Abstract: The disclosure generally relates to binding proteins that comprise antigen binding sites, a T cell receptor binding site, and a T cell co-stimulatory molecule binding site. The disclosure also relates to pharmaceutical compositions comprising such binding proteins, nucleic acid molecules encoding such binding proteins, and vectors comprising such nucleic acid molecules. The disclosure further relates to methods of treating a disorder or condition using such binding proteins and pharmaceutical compositions, binding proteins and pharmaceutical compositions for use in the treatment of a disorder or condition, and the use of such binding proteins and pharmaceutical compositions for the manufacture of a medicament for treating a disorder or condition.

Abstract: A display system can include a head-mounted display configured to project light to an eye of a user to display augmented reality image content to the user. The display system can include one or more user sensors configured to sense the user and can include one or more environmental sensors configured to sense surroundings of the user. The display system can also include processing electronics in communication with the display, the one or more user sensors, and the one or more environmental sensors. The processing electronics can be configured to sense a situation involving user focus, determine user intent for the situation, and alter user perception of a real or virtual object within the vision field of the user based at least in part on the user intent and/or sensed situation involving user focus. The processing electronics can be configured to at least one of enhance or de-emphasize the user perception of the real or virtual object within the vision field of the user.

Abstract: The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.

Abstract: A biopharmaceutical flow port, a biopharmaceutical liquid container assembly, and a method for manufacturing the biopharmaceutical flow port and the biopharmaceutical liquid container assembly are described. The biopharmaceutical flow port includes a hose barb coupled to an elliptic body. The hose barb includes a bore. The elliptic body includes a flow passage, a first edge, and a second edge. The flow passage is fluidly coupled to the bore. The first edge extends from the elliptic body away from the flow passage in a first direction and the second edge extends from the elliptic body away from the flow passage in a second direction opposite the first direction. The biopharmaceutical liquid container assembly includes a biopharmaceutical liquid container with an opening and the biopharmaceutical flow port coupled to the biopharmaceutical liquid container within the opening and in fluid communication with a volume of the biopharmaceutical liquid container.

Abstract: The embodiments herein provide a method and a system for security risk identification and controlling release management of software application. The method provides security risk identification in a software application as well as integrated tools to direct the efforts of developers to build and maintain secure software. The method provides a unique approach of defining a plurality of Service Level Agreement (SLA) to control a release build for a software application by checking vulnerabilities. Furthermore, the method is flexible enough to adapt in most complicated enterprises and different Software Development Life Cycle (SDLC) processes.

Abstract: A tablet-like device is configured to have a slightly negative buoyancy and to hold a sheet of waterproof synthetic paper, or another removable, waterproof recording sheet, onto which notes or messages or sketches can be recorded via a writing implement, in an underwater or marine environment, or another extreme or severe environment.

Abstract: Technologies are disclosed herein to secure flexible access to the healthcare information resources (HIR) contained within electronic health records (EHR) systems. By managing access permissions with certified self-sovereign identities and distributed ledger techniques, HIR may be secured. Patients and other users may be registered to access a distributed ledger, such as a healthcare blockchain, employed to set, host and adjudicate permissions to access HIR. Authorized owners and/or patients with rights to their own HIR may be able to grant fine-grained and conditional access permissions to third-parties. Information transfers and transactions occurring according to these permissions may be logged within smart contracts incorporated in the healthcare blockchain.

Abstract: A method of obtaining transuranic elements for nanofuel including: receiving spent nuclear fuel (SNF); separating elements from SNF, including a stream of elements with Z>92, fissile fuel, passive agent, fertile fuel, or fission products; and providing elements. A method of using transuranic elements to create nanofuel, including: receiving, converting, and mixing the transuranic elements with a moderator to obtain nanofuel.

Abstract: A nanofuel engine including receiving nanofuel (including a molecular mixture, where the molecular mixture includes at least one molecule with dimensions on a nanometer scale) internally in an internal engine that releases nuclear energy, is set forth. A nanofuel chemical composition of fissile fuel, passive agent, and moderator. A method of operating a nanofuel engine loaded with nanofuel in spark or compression ignition mode. A method of cycling a nanofuel engine, including compressing nanofuel; igniting nanofuel; capturing energy released in nanofuel, which is also the working fluid; and using the working fluid to perform mechanical work or generate heat.

Abstract: An exemplary embodiment can include an apparatus including: an internal-external hybrid nuclear reactor, which can include: at least one reciprocating internal engine; and at least one external reactor integrated with said at least one reciprocating internal engine. The reciprocating engine can receive nanofuel (including moderator, nanoscale molecular dimensions & molecular mixture) internally in an internal combustion engine that releases nuclear energy. A method of operating the hybrid nuclear reactor can include operating the reciprocating internal engine loaded with nanofuel in spark or compression ignition mode. A method of cycling the reciprocating internal engine, can include compressing nanofuel; igniting nanofuel; capturing energy released in nanofuel, which is also the working fluid; and using the working fluid to perform mechanical work or generate heat.

Abstract: A tablet-like device is configured to have a slightly negative buoyancy and to hold a sheet of waterproof synthetic paper, or another removable, waterproof recording sheet, onto which notes or messages or sketches can be recorded via a writing implement, in an underwater or marine environment, or another extreme or severe environment.

