DDA experiment with reduced data processing
    Patent number: 9697996
    Abstract: A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein the survey scan comprises analyzing the ion mobilities of the ions and mass analyzing the ions; determining the charge states of parent or precursor ions analyzed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting the selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: July 4, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Kevin Giles, Martin Raymond Green, John Brian Hoyes, Christopher Jones, Michael Raymond Morris, Steven Derek Pringle, Keith Richardson, Farnoush Salarzaei, Jason Lee Wildgoose
  • Monitoring Liquid Chromatography Elution to Determine When to Perform a Lockmass Calibration
    Publication number: 20170186594
    Abstract: A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time T during the single experimental run or acquisition for calibrating the mass spectrometer. The step of determining the first time T further comprises determining a time when the mass spectral data being acquired during the single experimental run or acquisition is equal to or below a threshold. The mass spectrometer is then calibrated by introducing calibrant or lockmass ions at the first time T.
    Type: Application
    Filed: May 29, 2015
    Publication date: June 29, 2017
    Inventors: Jeffery Mark BROWN, Paul MURRAY
  • SPACE AND TIME AWARE ORGANIZATION AND ISOLATION OF COMPONENTS IN REAL TIME SYSTEMS
    Publication number: 20170168792
    Abstract: A method includes obtaining, by a first processor, a first software architecture description file and obtaining, by the first processor, a platform independent model file. The method also includes obtaining, by the first processor, a platform architecture definition file and performing, by the first processor, a first source-to-source compilation in accordance with the first software architecture description file, the platform independent model file, and the platform architecture definition file, to produce generated interface code. Additionally, the method includes generating, by the first processor, run time code, in accordance with the generated interface code and running, by a second processor in real time, the run time code.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 15, 2017
    Inventors: Debashis Bhattacharya, Alan Gatherer, Mark Brown, Lee Dobson McFearin, Alex Elisa Chandra, Ashish Rai Shrivastava
  • System and Method for Data Warehouse Engine
    Publication number: 20170169034
    Abstract: A data warehouse engine (DWE) includes a central processing unit (CPU) core and a first data organization unit (DOU), where the first DOU is configured to aggregate read operations. The DWE also includes a first command queue coupled between the CPU core and the first DOU, where the first command queue is configured to convey commands from the CPU core to the first DOU.
    Type: Application
    Filed: November 30, 2016
    Publication date: June 15, 2017
    Inventors: Ashish Rai Shrivastava, Alex Elisa Chandra, Mark Brown, Debashis Bhattacharya, Alan Gatherer
  • Automated tuning for MALDI ion imaging
    Patent number: 9673029
    Abstract: A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionization device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionization device. A second portion of the sample is then analyzed using the one or more optimum or preferred parameters.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 6, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Paul Murray
  • Conversion of ion arrival times or ion intensities into multiple intensities or arrival times in a mass spectrometer
    Patent number: 9673031
    Abstract: A mass spectrometer is disclosed comprising a Time of Flight mass analyzer comprising an ion detector comprising an Analog to Digital Converter. Signals from the Analog to Digital Converter are digitized and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighboring time bins T(n), T(n+1).
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: June 6, 2017
    Assignee: Micromass UK Limited
    Inventors: Robert Harold Bateman, Jeffery Mark Brown, Martin Green, Jason Lee Wildgoose, Anthony James Gilbert, Steven Derek Pringle
  • Photo-Dissociation of Proteins and Peptides in a Mass Spectrometer
    Publication number: 20170140910
    Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
    Type: Application
    Filed: November 28, 2016
    Publication date: May 18, 2017
    Inventors: Jeffery Mark BROWN, Kevin GILES, Daniel James KENNY, Paul MURRAY, Keith RICHARDSON