Abstract: Systems and methods are described herein for disease knowledge modeling and clinical treatment decision support. Disease or indication information, including identification of biomolecular entities associated with the indication may be culled through data mining to create a knowledge model of the indication. In some embodiments, the knowledge model may comprise a network of associations between molecular entities, including drug targets and biomarkers, genes, pathways. The model is used for prioritizing treatment decisions, for treatments comprising one or more medications associated with one or more molecular entities in the model. The priority of a suggested treatment depends on at least one property of one or more medications of the suggested treatment.

Abstract: Methods of determining whether a patient is suitable for erythropoietin (EPO) therapy, including (A) isolating a tissue sample from said patient; (B) determining the level of expression of EPH-B4 in said sample; and (C) correlating a presence of EPH-B4 expression to a negative physiological response to EPO therapy). In addition, methods of enhancing the effectiveness of EPO therapy in a patient by administering to said patient, in conjunction with EPO therapy, an siRNA specific for EPH-B4.

Abstract: A system and methods are provided for or presenting a user interface by a device for exploring content associated with a media title. In one embodiment, a method includes displaying a tapestry interface for a plurality of assets, wherein the tapestry interface is an arrangement of graphical elements associated with the plurality of assets, the graphical elements having relevance based sizing, and updating relevance scoring of assets for display in the tapestry interface. The method may further include determining presentation characteristics of assets for display in a tapestry interface based on the updating, and updating the presentation of the tapestry interface on the device based on the presentation characteristics.

Abstract: A system and methods are provided for presenting a tapestry interface including graphical elements for a plurality of asset. In one embodiment, a method includes scoring assets for display in the tapestry interface, wherein the tapestry interface provides a presentation for a plurality of assets having relevance based sizing, arrangement of the assets based at least in part on a grid pattern, and determining presentation characteristics of assets for display of the tapestry interface by a device based on the scoring, the presentation characteristics including presentation size and arrangement of assets on the grid pattern for each asset. The method may also include presenting the tapestry interface on the device, wherein at least a portion of the tapestry interface is displayed based on the presentation characteristics determined for each asset and arrangement of assets on the grid pattern.

Abstract: A system and methods are provided for presenting a tapestry interface including graphical elements for a plurality of assets. In one embodiment, a method includes displaying a tapestry interface by a device for a plurality of assets, wherein the tapestry interface is an arrangement of graphical elements associated with the plurality of assets, the graphical elements having relevance based sizing and detecting a user input to the device, the input associated with at least one asset displayed in the tapestry interface. The method may also include displaying one or more graphical elements in a graphical display pane based on the user input, the one or more graphical elements for locating assets of the tapestry presentation.

Abstract: A system and methods are provided for scoring assets for display in a tapestry interface. In one embodiment, a method includes identifying assets for display in a tapestry interface presentation, wherein the tapestry interface provides a presentation for a plurality of assets having relevance based sizing, arrangement of the assets based at least in part on a grid pattern, receiving data for identified assets of the tapestry presentation, and scoring assets based on the received data to determine presentation characteristics for the assets in the tapestry interface. The method may also include updating the presentation of the tapestry interface on a device based on the presentation characteristics.

Abstract: A system and methods are provided for presenting a tapestry interface including graphical elements for a plurality of assets. In one embodiment, a method includes displaying a tapestry interface by a device for a plurality of assets, wherein the tapestry interface is an arrangement of graphical elements associated with the plurality of assets, the graphical elements having relevance based sizing, and detecting an input to the device for filtering the tapestry presentation based on geographic location data. The method may also include updating display of the tapestry interface presentation based on the geographic location data.

Abstract: A system and methods are provided for presenting a tapestry interface including graphical elements for a plurality of assets. In one embodiment, a method includes displaying a tapestry interface by a device for a plurality of assets, wherein the tapestry interface is an arrangement of graphical elements associated with the plurality of assets, the graphical elements having relevance based sizing, and receiving social media data associated with at least one asset displayed in the tapestry interface. The method may also include displaying one or more assets with graphical elements, the graphical elements based on social media data received for the one or more assets.

Abstract: Some embodiments, by way of example, provide a system, comprising a posture change detector configured to detect a posture transition indicative of an increased risk of syncope, and a neural stimulator configured to deliver a neural stimulation therapy. The neural stimulator may include a syncope avoidance module configured to respond to a detected posture transition by temporarily overriding the neural stimulation therapy to ameliorate the risk of increased syncope.

