Abstract: wherein R.sup.1 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, nitro, amino or protected amino,R.sup.2 is hydroxy, protected hydroxy, halogen, amino or protected amino,R.sup.3 is hydrogen or an organic group,R.sup.4 R is hydrogen or lower alkyl,R.sup.8 is hydrogen or lower alkyl, and--Z-- is --O-- or a group of the formula: ##STR2## (in which n is 0, 1 or 2), and pharmaceutically acceptable salts thereof which are useful as a medicament.

Abstract: This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by the general formula [I]: ##STR1## wherein R.sup.1 is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted lower alkenyl, acyl, nitro, substituted or unsubstituted amino, sulfo, substituted or unsubstituted sulfamoyl, N-containing heterocyclicsulfonyl, hydoxy, substituted or unsubstituted heterocyclic group,R.sup.2 is substituted or unsubstituted aryl, andR.sup.3 is substituted or unsubstituted aryl, provided that R.sup.3 is aryl substituted with substituent(s) selected from the group consisting of amino, mono(lower)-alkylamino, acylamino, lower alkyl(acyl)amino and sulfamoyl when R.sup.1 is hydrogen, halogen or cyano, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

Abstract: The present invention relates to new pyrazole derivatives represented by the following general formula (I) ##STR1## wherein R.sup.1 is aryl which is substituted with substituent(s) selected from the group consisting of lower alkylthio, cyclo(lower)alkyl, hydroxy, hydroxy(lower)alkyl, cyano, lower alkylenedioxy, acyl, acyloxy, aryloxy and lower alkoxy optionally substituted with acyl or lower alkoxy, R.sup.2 is halogen, halo(lower)alkyl, cyano or acyl, and R.sup.3 is aryl substituted with nitro, hydroxy, lower alkoxy, lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, provided that when R.sup.3 is aryl substituted with nitro, hydroxy or lower alkoxy, then R.sup.1 is aryl substituted with lower alkylthio, lower alkylsulfinyl or lower alkylsulfonyl, and pharmaceutically acceptable salts thereof.

Abstract: An image transfer apparatus comprises a platen (8) to which an image-forming material is to be attached and a transfer cylinder (1) to which an image receptor is to be attached. An image formed in a photosensitive layer of the image-forming material is transferred to image receptor by the introduction of the image-forming material and the image receptor into a nip formed by the platen and the transfer cylinder by the rotation of the platen and the transfer cylinder. The image transfer apparatus has an image receptor attaching device that includes holders (3,5) and holder seats (4,6) for holding the entire length of a top end side of the image receptor to a surface of the transfer cylinder and the entire length of a bottom end side of the image receptor to a surface of the transfer cylinder.

Abstract: An image transfer apparatus has a platen to which an image-forming material is to be attached and a transfer cylinder 1 to which an image receptor is to be attached. The apparatus is for transferring an image formed in a photosensitive layer of an image-forming material to an image receptor by the introduction of the image-forming material and the image receptor into a nip formed by the platen and the transfer cylinder. The apparatus has an image receptor attaching the apparatus having an image receptor attaching device comprising a device for holding the top end side of the image receptor to a transfer cylinder surface along the entire width of the image receptor and a device for holding the bottom end side of the image receptor to a transfer cylinder surface along the entire width of the image receptor.

Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is aryl, or a group of the formula: ##STR2## wherein X is CH or N, and Z is O or N--R.sup.5,in which R.sup.5 is hydrogen or lower alkyl,R.sup.2 is hydroxy or lower alkoxy,R.sup.3 is hydrogen or lower alkyl which may have suitable substituent(s),R.sup.4 is ar(lower)alkyl which may have suitable substituent(s),A is carbonyl or sulfonyl, andY is a bond or lower alkenylene,and pharmaceutically acceptable salt thereof. The disclosed compounds are useful for treating respiratory diseases such as bronchaedema.

Abstract: A substance P antagonistic peptide of the following formula is disclosed: ##STR1##

Abstract: An image transfer apparatus, which comprises a platen (8) to which an image-forming material is to be attached and a transfer cylinder (1) to which an image receptor is to be attached, and which is for transferring an image formed in a photosensitive layer of an image-forming material to an image receptor by the introduction of the image-forming material and the image receptor into a nip formed by the platen and the transfer cylinder by the rotation of the platen and the transfer cylinder, the apparatus having an image-forming material attaching device comprising a device for holding the top end side of the image receptor to a platen surface along the entire width of the image receptor and a device for holding the bottom end side of the image receptor to a platen surface along the entire width of the image receptor, the device for holding the top end side being a pin bar (13) having pins protruded from an inside of a blanket (10) in a slope portion (12) continued from a partial cut-off portion formed in the p

Abstract: An image transfer apparatus which has a platen to which an image-forming material is to be attached and a transfer cylinder 1 to which an image receptor is to be attached. The apparatus is for transferring an image formed in a photosensitive layer of an image-forming material to an image receptor by the introduction of the image-forming material and the image receptor into a nip formed by the platen and the transfer cylinder. The apparatus has an image receptor attaching device comprising a device for holding the top end side of the image receptor on a transfer cylinder surface along the entire width of the image receptor and a device for holding the bottom end side of the image receptor on a transfer cylinder surface along the entire width of the image receptor. The device for holding the bottom end side comprises a holder and a holder seat for holding the image receptor, provided in a partial cut-off portion of a surface of the transfer cylinder and in an axial-length direction of the transfer cylinder.

