Abstract: This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.

Abstract: A vane cluster for a gas turbine engine includes a first end-of-cluster vane, a second end-of-cluster vane, a neighbor vane adjacent to the second end-of-cluster vane at an interface that includes an angled load interface therebetween; and a multiple of base vanes between the first end-of-cluster vane and the neighbor vane, the angled load interface different than an interface between each of the multiple of base vane.

Abstract: Various implementations described herein refer to an integrated circuit having first clock circuitry that receives a first clock signal and provides sampled offset pulses associated with the first clock signal when enabled with enable signals. The integrated circuit may include second clock circuitry that receives a second clock signal and provides the enable signals to the first clock circuitry based on the second clock signal. The integrated circuit may include fault detector circuitry that receives the sampled offset pulses from the first clock circuitry, receives the enable signals from the second clock circuitry, and provides one or more error flags for detected faults of the first clock signal based on the sampled offset pulses from the first clock circuitry and based on the enable signals from the second clock circuitry.

Abstract: An assembly for measuring metal powder material mass flow rate during direct metal deposition is disclosed. A detection strip is placed in the gas-blown metal powder material flow path. The detection strip is fixed in one end and suspended at the other end. The flowing metal powder material particles induce displacement to the detection strip. A displacement measurement sensor measures the amount of displacement of the detection strip. The amount of displacement of the detection strip gives relationship to the amount of the metal powder material flowing in the metal powder material flow path. Preferably, the detection strip and the sensor are enclosed in a housing with a metal powder material inlet port and metal powder material outlet port and includes internal features for smooth travel of metal powder material particles.

Abstract: A thermal cycling system for processing a bio sample includes a chamber, a photonic system and a cooling device. The photonic system includes a light-emitting unit. The light-emitting unit is configured to irradiate the bio sample for heating the bio sample rapidly. The cooling device is attached outside the chamber for cooling the bio sample inside the chamber. The bio sample is continuously cooled by the cooling device, and the light-emitting unit is selectively enabled or disabled according to a thermal cycling profile. Therefore, an ultrafast thermal cycling and a precise control of temperature are implemented.

Abstract: A utility meter includes a meter housing that supports at least one current coil, a temperature sensor, and a processing circuit coupled to both. The current coil can be coupled to receive heat energy from a meter socket. The temperature sensor disposed generates a sensor signal based on a temperature within the meter housing. The processing circuit obtains the sensor signal and generates meter temperature information based at least in part thereon. The processing circuit also obtains a first predetermined threshold based on at least one of time of day information and date information. The processing circuit also determines whether an abnormal condition exists by comparing the meter temperature information to a value based on the first predetermined threshold, and generates an output signal to a memory, display or communication circuit responsive to determining that the abnormal condition exists.

Abstract: A virtual agent that utilizes an in-house natural language understanding (NLU) service and integrates a third party NLU service. The third-party NLU service is integrated with the virtual agent via a transformation script that establishes a transformation boundary through which communications are directed for adjustment and conditioning. The third party NLU service communicates with the virtual agent via an application programming interface (API). The virtual agent receives an utterance from a user via a chat session and provides the utterance to the third party NLU service. The third party NLU service may return intents, entities, and confidence, generate and return a response, and/or take actions within the cloud-based platform via the API, dependent upon the degree of integration. The virtual agent then provides a response to the user via the chat session.

Abstract: Present embodiments are directed to a virtual agent with improved natural language understanding (NLU) capabilities. The disclosed virtual agent enables topic selection and topic changes during natural language exchanges with a user. The virtual agent is designed to select suitable topic flows to execute based on intents identified in received user utterances, including selection of an initial topic flow in response to a topic identified in a first user utterance, as well as switching between topic flows mid-conversation based on identified topic changes. The virtual agent is also capable of considering all intents and entities conveyed during the conversation, which enables the virtual agent to avoid prompting the user to provide redundant information. Furthermore, the virtual agent is capable of executing topic flows as part of a global topic flow, which enables the virtual agent to perform a number of predefined activities as part of each interaction with the user.

Abstract: A system, apparatus and method for protecting coherent memory contents in a coherent data processing network by filtering data access requests and snoop response based on the Read/Write (R/W) access permissions. Requests are augmented with access permissions in memory protection units and the access permissions are used to control memory access by home nodes of the network.

Abstract: An aquarium structure for the housing and display of aquatic life, particularly jellyfish, adapted to provide a beneficial flow of fluid within it, such as a rising or suspending current. The aquarium structure includes a bottom surface, at least one sidewall, and a barrier disposed within in spaced apart relation to the bottom surface by a predetermined distance to form a gap therebetween. In preferred embodiments, the aquarium structure includes an air pump and also, is generally cylindrical in shape and disposed vertically along its major axis, to offer a wide area for viewing aquatic life within, and yet a relatively small and compact aquarium housing suitable for “desktop” use, although the invention may have other sizes and configurations. The aquarium housing can also include a lighting assembly disposed below the viewing area and configured to direct illumination therein and in some embodiments onto other surfaces above the aquarium housing.

