Abstract: The present application relates to a transdermal therapeutic system comprising a backing layer impermeable to active substances and a polymer matrix on one side of the backing layer impermeable to active substances, wherein the polymer matrix comprises at least one pharmaceutically active substance, at least one inherently non-self-adhesive polymer and at least one plasticizer, said polymer matrix being free of adhesive polymers. The invention further relates to a method of producing the transdermal therapeutic system and to the use thereof as a drug.

Abstract: The present invention additionally relates to a dosage form for an active substance, selected from the group of cannabinoids, for dissolving in the oral cavity, comprising a first film layer and a second film layer, arranged over the first film layer, wherein the composition of the first film layer can be identical to that of the second film layer and comprises a water soluble polymer, the first and second film layer being connected to each other via the overlapping edges thereof, forming at least one cavity, and the cavity being filled with an active substance selected from the group of cannabinoids.

Abstract: A piston and a method for producing a piston which can be secured to a piston sliding unit is provided. The piston sliding unit can be moved along its longitudinal axis in a cylinder. The piston includes a disc-shaped base body, wherein the piston is suitable and intended to seal two regions of the cylinder filled with a medium against one another. The method includes the following steps: a) producing the piston by pressing a material into a piston mold; b) smoothing the surface of the piston and/or pressing at least one flow path into the piston, by an embossing tool, which has a raised and rotationally symmetrical structure.

Abstract: The present disclosure relates to a hearing device, comprising at least one electronic component and at least two parts of a housing, at least one of them configured as a molded interconnect device comprising at least one electrically conductive trace and at least one pin seat, the molded interconnect device mechanically connected to another one of the parts of the housing or to a frame by at least one assembly pin held in the at least one pin seat, wherein the at least one assembly pin also directly or indirectly electrically connects the at least one electrically conductive trace to the at least one electronic component.

Abstract: Computer-implemented methods and apparatus that use neural modulation codes as an alternative to training many individual recognition models or to loosing performance by training mixed models. Large neural models are modulated by codes that model the different conditions. The codes directly alter (modulate) the behavior of connections in a multiconditional perceptual classifier, so as to permit the most appropriate neuronal units and their features to be applied to each condition. The approach may be applied to multilingual ASR, where the resulting multilingual network arrangement is able to achieve performance that is competitive or better than individually trained mono-lingual network. Moreover, the approach requires no adaptation data or extensive adaptation/training time to operate in a manner tuned to each condition. Beyond multilingual speech processing systems the approach can be applied to many other perceptual processing problems (e.g.

Abstract: The present invention relates to a chromatographic device for isolating and purifying nucleic acids, preferably genomic DNA, by gel filtration chromatography, a method for isolating and purifying nucleic acids, preferably genomic DNA, using this device and a kit comprising this device.

Abstract: A cerumen protection plug for a hearing device. The cerumen protection plug prevents cerumen from passing along a sound conduit in the hearing device and blocking sound output from a receiver in the hearing device. The cerumen protection plug includes a circular plug containing a cerumen barrier. A positioning handle allows the cerumen barrier to be positioned along the sound conduit, where it prevents cerumen that has entered the sound conduit from traveling along the sound conduit to the receiver or an output port of the receiver.

Abstract: The invention relates to film-like forms of administration for the transmucosal delivery of antidiabetic peptides via the oral mucosa and to processes for the production thereof. Antidiabetic peptides refers to peptides which are an active compound for the treatment of diabetes mellitus, and includes insulins, insulin analogs, incretins and incretin mimetics.

Abstract: The invention relates to crystalline folate salts. The salt consists of a folate anion and an organic cation. The folate anion is 5-methyl-(6S)-tetrahydrofolic acid, and the cation is an organic compound which is an alkanolamine selected from the group consisting of choline, N-methylaminoethanol, 2-amino-2-methylpropanol and 2-dimethylaminoethanol.

Abstract: A tool for replacing a cerumen filter in a sound conduit of a hearing aid. The tool is designed to position a cerumen filter along the sound conduit and to couple with and remove a cerumen filter that has been positioned along the sound conduit. The tool comprises an insertion tip and an removal tip, both configured to fit inside the sound conduit and to couple or engage with an engagement body extending centrally from the cerumen filter. The tool may be in the form of a stylus with the insertion tip on one and the removing tip on the other end. The tool may also be in the form of a disc dispenser with a plurality of insertion and removal tips attached to the dispenser and accessible for use by rotating plates making up the disc dispenser.

