Abstract: The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.

Abstract: GCI fuel compositions and methods of making them are described. The GCI fuel compositions comprises a fuel blend having an initial boiling point in a range of about 26° C. to about 38° C. and a final boiling point in a range of about 193° C. to less than 250° C., a density of about 0.72 kg/l to about 0.8 kg/l at 15° C., a research octane number of about 70 to about 85, and a cetane number of less than about 27, the fuel blend comprising a naphtha stream and a kerosene stream.

Abstract: A swimsuit garment having a shoulder securing means connected to a torso-covering section extending from a bustline to a hemline. The torso-covering section will have an opening mechanism extending from a terminus point on the bustline in a diagonal direction to a starting point on the hemline. The starting point on the hemline is situated on an opposite side of the terminus on the bustline. Further, the torso-covering section is connected to a back-covering section. The opening mechanism may be situated diagonally, with a starting point situated on a wearer's leg cuff on one side of the wearer's body to an ending point on the wearer's bustline on the side of the body opposite to the leg cuff, for example the starting point is on the left leg cuff and the ending point or terminus is on the bustline on the wearer's right-hand side.

Abstract: In an embodiment, a gift wrap is provided with a graphic. The user may customize the graphic with designs such as stickers, stencils, and stampers as well as with writing instruments. The user may also customize a design prior to placing the design on the gift wrap. The completed gift wrap can provide an educational experience for the person customizing the gift wrap while providing the recipient with a memorable package that a portion of which may be saved as a keepsake.

Abstract: The present invention is a stethoscope diaphragm including a disc and a rim. The rim includes a plurality of features extending from an inner circumference of the rim.

Abstract: A breast prosthesis device and method for making same are disclosed. The prosthesis has an inner wall mesh having a first density. The inner wall mesh is configured to align with a chest wall of the user. The prosthesis has an outer wall mesh having a second density. The outer wall mesh configured to have an ideal shape for the user. The prosthesis may also have a band with a density greater or equal to the inner and outer wall meshes. The prosthesis has a central portion disposed in between the inner and outer wall meshes. The prosthesis can be generated using 3D scans of the user manipulated such that the resulting structure mimics human tissue.

Abstract: In one aspect, the invention provides injectable compositions that comprise a suitable hydrophilic polymer (e.g., a suitable polysaccharide) and water, as well as other optional components. In various embodiments, the composition may be provided in a suitable container, for example, in a pre-loaded syringe. In another aspect, methods of performing medical procedures in a tract of a body are provided. In yet another aspect, the invention provides systems for performing medical procedures in a tract of a body.

Abstract: A shoe liner adapted to selectively couple to a vertical, rear, interior wall of a shoe includes a natural fabric body that is an elongated ovoid shape having a foot side and an opposite shoe side. The shoe side includes an adhesive back adapted to selectively adhere to the vertical backwall interior side of the shoe. The shoe liner further includes an interior chamber defined between the foot side and shoe side layers. The interior chamber is adapted to hold a volume of cotton batting filler material. The exterior surfaces of the shoe liner are made from a natural material and are available in a myriad of colors, textures, and patterns.

Abstract: Ventilator associated pneumonia (VAP) may be prevented in a patient, or its occurrence reduced in a population of patients, by using an anti-VAP device or an anti-VAP material such as an anti-VAP mouthpiece that absorbs secretions. By reducing the problem of bacterial-containing secretions that otherwise build up in the airway of, and elsewhere in, the intubated patient, VAP can be prevented from occurring in intubated patients, such as patients intubated with an endotracheal tube (ETT) or a nasogastric tube. Anti-VAP mouthpieces also are useable in non-intubated patients to maintain oral hygiene.

