Patents by Inventor Masakuni Okuhara

Masakuni Okuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INSECT REPELLENT
    Publication number: 20220330547
    Abstract: An insect repellent is suitable for an anti-tick treatment to living materials such as bedding and carpets with long-term replacement cycles in years and that also has a tick repellent effect stably lasting over a long period of time. The insect repellent contains 2,4-DHAP or xanthoxyline as an active ingredient. 2,4-DHAP and xanthoxyline can stably maintain repellency rates of at least 30-40% and about 90% respectively even if a heating treatment at 150° C. is continued for 5 minutes or longer, that is, for about 3 years in an environment of 25° C.
    Type: Application
    Filed: October 1, 2019
    Publication date: October 20, 2022
    Inventors: Tsutomu SUGINO, Atsushi HENMI, Kenichi NAKAMURA, Masakuni OKUHARA
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Publication number: 20050124646
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Application
    Filed: November 9, 2004
    Publication date: June 9, 2005
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Publication number: 20040029908
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplanation, graft-versus-host diseases by medulla ossium transplanation, autoimmune diseases, infectious diseases, and the like, which can be represented by the formula: 1
    Type: Application
    Filed: May 1, 2003
    Publication date: February 12, 2004
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Tricyclo compounds, a process for their production and pharmaceutical composition containing the same
    Publication number: 20030229115
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: 1
    Type: Application
    Filed: April 25, 2003
    Publication date: December 11, 2003
    Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Publication number: 20030170831
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: 1
    Type: Application
    Filed: September 20, 2002
    Publication date: September 11, 2003
    Applicant: Fujisawa Pharmaceutical Co. Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Method for inhibiting interleukin-2 production using tricyclo compounds
    Patent number: 6482845
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: November 19, 2002
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Method for inhibiting lymphokine production
    Patent number: 6201005
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: March 13, 2001
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Amino acid derivatives and their use as phospholipase A.sub.2 inhibitor
    Patent number: 6110933
    Abstract: The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: August 29, 2000
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Nobuharu Shigematsu, Seiji Yoshimura, Satoshi Okada, Keiji Hemmi, deceased, Hirokazu Tanaka, Takanao Otsuka, Yasuhisa Tsurumi, Masanori Okamoto, Masakuni Okuhara, Naoki Fukami
  • Method of immunosuppression
    Patent number: 6028097
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: February 22, 2000
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Process for production of tricyclo compounds with streptomyces
    Patent number: 5830717
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: November 3, 1998
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Strain of Streptomyces for the production of tricyclo compounds
    Patent number: 5624842
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: April 29, 1997
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Patent number: 5565559
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: October 19, 1995
    Date of Patent: October 15, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • WF11243 substance
    Patent number: 5547934
    Abstract: The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: August 20, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Akihiko Fujie, Shigehiro Takase, Michio Yamashita, Tomoko Sato, Seiji Hashimoto, Masakuni Okuhara
  • WB2663 substances and method for their production
    Patent number: 5545542
    Abstract: WB2663 substance-producing bacteria belonging to the genus Pseudomonas are cultured to produce a physiologically active substance, from which are isolated neutral substances WB2663A, WB2663B and WB2663C having respective specific rotations[.alpha.].sub.D.sup.23 : -36.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -12.degree. (C=0.5, CH.sub.2 Cl.sub.2),[.alpha.].sub.D.sup.23 : -9.degree. (C=0.5, CH.sub.2 Cl.sub.2),These substances have an excellent antitumor effect.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: August 13, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hidenori Nakajima, Yasuhiro Hori, Toshio Goto, Shigehiro Takase, Koen Verhaeghe, Hiroshi Terano, Masakuni Okuhara
  • Antimicrobial agent, FR109615 and production thereof
    Patent number: 5514715
    Abstract: A method of killing pathogenic fungi by contacting them with an effective amount of (1R,2S)-2-aminocyclopentanecarboxylic acid (FR109615) or a salt thereof.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: May 7, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara
  • Antimicrobial polypeptide compound a pharmaceutical composition comprising the same, and a method for treating infectious diseases
    Patent number: 5502033
    Abstract: A compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or hydroxy, R.sup.2 is hydrogen or hydroxy, R.sup.3 is hydroxy or hydroxysulfonyloxy, with proviso that when R.sup.1 is hydrogen, R.sup.2 is hydrogen, or a phamaceutically acceptable salt thereof. The compound can be used in a method for treating infectious diseases caused by pathogenic microorganism.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: March 26, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Patent number: 5496727
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: March 5, 1996
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Production of cyclosporin A and/or C with a strain of NECTRIA
    Patent number: 5447854
    Abstract: The invention relates to a method of producing cyclosporin A and/or C which is characterized by culturing a cyclosporin A and/or C-producing strain of microorganism belonging to the genus Nectria (e.g. Nectria sp. F-4908) and recovering cyclosporin A and/or C from the resulting cultured broth.
    Type: Grant
    Filed: November 10, 1993
    Date of Patent: September 5, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Toshio Goto, Toru Kino, Masakuni Okuhara, Hirokazu Tanaka, Yasuhisa Tsurumi, Shigehiro Takase
  • WF11243 substance
    Patent number: 5446022
    Abstract: The present invention relates to a novel polypeptide having the following presumed structure: ##STR1## and the compound has both excellent fungicidal and protozoicidal effects.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: August 29, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Akihiko Fujie, Shigehiro Takase, Michio Yamashita, Tomoko Sato, Seiji Hashimoto, Masakuni Okuhara
  • Use of the polypeptide compound
    Patent number: H1638
    Abstract: A pharmaceutical composition comprising an amount of a polypeptide of the formula: ##STR1## wherein R.sup.1 is hydrogen or an acyl group, R.sup.2 is hydroxy or an acyloxy group, R.sup.3 is hydrogen, hydroxy or hydroxysulfonyloxy, R.sup.4 is hydrogen or carbamoyl, and R.sup.5 and R.sup.6 are each hydrogen or hydroxy, with the proviso that (i) R.sup.2 is acyloxy when R.sup.3 is hydrogen, and (ii) R.sup.5 is hydrogen when R.sup.6 is hydrogen, or a pharmaceutically acceptable salt thereof, is useful in the prevention or treatment of Pneumocystis carinii infection.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: March 4, 1997
    Inventors: Takahisa Furuta, Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara