Abstract: An ambidextrous waterproof switch is provided for activating different modes of a butt-set. The switch is symmetrical about the midplane of the butt-set and therefore allows the technician to use the butt-set with either hand. The switch allows tactile or visual sensing of the position of the switch.

Abstract: An improved ion conductor layer for use in electrochromic devices and other applications is disclosed. The improved ion-conductor layer is comprised of at least two ion transport layers and a buffer layer, wherein the at least two ion transport layers and the buffer layer alternate within the ion conductor layer such that the ion transport layers are in communication with a first and a second electrode. Electrochromic devices utilizing such an improved ion conductor layer color more deeply by virtue of the increased voltage developed across the ion conductor layer prior to electronic breakdown while reducing the amount of electronic leakage. Also disclosed are methods of making electrochromic devices incorporating the improved ion conductor layer disclosed herein and methods of making ion conductors for use in other applications.

Abstract: A laser shock peening system including a workpiece is provided. The laser shock peening system includes a workholding fixture configured to hold the workpiece. The laser shock peening system also includes a laser source configured to emit multiple laser beam pulses on the workpiece. The laser shock peening system further includes an absorptive layer disposed on the workpiece, the absorptive layer configured to absorb the laser beam pulses from the laser source into the workpiece. The laser shock peening system also includes a transparent constraining layer disposed between the laser source and the absorptive layer. The transparent constraining layer is also configured to provide a pressure medium configured to direct multiple reflected laser generated shock waves from the workpiece back into the workpiece. The laser shock peening system also includes a transducer disposed on the workholding fixture and configured to detect multiple acoustic signals emitted from the workpiece.

Abstract: To reduce destructive effects of cotton picker high speed drum rotation, rearward spindle tip motion is adjusted in part by angularly positioning the spindles in the picking zone with an improved cam track arrangement. The cam rotates the picker bar about the upright axis of the bar to vary the speed of the spindle tip in the picking zone and allow a higher drum speed. In a first portion of the picking zone the spindle tips are closer together than the spindle bases at the picker bar. The spindle tip spacing in a second portion of the picking zone is approximately equal to spindle base spacing in the extremities. The resulting spindle tip movement facilitates higher cotton picker vehicle ground speed without picking efficiency loss or additional damage to the cotton plants.

Abstract: The present invention provides fluorescent cyanine dye-based nucleotide analogues, in which the cyanine dye is coupled to the ?-phosphate group of a nucleoside triphosphate. Preferred embodiments of the invention are directed to fluorescent cyanine dye-based GTP analogues which may be employed in an homogeneous FRET-based assay to measure the binding of guanine nucleotides to GPCR polypeptides, or alternatively, to measure the effect of an exogenous ligand on GPCR protein binding.

Abstract: A heat treated electrochromic device comprising an anodic complementary counter electrode layer comprised of a mixed tungsten-nickel oxide and lithium, which provides a high transmission in the fully intercalated state and which is capable of long term stability, is disclosed. Methods of making an electrochromic device comprising an anodic complementary counter electrode comprised of a mixed tungsten-nickel oxide are also disclosed.

Abstract: A system and method for extracting a biological fluid from an organism and continuously monitoring its characteristics. The system includes a tissue interface device suitable for positioning on or about the surface of the biological membrane of the organism and a monitor and control unit coupled to the tissue interface device. The tissue interface device includes a sensor positioned in a flow path of the fluid for continuously sensing a characteristic of the biological fluid as it flows out from the one or more artificial openings formed in the biological membrane. The sensor generates a sensor signal representative thereof. The monitor and control unit electrically or optically reads the sensor to obtain a measurement of a characteristic, such as concentration of a particular analyte, of the biological fluid on a continuous basis.

Abstract: A heat treated electrochromic device comprising an anodic complementary counter electrode layer comprised of a mixed tungsten-nickel oxide and lithium, which provides a high transmission in the fully intercalated state and which is capable of long term stability, is disclosed. Methods of making an electrochromic device comprising an anodic complementary counter electrode comprised of a mixed tungsten-nickel oxide are also disclosed.

Abstract: One or two conventional picking units are mounted on a two-wheel, high clearance running gear or frame. A two-point hitch is coupled to the draft links of a tractor or an equal-angle hitch is coupled to the tractor drawbar. Hitch and tongue interface on the harvester facilitates sharp turn angles between the implement and the tractor through use of a pivoting member containing the driveline powering the units from the tractor. A center pivot tongue allows offset for appropriate row alignment and provides improved maneuverability and implement steering on headlands and turn rows. A hydraulic cylinder connected to the tongue or a crossed four-bar linkage structure controls tongue angle. A basket is supported at the rear of the frame and the row units are located forwardly of the frame to provide counterbalancing forces about the wheel axis.

Abstract: One or two conventional picking units are mounted on a two-wheel, high clearance running gear or frame. A two-point hitch is coupled to the draft links of a tractor or an equal-angle hitch is coupled to the tractor drawbar. Hitch and tongue interface on the harvester facilitates sharp turn angles between the implement and the tractor through use of a pivoting member containing the driveline powering the units from the tractor. A center pivot tongue allows offset for appropriate row alignment and provides improved maneuverability and implement steering on headlands and turn rows. A hydraulic cylinder connected to the tongue or a crossed four-bar linkage structure controls tongue angle. A basket is supported at the rear of the frame and the row units are located forwardly of the frame to provide counterbalancing forces about the wheel axis.

