Abstract: A self-regulating damper unit comprising a cylinder having a first working chamber and a second working chamber, a piston, a piston rod, and a through-hole between the first working chamber and the second working chamber. The damper unit also comprises a shiftable weight which modifies a passage cross-section of the through-hole. The shiftable weight is movably mounted such that retardation of the piston causes enlargement of the passage cross-section. A seat belt unit comprises a seat belt and the damper unit.

Abstract: The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin and phenylethylbiguanidin. The cation is an organic compound with a complementary pharmacological activity.

Abstract: The present invention relates to a process for producing an oral thin film comprising microparticles, comprising the steps of: a) producing a solution comprising a hydrophobic polymer, a hydrophobic pharmaceutically active ingredient and hydrophobic solvent, b1) providing a hydrophilic polymer and providing a hydrophilic solvent immiscible with the solvent from a), or b2) providing a solution comprising a hydrophilic polymer and a hydrophilic solvent immiscible with the solvent from a), c1) mixing the solution from a) with the hydrophilic polymer from b1) followed by the addition of the hydrophilic solvent from b1) immiscible with the solvent from a) to obtain an emulsion, or c2) mixing the solution from a) and the solution from b2) to obtain an emulsion, and d) spreading and drying the emulsion from c1) or c2) to obtain an oral thin film comprising microparticles.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: The present disclosure relates to a hearing device, comprising at least one electronic component and at least two parts of a housing, at least one of them configured as a molded interconnect device comprising at least one electrically conductive trace and at least one pin seat, the molded interconnect device mechanically connected to another one of the parts of the housing or to a frame by at least one assembly pin held in the at least one pin seat, wherein the at least one assembly pin also directly or indirectly electrically connects the at least one electrically conductive trace to the at least one electronic component.

Abstract: An in-ear hearing device includes a light source configured to emit light, a photodetector configured to detect the emitted light after the emitted light passes through tissue of a subject, a spout; an audio receiver configured to deliver a sound to the subject through the spout, and a dome configured to conform to a shape of a subject's ear canal when the hearing device is in the ear canal. An output of the light source and an input of the photodetector are separated by the dome, and the dome absorbs and/or reflects at least part of the emitted light. The photodetector may be a forward biased photodiode. The sensor device can be realized with power levels, circuitry components, and in package sizes, of hearing devices.

Abstract: This invention relates to a method for the purification of nucleic acids, preferably DNA, from biological samples, comprising the steps (a) optional lysis of said sample, (b) optional heat incubation of said sample, (c) enzymatic digestion of non-nucleic acid components in the product of step (a) or (b), (d) heat inactivation of one or more enzyme(s) used in step (c), (e) transfer of the product of step (d) onto a resin capable of retaining non-nucleic acid components, while the nucleic acids pass through the resin, thereby purifying the nucleic acids.

Abstract: A method for producing a structural section of a vehicle comprises the steps of providing multiple separate skin panels of a fiber-reinforced plastic having an inner side, an outer side and a border running peripherally around the respective skin panel; arranging at least one stiffening component of a fiber-reinforced plastic on each skin panel, on the respective inner side; integrally connecting the respective at least one stiffening component to the skin panels concerned to form a structural component; arranging at least two structural components on a carrier, so that at least regions of the borders of the structural components concerned are in surface-area contact; and integrally connecting the regions of the borders that are in surface-area contact to one another.

Abstract: This invention relates to a method for the purification of nucleic acids, preferably DNA, from biological samples, comprising the steps (a) optional lysis of said sample, (b) optional heat incubation of said sample, (c) enzymatic digestion of non-nucleic acid components in the product of step (a) or (b), (d) heat inactivation of one or more enzyme(s) used in step (c), (e) transfer of the product of step (d) onto a resin capable of retaining non-nucleic acid components, while the nucleic acids pass through the resin, thereby purifying the nucleic acids.

