Abstract: The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flu infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and preventing orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

Abstract: A mobile device includes an opening defining a fluid connection between a fluid channel in the mobile device and ambient air, and a sensor arranged in the fluid channel, configured to sense at least one component of the ambient air. The mobile device further includes a micropump configured to draw in the ambient air through the opening and to convey the same to the sensor. According to the invention, the sensor is arranged spaced apart from the opening, and the volume of the fluid channel between the sensor and the opening is less than 200 microliters.

Abstract: The invention relates to a pump having a piezo diaphragm transducer arranged at a pump body of the pump, and to a method for producing a pump, wherein a piezo diaphragm transducer is mounted to a pump body, wherein the method, among other things, has providing a piezoceramic layer. In accordance with the invention, at least one piezo element is diced from the piezoceramic layer so that the at least one piezo element has a regular polygon shape having at least six corners. In addition, the method has forming the piezo diaphragm transducer by mounting the piezo element to a pump diaphragm.

Abstract: A high-lift system on a wing of an aircraft is provided. The wing includes a right-hand and a left-hand wing half with movably held high-lift flaps and the right-hand and left-hand wing half are attached to an aircraft fuselage, thus forming a wing root. Each wing half in a region in close proximity to the wing root, includes a drive unit. In each case this drive unit is joined to a transmission shaft mechanically connected to the respective drive unit, which transmission shaft extends from the drive unit in the direction of the end of the respective wing half and is designed to mechanically move the high-lift flaps arranged in the respective wing half. By means of such an arrangement it is possible to do without deflection gear arrangements from a central drive unit to the individual wing halves.

Abstract: A free jet dosage system serves for administering a fluid into an eye. The free jet dosage system includes a micropump having an inlet and an outlet, the micropump being configured to transfer the fluid from the inlet to the outlet and to dispense the fluid at the outlet to the eye as a free jet. The free jet dosage system further includes a sensor configured to sense the eye and to controller a control, and a micropump, wherein the controller is configured to activate the micropump as soon as the eye is sensed by the sensor.

Abstract: The invention relates to a free-jet dosing system for dosing a free fluid jet to be dispensed. The free-jet dosing system includes, inter alia, a pump including an inlet and an outlet and configured to deliver fluid to be dispensed to the outlet. The free-jet dosing system further includes a dosage monitoring device arranged on the outlet side of the pump, the dosage monitoring device having an opening through which at least some of the fluid to be dispensed may pass, and the dosage monitoring device having a flow rate meter configured to determine the flow rate of the fluid which passes through the opening of the dosage monitoring device. In the inventive free-jet dosing system, the opening of the dosage monitoring device is configured as an outlet nozzle for ejecting the free fluid jet.

Abstract: The invention relates to a method as well as a microdosing system for dosing an amount of fluid to be dispensed, wherein the microdosing system includes a micropump including an inlet and an outlet and configured to suck the fluid to be dispensed through the inlet and to dispense at least part of the fluid from the outlet. Further, the inventive microdosing system includes a first flow sensor arranged on the inlet side or the outlet side having an opening and a flow rate meter, wherein the flow rate meter is configured to determine the flow rate of the fluid passing through this opening. Additionally, the inventive microdosing system includes calibrators and/or fault detectors of the first flow sensor.

Abstract: A free-jet dosing system for administering a fluid into or under the skin having a micropump and a nozzle arranged on the outlet side. The micropump has an inlet and an outlet and is configured to transport a fluid from the inlet to the outlet and to generate a blocking pressure of at least 20 bar at the outlet. The nozzle is configured to output the fluid output at the outlet as a free jet at a fluid pressure so that the fluid of the free jet may be injected into the skin.

Abstract: A cylindrical drill body for a hole saw has cutting teeth on an end side and at least one cutout, which is located in a lateral surface of the cylindrical drill body at a distance from the cutting teeth. The cutout has a rectilinear boundary edge directed parallel to the end side.

Abstract: A sanding plate for a hand-guided electric power tool includes a receiving element and a carrier element. The receiving element is configured to fasten the sanding plate to a drive shaft of the electric power tool. In particular, the receiving element is configured to connect the sanding plate to the drive shaft in a rotationally fixed manner. The carrier element is formed of at least one yielding material. The carrier element is at least partially supported by a support element that is connected to the receiving element. The ratio of the radii of a circumcircle to circumscribe the carrier element to at least one circumcircle to circumscribe the support element is in the range of from 1.3 to 2. An electric power tool system includes a sander that has an oscillating drive shaft and the sanding plate.

