Abstract: A method for producing a micropump includes, among others, a step of providing a substrate, wherein the substrate includes at least one pump diaphragm for the micropump. Additionally, a diaphragm actuator for moving the pump diaphragm is provided, wherein the diaphragm actuator is arranged in an holding device. The holding device is aligned relative to the substrate such that the diaphragm actuator is arranged opposite to the pump diaphragm and the pump diaphragm is deflected in the direction of the diaphragm actuator by means of a fluid pressure that is higher than the ambient pressure. Additionally, the diaphragm actuator is mounted on the pump diaphragm.

Abstract: The invention relates to a device having an opening defining a fluid connection between a fluid channel in the device and ambient air, a sensor coupled to the fluid channel, configured to sense at least one component of the ambient air, and a micro fluid actuator connected downstream of the sensor, configured, in the suction stroke, to suck in fluid through the fluid channel and to transport the same towards the sensor, and, in the pressure stroke, to transport the sucked-in fluid through said fluid channel back towards the opening. According to the invention, the sensor is arranged spaced apart from the opening, and the volume of the fluid channel between the sensor and the opening is equal to or smaller than the stroke volume which the micro fluid actuator may convey with a single suction stroke.

Abstract: A free-jet dosing system for administering a fluid into or under the skin having a micropump and a nozzle arranged on the outlet side. The micropump has an inlet and an outlet and is configured to transport a fluid from the inlet to the outlet and to generate a blocking pressure of at least 20 bar at the outlet. The nozzle is configured to output the fluid output at the outlet as a free jet at a fluid pressure so that the fluid of the free jet may be injected into the skin.

Abstract: The invention relates to a combined pump-sensor arrangement having a substrate having a first main surface and an opposite second main surface. A package lid which defines a package having a measuring cavity is arranged on the first main surface of the substrate. Additionally, the pump-sensor arrangement has a micropump having a pump inlet and a pump outlet, the micropump being configured to suck in an analyte fluid present in the measuring cavity through the pump inlet and eject the same to an environment outside the measuring cavity via the pump outlet. Furthermore, the pump-sensor arrangement has a sensor for detecting at least one component of the analyte fluid present within the measuring cavity and movable by means of the micropump. In accordance with the invention, both the sensor and the micropump are commonly arranged on the first main surface of the substrate and within the measuring cavity.

Abstract: A controllable scent sample dispenser has a microdosing device for outputting, during an activation state, a scent sample at a scent sample outlet to the environment, wherein the microdosing device is placeable adjacent to an animal's nose so that a distance between the outlet of the microdosing device and a nare or nostril of the animal's nose is within a predefined range, and a microdosing driver unit for adjusting a dosing rate of the scent sample output at the scent sample outlet by selectively activating the microdosing device.

Abstract: A fluid sample dispenser includes a microdosing device for outputting, during an activation state, a fluid sample at a fluid sample outlet to the environment, wherein the microdosing device is placeable adjacent to a person's nose so that a distance between the outlet of the microdosing device and a nostril of the person's nose is within a predefined range, and a microdosing driver unit for adjusting a dosing rate of the scent sample output at the scent sample outlet by selectively activating the microdosing device.

Abstract: A light-mixing rod for emitting a homogeneous light beam corresponding to a desired outline shape, said light-mixing rod extending from its first longitudinal end with an entrance face for incident light for forming the light beam along a longitudinal axis to its second longitudinal end with an exit face having the outline shape for emitting the light beam, wherein a first part of the light-mixing rod is made from a first material and a second part of the light-mixing rod with the exit face is made from a second material that is optically more diffuse. A luminous arrangement contains the light-mixing rod and an optical unit, connected downstream of the exit face in the direction of the longitudinal axis, for the light beam for imaging the exit face on a target face that is situated in a specifiable relative position (R) with respect to the exit face.

Abstract: The invention relates to a method as well as a microdosing system for dosing an amount of fluid to be dispensed, wherein the microdosing system includes a micropump including an inlet and an outlet and configured to suck the fluid to be dispensed through the inlet and to dispense at least part of the fluid from the outlet. Further, the inventive microdosing system includes a first flow sensor arranged on the inlet side or the outlet side having an opening and a flow rate meter, wherein the flow rate meter is configured to determine the flow rate of the fluid passing through this opening. Additionally, the inventive microdosing system includes calibrators and/or fault detectors of the first flow sensor.

Abstract: The present application relates to a compound of formulae (I), (II) or (III) or a pharmaceutically acceptable salt thereof, methods and uses thereof for treating disorders associated with matriptase activity.

Abstract: An air conduction element for reducing the air resistance of a load-carrying vehicle having a load space structure. The air conduction element can be externally mounted in the rear region of the load space structure and includes an air conduction duct with a front air inlet opening and a rear air outlet opening, front and rear being in relation to the direction of travel (x). The air inlet opening overlaps the load space structure in the direction of travel (x) and the air outlet opening is arranged behind the load space structure within the cross-sectional contour thereof. The air conduction element has a cover which delimits the air conduction duct. It was therefore the aim to devise an air conduction element which does not increase the dimensions of the load space structure when the vehicle is driving slowly or is at a standstill. For this purpose, the cover is produced from a flexible flat material.

