Abstract: This invention relates to a method for the purification of nucleic acids, preferably DNA, from biological samples, comprising the steps (a) optional lysis of said sample, (b) optional heat incubation of said sample, (c) enzymatic digestion of non-nucleic acid components in the product of step (a) or (b), (d) heat inactivation of one or more enzyme(s) used in step (c), (e) transfer of the product of step (d) onto a resin capable of retaining non-nucleic acid components, while the nucleic acids pass through the resin, thereby purifying the nucleic acids.

Abstract: A method for producing a structural section of a vehicle comprises the steps of providing multiple separate skin panels of a fiber-reinforced plastic having an inner side, an outer side and a border running peripherally around the respective skin panel; arranging at least one stiffening component of a fiber-reinforced plastic on each skin panel, on the respective inner side; integrally connecting the respective at least one stiffening component to the skin panels concerned to form a structural component; arranging at least two structural components on a carrier, so that at least regions of the borders of the structural components concerned are in surface-area contact; and integrally connecting the regions of the borders that are in surface-area contact to one another.

Abstract: This invention relates to a method for the purification of nucleic acids, preferably DNA, from biological samples, comprising the steps (a) optional lysis of said sample, (b) optional heat incubation of said sample, (c) enzymatic digestion of non-nucleic acid components in the product of step (a) or (b), (d) heat inactivation of one or more enzyme(s) used in step (c), (e) transfer of the product of step (d) onto a resin capable of retaining non-nucleic acid components, while the nucleic acids pass through the resin, thereby purifying the nucleic acids.

Abstract: The invention relates to a multi-layer oral thin film comprising a matrix layer, which contains at least one polymer and at least one pharmaceutically active agent, and at least one backing layer, wherein the at least one backing layer comprises at least one polymer containing free carboxyl groups, wherein 10 to 100% of the free carboxyl groups of the at least one polymer comprising free carboxyl groups are present in a neutralised form as a salt; to a method for production thereof, and to use thereof as a medicament.

Abstract: A fluid damper for modulating a retaining force of a seat belt is provided. The fluid damper includes an outer cylinder and an inner cylinder. The inner cylinder encloses an inner space. The fluid damper includes a piston shiftable in the inner space. The fluid damper includes a duct. The duct conductively connects a front fluid chamber disposed in front of the piston to a rear fluid chamber disposed behind the piston and/or a reservoir for the damping fluid. The duct includes an outer duct portion and an inner duct portion. The inner cylinder is deflectable from a rest position by a force acting on the piston so that the deflection of the inner cylinder causes an adjustment of an overlap of the outer duct portion and the inner duct portion depending on the magnitude of the force.

Abstract: The invention relates to a transmucosal delivery system for idebenone, comprising an external phase, which contains at least one hydrophilic polymer, and an inner hydrophobic phase, which contains idebenone and at least one hydrophobic substance, wherein the inner hydrophobic phase is emulsified in the form of droplets in the external phase. The invention is characterized in that the inner hydrophobic phase is stabilized by at least one emulsifier in the external phase. The invention also relates to a method for producing the same and its use as a medicament.

Abstract: A mount for a double-walled vessel includes a first support to support the mount against an outer wall of the double-walled vessel, a second support to support the mount against an inner wall of the double-walled vessel, and a flexible member connecting the first support and the second support. The first support and can be arranged at a first end of the flexible member and the second support can be arranged at a second end of the flexible member opposite to the first end. Further described are a vessel including at least one such mount as well as a vehicle including such vessel.

Abstract: The invention relates to a method for monitoring operating parameters of an actuator (10), wherein the method comprises: providing the actuator (10), providing at least two detection units (26, 28, 30, 32, 34, 36) which are designed to detect different operating parameters of the actuator (10), detecting operating parameters of the actuator (10) via the detection units (26, 28, 30, 32, 34, 36), outputting data relating to the measured operating parameters to an evaluation unit, combining the measured operating parameters into a state information, which indicates whether or not the technical state of the actuator (10) is in a predetermined standard state.

Abstract: The present invention relates to an oral thin film comprising at least one polymer and at least one pharmaceutically active agent, wherein the concentration of the at least one pharmaceutically active agent in the oral thin film is greater than the saturation concentration of the at least one pharmaceutically active agent in the oral thin film, and wherein the oral thin film comprises at least one material which serves as crystal nucleus for the at least one pharmaceutically active agent, to a method for producing said oral thin film, and to the use of said oral thin film as a medicament.

