Patents by Inventor Mark Browne

Mark Browne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9318309
    Abstract: A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device. The potential at which a first length of the flight region is maintained is then changed from a first potential to a second potential while at least some ions are travelling within the first length of flight region. The changed potential provides a first potential difference at an exit of the length of flight region, through which the ions are accelerated as they leave the length of flight region. This increases the kinetic energy of the ions prior to them reaching the detector or fragmentation cell.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: April 19, 2016
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, David J. Langridge
  • Patent number: 9318308
    Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ?300 mm. The laser beam is directed onto the target substrate at an angle ? with respect to the perpendicular to the target substrate, wherein ??3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: April 19, 2016
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Paul Murray, Daniel James Kenny
  • Publication number: 20160103707
    Abstract: A method includes receiving, by a system on a chip (SoC) from a logically centralized controller, configuration information and reading, from a semantics aware storage module of the SoC, a data block in accordance with the configuration information. The method also includes performing scheduling to produce a schedule in accordance with the configuration information and writing the data block to an input data queue in accordance with the schedule to produce a stored data block. Additionally, the method includes writing a tag to an input tag queue to produce a stored tag, where the tag corresponds to the data block.
    Type: Application
    Filed: October 7, 2015
    Publication date: April 14, 2016
    Inventors: Debashis Bhattacharya, Alan Gatherer, Ashish Rai Shrivastava, Mark Brown, Zhenguo Gu, Qiang Wang, Alex Elisa Chandra
  • Patent number: 9293314
    Abstract: A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analyzing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analyzing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analyzing the third ions.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: March 22, 2016
    Assignee: Micromass UK Limited
    Inventors: Daniel James Kenny, Paul Murray, Keith Richardson, Kevin Giles, Jeffery Mark Brown
  • Publication number: 20160071716
    Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length?300 mm. The laser beam is directed onto the target substrate at an angle ? with respect to the perpendicular to the target substrate, wherein ??3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Inventors: Jeffery Mark Brown, Paul Murray, Daniel James Kenny
  • Patent number: 9281171
    Abstract: A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyzer arranged upstream of an ion guide. Ions are scanned out of the mass selective ion trap or mass analyzer and are received in one or more axial potential wells created or formed within the ion guide. One or more transient DC voltages or potentials are preferably applied to the ion guide in order to create a plurality of axial potential wells which are translated along the length of the ion guide. Ions are released in packets from the exit of the ion guide and are orthogonally acceleration into a drift or flight region of an orthogonal acceleration Time of Flight mass analyzer with a relatively high duty cycle.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: March 8, 2016
    Assignee: Micromass UK Limited
    Inventors: Robert Harold Bateman, Kevin Giles, Jeffery Mark Brown, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 9269554
    Abstract: A mass spectrometer is disclosed comprising a cooling cell for cooling ions so as to reduce their kinetic energy. The cooling cell comprises: a chamber for receiving the ions or for generating the ions therein, wherein said chamber is formed from walls defining a substantially enclosed region; and a cooling jacket surrounding said chamber, wherein said cooling jacket is arranged and configured to contain a cooling fluid and so as to remove heat from one or more walls of the chamber. The mass spectrometer further comprises a mass analyzer for receiving ions from the cooling cell after they have been cooled. The present invention reduced the kinetic energy of the ions prior to mass analysis and hence improves the resolution of the mass analyzer. The mass analyzer is preferably a time of flight mass analyzer.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: February 23, 2016
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Jason Lee Wildgoose
  • Publication number: 20160049282
    Abstract: A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 18, 2016
    Inventors: Jeffery Mark BROWN, Richard CHAPMAN, Paul MURRAY, Keith RICHARDSON, Emmy Maria HOYES
  • Patent number: 9255906
    Abstract: A method for the analysis of samples including one or more glycopeptides including the steps of separating one or more glycopeptides using a chromatography system to produce a chromatographic eluent, adding a supercharging reagent to the chromatographic eluent, providing the chromatographic eluent and supercharging reagent to a mass spectrometer, ionizing the chromatographic eluent and supercharging reagent in an ion source to produce glycopeptide ions, performing at least one ion ion reaction on at least some of the glycopeptides ions to produce fragment ions, mass analyzing the fragment ions to produce ion ion reaction mass spectral data, and interpreting the ion ion reaction mass spectral data to provide structural information relating to the glycopeptide.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: February 9, 2016
    Assignee: Micromass UK Limited
    Inventors: Jonathan P. Williams, Jeffery Mark Brown
  • Publication number: 20160035557
    Abstract: A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionisation (“SAII”) interface.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 4, 2016
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Jason Lee Wildgoose
  • Publication number: 20160035548
    Abstract: A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein said survey scan comprises analysing the ion mobilities of the ions and mass analysing the ions; determining the charge states of parent or precursor ions analysed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting said selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
    Type: Application
    Filed: March 10, 2014
    Publication date: February 4, 2016
    Inventors: Jeffery Mark Brown, Kevin Giles, Martin Raymond Green, John Brian Hoyes, Christopher Jones, Michael Raymond Morris, Steven Derek Pringle, Keith Richardson, Farnoush Salarzaei, Jason Lee Wildgoose
  • Publication number: 20160027625
    Abstract: A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionisation device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionisation device. A second portion of the sample is then analysed using the one or more optimum or preferred parameters.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Jeffery Mark BROWN, Paul MURRAY
  • Publication number: 20160024954
    Abstract: A seal assembly for sealing between a rotating component and a stationary component in a turbomachine. The seal assembly includes a plurality of radially inwardly projecting, axially spaced teeth extending from the stationary component, wherein at least one of the plurality of teeth has at least one axially extending hole therethrough. Axial flow of an operating fluid through the holes acts as an air-curtain to interrupt swirl flow in a seal cavity, therefore reducing steam force that could act to destabilize rotordynamics.