Abstract: A system motivates a user to achieve a goal by selecting electronic content that is relevant to the goal, and correlating the electronic content with at least one electronically interactive incentive geared toward achieving the goal. The system presents a challenge to the user via an electronic interface, where the challenge comprises the electronic content and/or the individualized electronically interactive incentive. The system receives, via the electronic interface, a response to the challenge from the user. The system then tracks the user's progress toward attaining at least one electronically interactive incentive by electronically monitoring the account associated with the user. The system renders a representation of the user's progress for the user via the electronic interface. The system provides the user with an option to receive at least one electronically interactive incentive as a physical item when the user has attained the electronically interactive incentive.

Abstract: Ventilator associated pneumonia (VAP) may be prevented in a patient, or its occurrence reduced in a population of patients, by using an anti-VAP device or an anti-VAP material such as an anti-VAP mouthpiece that absorbs secretions. By reducing the problem of bacterial-containing secretions that otherwise build up in the airway of, and elsewhere in, the intubated patient, VAP can be prevented from occurring in intubated patients, such as patients intubated with an endotracheal tube (ETT) or a nasogastric tube. Anti-VAP mouthpieces also are useable in non-intubated patients to maintain oral hygiene.

Abstract: An introducer adapted to facilitate positioning of a catheter, such as an intrauterine catheter, is provided. The introducer includes an elongate member having an outer wall defining a longitudinal axis and a longitudinal lumen for reception of a catheter, e.g., an intrauterine catheter. The outer wall includes first and second longitudinal edges defining a longitudinal slot in communication with the longitudinal lumen. The outer wall has a cross-section orthogonal to the longitudinal axis and defining a thickness at an opposed location generally opposing the longitudinal slot greater than a thickness at edge locations adjacent the first and second longitudinal edges, to thereby permit the first and second longitudinal edges to be displaced relative to each other to increase a dimension of the longitudinal slot to facilitate one of removal or insertion of the catheter via the longitudinal slot and relative to the longitudinal lumen.

Abstract: Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific PCR (QM-MSP), multiple genes can be quantitatively evaluated from samples usually yielding sufficient DNA for analyses of only 1 or 2 genes. DNA sequences isolated from the sample are simultaneously co-amplified in an initial multiplex round of PCR, and the methylation status of individual hypermethylation-prone gene promoter sequences is then determined separately or in multiplex using a real time PCR round that is methylation status-specific. Within genes of the panel, the level of promoter hypermethylation as well as the incidence of promoter hypermethylation can be determined and the level of genes in the panel can be scored cumulatively. The QM-MSP method is adaptable for high throughput automated technology.

Abstract: The present invention includes methods for reducing tissue damage in patients undergoing radiation treatment or with idiopathic pulmonary fibrosis or scleroderma by inhibiting PAI-1 activity in the tissue with a truncated PAI-1 agent, rPAI-123.

Abstract: A process for increasing the yields of light olefins and the yields of aromatics from a hydrocarbon stream is presented. The process includes a first separation to direct the light components that are not reformable to a cracking unit, with the remainder passed to a second separation unit. The second separation unit extracts normal components from the hydrocarbon stream to pass to the cracking unit. The resulting hydrocarbon stream with reduced light ends and reduced normals is passed to a reforming unit.

Abstract: A process for increasing the yields of light olefins and the yields of aromatics from a hydrocarbon stream is presented. The process includes a first separation to direct the light components that are not reformable to a cracking unit, with the remainder passed to a second separation unit. The second separation unit extracts normal components from the hydrocarbon stream to pass to the cracking unit. The resulting hydrocarbon stream with reduced light ends and reduced normals is passed to a reforming unit.

Abstract: A method, system, and computer program product for cognitive state supported automotive travel are provided in the illustrative embodiments. A detection is made that an event in a vehicle is outside of acceptable bounds for that event. A determination is made whether the event being outside of acceptable bounds is a result of a cognitive state of a person operating the vehicle. Responsive to the event being a result of the cognitive state of the person, an indication of the cognitive state of the person being below a threshold level of cognitive abilities is generated. An action corresponding to the cognitive state is performed. The action causes the vehicle to operate with improved safety.

Abstract: The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.