Patents by Inventor Mark S Leung
Mark S Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12251150Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: November 16, 2020Date of Patent: March 18, 2025Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J Clark, Michael Cummins, Danny Donovan, Mark Gelfand, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Mark S. Leung, Gwenda Francis, Barry Mullins, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Michael Turovskiy
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Publication number: 20240335226Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: June 20, 2024Publication date: October 10, 2024Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 12035959Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: GrantFiled: May 7, 2021Date of Patent: July 16, 2024Assignee: Medtronic Ireland Manufacturing Unlimited CompanyInventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Publication number: 20240156521Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: ApplicationFiled: June 9, 2023Publication date: May 16, 2024Inventors: Dorin PANESCU, Andrew WU, Zoar Jacob ENGELMAN, Mark GELFAND, Mark S. LEUNG, Howard LEVIN
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Patent number: 11844569Abstract: Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: GrantFiled: August 15, 2023Date of Patent: December 19, 2023Assignee: Axon Therapies, Inc.Inventors: Dorin Panescu, Andrew Wu, Zoar Jacob Engelman, Mark Gelfand, Mark S. Leung
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Publication number: 20230380901Abstract: Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: ApplicationFiled: August 15, 2023Publication date: November 30, 2023Inventors: Dorin PANESCU, Andrew WU, Zoar Jacob ENGELMAN, Mark GELFAND, Mark S. LEUNG
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Publication number: 20230380896Abstract: Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: ApplicationFiled: August 7, 2023Publication date: November 30, 2023Inventors: Dorin PANESCU, Andrew WU, Zoar Jacob ENGELMAN, Mark GELFAND, Mark S. LEUNG
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Publication number: 20230346380Abstract: A flow control device (300, 324, 330) for a bronchial passageway including: a flow control valve (307, 335); a braided wire structural frame (303) expandable from a collapsed configuration to an expanded configuration, in the collapsed configuration the frame is an extended tube and in the collapsed configuration the frame includes a wall contact section (310), a middle support section (312) within the wall contact section, and a fold (311) between and connecting the wall contact section and the middle support section; and a sealing membrane (305) mounted to at least a distal portion of the structural frame, wherein the sealing membrane forms an enclosed wall defining at least a portion of an airflow passage through the flow control device, and the flow control valve is included in the airflow passage and extending inward from the enclosed wall and at least partially within the wall contact section.Type: ApplicationFiled: January 22, 2021Publication date: November 2, 2023Inventors: Sean TOTTEN, Residenc LEE, Joe M. GUERRICABEITIA, Don TANAKA, Abha Prashant CHINUBHA, Mark S. LEUNG, Lucas SANTANNA, Claudia PHAM, Abigail BRAZIL
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Patent number: 11801092Abstract: Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.Type: GrantFiled: October 26, 2021Date of Patent: October 31, 2023Assignee: Axon Therapies, Inc.Inventors: Howard Levin, Mark Gelfand, Zoar Jacob Engelman, Dorin Panescu, Mark S. Leung
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Patent number: 11751939Abstract: Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: GrantFiled: January 28, 2019Date of Patent: September 12, 2023Assignee: Axon Therapies, Inc.Inventors: Dorin Panescu, Andrew Wu, Zoar Jacob Engelman, Mark Gelfand, Mark S. Leung
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Patent number: 11712296Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: GrantFiled: February 18, 2020Date of Patent: August 1, 2023Assignee: Axon Therapies, Inc.Inventors: Dorin Panescu, Andrew Wu, Zoar Jacob Engelman, Mark Gelfand, Mark S. Leung, Howard Levin
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Publication number: 20220257315Abstract: Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying simulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.Type: ApplicationFiled: October 26, 2021Publication date: August 18, 2022Inventors: Howard LEVIN, Mark GELFAND, Zoar Jacob ENGELMAN, Dorin PANESCU, Mark S. LEUNG
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Patent number: 11154354Abstract: Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying stimulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.Type: GrantFiled: July 31, 2017Date of Patent: October 26, 2021Assignee: Axon Therapies, Inc.Inventors: Howard Levin, Mark Gelfand, Zoar Jacob Engelman, Dorin Panescu, Mark S. Leung
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Publication number: 20210259760Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: May 7, 2021Publication date: August 26, 2021Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 11006999Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: GrantFiled: December 13, 2018Date of Patent: May 18, 2021Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Publication number: 20210128229Abstract: Systems, devices, and methods for transvascular ablation of target tissue are disclosed herein. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: ApplicationFiled: January 28, 2019Publication date: May 6, 2021Applicant: AXON THERAPIES, INC.Inventors: Dorin PANESCU, Andrew WU, Zoar Jacob ENGELMAN, Mark GELFAND, Mark S. LEUNG
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Publication number: 20210068886Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: November 16, 2020Publication date: March 11, 2021Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Mark Gelfand, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Mark S. Leung, Gwenda Francis, Barry Mullins, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Michael Turovskiy
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Patent number: 10842547Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: December 14, 2018Date of Patent: November 24, 2020Assignee: MEDTRONIC ARDIAN LUXEMBOURG S.A.R.L.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Mark Gelfand, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Mark S. Leung, Gwenda Francis, Barry Mullins, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Michael Turovskiy
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Publication number: 20200179045Abstract: Apparatuses and methods for treating a heart failure patient by ablating a nerve of the thoracic splanchnic sympathetic nervous system to increase venous capacitance and reduce pulmonary blood pressure. A method comprising: inserting a catheter into a vein adjacent the nerve, applying stimulation energy and observing hemodynamic effects, applying ablation energy and observing hemodynamic effects, applying stimulation energy after the ablation and observing hemodynamic effects and monitoring for presence of the lung in the ablation zone. An alternative method comprising: inserting a catheter into a vein adjacent the nerve, detecting that lung tissue is a safe distance from an ablation zone, and delivering ablation energy to the target nerve when lung tissue is a safe distance from the ablation zone.Type: ApplicationFiled: July 31, 2017Publication date: June 11, 2020Applicant: AXON THERAPIES, INC.Inventors: Howard LEVIN, Mark GELFAND, Zoar Jacob ENGELMAN, Dorin PANESCU, Mark S. LEUNG
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Publication number: 20200179047Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: ApplicationFiled: February 18, 2020Publication date: June 11, 2020Inventors: Dorin PANESCU, Andrew WU, Zoar Jacob ENGELMAN, Mark GELFAND, Mark S. LEUNG, Howard LEVIN