Abstract: The present invention relates to compounds, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of RIP2 kinase, including degrading RIP2 kinase, the treatment of diseases and conditions mediated by the RIP2 kinase, in particular for the treatment of inflammatory diseases or conditions.

Abstract: The present invention defines a unique structure and methodology for creating a plurality of configurable and extensible tools that can be affixed to a plurality of digits and equipment to form tool sets for working more easily with objects.

Abstract: A hosted client instance is provided over a network interface for communicatively coupling with a remote client device, the hosted client instance including a first plurality of application components for performing a plurality of actions associated with the hosted client instance. A metric is set to optimize one or more actions associated with the hosted client instance based on input from a user. One or more application components are detected based on the metric from among a second plurality of application components available on a resource server. The detected one or more application components are ranked based on: (i) a maturity score of each of the detected one or more application components; and (ii) dependency data indicating an operational dependency of each of the detected one or more application components. The ranked one or more application components are presented in a ranked order to a user.

Abstract: An actuator for use in a control valve assembly that has a structure amenable to manufacture. The actuator may comprise a housing comprising a plurality of walls secured to one another with fasteners to form an interior cavity, a torque hub disposed in the interior cavity, the torque hub comprising a torque body and a torque arm that are releasably engaged with one another via fasteners, each of the torque body and the torque arm having interfacing geometry that defines surfaces that engage with opposing surfaces on the other; and a load generator coupled with the torque hub.

Abstract: A valve control is configured for use with control valves and other flow controls. The valve control leverages a simplified structure to avoid problems with manufacture and reduce costs. This structure includes a support unit that compresses parts of a valve housing together. Inside of the valve housing, the structure incorporates diaphragms that cause a pair of balanced valves to move in response to changes in pressure of fluid in a conduit. For industrial application, the valve control finds use to maintain pressure of natural gas in pipelines downstream from a control valve.

Abstract: A critical access override list may be generated dynamically based on patient profile information for a single patient or a group of patients. A single patient or group of patients is initially identified. Patient profile information for the patient or group of patients is accessed. The patient profile information is analyzed, and medications are selected for critical access override. The selected medications are added to a critical access override list available to a medication dispensing apparatus to provide quicker access to the medications for emergency situation purposes via critical access override dispensing in which fewer steps are performed than normal medication dispensing events.

Abstract: A turbomachine airfoil element includes an airfoil that has pressure and suction sides spaced apart from one another in a thickness direction and joined to one another at leading and trailing edges. The airfoil extends in a radial direction a span that is in a range of 2.85-3.15 inch (72.4-80.0 mm). A chord length extends in a chordwise direction from the leading edge to the trailing edge at 50% span and is in a range of 1.52-1.82 inch (38.6-46.2 mm). The airfoil element includes at least two of a first mode with a frequency of 506±10% Hz, a second mode with a frequency of 1732±10% Hz, a third mode with a frequency of 2268±10% Hz, a fourth mode with a frequency of 4007±10% Hz, a fifth mode with a frequency of 4851±10% Hz and a sixth mode with a frequency of 6416±10% Hz.

Abstract: Systems and methods are described for delivering messages from one or more service hosts to clients via a network. A first request identifying the client is received at the message server, and a connection is established and maintained between the message server and the client in response to the first request. When a subsequent request that identifies the client is received from the service host, a message is transmitted from the message server to the client over the previously-established connection. The methods and techniques may be used, for example, to provide messages from various services to placeshifting devices or other clients communicating via the network.

Abstract: A quasi-systolic array includes: a primary quasi-systolic processor; an edge row bank and edge column bank of edge quasi-systolic processors; and an interior bank of interior quasi-systolic processors. The primary quasi-systolic processor, edge quasi-systolic processor, and interior quasi-systolic processor independently include a quasi-systolic processor and are disposed and electrically connected in rows and columns in the quasi-systolic array.

Abstract: A material-mapped actuator useful as, or as part of, a soft robot along with automated methods of design and manufacture. The actuator exhibits mechanical properties that spatially vary along a coordinate system of the actuator. The actuator body has an initial shape with a corresponding initial map of mechanical attributes consisting of locally-varying stiffness at each point in a volume of the actuator body. The actuator is configured to change to a different shape or distribution of mechanical properties upon being activated by an actuation medium. The map of mechanical attributes influences and determines the new shape or distribution. The material-mapped actuator can incorporate a spatially-varying distribution of mechanical properties that dictates multiple desired shapes as the actuation medium is applied, including an actuation sequence in which the actuator transitions from a first shape to a desired intermediate shape(s), and from the intermediate shape to a desired final shape.