Abstract: A specialized mortgage constant calculator may include at least four different modes, each mode associated with a graphical user interface tailored to the mode and displayed on an electronic display. In addition, the mortgage constant calculator may include an adjustable table with a persistent, adjustable frame of reference and other navigational tools that facilitate use of a table that may be far larger than a display area of the electronic display.

Abstract: A magnetic resonance imaging device having a field generation unit configured to provide a magnetic field in an imaging volume of the magnetic resonance imaging device. The field generation unit has at least one magnet. A surface of the field generation unit directed towards the imaging volume of the at least one magnet has a concave shape, wherein a direction of access to the imaging volume is oriented essentially perpendicular to a main direction of magnetic field lines in the imaging volume.

Abstract: A wear-out assessment for an oral care system (14) (e.g. an oral cleaning device) is disclosed. A sensor unit (16) of the oral care system is adapted to provide a sensor signal related to a cleaning efficacy of a cleaning function of the oral care system. The sensor unit (16) may be, or may be coupled to, a component which is used during execution of an oral care function of the device, for example a sensor for detecting cleaning progress in the mouth, or a component which drives a cleaning or treatment action in the mouth. The sensor signal (20) is used for performing a wear-out assessment via monitoring characteristics of a signal which is indicative of progress of the oral cleaning efficacy during an operation session (e.g. a clean level in the mouth) and monitoring a length of time that it takes for a certain threshold of efficacy to be reached in a session. If the length of time is over a certain threshold, this can be an indication that the relevant components of the oral care system are wearing out.

Abstract: An oral care system (10) comprises an oral care device (12). The oral care device is designed to either comprise or attach to a cleaning or treatment portion (14), e.g. a brush head or mouthpiece. The oral care device thus has a cleaning or treatment function. The oral care device is further provided with an electromagnetic (EM) field or radiation generator (22) adapted to generate and emit radio or microwave frequency electromagnetic energy in a space around an emitter arrangement (24) (sanitization area) used to emit the radiation or field. The EM emissions are configured to have electromagnetic properties suitable for heating water or water-containing fluid located within the sanitization area (34). This allows for a sanitization or disinfection function in a dedicated mode, wherein the EM emissions of the EM generator causes heating to a temperature of at least 50° C., preferably at least 70° C.

Abstract: A synthesized, advertisement-based, video stream is generated first by receiving a video stream essentially consisting of a representative image of a person, a video stream comprising a place, and a video stream comprising an advertisement, and then combining the video stream essentially consisting of the representative image of the person with the video stream comprising the place and with the video stream comprising the advertisement into the synthesized, advertisement-based, video stream for transmission to an end-user device via which to display the synthesized, advertisement-based, video stream.

Abstract: Techniques for updating blockchains using a proof of work determined serially include receiving a block of data for inclusion in a new block of a blockchain; deterministically determining an initial nonce, hashing a combination of the block of data and the initial nonce to create a hashed value; iteratively deterministically determining an updated nonce based on a combination of the hashed value and updating the hashed value by hashing the updated nonce until the updated hashed value satisfies a proof of work criteria; creating the new block based on the block of data, the initial nonce, and the updated hashed value that satisfies the proof of work criteria; and having the new block stored in the blockchain.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: Novel tools and techniques are provided for implementing network service ordering and provisioning of secure access service edge (“SASE”) software packages. In various embodiments, a computing system may provide a user experience (“UX”) platform for a customer portal, the UX platform being accessible by a user via a user device over a first network(s); may provide, via the UX platform, options to configure, via the customer portal, one or more SASE-based network services among a plurality of network services provided by a service provider; and may autonomously orchestrate deployment and configuration of the one or more SASE-based network services via one or more customer premises equipment (“CPE”) that are associated with the user or to an entity with which the user is associated, over a second network(s), based at least in part on user selection of at least one option to configure the one or more SASE-based network services.

Abstract: An aftertreatment device includes flow guides disposed within a dosing conduit. Exhaust enters through a perforated region of the dosing conduit and passes through the flow guides. The flow guides induce swirling or other turbulence to mix injected reactant with the exhaust gas. Various types of flow guides include cantilevered vanes, guide passageways, and louvered openings of a second conduit. Some types of flow guides induce localized mixing to inhibit deposit formation at the doser mounting unit. Other types of flow guides induce mixing downstream of the dosing conduit.

Abstract: A system is provided. The system comprises an image projection device (6) configured to project display information; a wearable or hand-held device (100) which when worn is subjected to spatial movement; and a compensation element (7) configured to adjust the image projection device (6) based on the spatial movement such that the movement of the wearable or hand-held device (100) is compensated for during projection of the display information by the image projection device (6). Further, a method of spatially stabilizing display information projected by an image projection device (6) upon operation of a wearable or hand-held device is provided.

Abstract: Some embodiments are directed to a health database system. The health database system receives health data relating to a patient and medical updates from multiple data generating systems. The system determines if a received medical update is relevant for the patient, and, if so, store the medical update in a database storage associated with the determined patient.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure: pharmaceutical compositions containing at least one such modulator, methods of treatment of CFTR mediated diseases, including cystic fibrosis, using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

Abstract: A drink making device including a hood, a base configured to support at least four bottles, a tower connecting the base and the hood; and a dispenser for dispensing a beverage. The hood includes at least four attachment connectors. Liquid from the bottles is selectively pumped through the connectors through the dispenser to dispense a beverage.

Abstract: The present application provides systems and methods for a mobile storefront having direct customer access to inventory and pricing from a mobile storefront. In particular, systems and methods provide an application usable by customers to purchase goods or services from a mobile storefront through an electronic communication device. This includes reserving and purchasing products in inventory of the mobile storefront or pooled inventory from multiple mobile storefronts in an area, reserving and purchasing services and/or support, and for communicating directly with an electronic communication device of the mobile storefront.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the structure: (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies, and processes and intermediates for making such modulators.

Abstract: In various embodiments, a gradient modeling application automatically generates designs of three-dimensional (3D) objects. The gradient modeling application generates a set of points based on a resolution and a perimeter. The gradient modeling application computes a set of displacement values based on the set of points, a first two-dimensional (2D) border, and a first displacement parameter that is associated with the first 2D border. Based on the set of displacement values, the gradient modeling application generates a 3D object design.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having the core structure, pharmaceutical compositions containing at least one such modulator, methods of treating CFTR mediated diseases, including cystic fibrosis using such modulators and pharmaceutical compositions, combination therapies and combination pharmaceuticals employing those modulators, and processes and intermediates for making such modulators.