Abstract: A virtual reality system providing a virtual robotic surgical environment, and methods for using the virtual reality system, are described herein. The virtual reality system may simulate a robotic surgical environment in which a user may operate both a robotically-controlled surgical instrument using a handheld controller and a manual laparoscopic surgical instrument while adjacent a patient table.

Abstract: Methods of storing and methods of stabilizing pharmaceutical compositions comprising cysteamine, or a pharmaceutically acceptable salt thereof, are provided. Methods of distributing pharmaceutical compositions comprising cysteamine, or a pharmaceutically acceptable salt thereof, and methods of treating cystinosis also are provided.

Abstract: Autopilot systems and related techniques are provided to improve the ability of mobile structures to maintain a desired reference path (e.g., to keep a desired track and/or to follow a desired contour). In various embodiments, a high quality turn rate signal and GPS based signals are used to generate high bandwidth cross track/contour errors and other associated signals. An adaptive controller uses the generated cross track/contour signals to provide robust track keeping and/or contour following in the directional control of a mobile structure. Techniques are also provided for systems and methods to provide directional control for mobile structures.

Abstract: A first sensitivity level is used to interpret an input signal received from an input device in a vehicle while the vehicle is in a first region. A second sensitivity level is used to interpret the input signal received from the input device in the vehicle while the vehicle is in a second region, wherein the second sensitivity level is greater than the first sensitivity level.

Abstract: Methods, devices and systems that use a control channel to coordinate quality of data communications in software-defined heterogenous multi-hop ad hoc networks are described. In some embodiments, an example apparatus for wireless communication in a network includes performing, using a control plane, network management functions over a control channel that has a first bandwidth, implements a frequency-hopping operation, and operates at in a first frequency band, and performing, using a data plane that is physically and logically decoupled from the control plane, data forwarding functions, based on a routing decision, over at least one data channel that has a second bandwidth and operates in a second frequency band different from the first frequency band.

Abstract: A self-adjusting flight control system is disclosed. In various embodiments, an input interface receives an input signal generated by an inceptor based at least in part on a position of an input device comprising the inceptor. A processor coupled to the input interface determines dynamically a mapping to be used to map input signals received from the inceptor to corresponding output signals associated with flight control and uses the determined mapping to map the input signal to a corresponding output signal. The processor determines the mapping at least in part by computing a running average of the output signal over an averaging period and adjusting the mapping at least in part to associate a neutral position of the input device comprising the inceptor with a corresponding output level that is determined at least in part by the computed running average.

Abstract: A flight-time variable associated with an aircraft is determined including by determining the flight-time variable while the aircraft is flying. It is determined whether the aircraft is airworthy based at least in part on the flight-time variable. In response to determining that the aircraft is not airworthy, the aircraft is automatically landed.

Abstract: A method for engaging and disengaging a surgical instrument of a surgical robotic system including receiving a sequence of user inputs from one or more user interface devices of the surgical robotic system; determining, by one or more processors communicatively coupled to the user interface devices and the surgical instrument, whether the sequence of user inputs indicates an intentional engagement or disengagement of a teleoperation mode in which the surgical instrument is controlled by user inputs received from the user interface devices; in response to determining of engagement, transition the surgical robotic system into the teleoperation mode; and in response to determining of disengagement, transition the surgical robotic system out of the teleoperation mode such that the user interface devices are prevented from controlling the surgical instrument.

Abstract: An obstacle in the use of many primary cells is the significant cytotoxicity observed following transfection with circular or linearized DNA. Methods are provided for improving the survival of any primary cell following transfection with circular or linearized DNA. The methods of the invention are also useful for improving gene editing by endonucleases in DNA-transfected primary cells, and for improving the efficiency of targeted insertion of exogenous sequences into the genome of DNA-transfected primary cells.

Abstract: Techniques are disclosed for systems and methods to provide casting guidance for users of mobile structures, including watercraft. A casting guidance system includes a sonar transducer assembly and a logic device configured to communicate with the sonar transducer assembly. The sonar transducer assembly is adapted to be mounted to a mobile structure and placed in a body of water. The logic device is configured to identify one or more underwater targets in sonar data received from the sonar transducer assembly, determine casting guidance parameters corresponding to the one or more identified underwater targets, and generate at least one casting guidance identifier based, at least in part, on the determined casting guidance parameters. Subsequent user input, the sonar data, and/or the casting guidance parameters may be used to adjust a steering actuator, a propulsion system thrust, and/or other operational systems of the mobile structure.

