Publication number: 20100192312
Abstract: A highly crosslinked polysiloxane dye comprising at least 10 Si atoms, including at least one moiety of the formula (I) whose open Si-bonds each are linked to an oxygen atom and open O-bond is linked to a silicon atom in the rest of the polysiloxane, and wherein T is a direct bond or an organic spacer group such as C1-C18alkylene, C2-C12alkenylene, C5-C10cycloalkylene, C5-C10arylene, —C5-C10arylene-(C1-C10alkylene)- each of which may be end-capped towards the linkage to Dye by CO, COO, NR1, CONR1, NR1CONR1, CS, CSS, CSNR1, NR1CSNR1, O, S, SO, SO2, C5-C10cycloalkylene, C5-C10arylene; or T is C3-C18alkylene interrupted, and optionally end-capped towards the linkage to Dye, by CO, COO, NR1, CONR1, NR1CONR1, CS, CSS, CSNR1, NR1CSNR1, O, S, SO, —SO2—, C5-C10cycloalkylene, C5-C10arylene; or is CO; (CH2CH2—O)1-5; COO; N(R1); CON(R1); O; S; SO; SO2; R1 is hydrogen; unsubstituted or substituted, straight-chain or branched, monocyclic or polycyclic, interrupted or uninterrupted C1-C14alkyl; C2-C14alkenyl; C6-C10aryl; C
Type:
Application
Filed:
April 25, 2008
Publication date:
August 5, 2010
Applicant:
CIBA CORPORATION
Inventors:
Christian Cremer, Richard Lewis Riggs, Beate Frohling, Martin Muller
Publication number: 20100021920
Abstract: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of
Type:
Application
Filed:
August 21, 2009
Publication date:
January 28, 2010
Inventors:
Christophe Barthe, Susan Branford, Amie Corbin, Brian Jay Druker, Justus Duyster, Andreas Hochhaus, Timothy Hughes, Sebastian Kreil, Thlbaut Leguay, Francois-Xavier Mahon, Gèrald Marit, Martin Müller, Christian Peschel, Claude Preudhomme, Catherine Roche Lestienne, Zbigniew Rudzki
Publication number: 20100021921
Abstract: The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of
Type:
Application
Filed:
August 21, 2009
Publication date:
January 28, 2010
Inventors:
Christophe Barthe, Susan Branford, Amie Corbin, Brian Jay Druker, Justus Duyster, Andreas Hochhaus, Timothy Hughes, Sebastian Kreil, Thibaut Leguay, Francois-Xavier Mahon, Gerald Marit, Martin Muller, Christian Peschel, Claude Preudhomme, Catherine Roche Lestienne, Zbigniew Rudzki