Patents by Inventor Mark Browne

Mark Browne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170125222
    Abstract: A method of calibrating a mass spectrometer is disclosed comprising mass analysing first ions derived from an analyte molecule, wherein the first ions have a first charge state; determining a first mass or mass to charge ratio of the first ions; mass analysing second ions derived from the analyte molecule, wherein the second ions have a second different charge state and wherein the second ions comprise protonated or adduct variants of the first ions; determining a second mass or mass to charge ratio of the second ions; a determining a calibration correction based upon the first mass or mass to charge ratio and the second mass or mass to charge ratio.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Inventors: Jeffery Mark BROWN, Paul MURRAY, Keith RICHARDSON
  • Publication number: 20170125232
    Abstract: A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte in a vacuum housing; electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions; conveying the charged droplets and/or reagent ions into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analysing the analyte ions with a mass analyser and/or ion mobility analyser. Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.
    Type: Application
    Filed: June 12, 2015
    Publication date: May 4, 2017
    Inventors: Jeffery Mark BROWN, David GORDON, Daniel James KENNY, Paul MURRAY
  • Patent number: 9638260
    Abstract: A wheel spindle drive element for a wheel disconnect system. The wheel spindle assembling onto an outer diameter of a spindle, displacing material to form a joint with high torque transmission characteristics.
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: May 2, 2017
    Assignee: SCHAEFFLER TECHNOLOGIES AG & CO. KG
    Inventor: Mark Brown
  • Publication number: 20170117125
    Abstract: A Matrix Assisted Laser Desorption Ionisation (“MALDI”) ion source is disclosed comprising a first device arranged and adapted to supply a flow of liquid on to the surface of a target or a sample to be analysed so that the liquid forms a liquid junction on the surface of the target or the sample to be analysed and wherein analyte molecules to be ionised are extracted into the liquid junction, and a laser source emits a laser beam which causes analyte ions or an analyte plume to be released or desorbed from the liquid junction.
    Type: Application
    Filed: March 18, 2015
    Publication date: April 27, 2017
    Inventor: Jeffery Mark Brown
  • Publication number: 20170110304
    Abstract: A method of mass spectrometry is disclosed that comprises transforming mass spectral data to produce frequency-domain mass spectral data, modifying the frequency-domain mass spectral data to produce modified frequency-domain mass spectral data by attenuating and/or removing one or more ranges of the frequency-domain mass spectral data that relate to noise associated with peaks of interest in the mass spectral data, and transforming the modified frequency-domain mass spectral data to produce modified mass spectral data.
    Type: Application
    Filed: October 14, 2016
    Publication date: April 20, 2017
    Inventors: Jeffery Mark BROWN, Keith George RICHARDSON, Richard CHAPMAN
  • Publication number: 20170103093
    Abstract: A method includes receiving, by a real-time Data Warehouse (rDW) from a first task, a first dataset and spreading the first dataset to produce a first plurality of objects, where the first plurality of objects includes a first object and a second object. The method also includes storing the first object in a first location in an rDW data repository and storing the second object in a second location in the rDW data repository.
    Type: Application
    Filed: May 31, 2016
    Publication date: April 13, 2017
    Inventors: Alex Elisa Chandra, Mark Brown, Debashis Bhattacharya, Alan Gatherer
  • Publication number: 20170103076
    Abstract: A computation system-on-a-chip (CSoC) includes a first scalable distributed real-time Data Warehousing (sdrDW) engine and a network interface coupled to the first sdrDW engine, where the network interface is coupled to an interconnect, and where the CSoC is configured to transmit a task request over the interconnect to a first networked bulk storage controller (NBSC) requesting that a task be performed on a bulk storage medium.
    Type: Application
    Filed: September 13, 2016
    Publication date: April 13, 2017
    Inventors: Debashis Bhattacharya, Alan Gatherer, Alex Elisa Chandra, Mark Brown, Hao Luan, Ashish Rai Shrivastava
  • Patent number: 9599202
    Abstract: An internal ball recirculation insert for a ball screw assembly. The ball screw assembly having a ball nut with at least one radial bore though it, a ball screw and load bearing balls. The ball screw and ball nut having complimental helical grooves, forming helical ball raceways when the ball screw and ball nut are assembled. The internal ball recirculation insert sized to fit into the radial bore of the ball nut, having a body portion, securing arms, a ball channel for channeling balls from one ball raceway to another and a friction or retention device around the circumference of the body portion. The friction device extending outwardly from a side wall of the recirculation insert, and contacting a wall of the radial bore in the ball nut.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: March 21, 2017
    Assignee: Schaeffler Technologies AG & Co. KG
    Inventor: Mark Brown
  • Publication number: 20170069475
    Abstract: A method is disclosed wherein parent or precursor ions are fragmented or reacted according to a first fragmentation or reaction mode, and when an ion of interest is detected the method then temporarily switches to a second mode of fragmentation or reaction. This enables a full un-biased MS/MS data set to be provided over a wide mass to charge ratio range with high-duty cycle, together with complementary detailed fragment data of interest, in a single experimental run or acquisition.