Abstract: A method for generating a program to run on multiple tiles. The method comprises: receiving an input graph comprising data nodes, compute vertices and edges; receiving an initial tile-mapping specifying which data nodes and vertices are allocated to which tile; and determining a subgraph of the input graph that meets one or more heuristic rules. The rules comprises: the subgraph comprises at least one data node, the subgraph spans no more than a threshold number of tiles in the initial tile-mapping, and the subgraph comprises at least a minimum number of edges outputting to one or more vertices on one or more other tiles. The method further comprises adapting the initial mapping to migrate the data nodes and any vertices of the determined subgraph to said one or more other tiles.

Abstract: A tablet-like device is configured to have a slightly negative buoyancy and to hold a sheet of waterproof synthetic paper, or another removable, waterproof recording sheet, onto which notes or messages or sketches can be recorded via a writing implement, in an underwater or marine environment, or another extreme or severe environment. Since the tablet device is configured for use of sheets of waterproof synthetic paper, divers can work with their own personal pre-printed material underwater. Further, the tablet device also has the advantages of cost savings and reduced environmental impact.

Abstract: Technologies are disclosed herein to secure flexible access to the healthcare information resources (HIR) contained within electronic health records (EHR) systems. By managing access permissions with certified self-sovereign identities and distributed ledger techniques, HIR may be secured. Patients and other users may be registered to access a distributed ledger, such as a healthcare blockchain, employed to set, host and adjudicate permissions to access HIR. Authorized owners and/or patients with rights to their own HIR may be able to grant fine-grained and conditional access permissions to third-parties. Information transfers and transactions occurring according to these permissions may be logged within smart contracts incorporated in the healthcare blockchain.

Abstract: An anti-pest film may be provided. The anti-pest film has an upward-facing reflective surface and one or more inner reflective layers overlaying an opaque downward-facing layer. The anti-pest film may include a barrier layer between two inner reflective layers, where sandwiching the barrier layer may be two malaic anhydride layers. The upward-facing reflective surface may be a vacuum metalized layer, and in certain embodiments, the vacuum metalized layer may be embossed for providing a plurality of half ellipsoid indentation for increasing the angles of incidents for reflected sunlight. Additional embodiments may include bookending opaque layers on opposing sides of the vacuum metalized layer.

Abstract: A sensor comprising three electrodes forming two electrode pairs, each pair having a gap between the electrodes, is disclosed. An electrically insulating layer is disposed in the gap of one electrode pair. The sensor may include a RC oscillator circuit connected to the electrode pair having the insulating layer such that the electrode pair contributes to the capacitance of the circuit. The sensor may include a power supply connected to the other electrode pair to provide a voltage across and current through material in the pair's gap. The sensor may be disposed in a borehole to allow borehole fluid to enter the gaps and the RC oscillator circuit and power supply may be operated to provide a measure of capacitance and resistance characteristics of the borehole fluid.

Abstract: A sensor comprising three electrodes forming two electrode pairs, each pair having a gap between the electrodes, is disclosed. An electrically insulating layer is disposed in the gap of one electrode pair. The sensor may include a RC oscillator circuit connected to the electrode pair having the insulating layer such that the electrode pair contributes to the capacitance of the circuit. The sensor may include a power supply connected to the other electrode pair to provide a voltage across and current through material in the pair's gap. The sensor may be disposed in a borehole to allow borehole fluid to enter the gaps and the RC oscillator circuit and power supply may be operated to provide a measure of capacitance and resistance characteristics of the borehole fluid.

Abstract: A method for generating a program to run on multiple tiles. The method comprises: receiving an input graph comprising data nodes, compute vertices and edges; receiving an initial tile-mapping specifying which data nodes and vertices are allocated to which tile; and determining a subgraph of the input graph that meets one or more heuristic rules. The rules comprises: the subgraph comprises at least one data node, the subgraph spans no more than a threshold number of tiles in the initial tile-mapping, and the subgraph comprises at least a minimum number of edges outputting to one or more vertices on one or more other tiles. The method further comprises adapting the initial mapping to migrate the data nodes and any vertices of the determined subgraph to said one or more other tiles.

Abstract: An exemplary embodiment can include an apparatus including: an internal-external hybrid nuclear reactor, which can include: at least one reciprocating internal engine; and at least one external reactor integrated with said at least one reciprocating internal engine. The reciprocating engine can receive nanofuel (including moderator, nanoscale molecular dimensions & molecular mixture) internally in an internal combustion engine that releases nuclear energy. A method of operating the hybrid nuclear reactor can include operating the reciprocating internal engine loaded with nanofuel in spark or compression ignition mode. A method of cycling the reciprocating internal engine, can include compressing nanofuel; igniting nanofuel; capturing energy released in nanofuel, which is also the working fluid; and using the working fluid to perform mechanical work or generate heat.

Abstract: Technologies are disclosed herein to secure flexible access to the healthcare information resources (HIR) contained within electronic health records (EHR) systems. By managing access permissions with certified self-sovereign identities and distributed ledger techniques, HIR may be secured. Patients and other users may be registered to access a distributed ledger, such as a healthcare blockchain, employed to set, host and adjudicate permissions to access HIR. Authorized owners and/or patients with rights to their own HIR may be able to grant fine-grained and conditional access permissions to third-parties. Information transfers and transactions occurring according to these permissions may be logged within smart contracts incorporated in the healthcare blockchain.