Abstract: This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found that boric or boronic acid derivatives are useful bridging elements for the attachment of a chiral group to a compound containing a carbonyl group to be alkylated. The said borates and boronates are thus useful in a process for the asymmetric alkylation of a carbonyl group in a compound containing a carbonyl group and an anchor group capable of reacting with a boric or boronic acid derivative. The asymmetric alkylation can be carried out by admixing the compound containing a carbonyl group to be alkylated and the anchor group capable of reacting with a boric or boronic acid derivative with a boric or boronic acid derivative, adding a chiral alcohol, and adding an organometallic compound. After the alkylation reaction, the borate and boronate can be easily removed by hydrolysis.

Abstract: A sortation conveyor has a plurality of pairs of slats which are generally aligned with each other and which define a portion of an upper conveying surface. A gap is defined between the slats of the pair which extends laterally. The gap may have an offset portion.

Abstract: A plurality of modules interact to form an adaptive network in which each module transmits and receives data signals indicative of proximity of objects. A central computer accumulates the data produced or received and relayed by each module for analyzing proximity responses to transmit through the adaptive network control signals to a selectively-addressed module to respond to computer analyzes of the data accumulated from modules forming the adaptive network. Interactions of local processors in modules that sense an intrusion determine the location and path of movements of the intruding object and control cameras in the modules to retrieve video images of the intruding object. Multiple operational frequencies in adaptive networks permit expansions by additional networks that each operate at separate radio frequencies to avoid overlapping interaction. Additional modules may be introduced into operating networks without knowing the operating frequency at the time of introduction.

Abstract: Systems and methods for non-invasively scanning and analyzing one or more characteristics of a sample utilizing electromagnetic radiation are described. More particularly, the systems and methods utilize an electromagnetic radiation source connected to a transmitter and an analyzer connected to a receiver. A sample to be analyzed is placed between the transmitter and receiver in a variety of different manners and a frequency sweep of electromagnetic radiation is transmitted through the sample to create a series of spectral data sets that are used to create one or more composite spectrograms, which are then analyzed to determine one or more characteristics of the sample. A magnetic field can alternatively be applied around the transmitter, receiver and sample to enhance some characteristic analysis applications. Samples include inert and living items, and the characteristics include a wide variety of different applications.

Abstract: The present invention relates to an improved process for the production of prostaglandins and prostaglandin analogs. In particular, this invention relates to the production of prostaglandins of the PGF2?-series, including latanoprost, travoprost, and bimatoprost, which are active pharmaceutical ingredients used for the reduction of elevated intra-ocular pressure in patients with glaucoma and ocular hypertension.

Abstract: A sortation conveyor has overlapping pusher shoes stealth profile upper surface and a “cow catcher” edge which reduces interference with mislocated packages. In a tube type sortation conveyor of one aspect of the present invention, the center of the tubes are vertically offset upwards from the center of the chain pins which allows a single pusher cap design to be used with a round tube type and a slat type sortation conveyor. In another aspect of the invention, the pusher cap has a single, common mounting surface which accepts pusher pads of different divert angles.

Abstract: A sortation conveyor has overlapping pusher shoes stealth profile upper surface and a “cow catcher” edge which reduces interference with mislocated packages. In a tube type sortation conveyor of one aspect of the present invention, the center of the tubes are vertically offset upwards from the center of the chain pins which allows a single pusher cap design to be used with a round tube type and a slat type sortation conveyor. In another aspect of the invention, the pusher cap has a single, common mounting surface which accepts pusher pads of different divert angles.

Abstract: A sortation conveyer has overlapping pusher shoes stealth profile upper surface and a “cow catcher” edge which reduces interference with mislocated packages. In a tube type sortation conveyer of one aspect of the present invention, the center of the tubes are vertically offset upwards from the center of the chain pins which allows a single pusher cap design to be used with a round tube type and a slat type sortation conveyor. In another aspect of the invention, the pusher cap has a single, common mounting surface which accepts pusher pads of different divert angles.

Abstract: Compounds of the formula I are suitable for the production of pharmaceuticals for the prophylaxis and therapy of conditions whose course involves an increased activity of matrix-degrading enzymes, in particular stromelysin.

Abstract: Compounds of the formula I 1