Abstract: The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.

Abstract: An optical-fiber-network (OFN) radio-frequency identification (RFID) system for deploying and/or maintaining and/or provisioning service and/or locating faults in an OFN. The system includes a plurality of OFN components, and at least one RFID tag that includes RFID tag data that has at least one property of the OFN component associated with the RFID tag. The RFID tag data is written to and read from the RFID tags using one or more mobile RFID readers either prior to, during or after deploying the OFN components. An OFN-component-data database unit is used to store and process the RFID tag data and is automatically updated by the one or more mobile RFID readers. This allows for different maps of the OFN to be made, such as an inventory map and a maintenance map, and for the maps to be automatically updated. The OFN-RFID system allows for mobile automated operations and management of OFN components by service personnel, and provides for faster and more accurate OFN system deployment and maintenance.

Abstract: A fuel vapor recovery system and method for an automotive vehicle are disclosed. The vehicle fuel tank is vented to atmosphere via a passageway having a carbon canister to remove fuel vapors, a bladder, and a normally-closed isolation valve. When fueling the vehicle, the gases in the fuel tank displaced by entering fuel are introduced into the carbon canister where the fuel vapors are stored. The isolation valve is commanded to open to allow such flow through the carbon canister. When the vehicle is parked for a period of a day, it undergoes a diurnal temperature change which causes fuel to vaporize into the fuel system. According to an aspect of the present development, the isolation valve remains closed and the gases are contained within the bladder as it expands or contracts as the volume of gases increases or decreases in response to temperature changes.

Abstract: An electronic circuit has an amplifier with an amplifying transistor and a cascode transistor. A capacitive voltage divider applies a fraction of an RF signal swing from the drain of the cascode transistor to the gate of the cascode transistor, the fraction being determined by a ratio between capacitance values. In addition a bias voltage supply circuit is provided. The bias voltage supply circuit is configured to define a relation between an average gate voltage of the cascode transistor and an average drain supply voltage at the drain of the cascode transistor. This relation increases the average gate voltage with increasing average drain voltage, and the relation provides a non zero average gate voltage when extrapolated to zero average drain supply voltage.

Abstract: Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer's disease and related conditions.

Abstract: A first hydraulic cylinder is associated with a boom. A first sensor detects a boom position based on a first linear position of a first movable member associated with the first hydraulic cylinder. An attachment is coupled to the boom. A second cylinder is associated with the attachment. A second sensor detects an attachment position based on a second linear position of a second movable member associated with the second hydraulic cylinder. A switch accepts a command to enter a ready position state from another position state. A controller controls the first hydraulic cylinder to attain a target boom position and for controlling the second cylinder to attain a target attachment position associated with the ready position state in response to the command.

Abstract: A first sensor detects a boom position of a boom based on a first linear position of a first movable member of a first hydraulic cylinder. A second sensor detects an attachment position of an attachment based on a second linear position of a second movable member of a second hydraulic cylinder. An accelerometer detects an acceleration or deceleration of the boom. A switch accepts a command to enter a ready position state from another position state. A controller controls the first hydraulic cylinder to attain a target boom position and for controlling the second cylinder to attain a target attachment position associated with the ready position state in response to the command in conformity with at least one of a desired boom motion curve and a desired attachment motion curve.

Abstract: A method of operation of an internal combustion engine including an intake valve coupled to a combustion chamber, and a port fuel injector positioned upstream of the intake valve in an intake manifold including a throttle, the port fuel injector fluidly coupled to a fuel rail included in a fuel delivery system housing a fuel at least partially composed of alcohol. The method including, during a start-up operation when the temperature of the engine is below a threshold value and fuel is actively being injected into the intake manifold, adjusting a cone angle of a fuel spray from the port fuel injector, via adjustment of the throttle and/or fuel delivery system, based on the position of the intake valve.

Abstract: A method for improving purging of fuel vapors from a boosted engine is presented. In one embodiment, the method increases the efficiency of a venturi that supplies vacuum to purge fuel vapors from a vapor storage canister.