Abstract: The invention relates to a multi-layer oral thin film comprising a matrix layer, which contains at least one polymer and at least one pharmaceutically active agent, and at least one backing layer, wherein the at least one backing layer comprises at least one polymer containing free carboxyl groups, wherein 10 to 100% of the free carboxyl groups of the at least one polymer comprising free carboxyl groups are present in a neutralised form as a salt; to a method for production thereof, and to use thereof as a medicament.

Abstract: A fluid damper for modulating a retaining force of a seat belt is provided. The fluid damper includes an outer cylinder and an inner cylinder. The inner cylinder encloses an inner space. The fluid damper includes a piston shiftable in the inner space. The fluid damper includes a duct. The duct conductively connects a front fluid chamber disposed in front of the piston to a rear fluid chamber disposed behind the piston and/or a reservoir for the damping fluid. The duct includes an outer duct portion and an inner duct portion. The inner cylinder is deflectable from a rest position by a force acting on the piston so that the deflection of the inner cylinder causes an adjustment of an overlap of the outer duct portion and the inner duct portion depending on the magnitude of the force.

Abstract: The invention relates to a transmucosal delivery system for idebenone, comprising an external phase, which contains at least one hydrophilic polymer, and an inner hydrophobic phase, which contains idebenone and at least one hydrophobic substance, wherein the inner hydrophobic phase is emulsified in the form of droplets in the external phase. The invention is characterized in that the inner hydrophobic phase is stabilized by at least one emulsifier in the external phase. The invention also relates to a method for producing the same and its use as a medicament.

Abstract: A mount for a double-walled vessel includes a first support to support the mount against an outer wall of the double-walled vessel, a second support to support the mount against an inner wall of the double-walled vessel, and a flexible member connecting the first support and the second support. The first support and can be arranged at a first end of the flexible member and the second support can be arranged at a second end of the flexible member opposite to the first end. Further described are a vessel including at least one such mount as well as a vehicle including such vessel.

Abstract: The invention relates to a method for monitoring operating parameters of an actuator (10), wherein the method comprises: providing the actuator (10), providing at least two detection units (26, 28, 30, 32, 34, 36) which are designed to detect different operating parameters of the actuator (10), detecting operating parameters of the actuator (10) via the detection units (26, 28, 30, 32, 34, 36), outputting data relating to the measured operating parameters to an evaluation unit, combining the measured operating parameters into a state information, which indicates whether or not the technical state of the actuator (10) is in a predetermined standard state.

Abstract: The present invention relates to an oral thin film comprising at least one polymer and at least one pharmaceutically active agent, wherein the concentration of the at least one pharmaceutically active agent in the oral thin film is greater than the saturation concentration of the at least one pharmaceutically active agent in the oral thin film, and wherein the oral thin film comprises at least one material which serves as crystal nucleus for the at least one pharmaceutically active agent, to a method for producing said oral thin film, and to the use of said oral thin film as a medicament.

Abstract: The present invention relates to methods of protein purification, in particular using ion exchange chromatography. Modified proteins and peptide tags suitable for use in purification by ion exchange chromatography are provided, as are related methods.

Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

Abstract: Provided is a method for the production of a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the piston divides the damping space into a first fluid chamber and a second fluid chamber. Also provided is a production method with the method according to the invention for a damper. Also provided is a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the nozzle piston can be obtained by means of ultra-short pulse lasering of the recess from a piston blank. Also provided is a damper having a nozzle piston according to the invention. Also provided is a production plant for the production of a damper having at least one ultra-short pulse laser station for machining a piston blank for the damper by ultra-short pulse lasering.

Abstract: A customized in-ear hearing device includes a light source, photodetector, light emission window, and light transmission window. The light source and the photodetector together function as a physiological sensor by emitting light from the light source through the light emission to the skin of a user's ear canal, and detecting at the photodetector light reflected by the skin that passes through the light detection window. The light emission window and light detection window are located at a customized portion of the sidewall of the device that contacts the skin in the ear canal.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.