Abstract: Disclosed is a multi-layer oral active-substance film comprising at least two non-adhesive layers each containing at least one hydrophilic polymer, and at least one water-soluble adhesive layer containing at least one water-soluble polymer and at least one plasticiser, wherein at least one of the at least two non-adhesive layers and/or the at least one water-soluble adhesive layer contains a pharmaceutically active substance, and wherein the at least two non-adhesive layers and the at least one water-soluble adhesive layer alternate in such a way that the at least one water-soluble adhesive layer is covered on both sides by at least one non-adhesive layer.

Abstract: The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin and phenylethylbiguanidin. The cation is an organic compound with a complementary pharmacological activity.

Abstract: An apparatus for dispensing a mixture of a diluent and an additive for sanitation, cosmetic or cleaning applications. The apparatus includes a mixing unit for creating a mixture of the diluent and the additive, a diluent supply supplying the diluent to the mixing unit, an additive supply supplying the additive to the mixing unit, an outlet for dispensing the mixture. The diluent supply includes a pump arranged to increase the pressure of the diluent before the diluent enters the mixing unit.

Abstract: Damper includes a housing having proximal and distal ends, a first attachment point proximate the distal end of the housing, a rod having proximal and distal ends at least partially disposed within the housing and moveable relative to the housing between an extended position and a compressed position, a second attachment point proximate the proximal end of the rod, a piston joined to the rod within the housing proximate the distal end of the rod, the piston including a bypass groove having a flow area defined therein to allow fluid to flow from a first side of the piston to an opposing side of the piston, and a first washer disposed proximate a first end of the piston and at least partially covering the flow area of the bypass groove.

Abstract: The invention relates to flat dosage forms that disintegrate or dissolve in an aqueous environment and release at least one active ingredient in a body orifice or body cavity. The inventive dosages are formed from a polymer matrix in the form of a solidified foam having cavities and contain at least one pharmaceutical active ingredient. The inventive dosage forms further have a high mass per unit area in the region of 50 to 350 g/m2. Despite their high mass per unit area and the resulting high active ingredient loading during administration, these dosage forms exhibit a substantially improved mouthfeel in comparison to conventional film dosage forms. The invention also relates to methods for producing a dosage form of this type.

Abstract: A system for preventing and/or extinguishing a fire in an enclosed target area in a vehicle. The system having a central compressed air source for supplying compressed air to a load circuit. A supply of compressed air is provided in a compressed air buffer tank is supplied to a gas separation device from the compressed air buffer tank. A nitrogen-enriched gas mixture is provided at an outlet of the gas separation device, and introduced into the target area. An inlet of the compressed air buffer tank is at least temporarily fluidically connected to an outlet of a central compressed air source, wherein compressed air can be supplied to the compressed air buffer tank. A fluidic connection is provided between the central compressed air source and the compressed air buffer tank if a load circuit is not drawing any compressed air from the central compressed air source.

Abstract: The invention relates to a method for monitoring operating parameters of an actuator (10), wherein the method comprises: providing the actuator (10), providing at least two detection units (26, 28, 30, 32, 34, 36) which are designed to detect different operating parameters of the actuator (10), detecting operating parameters of the actuator (10) via the detection units (26, 28, 30, 32, 34, 36), outputting data relating to the measured operating parameters to an evaluation unit, combining the measured operating parameters into a state information, which indicates whether or not the technical state of the actuator (10) is in a predetermined standard state.

Abstract: This invention relates to a method for the purification of nucleic acids, preferably DNA, from biological samples, comprising the steps (a) optional lysis of said sample, (b) optional heat incubation of said sample, (c) enzymatic digestion of non-nucleic acid components in the product of step (a) or (b), (d) heat inactivation of one or more enzyme(s) used in step (c), (e) transfer of the product of step (d) onto a resin capable of retaining non-nucleic acid components, while the nucleic acids pass through the resin, thereby purifying the nucleic acids.

Abstract: Provided is a method for the production of a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the piston divides the damping space into a first fluid chamber and a second fluid chamber. Also provided is a production method with the method according to the invention for a damper. Also provided is a nozzle piston for arrangement in a damping space of a damper, which contains a damping fluid, wherein the nozzle piston can be obtained by means of ultra-short pulse lasering of the recess from a piston blank. Also provided is a damper having a nozzle piston according to the invention. Also provided is a production plant for the production of a damper having at least one ultra-short pulse laser station for machining a piston blank for the damper by ultra-short pulse lasering.

Abstract: The present invention relates to reagents suitable in the mass spectrometric determination of analyte molecules such as carbohydrates as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.

Abstract: A method of customizing a component of a hearing device to the ear of a hearing device user. The method includes the steps of providing the hearing device component as a pre-form including a shape-memory material, heating the hearing device component, and bringing the hearing device component in contact with at least a portion of the ear after reaching a pre-set contact temperature such that the hearing device component conforms to the individual shape of the at least a portion of ear. The shape of the hearing device component is fixed by attending a hardening time of the shape-memory material. Therefore, the hearing device component perfectly fits to the geometry of the user's ear canal.