Abstract: A test station for testing at least one of fluidic component arranged on a substrate, each fluidic component having a fluidic port, comprises a carrier device for holding the substrate with the at least one fluidic component, a connecting device for fluidically connecting the fluidic port of the at least one fluidic component located in a testing position to a first adapter element of the connecting device, and a displacement device configured to displace the substrate and the connecting device relative to each other, and to bring the substrate into the testing position.

Abstract: A pump arrangement includes a microfluidic pump having a pump inlet and a pump outlet. The pump arrangement further includes a safety valve arrangement having first safety valve, the first safety valve being arranged between the pump outlet and an outlet of the pump arrangement and including a first valve seat and a first valve lid. The outlet of the pump arrangement and a first fluid region are formed in a first part of the pump arrangement, wherein the first valve lid is formed in a second integrated part of the pump arrangement, and wherein the first valve seat, the pump outlet and the pump inlet are patterned in a second surface of a third integrated part of the pump arrangement. The first fluid region is adjacent to the first valve lid, wherein a pressure in the first fluid region has a closing effect on the first safety valve.

Abstract: In a wall element for an interior of a vehicle, having a wall area to be illuminated and having an illuminating device which is used to illuminate the wall area, the illuminating device contains a plurality of lighting modules, wherein each of the lighting modules contains a multiplicity of light sources, wherein the lighting module extends straight along a central longitudinal axis and, in the direction of the central longitudinal axis, is placed against identical lighting modules without gaps at the ends, wherein the lighting module in operation has a cone of light which, by using a predefined area that is to be illuminated, extends away from the lighting module and the relative position (R) of which in relation to the lighting module is predefined, is configured in such a way that, on the part of the area that is illuminated by the cone of light, the result is a strip of light extending laterally transversely away from the lighting module, which extends at least over the entire length (L) of the lighting m

Abstract: A converter for an electric motor includes a semiconductor element connected at at least one contacting for converting a voltage, a voltage measuring device for measuring a voltage drop over the semiconductor component, and a control device for controlling the semiconductor component, the control device being configured to determine a state of the contacting based on the measured voltage drop.

Abstract: According to the invention, high lift leading-edge slats (13) and high lift flaps (14) are simultaneously deployed, when the speed of the aircraft is equal to and less than an AES threshold.

Abstract: A method of manufacturing a bending transducer having a drive element and a membrane includes providing the membrane and the drive element and applying a production signal to the drive element during a bonding of the drive element to the membrane such that the drive element is pre-stressed after the bonding, wherein the production signal is of a same kind as an operation signal to operate the bending transducer.

Abstract: A microfluidic device for detecting a flow parameter, includes a channel configured within a base body, the channel including a first inlet for feeding a first fluid and a second inlet for feeding a second fluid so as to form a fluid stream having the first and second fluids within the channel, and further including an output for providing the fluid stream on the output side, a first feeder including a micropump associated with the first inlet for selectively feeding the first fluid to the channel, a second feeder associated with the second inlet for feeding the second fluid to the channel; and a detector for detecting, on the basis of a different physical property of the first fluid and the second fluid within the channel, a measurement value dependent on a current flow parameter of the first or second fluid.

Abstract: The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flu infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and preventing orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

Abstract: The present invention provides matriptase inhibitors and compositions for treating and preventing orthomyxovirus infections such as flu infections. The present invention also provides novel compounds, compositions, methods of use, uses and kits thereof for inhibiting matriptase. Such compounds are useful for treating and preventing orthomyxovirus infections, such as flu infections, and for inhibiting tumor growth, progression and/or metastasis.

Abstract: An aircraft having a high lift system, including a control computer, high lift bodies on each wing, a drive coupled to these, an activation device connected to the drive via an analog connection, an input device, and sensors detecting a state of the high lift bodies connected via analog lines to the activation device. The input device connects via a digital connection to the activation device for transmitting commands for adjusting the high lift bodies. The activation device is installed in the payload area of the fuselage and in an area extending from a location spaced from the front of the wingbox by a distance of one third of the fuselage length extending from there to the aircraft's tip, as far as a location spaced from the rear of the wingbox by a distance of one third of the fuselage length extending from there to the aircraft's tail end.