    Type: Application
    Filed: October 6, 2015
    Publication date: January 28, 2016
    Inventors: Xiaoqing Zheng, Daniel Mark Brown, Jason Winfred Jewett, Fred Thomas Willett, JR.
  • Publication number: 20160027626
    Abstract: A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Richard Chapman, Jeffery Mark Brown, Paul Murray, Keith Richardson, Emmy Maria Hoyes
  • Patent number: 9245728
    Abstract: A mass spectrometer is disclosed comprising a RF confinement device, a beam expander and a Time of Flight mass analyzer. The beam expander is arranged to expand an ion beam emerging from the RF confinement device so that the ion beam is expanded to a diameter of at least 3 mm in the orthogonal acceleration extraction region of the Time of Flight mass analyzer.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: January 26, 2016
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Anthony James Gilbert, John Brian Hoyes, David J. Langridge, Jason Lee Wildgoose
  • Publication number: 20160020079
    Abstract: A sample plate 1 for an ion source is disclosed comprising a plurality of ionisation regions, each ionisation region comprising a first electrode 4 and a second separate electrode 4 separated by an insulator 4a.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 21, 2016
    Inventor: Jeffery Mark Brown
  • Publication number: 20160013039
    Abstract: A Time of Flight mass analyser is disclosed comprising one or more acceleration electrodes and a first device arranged and adapted to apply a DC voltage pulse to the one or more acceleration electrodes. The DC voltage pulse causes ions to be accelerated into a time of flight or drift region and the DC voltage pulse is applied, in use, to the one or more acceleration electrodes between a time T1 and a time T2. A second device is arranged and adapted to apply a single phase oscillating voltage to the one or more acceleration electrodes, wherein the single phase oscillating voltage undergoes multiple oscillations between the time T1 and the time T2. The application of the DC voltage pulse and the single phase oscillating voltage to the one or more acceleration electrodes establishes an homogeneous electric field having a net force towards the time of flight or drift region.
    Type: Application
    Filed: March 5, 2014
    Publication date: January 14, 2016
    Inventors: Jeffery Mark Brown, Martin Raymond Green
  • Publication number: 20150380231
    Abstract: A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. The collision or reaction device further comprises a second device arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the first device without causing the first ions to be substantially ejected from the first device.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Publication number: 20150380232
    Abstract: A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. A second device is arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the collision or reaction region. The collision or reaction device further comprises a device arranged and adapted to determine the time when the second ions and/or ions derived from the second ions are substantially ejected from the first device.
    Type: Application
    Filed: February 18, 2014
    Publication date: December 31, 2015
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Patent number: 9206037
    Abstract: A MEMS device chip manufacturing method including a grinding step of grinding a device forming area of a wafer to thereby form a recess and an annular reinforcing portion surrounding the recess, a MEMS device forming step of performing any processing including etching to the wafer after performing the grinding step to thereby form a plurality of MEMS devices partitioned by a plurality of crossing division lines in the device forming area, and a dividing step of dividing the wafer along the division lines after performing the MEMS device forming step to thereby manufacture a plurality of MEMS device chips.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: December 8, 2015
    Assignee: Disco Corporation
    Inventors: Aris Bernales, Devin Martin, Mark Brown