Patents by Inventor Masahiro Ishizuka
Masahiro Ishizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240141251Abstract: A method of manufacturing a non-aqueous secondary battery includes the steps of preparing a case main body, preparing a lid, applying a lubricant to a contact location, and assembling a lid to an open end of the case main body. In the step of preparing a lid, a lid to be fitted to the open end of the case main body is prepared. In the step of applying a lubricant, the lubricant is applied to at least a portion of the contact location at which the case main body and the lid are in contact with each other. In the step of assembling the lid to the open end, the lid is assembled to the open end with the lubricant having been applied to the contact location. The lubricant may be a solvent used in a non-aqueous electrolyte solution for non-aqueous secondary batteries.Type: ApplicationFiled: January 11, 2024Publication date: May 2, 2024Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventor: Masahiro ISHIZUKA
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Patent number: 11905487Abstract: A method of manufacturing a non-aqueous secondary battery includes the steps of preparing a case main body, preparing a lid, applying a lubricant to a contact location, and assembling a lid to an open end of the case main body. In the step of preparing a lid, a lid to be fitted to the open end of the case main body is prepared. In the step of applying a lubricant, the lubricant is applied to at least a portion of the contact location at which the case main body and the lid are in contact with each other. In the step of assembling the lid to the open end, the lid is assembled to the open end with the lubricant having been applied to the contact location. The lubricant may be a solvent used in a non-aqueous electrolyte solution for non-aqueous secondary batteries.Type: GrantFiled: August 19, 2019Date of Patent: February 20, 2024Assignee: TOYOTA JIDOSHA KABUSHIKI KAISHAInventor: Masahiro Ishizuka
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Publication number: 20220370395Abstract: The object of the present invention is to potentiate the photodynamic effect in ALA-PDT and ALA-PDD. The present invention provides a pharmaceutical related to a combination of ALAs and a dynamin inhibitor.Type: ApplicationFiled: July 1, 2022Publication date: November 24, 2022Inventors: Masahiro Ishizuka, Takuya ISHII, Motowo NAKAJIMA, Yuya KITAJIMA
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Patent number: 10675242Abstract: The object of the invention is to elevate the stability of an aqueous formulation comprising ALAs and an iron compound. The present invention provides an aqueous formulation comprising ALAs and an iron compound, characterized in that it further comprises 0.2-30% by weight of salts, said salts are sodium salts or potassium salts, and the pH of said aqueous formulation is 2-8.Type: GrantFiled: August 23, 2017Date of Patent: June 9, 2020Assignee: SBI PHARMACEUTICALS, CO., LTD.Inventors: Mika Morishita, Urara Ota, Masahiro Ishizuka
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Publication number: 20200075904Abstract: A method of manufacturing a non-aqueous secondary battery includes the steps of preparing a case main body, preparing a lid, applying a lubricant to a contact location, and assembling a lid to an open end of the case main body. In the step of preparing a lid, a lid to be fitted to the open end of the case main body is prepared. In the step of applying a lubricant, the lubricant is applied to at least a portion of the contact location at which the case main body and the lid are in contact with each other. In the step of assembling the lid to the open end, the lid is assembled to the open end with the lubricant having been applied to the contact location. The lubricant may be a solvent used in a non-aqueous electrolyte solution for non-aqueous secondary batteries.Type: ApplicationFiled: August 19, 2019Publication date: March 5, 2020Applicant: TOYOTA JIDOSHA KABUSHIKI KAISHAInventor: Masahiro ISHIZUKA
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Publication number: 20200030275Abstract: The object of the present invention is to potentiate the photodynamic effect in ALA-PDT and ALA-PDD. The present invention provides a pharmaceutical related to a combination of ALAs and a dynamin inhibitor.Type: ApplicationFiled: April 12, 2018Publication date: January 30, 2020Inventors: Masahiro ISHIZUKA, Takuya ISHII, Motowo NAKAJIMA, Yuya KITAJIMA
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Publication number: 20190201336Abstract: The object of the invention is to elevate the stability of an aqueous formulation comprising ALAs and an iron compound. The present invention provides an aqueous formulation comprising ALAs and an iron compound, characterized in that it further comprises 0.2-30% by weight of salts, said salts are sodium salts or potassium salts, and the pH of said aqueous formulation is 2-8.Type: ApplicationFiled: August 23, 2017Publication date: July 4, 2019Inventors: Mika Morishita, Urara Ota, Masahiro Ishizuka
