Abstract: The invention is directed to devices and methods for optically based nanopore analysis which employ FRET signaling wherein at least one member of a FRET pair is mobile within a lipid bilayer containing one or more nanopores. In some embodiments, mobile FRET donors are constrained to a lipid bilayer so that they may continuously diffuse into and within a FRET distance of acceptor-labeled analytes entering or exiting a nanopore so that bleached or degraded FRET donors are continuously replaced.

Abstract: An electrical device having a housing and a lid which may be placed on the housing. A sealing element is situated in a depression of the housing, in particular the wall of the housing, which is disposed between the housing and the lid. The sealing element has a recess for the feed-through of a cable. The cable is inserted into a curved groove of the housing, especially the wall of the housing. The housing has a claw segment, which hooks and/or cuts into into the shielding of the cable.

Abstract: A battery housing and a method for installing a battery are disclosed. In one embodiment, a battery housing for receiving a battery includes four plate-shaped side panels. Two of the side panel are opposite to each other, and each of the two opposite side panels have at least one elongated recess. The battery housing includes two cover plates. The four plate-shaped side panels and the two cover plates are connected to each other to form a box-shaped housing. The side panels are configured to connect together to hold the battery without the cover plates.

Abstract: Computer-assisted structuring of medical examination data and/or one or more examination data records is disclosed. A method of at least one embodiment includes providing at least one medical examination data record, which includes patient-specific data described textually and/or symbolically and/or at least one image data record created with the aid of a radiological examination device; providing at least one body model image, which represents a body model matching the examination data; and registering the at least one examination data record with the body model, wherein at least one position in the body model is assigned to the examination data record; the position being made known for interaction by way of a user interface.

Abstract: A contact carrier for an electrical contact device comprises a contact carrier body and a contact element disposed in the contact carrier body. The contact carrier body has a connecting section and a conductor clamping section. The conductor clamping section is substantially closed in a circumferential direction of the contact carrier body and extends along a longitudinal direction of the contact carrier body. The contact element has a contact section extending from the connecting section for contacting a mating contact element.

Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

Abstract: An electrical connector for a multi-wire electrical cable has two or more cable-side electrical contact elements including associated electrical terminals to each of which is to be connected a wire of the electrical cable, and has two or more output-side electrical contact elements, from each of which projects an electrical connector element via which an electrical connection is establishable to a mating connector. An inductive electrical device is disposed between the cable-side and the output-side electrical contact elements. The inductive electrical device is integrally formed with the cable-side and/or the output-side electrical contact elements. The cable-side and the output-side electrical contact elements are electrically connected to each other via the inductive electrical device.

Abstract: The invention provides an inhalation device for enabling a user to inhale at a desired inspiratory flow rate and/or pressure, comprising a feedback system configured to indicate to a user by means of a signal during an inhalation maneuver whether an inhalation parameter, such as the inspiratory flow rate, is within a predefined target range. The signal may be an optical or a non-optical signal, such as a light signal, an acoustic signal, or a tactile signal.

Abstract: This invention relates to a novel chemical process for the synthesis of N?-benzyl-5-methylisoxazole-3-carbohydrazide (Isocarboxazid) which comprises reacting 5-methyl-3-isoxazole carboxylic acid ester with benzylhydrazine or a salt thereof in an aprotic organic solvent and in the presence of an organic base.

Abstract: The invention is directed to a method for determining a monomer sequence of a polymer that is translocated through a nanopore. Monomers of the polymer are labeled with fluorescent labels such that in free solution fluorescent labels of adjacent monomers substantially quench each other and wherein the nanopore constrains fluorescent labels within its bore into a constrained state wherein no detectable fluorescent signal can be generated. By exciting the fluorescent label of each monomer as it exits the nanopore and transitions from a constrained state to a quenched state with an adjacent fluorescent label, a fluorescent signal can be generated by the exiting fluorescent label that allows its monomer to be identified, thereby permitting a monomer sequence to be determined from a sequence of fluorescent signals as the polymer translocates through the nanopore.

Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.

Abstract: An electrical cable includes a cable jacket surrounding a cable interior. At least one electrical cable conductor is disposed in the cable interior and has an insulating sheath. A cable shield shields the cable interior. At least one electrically conductive drain wire associated with the cable shield is disposed in the cable interior in electrical contact with the cable shield. The at least one drain wire includes a ferromagnetic material.

Abstract: An electrical connector for a multi-wire electrical cable includes at least two cable-side electrical contact elements including associated electrical terminals to each of which is to be connected a wire of the electrical cable. At least two output-side electrical contact elements, from each of which projects an electrical connector element by which an electrical connection can be established to a mating connector. An electrically conductive carrier body is disposed between the cable-side contact elements and the output-side contact elements. The electrically conductive carrier body carries an electrical device by which the cable-side contact elements and the output-side contact elements are electrically connected to each other. The electrical device is supported by the carrier body without any of the cable-side contact elements or the output-side contact elements being in electrical contact with the carrier body through the electrical device.

Abstract: An electrical connector for a multi-wire electrical cable includes at least two cable-side electrical contact elements including associated terminals to each of which is connected a wire of the electrical cable, and at least two output-side electrical contact elements, from each of which projects an electrical connector element by which a mating connector is electrically connectable. A tubular outer conductor extends along a longitudinal direction from a cable-side end to an output-side end and encloses the cable-side and output-side contact elements. At least one stranded drain wire of the electrical cable contacts a shield of the electrical cable and is guided to the electrical connector separately from the wires of the electrical cable. The outer conductor has at least one second slot extending along the longitudinal direction of the outer conductor, and the drain wire is received in the second slot in the outer conductor.

Abstract: An electrical connector for a multi-wire electrical cable includes two cable-side electrical contact elements, including associated terminals to each of which is to be connected a wire of the electrical cable, as well as two output-side electrical contact elements, from each of which projects an electrical connector element by which an electrical connection can be established to a mating connector. A carrier body is disposed between the cable-side contact elements and the output-side contact elements. The carrier body forms a support region which extends from a first connecting section to a second connecting section and with which both the cable-side and the output-side contact elements are in connection. At each of the two connecting sections, a respective supporting section of the carrier body extends from the support region in such a way that the support region and the two supporting sections form a ring-shaped circumferential structure.

Abstract: The present invention relates to the preparation of N-(2-(6-fluoro-1H-indol-3-yl)-ethyl)-3-(2,2,3,3-tetrafluoropropoxy)-benzylamine (Compound I), INN-name idalopirdine, and pharmaceutically acceptable salts thereof:

Abstract: Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise ratio) from released hydrogen ions during nucleic acid sequencing reactions.

Abstract: Various methods, systems and devices for optical detection and analysis of polymers, such as polynucleotides, using nanopores, e.g., for determining sequences of nucleic acids, are provided herein. In certain variations, methods and systems for determining a nucleotide sequence of a polynucleotide, which include measuring mixed FRET signals as a polynucleotide translocates through a nanopore and determining a nucleotide sequence of the polynucleotide from the mixed FRET signals, are provided.

Abstract: The present invention relates to a process for synthesis of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol abbreviated THIP, having the INN name gaboxadol, starting from pyrrolidin-2-one. The process comprises a new direct process to obtain the intermediate dimethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-5 dicarboxylate or the intermediate diethyl 5-hydroxy-3,6-dihydropyridine-1,4(2H)-dicarboxylate.