Abstract: Compounds of the formula: ##STR1## wherein A is S, SO, or SO.sub.2, R.sup.1 is H or acyl, R.sup.2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R.sup.3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

Abstract: A tachykinin-antagonistic compound of the following general formula:R.sup.1 --A.sup.1 --D--Trp(R.sup.2)--A.sup.2 --R.sup.3[whereinR.sup.1 is hydrogen or amino-protective groupR.sup.2 is amino-protective groupR.sup.3 is ar(lower)alkoxy or N-(lower)alkyl or N-ar(lower)alkylaminoA.sup.1 is single bond or one amino acid residueA.sup.2 is one amino acid residue other than Phe.]or the salt thereof.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, A, X and Y are as defined and pharmaceutically acceptable salts thereof; which have activities as leukotriene and Slow Reacting Substance of Anaphalaxis (SRS-a) antagonists or inhibitors, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or treatment of allergy or inflamation in human beings or animals.

Abstract: Compounds of the formula: ##STR1## wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as therapeutic agents for the treatment of e.g. rheumatism, nephritis and thrombocytopenia.

Abstract: The present invention relates to DTrp-Phe containing tripeptides and pharmaceuticals, which possess tachykinin antagonism activity as well as processes of making such peptides.

Abstract: Peptide compounds having Substance P antagonism of the formula: ##STR1## wherein R.sup.1 is lower alkyl, aryl, arylamino, pyridyl, pyrrolyl, pyrazolopyridyl, quinolyl, or a group of the formula: ##STR2## wherein the symbol of a line and dotted line is a single bond or a double bond; X is CH or N; Z is O, S or NH; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is hydrogen or hydroxy; R.sup.4 is lower alkyl which may have suitable substituent(s); R.sup.5 is ar(lower)alkyl which may have suitable substituent(s) or pyridyl(lower)alkyl, or R.sup.4 and R.sup.5 are linked together to form benzene-condensed lower alkylene; A is an amino acid residue excepting D-Trp, which may have suitable substituent(s); and Y is bond, lower alkylene or lower alkenylene;and their pharmaceutically acceptable salts are disclosed.

Abstract: The invention relates to a compound of the formula: ##STR1## in which R.sup.1 and R.sup.2 are each hydrogen or lower alkyl,R.sup.3 is aryl or unsaturated, 5- or 6-membered heterocyclic group containing a sulfur atom, each of which may be substituted by one or more substituent(s) selected from the group consisting of halogen, hydroxy, lower alkyl, aryloxy, trihalo(lower)alkyl, lower alkoxy and mono- or di(lower)alkylamino,R.sup.4 is hydrogen, halogen or lower alkyl,A is methylene, methine, oxa, thia, sulfinyl or sulfonyl,Y is vinylene or ethylene.Z is a group of the formula: ##STR2## wherein R.sup.5 is carboxy or protected carboxy, andR.sup.6 is hydrogen or hydroxy-protective group, andthe line is of a single or double bond, or a pharmaceutically acceptable salt thereof, useful as a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor.

Abstract: The present invention concerns pyrazole derivatives of formula: ##STR1## used for the treatment of inflammation, pain, thrombosis and rheumatism.

Abstract: A method of forming an image which comprises subjecting an image-forming material comprised of a substrate and a photosensitive layer containing a dye and/or a pigment and a photopolymerizable compound and disposed on the substrate to an image-exposure, thereby to allow the exposure to cause a difference of adhesion between an exposed portion and non-exposed portion in the photosensitive layer, and transferring the image to an image receptor on the basis of the difference of adhesion; wherein the photosensitive layer of the exposed image-forming material and the image receptor are allowed to face each other and directed into the nip between two rollers consisting of an elastic roller and a metallic roller having a surface temperature of between 50.degree. C. and 150.degree. C.

Abstract: This invention relates to new alkanesulfonanilide derivatives and pharmaceutically acceptable salts thereof which have inflammatory activities and analgesic activities, to pharmaceutical compositions containing the same and to a method for the treatment of inflammatory disease or pains in human beings and animals.

Abstract: An apparatus for forming a transfer image comprising at least a light source for exposure, an exposure cylinder and a second cylinder which can contact the exposure cylinder, wherein the light source for the exposure is arranged outside the radius of the exposure cylinder, the exposure cylinder has means of attaching an image-forming material thereto, and the second cylinder has means of receiving the image-forming material from the surface of the exposure cylinder and holds the received image-forming material, and a method of forming as transfer image on an image receptor by using the apparatus.