Abstract: An abrasive tool for a floor grinder, wherein the tool extends along a wear direction (D) from a grinding surface (G) to a mounting surface (M), wherein the abrasive tool comprises at least two sections (410, 420, 430) separated by a surface (P) transversal to the wear direction (D), where the at least two sections comprise respective abrasive materials associated with different grit sizes, where the section located closer to the grinding surface (G) is associated with a larger grit size compared to the section located closer to the mounting surface (M).

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract: A method of processing a semiconductor wafer includes: forming one or more epitaxial layers over a first main surface of the semiconductor wafer; forming one or more porous layers in the semiconductor wafer or in the one or more epitaxial layers, wherein the semiconductor wafer, the one or more epitaxial layers and the one or more porous layers collectively form a substrate; forming doped regions of a semiconductor device in the one or more epitaxial layers; and after forming the doped regions of the semiconductor device, separating a non-porous part of the semiconductor wafer from a remainder of the substrate along the one or more porous layers.

Abstract: The invention relates to a landing zone arrangement (1) for aircraft (19), in particular aircraft capable of vertical take-off, said arrangement comprising: a plurality of segments (3) which together form a landing zone in an operating state; a storage space (2) in which the plurality of segments (3) are at least partially stowable in a stored state; and a base (5) with a rotatable rotor element (4) in order to rotate the plurality of segments (3) for transfer into the operating state and/or into the stored state. In order to create a landing zone arrangement which allows a lighter technical design, the invention provides that at least individual segments of the plurality of segments (3) are secured removably to the rotor element (4), and a securing unit (8) of the landing zone arrangement (1) is designed to fasten the removable segments (3) to the rotor element (4) for transfer into the operating state and to release this fastening for transfer into the stored state.

Abstract: A dental milling machine (100) for manufacturing a dental object (101), having a microphone (103) for detecting sound signals during a milling operation or an accelerometer for detecting vibration signals; and a position determining device (105) for determining a position of a milling tool (107) and/or a workpiece (111) based on the sound signals or the vibration signals.

Abstract: In a computer-implemented method for providing a patient-specific medical action recommendation, a data record of the patient is received, and based on the data record, one or more observables are automatically determined. The one or more observables describe a clinical condition of the patient. The one or more observables are displayed via a user interface, and user input regarding the displayed one or more observables is received via the user interface. Based on the user input and, optionally, the data record, an action recommendation is provided to the user regarding further steps for diagnosing/treating the patient. An action recommendation device and a clinical examination and treatment system are also described.

Abstract: The invention relates to a metallic plug connector component (1), in particular an electrical contact element, or a support sleeve, of an electrical plug connector, having a main body (3) which has been coated with a coating (2) and which has been mechanically deformed in a processing portion (4). It is provided that a surface (6, 7) of the coating (2) in the processing portion (4) has a defined surface structure (8) at least in certain portions.

Abstract: The invention relates to a process for producing a dental restoration part using a machine tool (10), especially a dental processing machine intended for a dentist's office, wherein, in a first step, a rotating processing tool (16) rotationally mills or processes or grinds a workpiece (18) while, except from at least one entry and/or exit path, it is in continuous contact with the workpiece (18), i.e. with 0% air battle, by machining the outer profile (19) of the workpiece (18) substantially completely in helical-shape. The invention also relates to a dental processing machine.

Abstract: The invention is directed to a method for determining a monomer sequence of a polymer that is translocated through a nanopore. Monomers of the polymer are labeled with fluorescent labels such that in free solution fluorescent labels of adjacent monomers substantially quench each other and wherein the nanopore constrains fluorescent labels within its bore into a constrained state wherein no detectable fluorescent signal can be generated. By exciting the fluorescent label of each monomer as it exits the nanopore and transitions from a constrained state to a quenched state with an adjacent fluorescent label, a fluorescent signal can be generated by the exiting fluorescent label that allows its monomer to be identified, thereby permitting a monomer sequence to be determined from a sequence of fluorescent signals as the polymer translocates through the nanopore.

Abstract: An interconnection includes a circuit board assembly and a hybrid cable assembly. The circuit board assembly includes first and second outer layer assemblies and an intermediate layer assembly. The first and second outer layer assemblies each include an electrically conductive layer. A cable-receiving space is formed at a first side edge of the circuit board assembly. The hybrid cable assembly includes a dielectric waveguide system having a core and a cladding and being configured to transmit a radar wave in a frequency range from about 70 to about 300 GHz. A first conductor system configured to transmit power and/or data is disposed adjacent to the dielectric waveguide system and includes an electrically conductive inner conductor assembly inserted into the cable-receiving space and galvanically connected to a first inner-conductor connection region. The core of the dielectric waveguide system is inserted into the cable-receiving space and disposed at a waveguide connection region.

