Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and an EGFR antibody such as cetuximab. The anti-cancer effect of cetuximab is enhanced in the presence of SIRP?Fc. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgGl or preferably IgG4 isotype. These combinations are useful particularly to treat solid tumours and blood cancers including lymphomas, leukemias and myelomas.

Abstract: CD47+ disease cells such as cancer cells are treated using a combination of CD47 blocking agent and a CD38 antibody such as daratumumab. The anti-cancer effect of SIRP?Fc is enhanced in the presence of daratumumab. Specific combinations include SIRP?Fc forms that comprise an Fc that is either IgG1 or IgG4 isotype. These combinations are useful particularly to treat blood cancers including lymphomas, leukemias and myelomas.

Abstract: Methods and systems are provided for a turbine integrally formed with a cylinder head. In one example, a system includes a cylinder head and a turbine shaped from a single, continuous piece of metal.

Abstract: A methodology for operating an authoritative DNS server includes receiving a DNS query from a DNS client, in response to the DNS query, traversing a label tree stored in the authoritative DNS server to find a resource record that matches the DNS query, while traversing the label tree, encountering a LINK record in the label tree that is configured to redirect the traversing to a different branch of the label tree, and in response to the LINK record, redirecting the traversing to the different branch of the label tree, wherein the LINK record is a resource record type that is hidden from DNS clients and is configured to redirect for an owner of the record type and subordinates thereof.

Abstract: CD47+ disease cells, such as various cancers, are treated using a combination of CD47 blockade with T cell checkpoint inhibition. Preferred embodiments use SIRP?Fc in combination with a PD-1 pathway inhibitor such as nivolumab and/or a CTLA-4 inhibitor such as ipilimumab.

Abstract: A tubular member (1) with a relative rough (1.5-10 ?m) inner surface (5) coated solid lubricating film (10) which is transformed into a substantially viscous rubbery viscoelasto-plastic phase at temperatures in a range between 50° C. and 110° C. is expanded by moving an expansion member (24) with a relatively smooth outer surface (roughness<1.5 ?m) therethrough, such that during expansion a viscous viscoelastoplastic substantially rubbery lubricating film (44) is generated between the tubular member (1) and the expansion mandrel (24), which film remains bonded to the rough inner surface (5) of the expanded tubular (1), but does not stick to the relatively hot and smooth expansion member (24).

Abstract: Systems and methods for automatic repair, replacement, and/or configuration of various network devices within a communications network are disclosed. The system may receive indication of a failed network device and automatically perform diagnostic on the network device to determine any problems associated with the hardware and/or software components within the network device. Subsequently one or more repair, replacement, and/or configuration procedures may be automatically initiated in an attempt to resolve the problems and restore the failed network device.

Abstract: A card includes a substrate having a first surface and a second surface opposite the first surface. The first surface has a first surface area. The card also includes an image area on the first surface. The image area has a second surface area less than the first surface area. The cars further includes a contrast region between the image area and an edge of the substrate. The contrast region is a solid border surrounding the image area. The card additionally includes a plurality of markings extending from the contrast region into the image area. Each marking of the plurality of markings arranged in a pattern such that the markings of the plurality of markings are separated from one another by a portion of the image area.

Abstract: The present disclosure provides high-load tablet formulations of AG10 or a pharmaceutically acceptable salt thereof. In some aspects, provided herein are table formulations of AG10 or a pharmaceutically acceptable salt thereof that include at least 40% or more AG10 by weight and at least one pharmaceutical excipient selected from one or more fillers, one or more binders, one or more disintegrants, and one or more lubricants.

Abstract: A card includes a substrate having a first surface and a second surface opposite the first surface. The first surface has a first surface area. The card also includes an image area on the first surface. The image area has a second surface area less than the first surface area. The cars further includes a contrast region between the image area and an edge of the substrate. The contrast region is a solid border surrounding the image area. The card additionally includes a plurality of markings extending from the contrast region into the image area. Each marking of the plurality of markings arranged in a pattern such that the markings of the plurality of markings are separated from one another by a portion of the image area.

Abstract: An engine component includes stratified metal layers. The stratified metal layers form walls of a cylinder head having internal cavities defining a cooling jacket configured to direct coolant within and through the walls. The stratified metal layers also form a lattice disposed within and spanning between opposing surfaces of the cooling jacket configured to promote heat transfer between the stratified metal layers and coolant.

Abstract: An engine component includes stratified layers that form an integral cylinder head and an internally cooled valve guide located in a cylinder head guide boss. The integral cylinder head further includes a coolant passage within a body of the valve guide that is in fluid communication with a cylinder head cooling jacket.

Abstract: A laser receiver comprising a sensor; a first amplifier operatively connected to the sensor comprising a first gate, a first source and a first drain; a first subcircuit operatively connected between the first drain and the first gate comprising a first resistor, a first inductor and a decoupling capacitor configured to allow the first amplifier bias to be established by the at least one first biasing resistor; the impedance of the first gate being sufficient such that only a small proportion of the current from the sensor passes into the first gate; an inductor connecting the first gate to the at least one biasing resistor with high impedance at the receiver operating frequency; a second amplifier comprising a second gate operatively connected to the first drain; and an output configured to be operatively connected to a processing unit and a display unit configured to displaying output and method thereof.

Abstract: An automated laboratory system includes a vertical shelving system including a frame and at least one shelf movably mounted to the frame such that the at least one shelf is movable relative to the frame between a docked position and an undocked position, the at least one shelf being configured to carry at least one instrument. The system also includes a robotic device proximate the vertical shelving system and being configured to access the at least one instrument carried by the at least one shelf.

Abstract: A method includes causing a control cluster to be included in a user interface and overlapping with an interactive virtual environment. The control cluster includes a first icon area, a second icon area, and a trigger icon area. The method further includes causing a first image to be displayed in the first icon area and a second image to be displayed in the second icon area. The method additionally includes causing a copy of the first image to be displayed in the trigger icon area or a copy of the second image to be displayed in the trigger icon area. The method also includes causing a readiness level of a game play feature to change, and causing the copy of the first image displayed in the trigger icon area or the copy of the second image displayed in the trigger icon area to be replaced with a trigger image.

Abstract: An engine component includes stratified metal layers. The stratified metal layers form walls of a cylinder head having internal cavities defining a cooling jacket configured to direct coolant within and through the walls. The stratified metal layers also form a lattice disposed within and spanning between opposing surfaces of the cooling jacket configured to promote heat transfer between the stratified metal layers and coolant.

Abstract: Systems for defining an internally threaded bore in a composite material component include one or more thread forming tools each defining a thread forming portion and a locating fixture configured to hold the one or more thread forming tools in a predetermined configuration defining a pattern of internally threaded bores to be provided in the composite material component. The thread forming portions include a plurality of thread forming surfaces each defining a pitch, a crest fillet radius, and a root fillet radius, and define internally threaded bores having an interior helical thread defining a plurality of full crest radii and a plurality of full root radii. A component forming fixture is provided for abutting the locating fixture whereby the one or more thread forming tools are held in an interior of the forming fixture. Methods for forming composite material components having internally threaded bores using the described systems are described.

Abstract: A methodology for operating an authoritative DNS server includes receiving a DNS query from a DNS client, in response to the DNS query, traversing a label tree stored in the authoritative DNS server to find a resource record that matches the DNS query, while traversing the label tree, encountering a LINK record in the label tree that is configured to redirect the traversing to a different branch of the label tree, and in response to the LINK record, redirecting the traversing to the different branch of the label tree, wherein the LINK record is a resource record type that is hidden from DNS clients and is configured to redirect for an owner of the record type and subordinates thereof.