Abstract: The invention relates to a vehicle headlamp (1) for producing a main light distribution and an auxiliary light distribution, wherein the vehicle headlamp (1) comprises two or more LED light modules (10), wherein each of the LED light modules (10) comprises one or more primary LED light sources (11), wherein a primary LED light source (11?) comprises at least one light-emitting diode, comprises two or more secondary LED light sources (12, 12a), wherein a secondary LED light source (12, 12a) comprises at least one light-emitting diode (12?), and comprises a lens (13), wherein the light emitted by the at least one primary LED light source (11) is radiated directly onto the lens (13) and projected by the lens into the exterior space, wherein the light emitted by the primary LED light sources (11) of a all LED modules (10) forms the main light distribution, and wherein the light emitted by the secondary LED light sources (12, 12a) of an LED modules (10) is radiated onto the lens (13) of the LED module (10) by mean

Abstract: There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumor allows EPO to impinge on the survival of associated cells thereby enhancing tumor progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumor as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin.

Abstract: There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin.

Abstract: An adjustment device is provided for adjusting an inclination angle of a backrest of a vehicle seat, in particular for a motor vehicle, the adjustment device being able to be actuated by a ratchet mechanism.

Abstract: An adjusting device for adjusting an inclination angle of a backrest of a vehicle seat, in particular for a motor vehicle, wherein the adjusting device is arranged inside the vehicle seat.

Abstract: There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin.

Abstract: An integrated tracing and logging system for an enterprise network. One embodiment of the integrated logging and tracing system has an object-oriented architecture which includes a controller class with two sub-classes: a tracing sub-class and a logging sub-class. Instances of the tracing sub-class (tracing modules) are associated with specified program code regions of network applications. The tracing modules receive method calls from the network applications and process the method calls based on defined severity levels. Instances of the logging sub-class (logging modules) are associated with specified “categories” related to the enterprise network (e.g., system, database, etc). The logging modules receive and process method calls from network components associated with the categories. The integrated logging and tracing system may be accessed by a log viewer having a log viewer client to provide a user interface and a log viewer server to read one or more log messages.

Abstract: A vacuum system comprises, as an integral assembly, a vacuum pump with drive motor, a purge valve, a roughing valve and an electronic control module. A cryogenic vacuum pump and a turbomolecular vacuum pump are disclosed. The control module has a programmed processor for controlling the motor and valves and is user programmable for establishing specific control sequences. The integral electronic control module is removable from the assembly and is connected to the other devices through a common connector assembly. In the turbomolecular pump system proper introduction of a purge gas through the purge valve is detected by detecting the current load on the pump drive or by detecting foreline pressure. To test the purge gas status, the purge valve may be closed and then opened as drive current or pressure is monitored. After power failure, the controller will continue normal drive of the turbomolecular pump so long as the speed of the pump has remained above a threshold value.

Abstract: A vacuum system comprises, as an integral assembly, a vacuum pump with drive motor, a purge valve, a roughing valve and an electronic control module. A cryogenic vacuum pump and a turbomolecular vacuum pump are disclosed. The control module has a programmed processor for controlling the motor and valves and is user programmable for establishing specific control sequences. The integral electronic control module is removable from the assembly and is connected to the other devices through a common connector assembly. In the turbomolecular pump system proper introduction of a purge gas through the purge valve is detected by detecting the current load on the pump drive or by detecting foreline pressure. To test the purge gas status, the purge valve may be closed and then opened as drive current or pressure is monitored. After power failure, the controller will continue normal drive of the turbomolecular pump so long as the speed of the pump has remained above a threshold value.

Abstract: A mechanism for retrieving data over a network using an asynchronous buffer is described herein. According to one embodiment, an exemplary process includes, in response to a request for first data from a client via a first thread, determining whether a local circular buffer contains the requested first data, the local circular buffer having a head region and a tail region for identifying a head and a tail of the local circular buffer respectively, and the local circular buffer containing a portion of a data file maintained by a server over a network, generating a second thread to the server over the network to request the first data, if the local circular buffer does not contain the requested first data, and returning the first thread to the client while waiting for a result of the second thread from the server. Other methods and apparatuses are also described.

Abstract: An integrated tracing and logging system for an enterprise network. One embodiment of the integrated logging and tracing system has an object-oriented architecture which includes a controller class with two sub-classes: a tracing sub-class and a logging sub-class. Instances of the tracing sub-class (tracing modules) are associated with specified program code regions of network applications. The tracing modules receive method calls from the network applications and process the method calls based on defined severity levels. Instances of the logging sub-class (logging modules) are associated with specified “categories” related to the enterprise network (e.g., system, database, etc). The logging modules receive and process method calls from network components associated with the categories. The integrated logging and tracing system may be accessed by a log viewer having a log viewer client to provide a user interface and a log viewer server to read one or more log messages.