Abstract: The present invention provides RAD51 inhibitors having the structural formula (I): or a pharmaceutically acceptable salt or solvate thereof. Also provided are methods of treating or preventing cancer comprising administration of the compounds of the present invention, as well as uses of the compounds to induce a synergistic effect with known chemotherapeutic.

Abstract: An online document system provides a recommendation for one or more features within the online document system to an entity. The online document system accesses a set of feature training data to train a machine learning model. The set of feature training data may describe characteristics of entities associated with the online document system and historical activity associated with the entities' usage of the online document system's features. The machine learning model may be configured to identify a feature to recommend to an entity based on the entity's characteristics and history of using other features within the online document system. For example, data representing the entity's user accounts and use of an electronic signature feature is used by the machine learning model to identify a document authentication feature to recommend to the entity. The online document system may then provide the identified feature in a recommendation to the entity.

Abstract: A method, system, computer program product and a computer program for prioritizing queued tasks waiting to access a resource associated with a resource manager in an application server, wherein an incoming task received at the application server from a calling application may have a status indicating that the incoming task is in a final phase during which a response to the calling application is created, the method comprising: receiving the incoming task; identifying the status of the incoming task; in response to identifying that the status of the incoming task is in the final phase, placing the incoming task in a priority queue; analyzing any queued tasks waiting to access the resource in the priority queue and one or more other queues; and processing a queued task from the priority queue in preference to the one or more other queues.

Abstract: A platform for design of a lighting installation generally includes an automated search engine for retrieving and storing a plurality of lighting objects in a lighting object library and a lighting design environment providing a visual representation of a lighting space containing lighting space objects and lighting objects. The visual representation is based on properties of the lighting space objects and lighting objects obtained from the lighting object library. A plurality of aesthetic filters is configured to permit a designer in a design environment to adjust parameters of the plurality of lighting objects handled in the design environment to provide a desired collective lighting effect using the plurality of lighting objects.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: The disclosure provides an approach for certificate management for cryptographic agility. Embodiments include receiving, by a cryptographic agility system, a cryptographic request related to an application. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information associated with the cryptographic request. Embodiments include determining, by the cryptographic agility system, based on the cryptographic request, a certificate for authenticating a key related to the cryptographic technique. Embodiments include providing, by the cryptographic agility system, the certificate to an endpoint related to the cryptographic request for use in authenticating the key.

Abstract: Welded headgear sections can be produced by using a weld tool having pins protruding from a weld region contact surface to deliver high-frequency electromagnetic energy to a weld region defined by overlapping top and bottom headgear straps. The pins fully penetrate the top strap and at least partially penetrate the bottom strap. The pins concentrate the electromagnetic energy to achieve a weld joint of acceptable weld strength and aesthetic appeal.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: The disclosure provides an approach for cryptographic agility. Embodiments include establishing, by a proxy component associated with a cryptographic agility system, a first secure connection with an application. Embodiments include receiving, by the proxy component, via the first secure connection, a communication from the application directed to an endpoint. Embodiments include selecting, by the cryptographic agility system, a cryptographic technique based on contextual information related to the communication. Embodiments include establishing, by the proxy component, a second secure connection with the endpoint based on the cryptographic technique. Embodiments include transmitting, by the proxy component, a secure communication to the endpoint via the second secure connection based on the communication.

Abstract: Control methods are disclosed for continuous, unmodulated, multiple catalytic conversion step processes using at least two catalysts, a first catalyst and a second catalyst, that accommodate changes in the performance of each catalyst and the relative performances of the catalysts. In the methods, certain process parameters are used in a manner that is indicative of changes in catalyst performance, and the control methods provide for adjustment of at least one of: the absolute amount of catalytically active species and relative amounts of each of the first catalyst and second catalyst and at least one of the rate of feed or concentration of the raw material to the reaction zone.