Abstract: The invention is directed to optically based methods for nanopore sequencing of polynucleotides which comprise steps of (i) translocating a polynucleotide through a bore of a nanopore at a translocation speed, wherein nucleotides of the polynucleotide are labeled with fluorescent labels such that in free solution fluorescent labels of nucleotides are substantially quenched and wherein fluorescent labels within the bore are constrained such that substantially no detectable fluorescent signal is generated therein; (ii) exciting the fluorescent label of each nucleotide upon exiting the nanopore and prior to quenching with a preceding mutually quenching fluorescent label or a quenching agent; (iii) measuring a fluorescent signal generated by fluorescent labels exiting the nanopore, wherein the translocation speed is selected so that the measured fluorescent signal comprises fluorescence from substantially a single fluorescent label; and (iv) determining a nucleotide sequence of the polynucleotide from a sequence

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract: A dental milling machine is provided with a tool which is guided in a chuck. A workpiece arm is mounted opposite the tool to be able to be moved at least in the direction of the spindle axis. With a control device it can be moved in relation to the workpiece, especially by means of a drive motor of the workpiece arm. The workpiece arm has an abutment element, whereby the control device moves the tool and the abutment element towards each other until they abut each other. The control device can be used to detect abutment of the abutment element with respect to the tool, in particular with respect to its tip, in particular by decelerating the (relative) movement of the tool and the abutment element towards each another, upon contact of the tool and the abutment element. This position may be signaled as a reference position and, especially may be stored.

Abstract: A method includes forming a silicon substrate including first and second substrate layers, the first substrate layer extending to the rear surface, the second substrate layer extending to a first side of the silicon substrate that is opposite from the rear surface such that the first substrate layer is completely separated from the first side by the second substrate layer, forming a nucleation region on the first side of the silicon substrate, the nucleation region including a nitride layer, forming a lattice transition layer on the nucleation region, the lattice transition layer being configured to alleviate stress arising in the silicon substrate due to lattice mismatch between the silicon substrate and other layers in the compound semiconductor device structure, and epitaxially growing a type III-V semiconductor nitride region on the lattice transition layer.

Abstract: The invention is directed to nanopore-based methods for analyzing polymers, such as polynucleotides or proteins, containing optical labels specific for different kinds of monomers. In some embodiments, methods of the invention include steps of (a) translocating a polymer through a nanopore, wherein different kinds of monomers of the polymer are labeled with different optical labels that generate distinguishable optical signals and wherein the nanopore constrains the monomers to move single file through an excitation zone that encompasses a plurality of monomers; (b) detecting a time-ordered set of optical signals from the monomers as the polymer passes they pass through the excitation zone; (c) separating optical signals from different kinds of monomers to form monomer-specific time-ordered sets of optical signals; and (d) determining a sequence of monomers from the monomer-specific time-ordered sets of optical signals from the polymer.

Abstract: The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.

Abstract: A compound semiconductor device structure having a main surface and a rear surface includes a silicon substrate including first and second substrate layers. The first substrate layer extends to the rear surface. The second substrate layer extends to a first side of the substrate that is opposite from the rear surface such that the first substrate layer is completely separated from the first side by the second substrate layer. A nucleation region is formed on the first side of the silicon substrate and includes a nitride layer. A lattice transition layer is formed on the nucleation region and includes a type III-V semiconductor nitride. The lattice transition layer is configured to alleviate stress arising in the silicon substrate due to lattice mismatch between the silicon substrate and other layers in the compound semiconductor device structure. The second substrate layer is configured to suppress an inversion layer in the silicon substrate.

Abstract: This invention relates to new methods for treating cancer, including cancers characterized by expression of programmed death ligand 1 (PD-L1).

Abstract: A method for processing a wide band gap semiconductor wafer includes: depositing a support layer including semiconductor material at a back side of a wide band gap semiconductor wafer, the wide band gap semiconductor wafer having a band gap larger than the band gap of silicon; depositing an epitaxial layer at a front side of the wide band gap semiconductor wafer; and splitting the wide band gap semiconductor wafer along a splitting region to obtain a device wafer comprising at least a part of the epitaxial layer, and a remaining wafer comprising the support layer.

Abstract: An electrical connector for a multi-wire electrical cable includes at least two cable-side electrical contact elements, including associated terminals to each of which is to be connected a wire of the electrical cable, and at least two output-side electrical contact elements, from each of which projects an electrical connector element by which an electrical connection is establishable to a mating connector. A carrier body is disposed between the cable-side electrical contact elements and the output-side electrical contact elements. The cable-side electrical contact elements, the output-side electrical contact elements and the carrier body are disposed in a spaced-apart relationship to each other, and the cable-side and output-side contact elements are electrically connected to each other via an electrical device disposed on the carrier body.