    Type: Application
    Filed: April 17, 2015
    Publication date: March 9, 2017
    Inventor: Jeffery Mark BROWN
  • Publication number: 20170069478
    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
    Type: Application
    Filed: November 21, 2016
    Publication date: March 9, 2017
    Inventors: Jeffery Mark BROWN, Martin Raymond GREEN, Steven Derek PRINGLE
  • Publication number: 20170062199
    Abstract: A method of mass spectrometry is disclosed comprising mass analysing ions and obtaining mass spectral data and determining parent or precursor ions of interest. The method further comprises determining first adduct or chemical artefact ions which have mass to charge ratios which have a substantially linear relationship with the mass to charge ratio of the parent or precursor ions of interest and removing or attenuating the first adduct or chemical artefact ions from the mass spectral data.
    Type: Application
    Filed: April 21, 2015
    Publication date: March 2, 2017
    Inventor: Jeffery Mark BROWN
  • Publication number: 20170025260
    Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
    Type: Application
    Filed: October 6, 2016
    Publication date: January 26, 2017
    Inventors: Jeffery Mark BROWN, Steven Derek PRINGLE, Keith RICHARDSON
  • Patent number: 9552975
    Abstract: A method of mass spectrometry is disclosed comprising providing a flight region for ions to travel through and a detector or fragmentation device. A potential profile is maintained along the flight region such that ions travel towards the detector or fragmentation device. The potential at which a first length of the flight region is maintained is then changed from a first potential to a second potential while at least some ions are travelling within the first length of flight region. The changed potential provides a first potential difference at an exit of the length of flight region, through which the ions are accelerated as they leave the length of flight region. This increases the kinetic energy of the ions prior to them reaching the detector or fragmentation cell.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: January 24, 2017
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, David J. Langridge
  • Patent number: 9550869
    Abstract: We disclose a monovinylarene-conjugated diene block copolymer containing a plurality of monovinylarene-conjugated diene mixed blocks, wherein each mixed block contains conjugated diene units and monovinylarene units in a weight ratio of about 0.05 to about 0.33. We also disclose a composition containing (a) from about 50 parts by weight to about 95 parts by weight of the monovinylarene-conjugated diene block copolymer and (b) from about 5 parts by weight to about 50 parts by weight of polystyrene; wherein the monovinylarene-conjugated diene block copolymer and the polystyrene total 100 parts by weight.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: January 24, 2017
    Assignee: Chevron Phillips Chemical Company LP
    Inventors: John Mark Brown, Nathan E. Stacy, Carleton E. Stouffer, John D. Wilkey, Michael A. Smith
  • Publication number: 20160372313
    Abstract: A method of mass or ion mobility spectrometry is disclosed that uses the Leidenfrost effect to cause a liquid to be repelled away from a heated surface so as to levitate above there-above. The repelled liquid is urged so as to move along the surface in a predetermined direction, for example, by the geometric configuration of the heated surface.
    Type: Application
    Filed: March 3, 2015
    Publication date: December 22, 2016
    Inventors: Jeffery Mark Brown, Steve Bajic, Steven Derek Pringle
  • Patent number: 9513762
    Abstract: Disclosed are various embodiments for an updatable package application. Updated static content elements of the packaged application are obtained from a content delivery service. The content update is verified as a function of the component static content elements and a manifest file. The application is reconfigured to execute as a function of the updated static content elements.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: December 6, 2016
    Assignee: Amazon Technologies, Inc.
    Inventors: Mustafa Hakim, Patrick Lee Baumann, Abdullah Mohammed Jibaly, Jordan Petrov Marinov, Kenley Bryan Capps, Brigham Mark Brown
  • Patent number: 9508537
    Abstract: A method of mass spectrometry is disclosed comprising directing first photons from a laser onto ions located within a 2D or linear ion guide or ion trap. The frequency of the first photons is scanned and first photons and/or second photons emitted by the ions are detected. The ions are then mass analyzed using a Time of Flight mass analyzer.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: November 29, 2016
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Kevin Giles, Daniel James Kenny, Paul Murray, Keith Richardson
  • Patent number: 9500607
    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapor may be provided through the tubular electrode, which is then subsequently ionized by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: November 22, 2016
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Publication number: 20160336157
    Abstract: There is provided a method of introducing ions into a mass spectrometer, comprising ionising a sample using a Matrix Assisted Laser Desorption Ionisation (“MALDI”) ion source to form a plurality of ions, transporting said plurality of ions in a first, primary gas through a passageway and into an inlet of a mass spectrometer, introducing a second, auxiliary gas into said inlet, and controlling a flow rate of said second gas into said inlet so as to control a flow rate of said first gas through said passageway.
    Type: Application
    Filed: May 16, 2016
    Publication date: November 17, 2016
    Inventors: Jeffery Mark Brown, Rainer Cramer
  • Patent number: D774169
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: December 13, 2016
    Assignee: KOHLER MIRA LIMITED
    Inventors: Gary John Kington, Simon Mark Browning