Patents by Inventor Masahiko Hagihara
Masahiko Hagihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120184747Abstract: This is to provide a novel aniline compound represented by the following formula (I) having an excellent broncho dilatory action based on potent EP2 agonistic action. A compound represented by the formula (I): or a salt thereof.Type: ApplicationFiled: September 10, 2010Publication date: July 19, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Ryo Iwamura, Yoko Murakami, Masahiko Hagihara, Eiji Okanari
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Patent number: 8193358Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.Type: GrantFiled: April 6, 2007Date of Patent: June 5, 2012Assignees: Daiichi Sankyo Company, Limited, Ube Industries, Ltd.Inventors: Masahiko Hagihara, Hiroyuki Miyata, Yukinori Wada, Naoyuki Yokota
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Publication number: 20120095215Abstract: The present invention is to provide a medical composition for the treatment or prophylaxis of diseases caused by angiogenesis of eyes which comprises a compound represented by the following formula (I): wherein R1 represents a C1-C6 alkyl group or halogeno-C1-C6alkyl group, R2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or nitrogen atom, or a pharmaceutically acceptable salt thereof as an active ingredient.Type: ApplicationFiled: March 30, 2010Publication date: April 19, 2012Applicant: UBE INDUSTRIES, LTD.Inventors: Masahiko Hagihara, Yasuhiro Aga, Tohru Hasegawa
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Publication number: 20110039891Abstract: A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.Type: ApplicationFiled: October 20, 2010Publication date: February 17, 2011Applicants: UBE INDUSTRIES, LTD., SANTEN PHARMACEUTICAL CO., LTD.Inventors: Masahiko Hagihara, Ken-ichi Komori, Hidetoshi Sunamoto, Hiroshi Nishida, Takeshi Matsugi, Tadashi Nakajima, Masakazu Hatano, Kazutaka Kido, Hideaki Hara
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Patent number: 7855222Abstract: A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.Type: GrantFiled: June 19, 2009Date of Patent: December 21, 2010Assignees: UBE Industries, Ltd., Santen Pharmaceutical Co., Ltd.Inventors: Masahiko Hagihara, Ken-ichi Komori, Hidetoshi Sunamoto, Hiroshi Nishida, Takeshi Matsugi, Tadashi Nakajima, Masakazu Hatano, Kazutaka Kido, Hideaki Hara
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Publication number: 20100249396Abstract: The present invention relates to a benzazepinone compound represented by the following formula (I): wherein R1 represents a C1-C6 alkyl group or halogeno C1-C6 alkyl group, R2 represents a carboxyl group which may be protected, and Y represents a group represented by the formula (II): wherein Z represents CH or a nitrogen atom, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 14, 2008Publication date: September 30, 2010Inventors: Naoto Suzuki, Yasunori Tsuzaki, Kimihiko Yoshimura, Masahiko Hagihara, Yukinori Wada, Masao Maruyama, Nobuyoshi Fujii, Yasuhiro Aga
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Publication number: 20090264468Abstract: A method for treating a disease in which Rho kinase is involved. The method is carried out by administering to a patient in need thereof a pharmaceutically effective amount of a compound of the following formula or a pharmaceutically acceptable salt thereof: , wherein the ring X is a benzene ring or a pyridine ring; R1 and R2 are hydrogen or alkyl or together form a cycloalkene ring; R3 is hydrogen, substituted alkyl, unsubstituted alkenyl, carboxyl or an ester or an amide thereof, amino or a cyano; R4 is hydrogen, hydroxyl, substituted or unsubstituted alkoxy, unsubstituted alkenyloxy, unsubstituted cycloalkyloxy, substituted or unsubstituted alkyl, unsubstituted alkenyl, unsubstituted cycloalkyl, amino, substituted or unsubstituted alkylamino, nitro, cyano or a monocyclic heterocycle; and R5 is a halogen atom or a hydrogen atom.Type: ApplicationFiled: June 19, 2009Publication date: October 22, 2009Applicants: UBE INDUSTRIES, LTD., SANTEN PHARMACEUTICALS CO., LTD.Inventors: Masahiko Hagihara, Ken-ichi Komori, Hidetoshi Sunamoto, Hiroshi Nishida, Takeshi Matsugi, Tadashi Nakajima, Masakazu Hatano, Kazutaka Kido, Hideaki Hara
