Patents by Inventor Mark S Leung
Mark S Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190183569Abstract: Systems, devices, and methods for transvascular ablation of target tissue. The devices and methods may, in some examples, be used for splanchnic nerve ablation to increase splanchnic venous blood capacitance to treat at least one of heart failure and hypertension. For example, the devices disclosed herein may be advanced endovascularly to a target vessel in the region of a thoracic splanchnic nerve (TSN), such as a greater splanchnic nerve (GSN) or a TSN nerve root. Also disclosed are method of treating heart failure, such as HFpEF, by endovascularly ablating a thoracic splanchnic nerve to increase venous capacitance and reduce pulmonary blood pressure.Type: ApplicationFiled: December 17, 2018Publication date: June 20, 2019Inventors: Dorin PANESCU, Andrew WU, Zoar Jacob ENGELMAN, Mark GELFAND, Mark S. LEUNG, Howard LEVIN
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Publication number: 20190183560Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: December 13, 2018Publication date: June 20, 2019Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 10188445Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: August 5, 2016Date of Patent: January 29, 2019Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Mark Gelfand, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Mark S. Leung, Gwenda Francis, Barry Mullins, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Michael Turovskiy
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Patent number: 10179020Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: GrantFiled: August 1, 2017Date of Patent: January 15, 2019Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 10004550Abstract: Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: July 15, 2015Date of Patent: June 26, 2018Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Eric Ryba, Naomi Buckley, Benjamin J. Clark, Danny Donovan, Luke Hughes, Brian Kelly, Gwenda McMullin, Karun D. Naga, Stephen Nash, Roman Turovskiy, Lana Wooley, Denise Zarins, Mark Gelfand, Mark S. Leung
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Publication number: 20180147005Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: November 14, 2017Publication date: May 31, 2018Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Publication number: 20180028256Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: August 1, 2017Publication date: February 1, 2018Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 9855097Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: March 22, 2017Date of Patent: January 2, 2018Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Publication number: 20170258522Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: March 22, 2017Publication date: September 14, 2017Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Patent number: 9750560Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: GrantFiled: April 22, 2016Date of Patent: September 5, 2017Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 9636173Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: June 16, 2015Date of Patent: May 2, 2017Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Publication number: 20170056087Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: August 5, 2016Publication date: March 2, 2017Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Mark Gelfand, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Mark S. Leung, Gwenda McMullin, Barry Mullins, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vicenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Michael Turovskiy
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Publication number: 20170020597Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: April 22, 2016Publication date: January 26, 2017Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 9439708Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: October 23, 2011Date of Patent: September 13, 2016Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Gwenda McMullin, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins, Michael Turovskiy
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Patent number: 9402677Abstract: Methods and cryogenic devices for assessing, and treating patients having sympathetically mediated disease, involving augmented peripheral chemoreflex and heightened sympathetic tone by reducing chemosensor input to the nervous system via carotid body ablation. Some methods include advancing a cryo-ablation catheter into a patient's vasculature and ablating tissue within a carotid septum.Type: GrantFiled: June 3, 2013Date of Patent: August 2, 2016Assignee: CIBIEM, INC.Inventors: Mark S. Leung, Zoar Jacob Engelman, Martin M. Grasse, Mark Gelfand, Howard Levin
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Patent number: 9345530Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: GrantFiled: May 21, 2015Date of Patent: May 24, 2016Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Publication number: 20160095654Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: October 21, 2015Publication date: April 7, 2016Inventors: Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins
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Publication number: 20160095655Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: October 21, 2015Publication date: April 7, 2016Inventors: Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins
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Publication number: 20160095659Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: October 21, 2015Publication date: April 7, 2016Inventors: Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins
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Publication number: 20160038212Abstract: Catheter apparatuses, systems, and methods for cryogenically modulating neural structures of the renal plexus by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a cryo-applicator to a renal artery via an intravascular path. Cryogenic renal neuromodulation may be achieved via application of cryogenic temperatures to modulate neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: July 15, 2015Publication date: February 11, 2016Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Eric Ryba, Naomi Buckley, Benjamin J. Clark, Danny Donovan, Luke Hughes, Brian Kelly, Gwenda McMullin, Karun D. Naga, Stephen Nash, Roman Turovskiy, Lana Wooley, Denise Zarins, Mark Gelfand, Mark S. Leung