Patents by Inventor Masaaki Matsuo
Masaaki Matsuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5017703Abstract: The invention relates to novel indolylpiperidine compounds useful in the treatment of allergic disease and inflammation.Type: GrantFiled: September 28, 1989Date of Patent: May 21, 1991Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Masaaki Matsuo, Takashi Manabe, Shinji Shigenaga, Hiroshi Matsuda
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Patent number: 4935432Abstract: The invention relates to new compounds, of antiallergic activity, of the formula: ##STR1## wherein R.sup.1 is aryl substituted with substituent(s) selected from the group consisting of hydroxy, protected hydroxy, halogen and lower alkoxy, A is lower alkylene, and B is lower alkenylene, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 11, 1989Date of Patent: June 19, 1990Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Takashi Manabe, Shinji Shigenaga, Hiroshi Matsuda
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Patent number: 4921887Abstract: A thiazole compound of the formula: ##STR1## wherein R.sup.1 is amino or acylamino,R.sup.2 is ar(lower)alkoxy, andA is lower alkylene,and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical composition comprising the same.Type: GrantFiled: November 14, 1988Date of Patent: May 1, 1990Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Masaaki Matsuo, Takashi Manabe, Shinji Shigenaga, Hiroshi Matsuda
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Patent number: 4885297Abstract: An antithrombotic compound of the formula: ##STR1## wherein R.sup.1 is halogen,R.sup.2 is lower alkylene andR.sup.3 is lower alkyl, hydroxy(lower)alkyl, acyloxy (lower)alkyl or acyl(lower)alkyl, andpharmaceutically acceptable salts thereof.Type: GrantFiled: June 14, 1988Date of Patent: December 5, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Daizo Morino, Kiyoshi Tsuji, Hiroyuki Okumura
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Patent number: 4866091Abstract: This invention relates to new alkane-sulfonanilide derivatives of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.8 are each hydrogen, cyano, halogen, lower alkyl, halo (lower) alkyl, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl or lower alkoxy,R.sup.3 is lower alkyl,R.sup.4 is acyl, cyano, carboxy, hydroxy(lower)-alkyl, mercapto, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, 5-membered unsaturated heterocyclic group which may have amino, lower alkanoylamino, lower alkylthio or lower alkylsulfonyl, phenylthio which may have nitro or amino, lower alkanoyl(lower)alkenyl or a group of the formula: ##STR2## wherein R.sup.6 is hydrogen, amino or lower alkyl andR.sup.7 is hydroxy, lower alkoxy, carboxy(lower)alkoxy, lower alkoxycarbonyl(lower)alkoxy, ureido or thioureido, andR.sup.5 is hydrogen, halogen, lower alkyl or lower alkanoyl, and pharmaceutically acceptable salts thereof.Type: GrantFiled: June 2, 1988Date of Patent: September 12, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masaaki Matsuo, Kiyoshi Tsuji, Nobukiyo Konishi
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Patent number: 4835576Abstract: In the negative form of lith type film or photographic printing paper, the ground part is light-untransmissible and image part (letter, pattern) is light-transmissible. Apart from them, pinholes and stains also constitute light-transmissible areas. Although the light-transmissible areas of letter and pattern are necessary, the light-transmissible areas of pinhole and stain are unnecessary. Thus, the unnecessary light-transmissible areas must be distinguished from the necessary light-transmissible areas, and an opaque layer must be provided on the unnecessary areas to make them opaque. Generally, however, the unnecessary light-transmissible areas are minute and many in number, so that their detection and opaquing is a very laborious work. Thus, according to the opaquing method of the present invention, only the necessary light-transmissible area is detected and the other light-transmissible areas are regarded as unnecessary and the latter are stopped out.Type: GrantFiled: October 14, 1987Date of Patent: May 30, 1989Assignee: Toyo Ink Mfg. Co., Ltd.Inventors: Keiji Komori, Masaru Ohta, Takashi Sawada, Masaaki Matsuo
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Patent number: 4797399Abstract: The present invention relates to N-containing fused heterocyclic compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, halogen, aryl, lower alkyl, halo (lower) alkyl or nitro,R.sub.3 is lower alkylene,R.sub.4 and R.sub.5 are each lower alkylene,X is CH or N,Y is S, O, NH, C.dbd.N--OH or CO,Z is O or NH, andA is hydrogen, nitroso, amidino, a group of ##STR2## wherein R.sub.6 and R.sub.7 are each hydrogen, lower alkyl, acyl, or lower alkaneimidoyl which may be substituted with esterified carboxy, or a group of the formula:--N.dbd.R.sub.8,wherein R.sub.8 is lower alkylidene which may be substituted with aryl optionally substituted with suitable substituent(s).The compounds are useful for treatment of thrombosis, inflammation, or allergic disease.Type: GrantFiled: December 23, 1986Date of Patent: January 10, 1989Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Kiyoshi Tsuji, Hiroyuki Okumura, Osamu Nakaguchi