Abstract: A mobile device includes an opening defining a fluid connection between a fluid channel in the mobile device and ambient air, and a sensor arranged in the fluid channel, configured to sense at least one component of the ambient air. The mobile device further includes a micropump configured to draw in the ambient air through the opening and to convey the same to the sensor. According to the invention, the sensor is arranged spaced apart from the opening, and the volume of the fluid channel between the sensor and the opening is less than 200 microliters.

Abstract: The invention relates to an apparatus having a pressure chamber and a micropump in fluid connection with the pressure chamber. The pressure chamber includes a gas-carrying region and a liquid-carrying region. The micropump is configured to generate a pneumatic pressure within the gas-carrying region that is lower than a fluid pressure of a liquid flowing through the liquid-carrying region. According to the invention, a gas-permeable and liquid-impermeable separating element separates, at least in sections, the gas-carrying region and the liquid-carrying region. According to the present invention, the micropump is disposed on the pressure chamber.

Abstract: The invention relates to a device having an opening defining a fluid connection between a fluid channel in the device and ambient air, a sensor coupled to the fluid channel, configured to sense at least one component of the ambient air, and a micro fluid actuator connected downstream of the sensor, configured, in the suction stroke, to suck in fluid through the fluid channel and to transport the same towards the sensor, and, in the pressure stroke, to transport the sucked-in fluid through said fluid channel back towards the opening. According to the invention, the sensor is arranged spaced apart from the opening, and the volume of the fluid channel between the sensor and the opening is equal to or smaller than the stroke volume which the micro fluid actuator may convey with a single suction stroke.

Abstract: The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flue infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and prevention orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

Abstract: An air conduction element for reducing the air resistance of a load-carrying vehicle having a load space structure. The air conduction element can be externally mounted in the rear region of the load space structure and includes an air conduction duct with a front air inlet opening and a rear air outlet opening, front and rear being in relation to the direction of travel (x). The air inlet opening overlaps the load space structure in the direction of travel (x) and the air outlet opening is arranged behind the load space structure within the cross-sectional contour thereof. The air conduction element has a cover which delimits the air conduction duct. It was therefore the aim to devise an air conduction element which does not increase the dimensions of the load space structure when the vehicle is driving slowly or is at a standstill. For this purpose, the cover is produced from a flexible flat material.

Abstract: In a wall element for an interior of a vehicle, having a wall area to be illuminated and having an illuminating device which is used to illuminate the wall area, the illuminating device contains a plurality of lighting modules, wherein each of the lighting modules contains a multiplicity of light sources, wherein the lighting module extends straight along a central longitudinal axis and, in the direction of the central longitudinal axis, is placed against identical lighting modules without gaps at the ends, wherein the lighting module in operation has a cone of light which, by using a predefined area that is to be illuminated, extends away from the lighting module and the relative position (R) of which in relation to the lighting module is predefined, is configured in such a way that, on the part of the area that is illuminated by the cone of light, the result is a strip of light extending laterally transversely away from the lighting module, which extends at least over the entire length (L) of the lighting m

Abstract: In a wall element for an interior of a vehicle, having a wall area to be illuminated and having an illuminating device which is used to illuminate the wall area, the illuminating device contains a plurality of lighting modules, wherein each of the lighting modules contains a multiplicity of light sources, wherein the lighting module extends straight along a central longitudinal axis and, in the direction of the central longitudinal axis, is placed against identical lighting modules without gaps at the ends, wherein the lighting module in operation has a cone of light which, by using a predefined area that is to be illuminated, extends away from the lighting module and the relative position (R) of which in relation to the lighting module is predefined, is configured in such a way that, on the part of the area that is illuminated by the cone of light, the result is a strip of light extending laterally transversely away from the lighting module, which extends at least over the entire length (L) of the lighting m

Abstract: The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flue infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and prevention orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

Abstract: A method and arrangement for operating a motor vehicle having a vehicle electrical system having a semiconductor switch, which during the vehicle operation is loaded with load events based on at least one load-influencing factor, and for which a service life load relationship is predefined, for a nominal service life for a nominal load, and with which for at least one point in time within the nominal service life a nominal load proportion corresponding to the at least one point in time is ascertainable, and the method for the at least one point in time including ascertaining an actual load of the semiconductor switch based on establishing past load events at the at least one point in time, the ascertaining of the nominal load proportion corresponding to the at least one point in time with the predefined service life load relationship, and comparing of the actual and nominal load proportion at the at least one point in time and the reducing of the at least one load-influencing factor when the actual load excee

Abstract: A controllable scent sample dispenser has a microdosing device for outputting, during an activation state, a scent sample at a scent sample outlet to the environment, wherein the microdosing device is placeable adjacent to an animal's nose so that a distance between the outlet of the microdosing device and a nare or nostril of the animal's nose is within a predefined range, and a microdosing driver unit for adjusting a dosing rate of the scent sample output at the scent sample outlet by selectively activating the microdosing device.