Patents by Inventor Mark Browne

Mark Browne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180007945
    Abstract: A composition for supporting endogenous systems related to life span, inhibiting mTOR, and reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes regulation of mitophagy through mTOR mediated regulation, and a Nrf2 transcription factors that promotes transcription of antioxidant genes.
    Type: Application
    Filed: July 6, 2017
    Publication date: January 11, 2018
    Inventors: Mark Brown, John Cuomo, Jeremy Tian
  • Publication number: 20170292960
    Abstract: A method of mass spectrometry is disclosed for determining if a mutated variant of a target protein is present in a sample. The method comprises subjecting the sample to fragmentation so as to cause said target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. The method determines if a mutated variant is present in the sample by determining that an ion in the spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if said target protein was a normal unmutated version of said target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of said target protein. This method of analysing second generation fragment ions if a rapid and efficiency method of analysing a sample.
    Type: Application
    Filed: October 1, 2015
    Publication date: October 12, 2017
    Inventors: Jeffery Mark BROWN, Michael Raymond MORRIS, Jonathan WILLIAMS, Brian GREEN
  • Publication number: 20170293512
    Abstract: Methods and apparatus for inter-process communication are provided. A circuit may have a plurality of clusters, and at least one cluster may have a computation element (CE), a memory operatively coupled with the CE, and an autonomic transport system (ATS) block operatively coupled with the CE and the memory. The ATS block may be configured to perform inter-process communication (IPC) for the at least one cluster. In one embodiment, the ATS block may transfer a message to a different cluster based on a request from the CE. In another embodiment, the ATS block may receive a message by allocating a buffer in the memory and write the message into the buffer. The ATS block may also be configured to manage synchronization and schedule tasks for the CE.
    Type: Application
    Filed: April 12, 2016
    Publication date: October 12, 2017
    Inventors: Peter Yan, Alan Gatherer, Alex Elisa Chandra, Lee Dobson Mcfearin, Mark Brown, Debashis Bhattacharya, Fang Yu, Xingfeng Chen, Yan Bei, Ke Ning, Chushun Huang, Tong Sun, Xiaotao Chen
  • Patent number: 9761425
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: September 12, 2017
    Assignee: Micromass UK Limited
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Patent number: 9761428
    Abstract: A mass spectrometer is disclosed comprising a dual channel Solvent Assisted Inlet Ionization (“SAII”) interface.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: September 12, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Jason Lee Wildgoose
  • Publication number: 20170221690
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises providing a spectrometer comprising an orifice between an atmospheric pressure region and a sub-atmospheric pressure region of the spectrometer, wherein the sub-atmospheric pressure region comprises an ion guide or ion trap; providing a sample probe comprising a needle assembly on which a sample is deposited or that is supplied with a sample; inserting the needle assembly through the orifice and into the sub-atmospheric pressure region so that the sample is arranged within or adjacent to the ion guide or ion trap in the sub-atmospheric pressure region; and then desorbing the sample from the needle assembly within the sub-atmospheric pressure region and/or ionising the sample within the sub-atmospheric pressure region so as to generate ions that enter the ion guide or ion trap.
    Type: Application
    Filed: August 5, 2015
    Publication date: August 3, 2017
    Inventors: Jeffery Mark BROWN, Martin Raymond GREEN
  • Patent number: 9721775
    Abstract: A sample plate for an ion source is disclosed comprising a plurality of ionization regions, each ionization region comprising a first electrode and a second separate electrode separated by an insulator.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: August 1, 2017
    Assignee: Micromass UK Limited
    Inventor: Jeffery Mark Brown
  • Patent number: 9697996
    Abstract: A method of mass spectrometry is disclosed comprising: performing a survey scan of a plurality of different types of parent or precursor ions, wherein the survey scan comprises analyzing the ion mobilities of the ions and mass analyzing the ions; determining the charge states of parent or precursor ions analyzed in the survey scan based on their determined combinations of ion mobility and mass to charge ratio; selecting a parent or precursor ion for fragmentation or reaction; and fragmenting or reacting the selected ion, wherein the fragmentation or reaction conditions are selected from a plurality of different fragmentation or reaction conditions based upon the determined charge state of the selected ion.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: July 4, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Kevin Giles, Martin Raymond Green, John Brian Hoyes, Christopher Jones, Michael Raymond Morris, Steven Derek Pringle, Keith Richardson, Farnoush Salarzaei, Jason Lee Wildgoose
  • Publication number: 20170186594
    Abstract: A method of mass spectrometry is disclosed that comprises acquiring mass spectral data during a single experimental run or acquisition of a mass spectrometer and determining a first time T during the single experimental run or acquisition for calibrating the mass spectrometer. The step of determining the first time T further comprises determining a time when the mass spectral data being acquired during the single experimental run or acquisition is equal to or below a threshold. The mass spectrometer is then calibrated by introducing calibrant or lockmass ions at the first time T.
    Type: Application
    Filed: May 29, 2015
    Publication date: June 29, 2017
    Inventors: Jeffery Mark BROWN, Paul MURRAY
  • Publication number: 20170169034
    Abstract: A data warehouse engine (DWE) includes a central processing unit (CPU) core and a first data organization unit (DOU), where the first DOU is configured to aggregate read operations. The DWE also includes a first command queue coupled between the CPU core and the first DOU, where the first command queue is configured to convey commands from the CPU core to the first DOU.