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Patent number: 4742057Abstract: A thiazole compound of allergically activity of the formula: ##STR1## wherein R.sup.1 is amino optionally having suitable substituent(s),R.sup.2 is hydrogen, lower alkyl or aryl,R.sup.3 is hydrogen, nitro, amino optionally having suitable substituent(s), hydroxy or lower alkoxy,A is lower alkylene,Q is hydrogen or halogen, anda heavy solid line means a single or double bond,or a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical composition comprising the same.Type: GrantFiled: November 20, 1986Date of Patent: May 3, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Takashi Manabe, Hiroshi Matsuda
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Patent number: 4735952Abstract: This invention provides a piperidine compound of the formula: ##STR1## wherein R.sup.1 is hydrogen or trihalomethyl,R.sup.2 is hydrogen or protected carboxy,R.sup.3 is heterocyclic group or aryl which may be halogen substituted, andX is --S--, ##STR2## --O--, --NH-- or lower alkylene which may be hydroxy substituted, and pharmaceutically acceptable salt thereof, These compounds possess hypotensive activity and are useful as anti-hypertensive agents. The invention further relates to processes for the preparation of these compounds and pharmaceutical compositions comprising compounds of the above formula.Type: GrantFiled: January 24, 1986Date of Patent: April 5, 1988Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Kiyoshi Taniguchi, Takatomo Ogahara
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Patent number: 4565877Abstract: A naphthalene derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen and R.sup.2 is lower alkyl or phenyl-lower alkyl; or R.sup.1 and R.sup.2 are combined together to form lower alkylene; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration, and a method of preparation thereof are disclosed. Said naphthalene derivative is useful as a chiral reagent for determining the optical purity of an optically active compound containing within its molecule at least one functional group selected from hydroxy, amino and imino groups.Type: GrantFiled: October 11, 1983Date of Patent: January 21, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Hiroshi Wada, Kazuhiro Ishii, Nobuchika Tsumagari, Masaaki Matsuo, Mikio Matsumoto
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Patent number: 4563524Abstract: The invention relates to novel intermediates for preparing novel cephem compounds of high antimicrobial activity, the intermediates being of the formula: ##STR1## wherein A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, protected carboxy, lower alkyl, lower alkenyl, hydroxy(lower)alkyl, phenyl(lower)alkyl or aryl; andR.sup.7a is hydrogen or a mercapto-protective group, or a salt thereof.Type: GrantFiled: January 13, 1984Date of Patent: January 7, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Kiyoshi Tsuji, Masayuki Kato
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Patent number: 4443443Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group;R.sup.2 is carboxy or a protected carboxy group;A is lower alkylene which may have an oxo group;R.sup.3 is carboxy, a protected carboxy group, lower alkyl, lower alkenyl, hydroxy (lower) alkyl, phenyl (lower) alkyl, phenyl, tolyl, xylyl, cumenyl, or naphthyl; andR.sup.4 is hydrogen or lower alkoxy, and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 5, 1980Date of Patent: April 17, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Kiyoshi Tsuji, Masayuki Kato
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Patent number: 4438126Abstract: The invention is directed to compounds of the formula ##STR1## wherein R.sub.a.sup.1 is phenyl,R.sup.2 is halogen,R.sup.3 is carboxy or lower alkoxycarbonyl,Y.sub.a is oxygen,A is C.sub.1 -C.sub.6 alkylene,pharmaceutically acceptable salts thereof, and aldose reductase inhibiting pharmaceutical compositions thereof.Type: GrantFiled: August 18, 1982Date of Patent: March 20, 1984Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Susumu Satoh, Takao Watanabe
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Patent number: 4370340Abstract: A pharmaceutical composition comprising certain benzothiazoline alkanoic acid derivatives for the prevention and treatment of various diabetic complications, said derivatives being inhibitors of aldose reductase.Type: GrantFiled: June 2, 1980Date of Patent: January 25, 1983Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo, Susumu Satoh, Takao Watanabe
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Patent number: 4367238Abstract: This invention relates to new phenyl-alkanoic acids, their derivatives at the carboxy group, and pharmaceutically acceptable salts thereof, which have anti-inflammatory, analgesic and antipyretic activities.Type: GrantFiled: January 21, 1981Date of Patent: January 4, 1983Assignee: Fujisawa Pharmaceutical Company, Ltd.Inventors: Ikuo Ueda, Yoshihiko Kitaura, Masaaki Matsuo, Nobukiyo Konishi