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Publication number: 20090203729Abstract: The present invention is directed to providing prasugrel hydrochloride or the like with a reduced content of OXTP. A method for producing prasugrel hydrochloride with a reduced content of OXTP, comprising dissolving free prasugrel containing OXTP in an inert solvent and adding hydrochloric acid optionally dropwise to the solution for reaction is also provided.Type: ApplicationFiled: April 6, 2007Publication date: August 13, 2009Inventors: Teruhiko Inoue, Kazuyoshi Nakamura, Masahiko Hagihara, Hiroyuki Miyata, Yukinori Wada, Naoyuki Yokota
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Patent number: 7563906Abstract: An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.Type: GrantFiled: October 15, 2004Date of Patent: July 21, 2009Assignees: Ube Industries, Ltd., Santen Pharmaceutical Co., Ltd.Inventors: Masahiko Hagihara, Ken-ichi Komori, Hidetoshi Sunamoto, Hiroshi Nishida, Takeshi Matsugi, Tadashi Nakajima, Masakazu Hatano, Kazutaka Kido, Hideaki Hara
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Publication number: 20090170827Abstract: There is provided an excellent medicine for treating or preventing hypertension or the like. A specific acid addition salt of 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl)ester 5-isopropyl ester is useful as a medicine for treating or preventing hypertension or the like.Type: ApplicationFiled: November 28, 2006Publication date: July 2, 2009Applicants: Daiichi Sankyo Company , Limited, UBE INDUSTRIES , LTD.Inventors: Masahiko Hagihara, Motohisa Shimizu, Yasuo Seta, Katsuhiro Kobayashi, Yasushi Yoshigae
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Publication number: 20090170887Abstract: An object of the present invention is to create a novel indazole derivative having a spiro ring structure in a side chain, which is useful as a pharmaceutical, and to find a new pharmacological activity of the derivative. The present invention compound is represented by the general formula [I] and has an excellent Rho kinase inhibitory activity. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 and R2 represent halogen, H, OH, alkoxy, cycloalkyloxy, aryloxy, alkyl, cycloalkyl or the like; R3 represents halogen, H or the like; R4 and R5 represent halogen, H or the like; R6 and R7 represent H, alkyl or the like; and m, n, p and q represent an integer of 0 to 3. In this connection, each group may have a substituent.Type: ApplicationFiled: June 8, 2007Publication date: July 2, 2009Inventors: Masahiko Hagihara, Yasunori Tsuzaki, Ken-ichi Komori, Hiroshi Nishida, Kazutaka Kido, Tomokazu Fujimoto, Takeshi Matsugi, Atsushi Shimazaki
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Publication number: 20090170826Abstract: There is provided an excellent medicine for treating or preventing hypertension or the like. A specific acid addition salt of (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenyl-methylazetidin-3-yl) ester 5-isopropyl ester is useful as a medicine for treating or preventing hypertension or the like.Type: ApplicationFiled: November 28, 2006Publication date: July 2, 2009Applicants: Daiichi Sankyo Company ,Limited, Ube Industries ,Ltd.Inventors: Masahiko Hagihara, Motohisa Shimizu, Katsuhiro Kobayashi, Yasushi Yoshigae
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Publication number: 20090036453Abstract: The present invention discloses a pyrrolopyridazinone compound represented by the formula (1): wherein R1 represents C1-C2 alkyl group or halogeno C1-C2 alkyl group, R2 repersents C3-C5 cycloalkyl group, (C3-C5 cycloalkyl)C1-C2 alkyl group or C1-C3 alkyl group, R3 represents hydrogen atom, or methylene group or cis-vinylene group for forming substituted oxygen-containing hetero ring in combination with group —O—R2, R4 represents hydrogen atom, halogen atom, C1-C8 alkyl group, C2-C6 alkenyl group, C2-C6 alkynyl group, hydroxy C3-C6 alkenyl group, hydroxy C3-C6 alkynyl group, C1-C6 alkyl group substituted by substituent(s) selected from Substituent group (a), C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), “C1-C3 alkyl group which is substituted by C3-C6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), and which may be substituted by a hydroxy group”, an aromatic ring group or heteroaromatic ring group eType: ApplicationFiled: January 16, 2007Publication date: February 5, 2009Inventors: Masahiko Hagihara, Masayuki Tanaka, Tetsushi Katsube, Makoto Okudo, Noriaki Iwase, Manabu Shigetomi, Tomoko Kanda, Takayuki Nakanishi