    Type: Application
    Filed: November 30, 2016
    Publication date: June 15, 2017
    Inventors: Ashish Rai Shrivastava, Alex Elisa Chandra, Mark Brown, Debashis Bhattacharya, Alan Gatherer
  • Publication number: 20170168792
    Abstract: A method includes obtaining, by a first processor, a first software architecture description file and obtaining, by the first processor, a platform independent model file. The method also includes obtaining, by the first processor, a platform architecture definition file and performing, by the first processor, a first source-to-source compilation in accordance with the first software architecture description file, the platform independent model file, and the platform architecture definition file, to produce generated interface code. Additionally, the method includes generating, by the first processor, run time code, in accordance with the generated interface code and running, by a second processor in real time, the run time code.
    Type: Application
    Filed: December 14, 2016
    Publication date: June 15, 2017
    Inventors: Debashis Bhattacharya, Alan Gatherer, Mark Brown, Lee Dobson McFearin, Alex Elisa Chandra, Ashish Rai Shrivastava
  • Patent number: 9673031
    Abstract: A mass spectrometer is disclosed comprising a Time of Flight mass analyzer comprising an ion detector comprising an Analog to Digital Converter. Signals from the Analog to Digital Converter are digitized and the arrival time and intensity of ions are determined. The arrival time T0 and intensity S0 of each ion arrival event is converted into two separate intensities S(n),S(n+i) which are stored in neighboring time bins T(n), T(n+1).
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: June 6, 2017
    Assignee: Micromass UK Limited
    Inventors: Robert Harold Bateman, Jeffery Mark Brown, Martin Green, Jason Lee Wildgoose, Anthony James Gilbert, Steven Derek Pringle
  • Patent number: 9673029
    Abstract: A method of ion imaging is disclosed comprising testing a first portion of a sample by automatically varying one or more parameters of a laser or other ionization device and manually or automatically determining from the first portion one or more optimum or preferred parameters of the laser or other ionization device. A second portion of the sample is then analyzed using the one or more optimum or preferred parameters.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 6, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Paul Murray
  • Publication number: 20170140910
    Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analysed using a Time of Flight mass analyser.
    Type: Application
    Filed: November 28, 2016
    Publication date: May 18, 2017
    Inventors: Jeffery Mark BROWN, Kevin GILES, Daniel James KENNY, Paul MURRAY, Keith RICHARDSON
  • Patent number: 9653279
    Abstract: A collision or reaction device for a mass spectrometer is disclosed comprising a first device arranged and adapted to cause first ions to collide or react with charged particles and/or neutral particles or otherwise dissociate so as to form second ions. A second device is arranged and adapted to apply a broadband excitation with one or more frequency notches to the first device so as to cause the second ions and/or ions derived from the second ions to be substantially ejected from the collision or reaction region. The collision or reaction device further comprises a device arranged and adapted to determine the time when the second ions and/or ions derived from the second ions are substantially ejected from the first device.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: May 16, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose
  • Publication number: 20170131290
    Abstract: A method of screening or testing a sample is disclosed that comprises ionising a native human hemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to Electron Transfer Dissociation fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and determining whether or not the fragment ions include fragment ions which are indicative of a variant of hemoglobin.
    Type: Application
    Filed: March 31, 2015
    Publication date: May 11, 2017
    Inventors: Malcolm Anderson, Jeffery Mark Brown, Jonathan Williams
  • Publication number: 20170133213
    Abstract: A mass spectrometer is disclosed comprising: an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected whilst they separate according to mass to charge ratio in the flight region and such that the ions are focussed to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, whilst naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small whilst still maintaining high ion transmission efficiency.
    Type: Application
    Filed: November 10, 2016
    Publication date: May 11, 2017
    Inventors: Jeffery Mark BROWN, Paul MURRAY
  • Patent number: 9646814
    Abstract: A method of mass spectrometry is disclosed having a mode comprising: providing a source of precursor ions and reagent ions for reacting with said precursor ions; providing a reaction region downstream of said source; providing an ion mobility separator between said source and said reaction region; providing a bypass cell between said source and said reaction region for guiding ions from said source to said reaction region without the ions passing through said ion mobility separator; guiding said precursor ions from said source, through said ion mobility separator so that said precursor ions separate according to their ion mobility and into said reaction region; and guiding said reagent ions from said source, through said bypass cell and into said reaction region; wherein the reagent ions react with the precursor ions within the reaction region to produce product ions.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: May 9, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Kevin Giles, Steven Derek Pringle
  • Publication number: 20170125225
    Abstract: A method of charge stripping analyte ions is disclosed. The method comprises reacting the analyte ions with reagent ions or charged particles; and then urging the reacted analyte ions through a neutral, inert gas such that said analyte ions interact or collide with the gas molecules in a manner that reduces the charge state of the reacted analyte ions, thereby forming product ions of reduced charge state. The combination of reacting the analyte ions and then urging the reacted ions through the gas results in a charge reduction that is greater than that which would be caused by either of the individual steps of reacting the ions or urging the ions through the gas.
    Type: Application
    Filed: March 24, 2015
    Publication date: May 4, 2017
    Inventors: Jeffery Mark Brown, Jonathan Paul Williams
  • Patent number: D795395
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: August 22, 2017
    Assignee: KOHLER MIRA LIMITED
    Inventors: Gary John Kington, Simon Mark Browning