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Patent number: 9707196Abstract: A method for treating side effects of anticancer agent includes administering to a subject in need thereof a prophylactic and/or therapeutic agent containing a therapeutically effective amount of a compound shown by the following Formula (I): R1—NHCH2COCH2CH2COOR2??(I) wherein R1 represents a hydrogen atom or an acyl group, and R2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group, or a salt thereof.Type: GrantFiled: October 5, 2012Date of Patent: July 18, 2017Assignees: SBI Pharmaceuticals Co., Ltd., National University Corporation Kochi UniversityInventors: Tohru Tanaka, Kyoko Tsuchiya, Masahiro Ishizuka, Motowo Nakajima, Hitoshi Nakagawa, Taro Shuin, Keiji Inoue, Hideo Fukuhara, Masayuki Tsuda, Mutsuo Furihata
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Patent number: 9603928Abstract: The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.Type: GrantFiled: June 13, 2014Date of Patent: March 28, 2017Assignees: SBI Pharmaceuticals Co., Ltd., Osaka City UniversityInventors: Masahiro Ishizuka, Urara Oto, Atsuko Kamiya, Kiwamu Takahashi, Tohru Tanaka, Toshiyuki Ozawa, Kuniyuki Morimoto, Keitaro Watanabe
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Patent number: 9517267Abstract: The objects of the present invention are to inhibit photobleaching of porphyrins as well as to provide a superior photodynamic diagnostic agent and a photodynamic diagnostic method employing the photobleaching inhibitor for porphyrins. The present invention provides a photodynamic diagnostic agent containing a precursor of porphyrins and a gallic acid. The present invention also provides a photobleaching inhibitor for porphyrins containing a gallic acid.Type: GrantFiled: January 22, 2013Date of Patent: December 13, 2016Assignees: SBI Pharmaceuticals Co., Ltd., Tokyo Institute of TechnologyInventors: Masahiro Ishizuka, Tohru Tanaka, Shun-ichiro Ogura, Takuya Ishii
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Patent number: 9488664Abstract: It is to provide a tumor diagnostic agent and a tumor determination method enabling not only determination of the presence or absence of a tumor in a subject, but also determination of whether the tumor is a malignant tumor or a benign tumor, which can be used simply at low cost with reduced side effects and burden. 5-aminolevulinic acid (ALA) or its derivative, or a salt thereof is orally administered at a dose of 5 to 7 mg in terms of ALA per kg of body weight, and a urine sample 4 to 12 hours after the administration is collected. Porphyrins and creatinine in the urine sample are quantitated, and based on the value (nmol/gCre) obtained by dividing the amount of porphyrins by the amount of creatinine, a distinction among an individual without a tumor, an individual with a benign tumor, and an individual with a malignant tumor is determined. The presence or absence of a malignant tumor in a subject can be clearly determined by administering 1 to 3 mg of ALAs in terms of ALA per kg of body weight.Type: GrantFiled: January 15, 2013Date of Patent: November 8, 2016Assignee: SBI Pharmaceuticals Co., Ltd.Inventors: Tohru Tanaka, Kiwamu Takahashi, Motowo Nakajima, Fuminori Abe, Masahiro Ishizuka, Urara Ota
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Publication number: 20160136274Abstract: The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.Type: ApplicationFiled: June 13, 2014Publication date: May 19, 2016Inventors: Masahiro Ishizuka, Urara Oto, Atsuko Kamiya, Kiwamu Takahashi, Tohru Tanaka, Toshiyuki Ozawa, Kuniyuki Morimoto, Keitaro Watanabe
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Patent number: 9340490Abstract: According to the present invention, a tumor diagnostic agent which carries out early stage detection, monitoring of therapeutic effect and prognostic diagnosis of all tumors The tumor diagnostic agent of the present invention is a tumor diagnostic agent comprising ?-aminolevulinic acid represented by formula (I), a derivative thereof and a salt thereof: R2R1NCH2COCH2CH2COR3??(I) wherein R1 and R2 each independently represents hydrogen, alkyl, acyl, alkoxycarbonyl, aryl or aralkyl; and R3 represents hydroxy, alkoxy, acyloxy, alkoxycarbonyloxy, aryloxy, aralkyloxy or amino, which is used for diagnoses by measuring porphyrins in a sample collected from the inside or outside of the body after its administration.Type: GrantFiled: September 22, 2005Date of Patent: May 17, 2016Assignee: SBI PHARMACEUTICALS CO., LTD.Inventors: Ichiro Okura, Toshiaki Kamachi, Shunichiro Ogura, Masahiro Ishizuka, Tohru Tanaka
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Publication number: 20150297720Abstract: The objects of the present invention are to inhibit photobleaching of porphyrins as well as to provide a superior photodynamic diagnostic agent and a photodynamic diagnostic method employing the photobleaching inhibitor for porphyrins. The present invention provides a photodynamic diagnostic agent containing a precursor of porphyrins and a gallic acid. The present invention also provides a photobleaching inhibitor for porphyrins containing a gallic acid.Type: ApplicationFiled: January 22, 2013Publication date: October 22, 2015Inventors: Masahiro Ishizuka, Tohru Tanaka, Shun-Ichiro Ogura, Takuya Ishii