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Patent number: 7309718Abstract: The present invention discloses a dibenzocycloheptene compound represented by the formula (I): wherein R1: hydrogen atom, halogen atom, etc., R2: hydrogen atom, halogen atom, etc., A: 5-membered or 6-membered heteroaromatic ring group containing 1 to 3 hetero atom(s) selected from the group consisting of nitrogen atom, oxygen atom and sulfur atom, and the heteroaromatic ring group, etc. may have halogen atom, nitrogen atom, etc. as substituent(s), B: formula; —CH?CH—, formula; —CH2O—, etc., Y: C1-C10 alkylene group which may have halogen atom, etc. as substituent(s), etc., Z: carboxyl group which may be protected, etc.Type: GrantFiled: June 27, 2002Date of Patent: December 18, 2007Assignee: UBE Industries, Ltd.Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Ichiro Tanaka, Masayuki Tanaka, Masahiko Hagihara
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Patent number: 7294625Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.Type: GrantFiled: September 25, 2003Date of Patent: November 13, 2007Assignee: Ube Industries, Ltd.Inventors: Masahiko Hagihara, Nobuhiko Shibakawa, Masamichi Nishihara, Toshiyuki Shirai, Motohisa Shimizu, Tohru Hasegawa, Yasunori Tokunaga, Naoto Suzuki, Yukinori Wada
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Publication number: 20070129404Abstract: An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.Type: ApplicationFiled: October 15, 2004Publication date: June 7, 2007Inventors: Masahiko Hagihara, Ken-ichi Komori, Hidetoshi Sunamoto, Hiroshi Nishida, Takeshi Matsugi, Tadashi Nakajima, Masakazu Hatano, Kazutaka Kido, Hideaki Hara
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Publication number: 20060063934Abstract: The present invention relates to pyrazole compounds represented by the formula (I): wherein R1 represents phenyl which may be substituted, R2 represents H, halogen, alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl or substituted amino, Q represents CH or N, R3 represents H, alkyl or amino, R4 represents the formula (II) to (V): wherein R7 represents H or alkyl, R8 represents H, alkyl or substituted amino, R9 represents H or alkyl, R12 represents H, alkyl, halogeno alkyl or substituted amino, or pharmaceutically acceptable salts thereof, and a medical composition containing the same as effective ingredient.Type: ApplicationFiled: September 25, 2003Publication date: March 23, 2006Inventors: Masahiko Hagihara, Nobuhiko Shibakawa, Masamichi Nishihara, Toshiyuki Shirai, Motohisa Shimizu, Tohru Hasegawa, Yasunori Tokunaga, Naoto Suzuki, Yukinori Wada
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Publication number: 20040180884Abstract: The present invention discloses a dibenzocycloheptene compound represented by the formula (I): 1Type: ApplicationFiled: December 23, 2003Publication date: September 16, 2004Inventors: Yoshiaki Kuroki, Hitoshi Ueno, Tetsushi Katsube, Tetsuo Kawaguchi, Eiji Okanari, Ichiro Tanaka, Masayuki Tanaka, Masahiko Hagihara
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Patent number: 6734181Abstract: A pyrrolopyridazine compound having the formula (I) or a pharmaceutically acceptable salt thereof: wherein, R1 is a C2-C6 alkenyl group, a halogeno C2-C6 alkenyl group, a C3-C7 cycloalkyl group which may be optionally substituted or a C3-C7 cycloalkyl- C1-C6 alkyl group which may be optionally substituted. R2 is a C1-C6 alkyl group. R3 is a hydroxymethyl group, a C2-C6 aliphatic acyloxymethyl group, a C6-C10 arylcarbonyloxymethyl group which may be optionally substituted, a C1-C6 alkoxycarbonyloxymethyl group, a formyl group, a carboxyl group, a C1-C6 alkoxycarbonyl group or a C6-C10 aryloxycarbonyl group which may be optionally substituted. R4 is a C6-C10 aryl group which may be optionally substituted. A is an imino group, an oxygen atom or a sulfur atom. These compounds exhibit excellent gastric acid secretory inhibition activity and gastric mucous membrane protection activity etc. They are useful for prevention or treatment of ulcerative diseases and for Helicobacter pylori infections.Type: GrantFiled: August 8, 2002Date of Patent: May 11, 2004Assignees: Sankyo Company, Limited, Ube Industries, Ltd.Inventors: Haruo Iwabuchi, Masahiko Hagihara, Nobuhiko Shibakawa, Keiji Matsunobu, Hiroshi Fujiwara
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Publication number: 20040014762Abstract: A pyrrolopyridazine compound having the formula (I) or a pharmaceutically acceptable salt thereof: 1Type: ApplicationFiled: August 8, 2002Publication date: January 22, 2004Applicant: SANKYO COMPANY, LIMITEDInventors: Haruo Iwabuchi, Masahiko Hagihara, Nobuhiko Shibakawa, Keiji Matsunobu, Hiroshi Fujiwara