Abstract: The present invention relates to methods of protein purification, in particular using ion exchange chromatography. Modified proteins and peptide tags suitable for use in purification by ion exchange chromatography are provided, as are related methods.

Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

Abstract: Provided is a method for the production of a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the piston divides the damping space into a first fluid chamber and a second fluid chamber. Also provided is a production method with the method according to the invention for a damper. Also provided is a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the nozzle piston can be obtained by means of ultra-short pulse lasering of the recess from a piston blank. Also provided is a damper having a nozzle piston according to the invention. Also provided is a production plant for the production of a damper having at least one ultra-short pulse laser station for machining a piston blank for the damper by ultra-short pulse lasering.

Abstract: A customized in-ear hearing device includes a light source, photodetector, light emission window, and light transmission window. The light source and the photodetector together function as a physiological sensor by emitting light from the light source through the light emission to the skin of a user's ear canal, and detecting at the photodetector light reflected by the skin that passes through the light detection window. The light emission window and light detection window are located at a customized portion of the sidewall of the device that contacts the skin in the ear canal.

Abstract: Described is an oral thin film comprising at least one matrix layer, wherein the at least one matrix layer comprises at least one pharmaceutically active agent, at least one polyvinyl alcohol and at least one polyvinyl alcohol-polyethylene glycol graft copolymer, a method for producing same, and use thereof as a medicament.

Abstract: The present application relates to a transdermal therapeutic system comprising a backing layer impermeable to active substances and a polymer matrix on one side of the backing layer impermeable to active substances, wherein the polymer matrix comprises at least one pharmaceutically active substance, at least one inherently non-self-adhesive polymer and at least one plasticizer, said polymer matrix being free of adhesive polymers. The invention further relates to a method of producing the transdermal therapeutic system and to the use thereof as a drug.

Abstract: The present invention additionally relates to a dosage form for an active substance, selected from the group of cannabinoids, for dissolving in the oral cavity, comprising a first film layer and a second film layer, arranged over the first film layer, wherein the composition of the first film layer can be identical to that of the second film layer and comprises a water soluble polymer, the first and second film layer being connected to each other via the overlapping edges thereof, forming at least one cavity, and the cavity being filled with an active substance selected from the group of cannabinoids.

Abstract: A piston and a method for producing a piston which can be secured to a piston sliding unit is provided. The piston sliding unit can be moved along its longitudinal axis in a cylinder. The piston includes a disc-shaped base body, wherein the piston is suitable and intended to seal two regions of the cylinder filled with a medium against one another. The method includes the following steps: a) producing the piston by pressing a material into a piston mold; b) smoothing the surface of the piston and/or pressing at least one flow path into the piston, by an embossing tool, which has a raised and rotationally symmetrical structure.

Abstract: The present disclosure relates to a hearing device, comprising at least one electronic component and at least two parts of a housing, at least one of them configured as a molded interconnect device comprising at least one electrically conductive trace and at least one pin seat, the molded interconnect device mechanically connected to another one of the parts of the housing or to a frame by at least one assembly pin held in the at least one pin seat, wherein the at least one assembly pin also directly or indirectly electrically connects the at least one electrically conductive trace to the at least one electronic component.

Abstract: Computer-implemented methods and apparatus that use neural modulation codes as an alternative to training many individual recognition models or to loosing performance by training mixed models. Large neural models are modulated by codes that model the different conditions. The codes directly alter (modulate) the behavior of connections in a multiconditional perceptual classifier, so as to permit the most appropriate neuronal units and their features to be applied to each condition. The approach may be applied to multilingual ASR, where the resulting multilingual network arrangement is able to achieve performance that is competitive or better than individually trained mono-lingual network. Moreover, the approach requires no adaptation data or extensive adaptation/training time to operate in a manner tuned to each condition. Beyond multilingual speech processing systems the approach can be applied to many other perceptual processing problems (e.g.

Abstract: The present invention relates to a chromatographic device for isolating and purifying nucleic acids, preferably genomic DNA, by gel filtration chromatography, a method for isolating and purifying nucleic acids, preferably genomic DNA, using this device and a kit comprising this device.