Abstract: Aspects of the present disclosure relate to a method of making a one piece diaphragm. The method includes providing a tool die, providing a disc formed from a first material, positioning the disc within an injection mold, providing a second material; heating the second material. The method includes melt molding the second material into the tool die and around a peripheral edge of the disc to form the one piece diaphragm comprising a rim, and removing the one piece diaphragm from the injection mold.

Abstract: Embodiments relate to determining the health of a network community. Aspects include defining, via a computer processor, measurable aspects associated with the network community. The measurable aspects include metrics for one or more of: quantified interactions among users in the network community, quantified activities among the users that are associated with a topic, and quantified activities indicative of network community accessibility. Aspects also include monitoring activities conducted via the network community, collecting data from monitored activities that correspond to the measurable aspects, and analyzing collected data from the monitored activities. The analyzing is performed as a function of the metrics. Aspects further include determining, via the computer processor, a health status of the network community from results of the analyzing.

Abstract: A candle blowing apparatus may have a main housing, a mouthpiece, at least one filter cartridge, and an ornamental endpiece. The main housing may have a first end and a second end. The mouthpiece may be removably attached to the first end of the main housing. The at least one filter cartridge may include at least one filter. The filter cartridge may be removably disposed within the main housing between the first end and the second end. The filter cartridge may be in fluid communication with the mouthpiece. The ornamental endpiece may be removably attached to the second end of the main housing and be in fluid communication with the filter cartridge. The ornamental endpiece together with the mouthpiece and the filter cartridge may define an air flow path for hygienic delivery of an extinguishing gust of air to a candle.

Abstract: The cMethDNA method of the present invention is a novel modification of the QM-MSP method (U.S. Pat. No. 8,062,849), specifically intended to quantitatively detect tumor DNA (or other circulating DNAs) in fluids such as serum or plasma at the lowest copy number yet reported. Unique compared to any other PCR-based assay, a small number of copies of a synthetic polynucleotide standard (STDgene) is added to an aliquot of patient serum with standards for a plurality of genes of interest (TARGETgene). Once total DNA is purified PCR is performed wherein the STDgene and the TARGETgene are co-amplified with the same external primer set, and the amplicons present in a dilution of the first PCR reaction are subjected to real time PCR, and quantified for each gene. Methods of making the STDgene standards and the use of the cMethDNA methods and kits containing the same are disclosed.

Abstract: The present invention is a diaphragm including a disc formed from a first material and a rim formed from a second material. The disc and the rim are a unitary piece. The rim has a Shore A durometer hardness of between about 40 and 110.

Abstract: The present invention relates to strategies by which one or more phenolic resins are provided in aqueous phenolic dispersions in a manner so that the resultant aqueous phenolic dispersions are more easily combined with water-based latex compositions. The principles of the present invention make it much easier to formulate water-based latex compositions in which substantial phenolic resin content can be stably dispersed for long periods of time. In one aspect, the present invention relates to a method of making a coating composition, comprising a) providing an inverted aqueous dispersion comprising i) at least one polymer having one or more polar, hydrophilic groups; and ii) at least one phenolic resin; b) providing a latex composition; and c) blending the latex composition with the aqueous dispersion to form the coating composition.

Abstract: Items associated with radio frequency (RF) identification (RFID) tags sequentially arranged in a list are to be retrieved from a venue. A mobile RFID tag reader is jointly movable with an operator. The reader is controlled to non-sequentially read the tags from the list. The operator is guided to find any one of the items by reading the tag associated with the any one item. The operator is prompted to retrieve the any one item and to remove the associated tag from the list. The guiding operation to the any one item is discontinued after retrieval of the one item. The guiding operation, the prompting operation, and the discontinuing operation are repeated for any others of the items from the list in a non-ordered sequence.

