Abstract: The disclosure features macrocyclic compounds, alone and in combination with other therapeutic agents, as well as pharmaceutical compositions and protein complexes thereof, capable of modulating biological processes including RAS and RAS-RAF inhibition, and their uses in the treatment of cancers.

Abstract: Disclosed are multi-ply tissue products comprising a non-crosslinked binder that are durable and dispersible. The products generally have a Slosh time less than 2 minutes, such as less than about 60 seconds, such as less than about 45 seconds. Surprisingly, the foregoing Slosh times are achieved despite the tissue products having relatively high cross-machine direction (CD) wet tensile strength, such as greater than about 100 g/3?. Typically, increasing wet tensile strength, particularly wet CD tensile strength, negatively effects dispersability and increases Slosh time. Despite this trend, the present invention surprisingly provides a tissue product having a relatively high degree of wet strength and good dispersability.

Abstract: Filaments that contain a filament-forming material and an additive, nonwoven webs, and methods for making such filaments are provided.

Abstract: Certain aspects of the present disclosure provide techniques for providing an augmented reality user interface, including: receiving, by an image sensor of an electronic device, an image of a physical document; determining a document type associated with the physical document by performing image recognition on the image of the physical document; determining an augmented reality template to display on a display of the electronic device; displaying the augmented reality template on the display of the electronic device, wherein the augmented reality template is aligned in three dimensions with the physical document; determining a distance between the physical document and the electronic device; and enabling one or more interactive user interface elements within the augmented reality template displayed on the display of the electronic device if the determined distance between the physical document and the electronic device is less than a threshold distance.

Abstract: A vehicle closure module overtravel accommodating system includes a closure module of a vehicle. The closure module is pivotably coupled to a vehicle frame and is configured to pivot relative to the vehicle frame back-and-forth between a closed position and an open position. The system further includes a breakaway mount of the vehicle, and a bumper assembly having a head disposed on a base. The bumper assembly engages the breakaway mount to secure the bumper assembly within the vehicle.

Abstract: The following description is directed to a configurable logic platform. In one example, a configurable logic platform includes host logic and a reconfigurable logic region. The reconfigurable logic region can include logic blocks that are configurable to implement application logic. The host logic can be used for encapsulating the reconfigurable logic region. The host logic can include a host interface for communicating with a processor. The host logic can include a management function accessible via the host interface. The management function can be adapted to cause the reconfigurable logic region to be configured with the application logic in response to an authorized request from the host interface. The host logic can include a data path function accessible via the host interface. The data path function can include a layer for formatting data transfers between the host interface and the application logic.

Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Described herein are methods of eliciting an immune response in human subject in need thereof, the methods including transdermally delivering to the human subject a composition comprising particles, the composition contained in a housing of a microneedle patch device, wherein transdermally delivering includes transdermally delivering an initial dose; transdermally delivering a booster dose within 4-6 weeks of the initial dose; and transdermally delivering a subsequent dose at 1 year or more after delivering the booster dose, wherein no dose is given between the booster dose and the subsequent dose. The composition includes particles including an antigenic multilayer film.

Abstract: This invention relates to compounds of Formula (I): and enantiomers thereof, and to pharmaceutically acceptable salts of Formula (I) and said enantiomers, wherein L1, L2, R1, R2, R3 and n are as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof.

Abstract: Compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Abstract: The creped multi-ply tissue products are durable, smooth and have low levels of Slough. In certain instances, the creped multi-ply tissue products are produced using a creping composition comprising a non-crosslinked latex polymer. The creped multi-ply tissue products may have a geometric mean tensile (GMT) from about 700 to about 1,500 g/3?, a basis weight from about 45 to about 60 gsm and a Slough less than about 2.00 mg, such as from about 0.10 to about 2.00 mg. The inventive tissue products also have good durability, such as a Durability Index from about 10.0 to about 20.0, smooth surfaces, such as a TS750 value from about 15.0 to 40.0 and low stiffness, such as a Stiffness Index less than about 10.0.

Abstract: A system for performing interactions within a physical environment, the system including: a robot having a robot base that undergoes movement relative to the environment and a robot arm mounted to the robot base, the robot arm including an end effector mounted thereon; a communications system including a fieldbus network; a tracking system including a tracking base positioned in the environment and connected to the fieldbus network, and a tracking target mounted to a component of the robot, wherein the tracking base is configured to detect the tracking target to allow a position and/or orientation of the tracking target relative to the tracking base to be determined; and a control system that communicates with the tracking system via the fieldbus network to determine the relative position and/or orientation of the tracking target and controls the robot arm in accordance with the relative position and/or orientation of the tracking target.

