Abstract: The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

Abstract: A system for performing interactions within a physical environment including a robot base that undergoes movement relative to the environment, a robot arm mounted to the robot base, the robot arm including an end effector mounted thereon and a tracking system that measures a robot base position indicative of a position of the robot base relative to the environment. A control system acquires an indication of an end effector destination, determines a reference robot base position, calculates an end effector path extending to the end effector destination and repeatedly determines a current robot base position using signals from the tracking system, calculates a correction based on the current robot base position, the correction being indicative of a path modification, and controls the robot arm in accordance with the correction to move the end effector towards the end effector destination.

Abstract: Systems and methods are provided for assessing an account takeover risk for one or more accounts of an individual. The account security procedures for each of a number of services with which the user has an account may be analyzed. Publicly accessible information regarding the user may also be collected and analyzed. The collected information and security procedures may be compared in order to determine one or more vulnerabilities to hostile account takeover of one or more of the analyzed accounts. An alert may be generated regarding a determined takeover risk, which may include suggested actions for remedying the risk.

Abstract: A process for generating a metal sulfate that involves crystallizing a metal sulfate from an aqueous solution to form a crystallized metal sulfate in a mother liquor with uncrystallized metal sulfate remaining in the mother liquor; separating the crystallized metal sulfate from the mother liquor; basifying a portion of the mother liquor to convert the uncrystallized metal sulfate to a basic metal salt; and using the basic metal salt upstream of crystallizing the metal sulfate. So crystallized, the generated metal sulfate may be battery-grade or electroplating-grade.

Abstract: In some embodiments, a computer system is described. In some embodiments, the computer system generates a suggested collection of applications based at least in part on a first application selected by a client device, receives a second selection of a second application from the suggested collection of applications, integrates the first application and second application with a client application on the host platform, receives a request to perform an operation on the client application, selects at least one of the first application or the second application of the client application to perform the operation based on a determination that the at least one of the first application or the second application have access to the database, sends a request to perform the operation to the selected first or second application, and receives a set of results based on performance of the operation.

Abstract: Provided is an air treatment apparatus comprising an air flow generator arranged to generate an air flow, a moisture source arranged to introduce water vapour into the air flow, and a water supply system. The water supply system comprises a water tank, a water supply pipe arranged to convey water from the water tank, a water pump arranged to pump water through the water supply pipe, and an ultraviolet light source arranged to irradiate the water passing through the water supply pipe. The water supply system further comprises a flow regulator. The flow regulator comprises a receptacle or flow regulation chamber that is arranged to receive water from the water pump and that is fluidically connected to the water supply pipe, and the receptacle comprises a crest or brim that is arranged to allow water to flow of the receptacle.

Abstract: A head wearable air purifier includes a headgear, an air purifier assembly supported by the headgear, a nozzle assembly and a mask body. The air purifier assembly includes a filter and an airflow generator for generating an airflow through the filter. The nozzle assembly is configured to extend in front of a face of a wearer in use. The nozzle assembly includes an inlet aperture configured to receive a filtered airflow from the air purifier assembly, and an air outlet for emitting the filtered airflow from the nozzle assembly. The mask body detachably connects to the nozzle assembly and defines a cavity for receiving a mouth and/or nose of the wearer. The cavity is in fluid communication with the air outlet.

Abstract: A solid-state device having a substrate that receives an ionizing radiation, logic circuits, integrity circuits, and a collection circuit. The logic circuits are operational to perform logic functions. The logic circuits are located in an area on the substrate, and are individually susceptible to a possible corruption by the ionizing radiation. Each integrity cell is initialized to a predetermined state. The integrity cells are located in the area on the substrate, arranged in a pattern neighboring the logic circuits, and individually susceptible to disrupting the predetermined state in response to the ionizing radiation. The collection circuit is located on the substrate. The collection circuit is operational to read the plurality of integrity cells, and assert a report signal that identifies the possible corruption in a subset of the logic circuits due to the ionizing radiation in response to reading an incorrect state in a neighboring one of the integrity cells.

Abstract: Methods and apparatus for voltage contrast defect inspection are disclosed. An example apparatus includes a substrate. The example apparatus further includes a virtual ground layer coupled to the substrate. The example apparatus also includes at least one process layer coupled to the virtual ground layer, the at least one process layer including a conductive feature.

