Patents by Inventor Mark S Leung
Mark S Leung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150351833Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: June 16, 2015Publication date: December 10, 2015Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Publication number: 20150257815Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: ApplicationFiled: May 21, 2015Publication date: September 17, 2015Inventors: Sowmya Ballakur, Robert J. Beetel, Paul Friedrichs, David Herzfeld, Andrew Wu, Denise Zarins, Mark S. Leung
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Patent number: 9084610Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: October 21, 2011Date of Patent: July 21, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Patent number: 9066720Abstract: The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.Type: GrantFiled: October 25, 2011Date of Patent: June 30, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Sowmya Ballakur, Robert Beetel, Paul Friedrichs, Andrew Wu, Denise Zarins, David Herzfeld, Mark S. Leung
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Patent number: 9060755Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: October 23, 2011Date of Patent: June 23, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Micheal Moriarty, Karun D. Naga, Fiachra Sweeney, Vincenzo Tilotta, Ronan Wood, Lana Woolley, Denise Zarins, Mark S. Leung, Mark Gelfand, Barry Mullins
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Patent number: 9060754Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment includes an elongated shaft and a cooling assembly at a distal portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site within or otherwise proximate a renal artery. The cryotherapeutic device can further include a supply lumen configured to carry liquid refrigerant toward the cooling assembly. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when in a deployed state.Type: GrantFiled: October 23, 2011Date of Patent: June 23, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Seamus Ledwith, Gwenda McMullin, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins
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Publication number: 20150057654Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: June 26, 2014Publication date: February 26, 2015Inventors: Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins
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Patent number: 8945107Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: GrantFiled: October 23, 2011Date of Patent: February 3, 2015Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Seamus Ledwith, Gwenda McMullin, Karun D. Naga, Stephen Nash, Francesco Piccagli, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins
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Patent number: 8870863Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: May 28, 2010Date of Patent: October 28, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Mark S. Leung, Benjamin J. Clark, Kenneth J. Michlitsch, Erik Thai, Andrew Wu, Denise Zarins
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Publication number: 20140303618Abstract: Multi-directional deflectable catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: April 3, 2014Publication date: October 9, 2014Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai, Kenneth J. Michlitsch, Mark S. Leung
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Publication number: 20140277310Abstract: A catheter including an elongate shaft having a distal end portion locatable within or otherwise proximate to a body lumen of a patient, the catheter having a delivery state and a deployed state, and a tether secured to the neuromodulation unit and operationally associated with the shaft. The neuromodulation unit includes a therapeutic element and a support structure carrying the therapeutic element. The support structure is configured to resiliently urge the therapeutic element radially outward relative to a longitudinal axis of the support structure. The tether is sufficiently flexible to allow the neuromodulation unit to move independently of the distal end portion of the shaft when the catheter is in the deployed state and the neuromodulation unit is within the body lumen.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Robert J. Beetel, Maria G. Aboytes, Mark S. Leung
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Publication number: 20140243809Abstract: Methods, devices, and systems for carotid body modulation via accessing a target site with an endovascular approach through a superficial temporal artery.Type: ApplicationFiled: February 24, 2014Publication date: August 28, 2014Inventors: Mark GELFAND, Howard LEVIN, Charles LENNOX, Marcus W. WILBORN, Paul A. SOBOTKA, Zoar Jacob ENGELMAN, Martin M. GRASSE, Mark S. LEUNG
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Patent number: 8728075Abstract: Multi-directional deflectable catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: GrantFiled: August 30, 2010Date of Patent: May 20, 2014Assignee: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Andrew Wu, Benjamin J. Clark, Denise Zarins, Erik Thai, Kenneth J. Michlitsch, Mark S. Leung
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Publication number: 20130310823Abstract: Systems, devices, and methods for treating a patient having a sympathetically mediated disease associated at least in part with augmented peripheral chemoreflex or heightened sympathetic activation. The treatments include ablating one or more peripheral chemoreceptors or associated afferent nerves to reduce or remove afferent neural signals from the peripheral chemoreceptor.Type: ApplicationFiled: April 24, 2013Publication date: November 21, 2013Inventors: Mark Gelfand, Howard Levin, Charles Lennox, Marat Fudim, Zoar Jacob Engelman, Martin M. Grasse, Mark S. Leung, Brett Schleicher
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Publication number: 20120150267Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: October 23, 2011Publication date: June 14, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.lInventors: Naomi Buckley, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Micheal Moriarty, Karun D. Naga, Fiachra Sweeney, Vincenzo Tilotta, Ronan Wood, Lana Woolley, Denise Zarins, Mark S. Leung, Mark Gelfand, Barry Mullins
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Publication number: 20120136417Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: October 23, 2011Publication date: May 31, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.lInventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Seamus Ledwith, Gwenda McMullin, Karun D. Naga, Stephen Nash, Francesco Piccagli, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins
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Publication number: 20120136350Abstract: Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver an energy delivery element to a renal artery via an intravascular path. Thermal or electrical renal neuromodulation may be achieved via direct and/or via indirect application of thermal and/or electrical energy to heat or cool, or otherwise electrically modulate, neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.Type: ApplicationFiled: October 21, 2011Publication date: May 31, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Justin Goshgarian, Benjamin J. Clark, Rajeshkumar Dhamodharasamy, Mark S. Leung, Maria G. Aboytes
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Publication number: 20120136344Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: October 23, 2011Publication date: May 31, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Gwenda McMullin, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins
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Publication number: 20120136418Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: October 23, 2011Publication date: May 31, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.lInventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Seamus Ledwith, Gwenda McMullin, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins
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Publication number: 20120130360Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.Type: ApplicationFiled: October 23, 2011Publication date: May 24, 2012Applicant: Medtronic Ardian Luxembourg S.a.r.l.Inventors: Naomi Buckley, Benjamin J. Clark, Michael Cummins, Danny Donovan, Luke Hughes, Brian Kelly, Gary Kelly, Grace Kelly, John Kelly, Gwenda McMullin, Karun D. Naga, Stephen Nash, Eric Ryba, Fiachra Sweeney, Vincenzo Tilotta, Roman Turovskiy, Lana Woolley, Denise Zarins, Mark Gelfand, Mark S. Leung, Barry Mullins, Michael Turovskiy