Abstract: Systems, devices, and methods for collimating a neutron beam to specified deliverable formats having targeted beam diameters and direction are described. Examples of a neutron collimator assembly can include numerous components based on location, function, dimension, and/or constituent material. The components can include, neutron beam collimators, a beam stop, a mounting assembly, electro-mechanical actuators, an electronic controller, a safety interlock system, a moveable radiation shield, a safety cover, and an adjustable patient platform. In addition, examples of variable aperture neutron beam collimators such as nested neutron beam collimators and collimators with a diaphragm iris are described. Materials are also described.

Abstract: Methods and systems are provided for generating alerts in association with a request to open an account for an individual. For example, information identifying an individual may be received from a financial entity in association with the financial entity receiving a request to open an account for the individual from a requesting entity. The requesting entity may be a vendor or service provider associated with the financial entity. An electronic notification may then be sent to the individual, which may include a selectable option to indicate that the individual does not authorize opening of the account. In response to receiving an indication that the individual does not authorize opening of the account, notifications may be sent to both the financial entity and the requesting entity indicating that the individual has not authorized opening of the account.

Abstract: Described and claimed herein are radiation curable compositions for coating an optical fiber, particularly primary coating compositions, wherein the composition possesses specified liquid glass transition temperatures, and/or viscosity ratios between, e.g., 25° C. and 85° C. Such compositions possess preferably high amounts of a reactive oligomer component with a backbone not derived from polypropylene glycol, preferably reactive oligomers with select diisocyanate constituents, one or more reactive diluent monomers, a photoinitiator, and optionally, one or more additives. Such compositions also are preferably sufficiently viscous at room temperature to ensure optimum optical fiber coating processability. Also described are methods of coating the radiation curable compositions elsewhere described, and the fiber optic coatings resulting therefrom.

Abstract: The present disclosure relates to a tracking system for tracking a position and orientation of an object, the tracking system including: a tracking base provided in an environment, the tracking base including: a tracking head support; and, at least three tracking heads mounted to the tracking head support, a target system including at least three targets mounted to the object, each target including a reflector that reflects a radiation beam to the base sensor of a respective tracking head; and, a control system that: causes each tracking head to track a respective target as it moves throughout the environment; determines a position of each target with respect to a respective tracking head; determines an orientation of the target system using at least in part the determined position of each target; and, determines the position and orientation of the object using at least in part the position and orientation of the target system.

Abstract: The following description is directed to a logic repository service. In one example, a method of a logic repository service can include receiving a first request to generate configuration data for configurable hardware using a specification for application logic of the configurable hardware. The method can include generating the configuration data for the configurable hardware. The configuration data can include data for implementing the application logic. The method can include encrypting the configuration data to generate encrypted configuration data. The method can include signing the encrypted configuration data using a private key. The method can include transmitting the signed encrypted configuration data in response to the request.

Abstract: A smart irrigation system including a mechanized irrigation machine having a main machine controller, a plurality of distributed controllers, and a communications network. The distributed controllers may be located at a plurality of spaced apart locations on the mechanized irrigation machine. The communications network may communicably couple the plurality of distributed controllers, the main machine controller, and local or remote cloud storage. Furthermore, the main machine controller and the plurality of distributed controllers may retrieve or store information from the local or remote cloud storage for maintenance, firmware updates, or troubleshooting of the mechanized irrigation machine. The distributed controllers may perform the following functions: individual tower motor control, span joint control, corner arm control, GPS guidance or positioning of one or more actuatable features of the smart irrigation system, and/or valve control of individual sprinklers for variable rate irrigation.

Abstract: A medical imaging device for use in imaging a subject using both gamma rays and light rays emanating from the subject, the device comprising: separation means to separate gamma rays and light rays emanating from the subject into a gamma ray channel comprising gamma rays and a light ray channel comprising light rays; first sensor means arranged to receive and detect gamma rays from the gamma ray channel and to generate first signals for use in forming a first image of the subject; second sensor means arranged to receive and detect light rays from the light ray channel and to generate second signals for use in forming a second image of the subject; wherein the first sensor means and the second sensor means are arranged to receive gamma rays and light rays, respectively, which propagate from the subject upon substantially coincident paths.