Abstract: A movable wall system includes a plurality of movable wall panels including a first movable wall panel and a second moveable wall panel rotatably coupled together through at least one hinge. The movable wall system further includes a biasing system which biases the first movable wall panel and the second movable wall panel into an arrangement wherein a panel face of the first movable wall panel and a panel face of the second moveable wall panel are generally parallel.

Abstract: A powder scooper with a funnel having a unitary body with a bottom wall and a sidewall both defining a scooping cavity, wherein the sidewall defines a funnel entrance aperture and has an upper terminal edge defining an upper aperture. The scooper also includes a funnel portion coupled to the sidewall and a distal terminal end defining a distal opening, and a funnel channel separating the funnel entrance aperture and the distal opening, wherein the funnel portion extends outwardly away from an outer surface of the sidewall. The scooper also includes a handle portion coupled to, and extending outwardly away from, the outer surface of the sidewall in a substantially perpendicular orientation and angle of a funnel axis defined by the funnel channel.

Abstract: Autonomous flight is performed in an open loop mode over a first range of altitudes, wherein a plurality altitude-related data from a plurality of altitude-related sensors is ignored while performing the autonomous flight in the open loop mode. The autonomous flight is performed in a closed loop mode over a second range of altitudes, wherein: the plurality of altitude-related data from the plurality of altitude-related sensors is used while performing the autonomous flight in the closed loop mode, and the first range of altitudes is a non-overlapping, lower range of altitudes compared to the second range of altitudes.

Abstract: A powder scooper with a funnel having a unitary body with a bottom wall and a sidewall both defining a scooping cavity, wherein the sidewall defines a funnel entrance aperture and has an upper terminal edge defining an upper aperture. The scooper also includes a funnel portion coupled to the sidewall and a distal terminal end defining a distal opening, and a funnel channel separating the funnel entrance aperture and the distal opening, wherein the funnel portion extends outwardly away from an outer surface of the sidewall. The scooper also includes a handle portion coupled to, and extending outwardly away from, the outer surface of the sidewall in a substantially perpendicular orientation and angle of a funnel axis defined by the funnel channel.

Abstract: A flight-time variable associated with an aircraft is determined including by determining the flight-time variable while the aircraft is flying. It is determined whether the aircraft is airworthy based at least in part on the flight-time variable. In response to determining that the aircraft is not airworthy, the aircraft is automatically landed.

Abstract: Methods for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof, include administering once-daily to the subject, at least 80 mg of N-(4-(1-(2,6-difluorobenzyl)-5-((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-N?-methoxyurea, or a corresponding amount of a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the cellular circuit with a nucleic acid molecule encoding a tethered ligand, and a second-order cell in the cellular circuit with a nucleic acid molecule encoding a receptor and an effector fusion polypeptide, a nucleic acid molecule encoding a receptor interactor and protease fusion polypeptide, and a nucleic acid molecule encoding a reporter/modifier gene.

Abstract: A virtual reality system providing a virtual robotic surgical environment, and methods for using the virtual reality system, are described herein. The virtual reality system may simulate a robotic surgical environment in which a user may operate both a robotically-controlled surgical instrument using a handheld controller and a manual laparoscopic surgical instrument while adjacent a patient table.

Abstract: An inner middle rotor is rotated while an inner front rotor, an inner back rotor, and an outer rotor are not rotated. The inner middle rotor is surrounded by the inner front rotor, the inner back rotor, the outer rotor, and a fuselage. After rotating the inner middle rotor while not rotating the inner front rotor, the inner back rotor, and the outer rotor, the inner middle rotor, the inner front rotor, the inner back rotor, and the outer rotor are simultaneously rotated.

Abstract: A set of one or more desired forces or desired moments associated with an aircraft having a plurality of rotor modules is received. A plurality of health metrics associated with the plurality of rotor modules is received. A plurality of commands for the plurality of rotor modules is determined based at least in part on the set of desired forces or desired moments and the plurality of health metrics. The plurality of commands is sent to the plurality of rotor modules where each rotor module in the plurality of rotor modules is configured to perform a corresponding command in the plurality of commands.