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Patent number: 4105781Abstract: Chromone compounds having the structure ##STR1## wherein R is aryl, substituted aryl, thienyl, furyl or pyridyl, Y is hydroxy (lower) alkylene, R.sub.1 is hydrogen, lower alkyl, aryl, substituted aryl or a heterocyclic group, R.sub.2 is hydrogen or lower alkoxy, Y.sub.1 is lower alkylene or hydroxyl (lower) alkylene, Z is oxygen or sulfur and R.sub.3 is hydrogen, lower alkyl, aryl, substituted aryl, or ar (lower) alkyl have anti-allergic activity and are useful in the treatment of asthma. Compounds of the structure [I] are prepared by reacting ##STR2## wherein Y' is hydroxy (lower) alkylene whose hydroxy group is optimally protected or a reactive derivative of [II] with a carboxylic acid of the formula R--COOH in the presence of a basic catalyst. The resulting compound is then reacted with an acid. Compounds of the structure [I'] are prepared by reacting the compound ##STR3## with the compound X--Y.sub.1 '--Z--R.sub.Type: GrantFiled: April 19, 1977Date of Patent: August 8, 1978Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Suminori Umio, Shizuo Maeno, Ikuo Ueda, Yoshinari Sato, Masaaki Matsuo
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Patent number: 4094870Abstract: 2-substituted thio-1,4-benzodiazepine derivatives having medicinal use of the general formula ##STR1## wherein R.sub.1 and R.sub.2 individually signify hydrogen atom or a halogen atom, or a nitro, amino, hydroxy, cyano, alkyl, haloalkyl, alkoxy, alkylthio, alkanesulfinyl, alkanesulfonyl, alkanoylamino or dialkylamino group, R.sub.3 signifies an alkylene group, and R.sub.4 and R.sub.5 individually signify hydrogen atom or an alkyl group and, when R.sub.4 and R.sub.5 are both alkyl groups, said alkyl groups together may form a ring with or without oxygen atom or an imino group, said ring optionally having a substituent or substituents, and its non-toxic pharmaceutically acceptable salts.Type: GrantFiled: October 15, 1976Date of Patent: June 13, 1978Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Ikuo Ueda, Masaaki Matsuo
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Patent number: 4049664Abstract: Chromone compounds having the structure ##STR1## wherein R is aryl, substituted aryl, thienyl, furyl or pyridyl, Y is hydroxy (lower) alkylene, R.sub.1 is hydrogen, lower alkyl, aryl, substituted aryl or a heterocyclic group, R.sub.2 is hydrogen or lower alkoxy, Y.sub.1 is lower alkylene or hydroxyl (lower) alkylene, Z is oxygen or sulfur and R.sub.3 is hydrogen, lower alkyl, aryl, substituted aryl, or ar(lower)alkyl have anti-allergic activity and are useful in the treatment of asthma. Compounds of the structure [I] are prepared by reacting ##STR2## wherein Y' is hydroxy (lower) alkylene whose hydroxy group is optimally protected or a reactive derivative of [II] with a carboxylic acid of the formula R--COOH in the presence of a basic catalyst. The resulting compound is then reacted with an acid. Compounds of the structure [I] are prepared by reacting the compound ##STR3## with the compound X--Y.sub.1 '--Z--R.sub.Type: GrantFiled: April 22, 1976Date of Patent: September 20, 1977Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Suminori Umio, Shizuo Maeno, Ikuo Ueda, Yoshinari Sato, Masaaki Matsuo
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Patent number: 4001280Abstract: Chromone derivatives of the formula: ##STR1## wherein R.sup.1 is alkoxy, an N,S-containing heterocyclic group or aryloxy in which heterocyclic group may be substituted with halogen or acyl, and aryl may be substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy; R.sup.2 is alkylene; R.sup.3 is hydroxy, alkoxy or a group of the formula ##STR2## in which R.sup.4 is hydrogen, R.sup.5 is hydroxy or amino or R.sup.4 and R.sup.5 means taken together with the adjacent nitrogen atom, piperazinyl substituted with alkyl or hydroxyalkyl; provided that when R.sup.3 is hydroxy or alkoxy, R.sup.1 is an N,S-containing heterocyclic group or aryloxy in which heterocyclic group is substituted with halogen or acyl, and aryl is substituted with amino, alkylamino, acylamino, nitro or alkylenedioxy, and nontoxic, pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents.Type: GrantFiled: June 20, 1973Date of Patent: January 4, 1977Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Suminori Umio, Ikuo Ueda, Masaaki Matsuo, Masakazu Kobayashi, Osamu Nakaguti, Yoshinari Sato
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Patent number: 3965122Abstract: Chromone compounds having the structure ##SPC1##Wherein R is aryl, substituted aryl, thienyl, furyl or pyridyl, Y is hydroxy(lower)alkylene, R.sub.1 is hydrogen, lower alkyl, aryl, substituted aryl or a heterocyclic group, R.sub.2 is hydrogen or lower alkoxy, Y.sub.1 is lower alkylene or hydroxyl(lower)alkylene, Z is oxygen or sulfur and R.sub.3 is hydrogen, lower alkyl, aryl, substituted aryl, or ar(lower)alkyl have anti-allergic activity and are useful in the treatment of asthma. Compounds of the structure [I] are prepared by reacting ##SPC2##Wherein Y' is hydroxy(lower)alkylene whose hydroxy group is optimally protected or a reactive derivative of [II] with a carboxylic acid of the formula R--COOH in the presence of a basic catalyst. The resulting compound is then reacted with an acid. Compounds of the structure [I'] are prepared by reacting the compound ##SPC3##With the compound X--Y.sub.1 '--Z--R.sub.Type: GrantFiled: December 28, 1971Date of Patent: June 22, 1976Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Suminori Umio, Shizuo Maeno, Ikuo Ueda, Yoshinari Sato, Masaaki Matsuo