Abstract: The invention relates to a transmucosal delivery system for idebenone, comprising an external phase, which contains at least one hydrophilic polymer, and an inner hydrophobic phase, which contains idebenone and at least one hydrophobic substance, wherein the inner hydrophobic phase is emulsified in the form of droplets in the external phase. The invention is characterized in that the inner hydrophobic phase is stabilized by at least one emulsifier in the external phase. The invention also relates to a method for producing the same and its use as a medicament.

Abstract: The present invention refers to a device, comprising a hollow body having at least one open end comprising at least one solid matrix binding, adsorbing, absorbing, chelating or retaining compounds which are not desired in a sample and preferably at least one barrier which is non-permeable for liquids and solids under ambience conditions, however, becomes liquid-permeable by applying an external force to the barrier, the use of such a device for isolating or purifying a biomolecule from a sample, a method for preparation of the device and a method for isolation or purification of any biomolecule using said device.

Abstract: A pressure bulkhead for an aircraft fuselage including a sandwich structure defining a central axis and extending between a circumferential border area, the sandwich structure including an inner face sheet and an outer face sheet extending transverse to the central axis, and a core assembly sandwiched between the inner face sheet and the outer face sheet. The pressure bulkhead can receive pressure loads and can be used as a structural bearing element for receiving loads introduced by other structural parts. The inner face sheet and/or the outer face sheet has a corrugated shape. The distance between the outer face sheet and the inner face sheet increases and subsequently decreases from the border area to a central area about the central axis, forming a thickened area where the distance between the outer face sheet and the inner face sheet has a peak.

Abstract: The invention relates to a system comprising a seat (10) and a mobile terminal that are or can be connected to one another in order to transmit data, wherein the seat (10) comprises at least one electromechanical actuator (22, 24, 26, 28) and/or at least one sensor element (32, 34, 36, 38), the mobile terminal is designed to receive inputs from a user and control the at least one actuator (22, 24, 26, 28) on the basis of these inputs and/or to receive and process data collected by the at least one sensor element (32, 34, 36, 38), and the seat (10) and the mobile terminal are each provided with at least one communication means (44), which are designed to wirelessly transmit data between the seat (10) and the mobile terminal. The invention also relates to a corresponding method.

Abstract: A pressure bulkhead for an aircraft fuselage having a skin element, with a first surface and a second surface, a circumferential edge and a center axis, and a reinforcement assembly, which has radially disposed reinforcement elements extending along the first surface radially between an outer end at the edge of the skin element and an inner end, which faces the center axis, wherein, in a cross section, which extends radially along the center axis, each of the radially disposed reinforcement elements defines first and second contour lines, each extending from the outer end of the radially disposed reinforcement elements to the inner end thereof, and the reinforcement assembly resting with the first contour lines thereof on the first surface of the skin element. A pressure bulkhead for an aircraft fuselage can efficiently absorb occurring pressure loads.

Abstract: An aircraft structural component having a skin element, including an inner surface, a multitude of transverse stiffening elements, which lie against the inner surface of the skin element, and a multitude of longitudinal stiffening elements, perpendicular to the transverse stiffening elements against the inner surface of the skin element, wherein between a first and a second transverse stiffening element and also between a first and a second longitudinal stiffening element, a first skin section is defined. An aircraft structural component is provided with the quantity of the longitudinal stiffening elements reduced. A first applied reinforcement includes a core layer having a contour line running along the circumference of the skin element, the first applied reinforcement including a face sheet surrounding the core layer on the side thereof which faces away from the skin element, which face sheet is connected to the skin element along the core layer contour line.

Abstract: A method, system and dispensing head for manufacturing a three-dimensional object by additive manufacturing. The three-dimensional object includes a three-dimensional component. The method provides a substrate and forming layers there-on, each layer formed in a pattern corresponding to a three-dimensional component being manufactured and each layer formed by dispensing a curable material from a nozzle of a dispensing head and subsequently curing the curable material. The three-dimensional object comprises the combination of the substrate and the three-dimensional component, wherein the substrate has a non-planar surface portion and the three-dimensional component is formed on the non-planar surface portion such that it is fixedly secured to the substrate.

Abstract: A corona ignition device is described, with a central electrode, an insulator, in which the central electrode sits, a coil, which is connected to the central electrode, a metal housing, which holds the insulator and surrounds the coil, and a cover, which closes the metal housing at its end facing away from the insulator. According to this disclosure, provision is made for a spring arranged between the cover and the coil. In another aspect, a shield is provided that surrounds the housing and comprises several shell elements which each surround a section of the circumference of the coil.

Abstract: The invention relates to a calibration array (10; 50) for calibrating a network analyzer, the array having multiple calibration points (18, 20, 22, 24) for direct or indirect connection to a network analyzer, and a main body connected to said calibration points (18, 20, 22, 24), at least one of the calibration points (18, 20, 22, 24) being rotatable in relation to the main body.