Abstract: A conditioning mechanism is placed forwardly of the cotton harvesting mechanism on a cotton harvester. Opposing elements compress portions of the cotton plant to compress the cotton bolls and deform the cotton boll hulls. The deformation loosens the cotton fiber relative to the hulls to improve the ability of the harvesting mechanism to harvest the seed and fiber. In one embodiment, differential surface velocity of the opposing elements improves boll opening and fiber orientation for more effective spindle contact.

Abstract: A method for laser shock peening an article, such as a gas turbine engine airfoil, with varying thickness by varying a surface fluence of a laser beam over a laser shock peening surface as a function of the thickness beneath a laser shock peened spot formed by the beam on the surface. The fluence may be equal to the thickness multiplied by a volumetric fluence factor, the volumetric fluence factor being held constant over the laser shock peening surface. The volumetric fluence factor may be in a range of about 1200 J/cm3 to 1800 J/cm3 and more particularly about 1500 J/cm3. The method may include varying energy in the laser beam using a computer program controlling firing of the laser beam. A device such as an optical attenuator external to a laser performing firing may be used to vary the energy.

Abstract: The present invention relates to the discovery that mutations in SCN9A are causative of Congenital Indifference to Pain (CIP) in humans. The invention also relates to methods of utilizing the SCN9A gene and expression products thereof for the screening and identification of therapeutic agents, including small organic compounds, which are selective for SCN9A, and are useful in the treatment of pain and other disorders. The invention also relates to methods of using these compounds to treat or otherwise ameliorate such disorders.

Abstract: Polynucleotide and polypeptide sequences for HFE2A, as well as mutations associated with juvenile hemochromatosis, and methods of utilizing these for the screening and identification of agents for the treatment of diseases of iron metabolism, including small organic compounds, are disclosed along with methods of treating and/or ameliorating diseases of iron metabolism, especially in human patients are disclosed. Diagnostic compounds, kits and methods using HFE2A are also described.

Abstract: A vacuum device and method for extraction of a substance from a fluid source, the vacuum device including an upper member that may be selectively, and operably, connected to a lower member. The upper member defines a bottom opening, and has a vacuum pump in fluid communication with the bottom opening. The vacuum pump is selectively coupled to an energy source. The lower member defines an inner cavity, a first opening, and a second opening, the inner cavity in communication with the first opening and the second opening. An elastic membrane defining an interior cavity is disposed in the inner cavity and is coupied to the first opening of the lower member.

Abstract: A method of providing information through an intelligent agent with human appearance. The method comprises: executing a script for providing the intelligent agent to a user; receiving queries directed to the intelligent agent by the user; querying a knowledge base associated with the intelligent agent to determine an appropriate response to the query; should the knowledge base associated with the intelligent agent fail to provide an appropriate response to the query, querying a general knowledge base to determine an appropriate response to the query; and providing the appropriate response to the query to the user via the intelligent agent.

Abstract: Methods of utilizing a gene related to pain perception, herein dubbed HSN2, or its encoded protein, dubbed herein “sensorin,” for the screening and identification of agents for the treatment of pain, neuropathy and related disorders, especially small organic compounds, as well as methods of using these compounds to treat or otherwise ameliorate pain, neuropathy and related disorders in human patients. Novel polypeptides and polynucleotides, along with their nucleotide and amino acid sequences, are also disclosed.

Abstract: A compact three-bar linkage steering probe assembly, particularly useful with ultra-narrow row cotton harvester units, includes two vertical rocker arms pivotally connected to a harvester row unit at mid-point locations and upper ends connected by a cross link to generally constrain the arms for rocking in unison. Crop guides connected to the lower ends of the rocker arms follow the bases of the plant stalks as the row of plants enter the unit. The vertical arms are maintained within spacer tubes which prevent interference with adjacent rows of plants and which assure the arms are not disturbed by the adjacent rows. A sensor responsive to rotation of the rocker arms is located at the central pivotal connection. Arm leaf springs or a spring biased adjustable upper cross link provides probe flexibility for accommodating different plant stalk sizes.

Abstract: An alignment device and related systems and methods for aligning at least one apparatus with respect to a surface of a tissue. The alignment device comprises a tissue interface member suitable for positioning on the surface of the tissue and mating with the apparatus to maintain alignment of the apparatus during an operation of the apparatus. The alignment device is useful to align various apparatus that are part of a continuous analyte monitoring system.

Abstract: An integrated device for poration of biological tissue, harvesting a biological fluid from the tissue, and analysis of the biological fluid. The device comprises a tissue-contacting layer having an electrically or optically heated probe to heat and conduct heat to the tissue to form at least one opening, such as a micropore to collect biological fluid from the opening, and a detecting layer responsive to the biological fluid to provide an indication of a characteristic of the biological fluid, such as the concentration of an analyte in interstitial fluid. In the embodiment in which, the probe comprises a photosensitizing assembly designed for the uniform application of a photosensitizing material, such as, for example, a dye or a pigment, to a tissue, e.g., the stratum comeum.