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Patent number: 9061949Abstract: A metal component absorption enhancer which enhances the absorption of at least one metal component selected from the elements belonging to groups 2 to 12 in the third to fourth periods when a plant grows. The metal component absorption enhancer contains 5-aminolevulinic acid or a derivative thereof represented by the following general formula (1), or a salt thereof as an active ingredient: R2R1NCH2COCH2CH2COR3??(1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, and is used for performing a treatment with 0.001 to 20 ppm of the 5-aminolevulinic acid, the derivative thereof, or the salt thereof per each time.Type: GrantFiled: September 5, 2007Date of Patent: June 23, 2015Assignee: COSMO OIL CO., LTD.Inventors: Naohisa Tachiya, Shigeyuki Funada, Masahiro Ishizuka
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Patent number: 8999296Abstract: Provided is a sensitizing detection agent of an oral or intravenous administration type which enables the detection of bladder cancer with a higher sensitivity without causing pain to the patient. A sensitizing detection agent for bladder cancer comprising 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these is orally or intravenously administered, and a video camera system is inserted via the urethra and a blue light at 380-440 nm is irradiated to observe the red fluorescent part. Further, VLD-M1 is inserted and a blue light at 405 nm is irradiated to observe fluorescence intensity (relative intensity) of the red light part. For oral administration, 20 mg/kg (maximum of 1 g) of ALA is dissolved in 50 mL of a 5% glucose solution prior to the administration.Type: GrantFiled: April 21, 2009Date of Patent: April 7, 2015Assignees: Kochi University, SBI Pharmaceuticals Co., Ltd.Inventors: Keiji Inoue, Masahiro Ishizuka, Tohru Tanaka
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Publication number: 20150031013Abstract: It is to provide a tumor diagnostic agent and a tumor determination method enabling not only determination of the presence or absence of a tumor in a subject, but also determination of whether the tumor is a malignant tumor or a benign tumor, which can be used simply at low cost with reduced side effects and burden. 5-aminolevulinic acid (ALA) or its derivative, or a salt thereof is orally administered at a dose of 5 to 7 mg in terms of ALA per kg of body weight, and a urine sample 4 to 12 hours after the administration is collected. Porphyrins and creatinine in the urine sample are quantitated, and based on the value (nmol/gCre) obtained by dividing the amount of porphyrins by the amount of creatinine, a distinction among an individual without a tumor, an individual with a benign tumor, and an individual with a malignant tumor is determined. The presence or absence of a malignant tumor in a subject can be clearly determined by administering 1 to 3 mg of ALAs in terms of ALA per kg of body weight.Type: ApplicationFiled: January 15, 2013Publication date: January 29, 2015Inventors: Tohru Tanaka, Kiwamu Takahashi, Motowo Nakajima, Fuminori Abe, Masahiro Ishizuka, Urara Ota
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Patent number: 8927532Abstract: To provide a therapeutic agent and a diagnostic agent for mitochondrial dysfunction brain diseases including cerebral infarction as a representative. A therapeutic agent for a mitochondrial dysfunction brain disease, which comprises (A) ?-aminolevulinic acid represented by the formula (1), a derivative thereof, or a salt thereof and (B) an iron compound in combination. R2R1NCH2COCH2CH2COR3??(1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.Type: GrantFiled: September 13, 2012Date of Patent: January 6, 2015Assignee: SBI Pharmaceuticals Co., Ltd.Inventors: Toshihiko Kuroiwa, Yoshinaga Kajimoto, Takahiro Masubuchi, Masahiro Ishizuka, Tohru Tanaka
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Publication number: 20140302173Abstract: A method for treating side effects of anticancer agent includes administering to a subject in need thereof a prophylactic and/or therapeutic agent containing a therapeutically effective amount of a compound shown by the following Formula (1): R1—NHCH2COCH2CH2COOR2 ??(I) wherein R1 represents a hydrogen atom or an acyl group, and R2 represents a hydrogen atom, a linear or branched alkyl group, a cycloalkyl group, an aryl group, or an aralkyl group, or a salt thereof.Type: ApplicationFiled: October 5, 2012Publication date: October 9, 2014Applicants: NATIONAL UNIVERSITY CORPORATION KOCHI UNIVERSITY, SBI PHARMACEUTICALS CO., LTD.Inventors: Tohru Tanaka, Kyoko Tsuchiya, Masahiro Ishizuka, Motowo Nakajima, Hitoshi Nakagawa, Taro Shuin, Keiji Inoue, Hideo Fukuhara, Masayuki Tsuda, Mutsuo Furihata
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Patent number: 8790712Abstract: The present invention is drawn to a method of inducing thymocyte proliferation in a vertebrate animal with an impaired immune system comprising administering ?-aminolevulinic acid or a salt thereof every day in succession. The method further comprises administering at least one mineral.Type: GrantFiled: August 26, 2005Date of Patent: July 29, 2014Assignees: Cosmo Oil Co., Ltd., SBI Pharmaceuticals Co., Ltd.Inventors: Masao Kondo, Naomi Aiba, Setsuko Miyanari, Tohru Tanaka, Takaya Suzuki, Masahiro Ishizuka