Abstract: Methods and apparatus for localized temperature control and leakage protection in a server housing are disclosed. An example system includes interface circuitry, machine readable instructions, and at least one programmable circuit of a server disposable inside a portion of a server housing. The at least one programmable circuit are to at least one of instantiate or execute the machine readable instructions to identify a temperature of the server, determine a target temperature for a workload for the server, and control an actuator based on the temperature and the target temperature, the actuator to control a local flow rate of a coolant in the portion of the server housing.

Abstract: Techniques for predicting health conditions of patients using machine learning are described. Nuclei of cells from an image of a biological sample of the patient are identified. Cell type regions are identified that include one or more cells that are shown in the image. Cell types of the identified nuclei are identified based in part on locations of the nuclei relative to some or all of the identified cell type regions. Sets of scores for the identified nuclei are predicted using prediction models associated with different cell types. A set of aggregate scores for each of the cell types is generated using the sets of scores. A cancer risk or health outcome is estimated by applying at least some of the set of aggregate scores to a risk model.

Abstract: A stand-alone modular removable rudder system for watercraft having a rudder comprising a steering handle coupled to a quick release mechanism adapted to releasably secure said steering handle to said watercraft in proximity to the operator, said system further comprising, a rudder mount adapted to be coupled to the rear of the watercraft by a quick release mechanism adapted to releasably secure said rudder mount to said watercraft, said rudder being carried by a rudder support pivotal about said rudder mount and cables operatively connecting said steering handle to said rudder mount whereby the steering handle can be operated to steer the rudder.

Abstract: A shipping package (1) comprises an enclosure for receiving content within, a closure (14) for sealing the enclosure, a label comprising shipping information, a network module (380), a sensor module (382), and a battery module (384). The battery module provides power to the network module and the sensor module. The sensor module (382) providing location information to the network module, the network module transmits a shipping status message to an external device.

Abstract: Disclosed herein are various systems, sub-system, and methods for the manufacture of a wall module for using in building a modular construction unit, e.g., for using in building residential homes, commercial offices, educational or service facilities, etc. using a substantially entirely automated modular construction technique. According to the disclosure herein, the resulting wall module includes an internal wall frame including wall studs attached between a top plate and a bottom plate, with, in some embodiment, one or more framing sub-assemblies attached therein to define openings through the wall module. The wall frame has suitable panel members the respective surfaces thereof corresponding to the interior and exterior surfaces of the modular construction unit. The wall frames, when completely assembled, can be transported to be assembled with other constituent components of the modular construction unit to complete the manufacture of the modular construction unit.

Abstract: The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present disclosure is directed to pharmaceutical compositions comprising apraclonidine and a polymer, wherein the apraclonidine is present at greater than 0.05% (w/v) to no more than 0.2% (w/v) based on the total volume of the pharmaceutical composition, methods of preparing the same and methods for reducing ocular redness by administering the same.

Abstract: In some embodiments, a computer system is described. In some embodiments, the computer system receives, from a client application, a first request to access a collection of applications associated with an operation, wherein the collection of applications is associated with at least one third-party entity. In some embodiments, the computer system receives a selection of an application associated with a third-party entity from the collection of applications. In some embodiments, in response to receiving the selection, the computer system identifies a set of data comprising an aggregation of data stored on a plurality of databases required to perform the operation associated with the application. In some embodiments, the computer system determines that the application has access to the aggregation of data. In some embodiments, the computer sends a request to perform the operation to the application. In some embodiments, the computer system receives a set of results based on the performance of the operation.

Abstract: Embodiments disclosed herein include methods of depositing a metal oxo photoresist using dry deposition processes. In an embodiment, the method for forming a photoresist layer over a substrate in a vacuum chamber comprises providing a metal precursor vapor into the vacuum chamber. In an embodiment, the method further comprises providing an oxidant vapor into the vacuum chamber, where a reaction between the metal precursor vapor and the oxidant vapor results in the formation of the photoresist layer on a surface of the substrate. In an embodiment, the photoresist layer is a metal oxo containing material.

Abstract: Device, systems, and methods for secure attachment and alignment of modular building units. The system includes one or more lock brackets on a first modular building unit and one or more receiver brackets on a second modular building unit. The lock brackets include a lock bracket protrusion. The lock bracket protrusion includes a locking tab having a locking tab profile including an aligning portion and a locking portion. The receiver brackets include an alignment hole. The lock bracket protrusion is inserted into the alignment hole as the second modular building unit is lowered onto the first modular building unit. The receiver brackets slide vertically and laterally along the aligning portion and the locking portion as the lock bracket protrusion is inserted into the alignment hole. The locking portion prevents vertical movement of the second modular building unit without a corresponding lateral movement.