Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: In an example, there is disclosed a computing apparatus, having a computing resource; a bespoke sensor for measuring at least one parameter of usage of the computing resource; and one or more logic elements providing a trusted compute meter (TCM) agent to: receive an external workload; provision a workload enclave; execute the external workload within the TCM enclave; and measure resource usage of the external workload via the bespoke sensor. There is also disclosed a computer-readable medium having stored thereon executable instructions for providing a TCM agent, and a method of providing a TCM agent.

Abstract: Embodiments of techniques and systems associated with roots-of-trust (RTMs) for measurement of virtual machines (VMs) are disclosed. In some embodiments, a computing platform may provide a virtual machine RTM (vRTM) in a first secure enclave of the computing platform. The computing platform may be configured to perform an integrity measurement of the first secure enclave. The computing platform may provide a virtual machine trusted platform module (vTPM), for a guest VM, outside the first secure enclave of the computing platform. The computing platform may initiate a chain of integrity measurements between the vRTM and a resource of the guest VM. Other embodiments may be described and/or claimed.

Abstract: A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.

Abstract: A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.

Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of ?3-adrenoceptor.

Abstract: In an embodiment, at least one computer readable medium has instructions stored thereon for causing a system to cryptographically sign, at a secure platform services enclave (PSE) of a computing system and using a secure attestation key (SGX AK), a public portion of a trusted platform module attestation key (TPM AK) associated with a trusted computing base of a physical platform, to form a certified TPM AK public portion. Also included are instructions to store the certified TPM AK public portion in the PSE, and instructions to, responsive to an attestation request received from a requester at a virtual trusted platform module (vTPM) associated with a virtual machine (VM) that has migrated onto the physical platform, provide to the requester the certified TPM AK public portion stored in the PSE. Other embodiments are described and claimed.

Abstract: Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: The instant invention provides compounds of formula I which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Abstract: Methods, apparatus, and systems are described for generating a content related notification based upon managed logistics information related to a container using a container interface display apparatus. Such a container interface display apparatus records an update to the managed logistics information maintained in a memory of the container interface display apparatus and then accesses at least a portion of the managed logistics information maintained in the memory after recording the update. The container interface display apparatus then detects a notification event based upon the accessed portion of the managed logistics information. Such notification event is related to status information associated with the container or an item stored within the container.

Abstract: Methods, apparatus, and systems are described for managing logistics information related to a container using a container interface display apparatus. The container interface display apparatus may comprise a mountable housing, a display screen, a memory, a scanner, and a wireless communication interface. The housing is coupled to the container to permit the scanner to identify an item being loaded for shipment within the container. The scanner identifies the item, and the apparatus records an association in memory as part of managed logistics information that reflects an established and tracked relationship between the container and the item. The apparatus increments package count information (another part of the managed logistics information) to reflect that the item is loaded within the container. The apparatus generates electronic logistics monitor information on the display screen to include at least a portion of the managed logistics information related to the container.

Abstract: Systems and methods are disclosed for managing logistics information related to a container using a container interface display apparatus. A scanner on the container interface display apparatus identifies an item during loading of the container. An association between the container and the item is recorded in memory of the container interface display apparatus as part of managed logistics information related to the container. A scale within the container detects a weight of the item and sends a signal to the container interface display apparatus indicating the detected weight of the item (which is also recorded in memory as part of the managed logistics information related to the container). Electronic logistics monitor information (e.g., at least a portion of the managed logistics information) is then generated on the display screen of the container interface display apparatus.

Abstract: The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of us ing the same in the treatment or prevention of diseases mediated by the activation of ?3-adrenoceptor.

Abstract: In an embodiment, at least one computer readable medium has instructions stored thereon for causing a system to cryptographically sign, at a secure platform services enclave (PSE) of a computing system and using a secure attestation key (SGX AK), a public portion of a trusted platform module attestation key (TPM AK) associated with a trusted computing base of a physical platform, to form a certified TPM AK public portion. Also included are instructions to store the certified TPM AK public portion in the PSE, and instructions to, responsive to an attestation request received from a requester at a virtual trusted platform module (vTPM) associated with a virtual machine (VM) that has migrated onto the physical platform, provide to the requester the certified TPM AK public portion stored in the PSE. Other embodiments are described and claimed.

Abstract: A novel process is provided for the efficient preparation of an asymmetric compound of structural formula I: comprising a copper-catalyzed, carbon-nitrogen cross-coupling step. The process described as part of the present invention can be used to manufacture poly (ADP-ribose) polymerase (PARP) inhibitors, which may be useful for the treatment of cancer. In particular, the present invention describes a process for the manufacture of the PARP inhibitor, 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide.

Abstract: Embodiments of techniques and systems associated with roots-of-trust (RTMs) for measurement of virtual machines (VMs) are disclosed. In some embodiments, a computing platform may provide a virtual machine RTM (vRTM) in a first secure enclave of the computing platform. The computing platform may be configured to perform an integrity measurement of the first secure enclave. The computing platform may provide a virtual machine trusted platform module (vTPM), for a guest VM, outside the first secure enclave of the computing platform. The computing platform may initiate a chain of integrity measurements between the vRTM and a resource of the guest VM. Other embodiments may be described and/or claimed.

Abstract: Technologies for sensor privacy on a computing device include receiving, by a sensor controller of the computing device, sensor data from a sensor of the computing device; determining a sensor mode for the sensor; and sending privacy data in place of the sensor data in response to a determination that the sensor mode for the sensor is set to a private mode. The technologies may also include receiving, by a security engine of the computing device, a sensor mode change command from a user of the computing device via a trusted input/output path of the computing device; and sending a mode command to the sensor controller to set the sensor mode of the sensor based on the sensor mode change command, wherein the sending the mode command comprises sending the mode command over a private bus established between the security engine and the sensor controller. Other embodiments are described herein.

Abstract: Embodiments of techniques and systems associated with roots-of-trust (RTMs) for measurement of virtual machines (VMs) are disclosed. In some embodiments, a computing platform may provide a virtual machine RTM (vRTM) in a first secure enclave of the computing platform. The computing platform may be configured to perform an integrity measurement of the first secure enclave. The computing platform may provide a virtual machine trusted platform module (vTPM), for a guest VM, outside the first secure enclave of the computing platform. The computing platform may initiate a chain of integrity measurements between the vRTM and a resource of the guest VM. Other embodiments may be described and/or claimed.