Abstract: A method of operation of an internal combustion engine including an intake valve coupled to a combustion chamber, and a port fuel injector positioned upstream of the intake valve in an intake manifold including a throttle, the port fuel injector fluidly coupled to a fuel rail included in a fuel delivery system housing a fuel at least partially composed of alcohol. The method including, during a start-up operation when the temperature of the engine is below a threshold value and fuel is actively being injected into the intake manifold, adjusting a cone angle of a fuel spray from the port fuel injector, via adjustment of the throttle and/or fuel delivery system, based on the position of the intake valve.

Abstract: A method and system for controlling a vehicle comprises a torque detector for detecting a first torque level and a second torque level applied to at least one wheel of the vehicle. The first torque level is associated with a lower boom position of a boom. An accelerometer detects an acceleration level of the boom during or after raising of the boom. A first hydraulic cylinder is capable of raising a boom from the lower boom position to raise an available torque from the first torque level. A second hydraulic cylinder is adapted to upwardly rotate or curl a bucket associated with the vehicle if the detected acceleration level of the boom is less than a minimum level during an attempt to raise the boom.

Abstract: A method of operation of an internal combustion engine including an intake valve coupled to a combustion chamber, and a port fuel injector positioned upstream of the intake valve in an intake manifold including a throttle, the port fuel injector fluidly coupled to a fuel rail included in a fuel delivery system housing a fuel at least partially composed of alcohol. The method including, during a start-up operation when the temperature of the engine is below a threshold value and fuel is actively being injected into the intake manifold, adjusting a cone angle of a fuel spray from the port fuel injector, via adjustment of the throttle and/or fuel delivery system, based on the position of the intake valve.

Abstract: A method of operation of an internal combustion engine including an intake valve coupled to a combustion chamber, and a port fuel injector positioned upstream of the intake valve in an intake manifold including a throttle, the port fuel injector fluidly coupled to a fuel rail included in a fuel delivery system housing a fuel at least partially composed of alcohol. The method including, during a start-up operation when the temperature of the engine is below a threshold value and fuel is actively being injected into the intake manifold, adjusting a cone angle of a fuel spray from the port fuel injector, via adjustment of the throttle and/or fuel delivery system, based on the position of the intake valve.

Abstract: Compounds of formula (I) modulate the activity of gamma secretase and hence find use in treatment or prevention of Alzheimer's disease and related conditions.

Abstract: A fuel vapor recovery system and method for an automotive vehicle are disclosed. The vehicle fuel tank is vented to atmosphere via a passageway having a carbon canister to remove fuel vapors, a bladder, and a normally-closed isolation valve. When fueling the vehicle, the gases in the fuel tank displaced by entering fuel are introduced into the carbon canister where the fuel vapors are stored. The isolation valve is commanded to open to allow such flow through the carbon canister. When the vehicle is parked for a period of a day, it undergoes a diurnal temperature change which causes fuel to vaporize into the fuel system. According to an aspect of the present development, the isolation valve remains closed and the gases are contained within the bladder as it expands or contracts as the volume of gases increases or decreases in response to temperature changes.

Abstract: The present invention relates to a heat exchanger unit (13) for exchanging heat between a first fluid and a second fluid. The unit (13) comprises a flow passage for the first fluid and a flow passage for the second fluid, the flow passages are connected to inlets (9) and outlets (10) of the heat exchanger unit (13) through which the first and the second fluid flow into and out of the heat exchanger unit (13).

Abstract: A pickling solution for the surface pre-treatment of plastic surfaces in preparation for metallization, the solution comprising a source of Mn(VII) ions; and an inorganic acid; wherein the pickling solution is substantially free of chromium (VI) ions, alkali ions, and alkaline-earth ions.

Abstract: A floating command object is provided for offering a set of commonly or frequently used commands in close proximity to a selected text, data or other object in a document. When a given object is selected for editing, the floating object automatically displays near the object to allow easy selection of relevant commands such as formatting property commands. The object remains displayed to allow multiple command selections until it is closed by user action. If a mouse or touchpad pointer is moved away from the displayed object, the displayed object becomes increasingly translucent to visually deemphasize the relevance of the object to the new position of the pointer.

Abstract: A method for controlling an automotive canister purge valve in fluid communication with an evaporative canister includes selecting a purge flow rate of increase for the purge valve based on a hydrocarbon concentration in a fluid stream exiting the evaporative canister, and operating the purge valve based on the selected rate.