Abstract: Systems and methods capable for use in the development of high-speed, shape-transitioning, inward-turning inlets for air-breathing hypersonic vehicles, and inlets formed thereby. The systems and methods preferably provide for designing high-speed inlets for air-breathing hypersonic vehicles, wherein unique solutions are defined in each osculating plane of the inlet. Such systems and methods optionally provide an optimization process for tuning the post throat-shock Mach number of the inlet, and/or designs a shock-capture surface using a parallel-streamlines methodology, and/or a double cowl-lip geometry to allow flow to spill overboard.

Abstract: A container having a base and a lid is provided. The lid may be rotatable about a hinge from a closed configuration to an open configuration and may be secured, via one or more latching assemblies. The latch assembly may comprise a latch body, a locking member, a biasing member, and an activating member. The lid may have a handle that has a stowed and a carry position, where the handle may be maintained in the stowed position until acted upon by a first force greater than a threshold force to move the handle from the stowed position to the carry position. Similarly, when in the carry position, the handle may be maintained in the carry position until acted upon by a second force greater than the threshold force to move the handle from the carry position to the stowed position.

Abstract: Systems and methods are provided for controlling playback of media content items on a media playback device. A graphical user interface displays media playback controls including an automatic playback switch. The switch is configured to enable or disable automatic playback of an autoplay queue of media content items. An initial queue of media content is selected for playback on the media playback device. When automatic playback is enabled, the system automatically generates a queue of media that is related to the initial queue and initiates playback on the media playback device after the initial queue concludes. Automatic playback options can also include repeating the initial queue or a single track within the initial queue.

Abstract: Provided herein are genetically engineered mammalian (e.g., human) cells that express one or more transgenes at a sustained expression level. Also provided are methods of making and using the cells.

Abstract: An apparatus forms an aggregation module. The apparatus includes a support structure to support multiple plug-in cards. The plug-in cards are insertable along an insertion direction. The apparatus further includes a front access panel openable to access the plug-in cards. The apparatus further includes the support structure and the plug-in cards forming an airflow path along an airflow direction.

Abstract: In a general aspect, a machine learning process is performed using data-parallel quantum processing. In some cases, a machine learning model is operated in a hybrid computing system. The hybrid computing system includes a quantum computing resource and a classical computing resource. The quantum computing resource includes quantum processing unit (QPU) sublattices, each including a subset of qubit devices.

Abstract: A system for an attraction includes a sensor configured to capture imagery of a real world environment and a control system communicatively coupled to the sensor. The control system is configured to receive the imagery captured by the sensor, identify a real world element of the imagery, generate image data that includes a virtual element that corresponds to the real world element, and transmit the image data for presentation in the attraction.

Abstract: A hinged system includes a preassembled hinge module for pivotally coupling a first component to a second component. The preassembled hinge module includes a shaft, a torque element frictionally engaging the shaft, and a housing. The housing includes a cover, a side wall, and a rear wall that define an interior space enclosed within the housing. The interior space receives the torque element inside the housing. The cover defines a first aperture, and the rear wall defines a second aperture, the first aperture and the second aperture aligned with a pivot axis of the shaft. The shaft extends through at least the first aperture, the interior space, and the second aperture. The shaft is separate from, and configured to be mounted to, the first component. The housing is separate from, and configured to be mounted to, the second component.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for monitoring technology usage and performance. In some implementations, use of a technology item by one or more individuals assigned to use the technology item is monitored. Based on the monitoring, usage data that indicates usage of the technology item is generated. One or more criteria for evaluating the usage of the technology item by the one or more individuals is identified. It is determined whether usage data satisfies the one or more criteria. A system provides, for display on a user interface, output data indicating whether the usage data satisfies the one or more criteria.

Abstract: A phase shifter for altering the phase of a radio frequency signal is disclosed herein. A Lange coupler is used having reflective ports that are coupled to artificial transmission lines. The artificial transmission lines provide a reflection transmission path, the length of which can be determined by digital control lines. Transistors placed along the length of the central trace provide independent paths to ground that serve to shorten the electrical length of the ATL. Accordingly, by selectively turning the transistors on/off, the electrical length of the ATL can be selected and thus the amount of phase delay introduced by the phase shifter.