Abstract: An in-ear hearing device includes a light source configured to emit light, a photodetector configured to detect the emitted light after the emitted light passes through tissue of a subject, a spout; an audio receiver configured to deliver a sound to the subject through the spout, and a dome configured to conform to a shape of a subject's ear canal when the hearing device is in the ear canal. An output of the light source and an input of the photodetector are separated by the dome, and the dome absorbs and/or reflects at least part of the emitted light. The photodetector may be a forward biased photodiode. The sensor device can be realized with power levels, circuitry components, and in package sizes, of hearing devices.

Abstract: Processes for determining carbon dioxide emission impact. In one process, a carbon dioxide emission impact is determined for each stage of a multi-stage trip. A traveler may make adjustments to the trip to offset the carbon dioxide emission impact of the entire trip and achieve a desired sustainability level for the trip. In another process, that may be used in the first process, the carbon dioxide emission impact for a vehicle is determined based on the entire life span of the vehicle, including a carbon dioxide emission impact for a production stage, a carbon dioxide emission impact for a usage stage, and a carbon dioxide emission impact for an end of life stage.

Abstract: An apparatus for cleaning a floor includes a housing, chassis, wheels, motor, steering mechanism, cleaning assembly, optionally a squeegee assembly, and at least one of a side sweeping system, front sweeping system, and pick-up system. The side sweeping system includes a turntable with central axis, a drive wheel disposed in coaxial relationship with the turntable, a sweeper motive device in communication with the drive wheel, a plurality of brushes distributed radially around the drive wheel and adapted to be driven by rotation of the drive wheel, and a pivoting connector configured to enable the side sweeping system to pivot laterally in response to contact with a wall while at least one of the brushes maintains contact with the floor adjacent the wall while the apparatus is in operation, and the brushes move debris disposed on the floor adjacent the wall toward the front of the apparatus.

Abstract: A calibration array for calibrating a network analyzer, the array having multiple calibration points for direct or indirect connection to a network analyzer, and a main body connected to the calibration points, at least one of the calibration points being rotatable in relation to the main body.

Abstract: A piston and a method for producing a piston which can be secured to a piston sliding unit is provided. The piston sliding unit can be moved along its longitudinal axis in a cylinder. The piston includes a disc-shaped base body, wherein the piston is suitable and intended to seal two regions of the cylinder filled with a medium against one another. The method includes the following steps: a) producing the piston by pressing a material into a piston mold; b) smoothing the surface of the piston and/or pressing at least one flow path into the piston, by an embossing tool, which has a raised and rotationally symmetrical structure.

Abstract: A rail brake damper includes a cylinder-piston arrangement. A damping device assigned to the piston comprises at least one damping valve having at least one piston channel, which passes through the piston, connecting the two operating chambers of the cylinder, and a closure element assigned to the piston channel. The closure element is spring pre-loaded with the effect of closing the piston channel and is acted on by the hydraulic pressure which prevails in the operating chamber facing away from the piston rod with the effect of opening the damping valve.

Abstract: An electrically adjustable seating device includes at least one sensor element, a processor, a memory unit and at least one electromechanical actuator. The at least one sensor element is designed to detect predetermined seating parameter data relating to a person sitting on the seating device and to transmit the data to the processor. The processor is designed to determine person parameter data, relating to the person, from the seating parameter data, to extract control data, which are associated with the person parameter data, from the memory unit and to control the at least one electromechanical actuator on the basis of the control data.

Abstract: The present invention relates to, among other things, a rotational damper comprising a fluid-filled damper housing and within the damper housing a piston rotatably accommodated by a rotation axis of the rotational damper in a first direction and an opposite second direction with a piston rod extending in the direction of the rotation axis; whereby the piston has at least one opening with a flow cross-section which allows for the flow of fluid through the piston, whereby a total flow cross-section is calculated as the sum of the flow cross-sections of the at least one opening. A blocking device can be furthermore assigned to the piston which is capable of reducing the flow cross-section of at least one of the openings during a rotation of the piston in a first direction relative to a rotation of the piston in the second direction.

Abstract: The present invention relates to an oral thin film comprising at least one cellulose derivative and at least one pharmaceutically active agent, the at least one pharmaceutically active agent having a water solubility of at most 50 g/L at 20° C. and a pH of 6 to 7 and being contained in the oral thin film in an amount of at least 20 wt. % in relation to the total weight of the oral thin film, and to a method for production of said oral thin film, and use thereof as a medicament.

Abstract: A cerumen protection plug for a hearing device. The cerumen protection plug prevents cerumen from passing along a sound conduit in the hearing device and blocking sound output from a receiver in the hearing device. The cerumen protection plug includes a circular plug containing a cerumen barrier. A positioning handle allows the cerumen barrier to be positioned along the sound conduit, where it prevents cerumen that has entered the sound conduit from traveling along the sound conduit to the receiver or an output port of the receiver.