Abstract: To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis was performed on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. Forty CpG loci showed differential methylation specific to either ER-positive or ER-negative tumors. Each of the 40 ER-subtype-specific loci was validated in silico using an independent, publicly available methylome dataset from The Cancer Genome Atlas (TCGA). In addition, 100 methylated CpG loci were identified that were significantly associated with disease progression. Arrays containing the ER-subtype-specific loci and their use in methods of diagnosis and treatment of breast cancer are provided.

Abstract: GCI fuel compositions and methods of making them are described. The GCI fuel compositions comprises a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream.

Abstract: The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: The present invention is a stethoscope diaphragm including a disc and a rim. The rim includes a plurality of features extending from an inner circumference of the rim.

Abstract: A process is presented for recovering the hydrocarbon components from a naphtha feed to pass to a gasoline blending pool or to change the operations to increase the production of light olefins. The process includes the separation of the naphtha feedstock into a light naphtha stream and a heavy naphtha stream. The process further includes separating the light naphtha stream to recovery high quality non-normal hydrocarbons, and to separate normal hydrocarbons to the feed to the cracking unit.

Abstract: A process is presented for improving the feed to a cracking unit and a reforming unit from a naphtha feedstock. The process includes the use of a separation unit to generate a light naphtha feed and a heavy naphtha feed. The process further includes separating the light naphtha feed into a light naphtha feed comprising normal hydrocarbons and a light naphtha feed comprising non-normal hydrocarbons. The light naphtha feed comprising normal hydrocarbon is passed to the cracking unit and the heavy naphtha feed is passed to the reforming unit.

Abstract: Techniques are described for taking actions based on multidimensional profile matching. A system defines a multi-dimensional user space that describes users and a multi-dimensional product space that describes products. The system also generates, for a user, a user profile that represents a vector within the multi-dimensional user space and generates, for multiple products, product profiles that each represent a vector within the multi-dimensional product space. The system further maps the user profile to a recommendation vector within the multi-dimensional product space and compares the recommendation vector to vectors within the multi-dimensional product space represented by the product profiles. Based on the comparison, the system determines, from among the multiple products, a subset of the multiple products to recommend to the user and outputs an interface that includes a recommendation for the user.

Abstract: Provided is a tissue staining composition containing carbon particles having a mean particle diameter less than 0.3 ?m in diameter (optionally less than 0.2 ?m in diameter) together with one or more agents that maintain the carbon particles in suspension (for example, an anti-settling agent and/or surfactant). In certain circumstances, the anti-settling agent may also have mucoadhesive properties. The tissue staining composition is visually dark and does not disperse rapidly when introduced into regions of tissue of interest making it ideal for marking the regions that can be visualized clearly and over prolonged periods of time via, for example, direct visualization, endoscopic or laparoscopic inspection. The invention also provides methods of making and using the tissue staining composition for marking regions of tissue of interest, for example, gastrointestinal tissue, as well as other tissues.

Abstract: The present invention is a diaphragm including a disc formed from a first material and a rim formed from a second material. The disc and the rim are a unitary piece. The rim has a Shore A durometer hardness of between about 40 and 110.

Abstract: In one aspect, a cordless covering may include a roller and a shade panel configured to be wound around and unwound from the roller to move the shade panel between an extended position and a retracted position. The shade panel may include a front panel, a back panel, and a plurality of vanes extending between the front and back panels. The covering may also include a roller shaft extending through the roller and a tilt adjustment mechanism coupled to the roller shaft. The tilt adjustment mechanism may be configured to rotate the roller shaft to adjust a tilt angle of the vanes between an opened position and a closed position.

Abstract: Items associated with radio frequency (RF) identification (RFID) tags sequentially arranged in a list are to be retrieved from a venue. A mobile RFID tag reader is jointly movable with an operator. The reader is controlled to non-sequentially read the tags from the list. The operator is guided to find any one of the items by reading the tag associated with the any one item. The operator is prompted to retrieve the any one item and to remove the associated tag from the list. The guiding operation to the any one item is discontinued after retrieval of the one item. The guiding operation, the prompting operation, and the discontinuing operation are repeated for any others of the items from the list in a non-ordered sequence.