Patents by Inventor Masakuni Okuhara

Masakuni Okuhara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing WS-9326A and WS-9326B
    Patent number: 5436140
    Abstract: The novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof have useful pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain. A method for the production of the peptides WS-9326A and WS-9326B and derivatives thereof using Streptomyces violaceoniger No. 9326 in a biologically pure form is described herein.
    Type: Grant
    Filed: April 11, 1994
    Date of Patent: July 25, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu
  • FR901451 substance, process for preparation thereof and use thereof
    Patent number: 5409701
    Abstract: A new FR901451 substance which is produced by culturing a FR901451 substance-producing strain of the genus Flexibacter in a nutrient medium, this new substance possessing a human leukocyte elastase-inhibiting activity.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: April 25, 1995
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Hatanaka, Shigehiro Takase, Takashi Fujita, Masanori Okamoto, Masakuni Okuhara
  • Polypeptide compound and a process for preparation thereof
    Patent number: 5376634
    Abstract: A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,R.sup.3 is hydroxysulfonyloxy, andR.sup.4 is hydrogen or carbamoyl,with proviso thatR.sup.1 is not palmitoyl, when R.sup.2 is hydroxy,R.sup.3 is hydroxysulfonyloxy andR.sup.4 is carbamoyl,and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 17, 1991
    Date of Patent: December 27, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Toshiro Iwamoto, Akihiko Fujie, Kumiko Nitta, Yasuhisa Tsurumi, Nobuharu Shigematsu, Chiyoshi Kasahara, Motohiro Hino, Masakuni Okuhara, Kazuo Sakane, Kohji Kawabata, Hidenori Ohki
  • WS7622A mono- or di-sulfate, process for preparation thereof and use thereof
    Patent number: 5364624
    Abstract: A degenerative disease selected from the group consisting of cystic fibrosis, chronic bronchitis and bronchiectasia is treated by administering to a subject a therapeutically effective amount of WS7622A mono-or disulfate or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: November 15, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • WS7622A mono- or di- sulfate, process for preparation thereof and use thereof
    Patent number: 5292510
    Abstract: WS7622A mono- or di-sulfate and pharmaceutically acceptable salts thereof. WS7622A exhibits human leukocyte elastase-inhibiting activity.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: March 8, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara
  • Prophylactic/therapeutic composition for disseminated intravascular coagulation, chronic respiratory tract infectious disease or chronic bronchitis
    Patent number: 5279826
    Abstract: A method for therapy of disseminated intravascular coagulation, or chronic respiratory tract infectious disease characterized by administering to a patient in need thereof an effective dose suitable for therapeutic treatment of said condition of WS7622A mono- or di-sulfate ester or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: January 18, 1994
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Noriaki Inamura, Yasuhiko Shinguh, Kunio Nakahara, Yoshitada Notsu, Masanori Okamoto, Shigehiro Takase, Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Nobuharu Shigematsu, Masakuni Okuhara
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Patent number: 5266692
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: November 30, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Patent number: 5254562
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: October 19, 1993
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Peptides WS-9326a and WS-9326b, derivatives thereof and uses thereof
    Patent number: 5217952
    Abstract: This invention relates to the novel peptides WS-9326A, WS-9326B, their derivatives and pharmaceutically acceptable salts thereof which have pharmacological activities, particularly in the treatment and/or prevention of asthma and/or pain.
    Type: Grant
    Filed: November 20, 1991
    Date of Patent: June 8, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tohru Kino, Motoaki Nishikawa, Masami Ezaki, Sumio Kiyoto, Masakuni Okuhara, Shigehiro Takase, Satoshi Okada, Nobuharu Shigematsu
  • Anthraquinone derivatives and preparation thereof
    Patent number: 5187195
    Abstract: Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,R.sup.2 is hydrogen or acyl,R.sup.3 is acyl,R.sup.4 is hydrogen or acyl,R.sup.5 is hydrogen or acyl,R.sup.6 is hydrogen or acyl, andR.sup.7 is hydrogen or acylhave been found to possess endothelin antagonistic properties and are producible by various synthetic and fermentation processes.
    Type: Grant
    Filed: June 26, 1990
    Date of Patent: February 16, 1993
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Nobutaka Oohata, Motoaki Nishikawa, Sumio Kiyoto, Shigehiro Takase, Keiji Hemmi, Hidetsugu Murai, Masakuni Okuhara
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use for treatment of pulmonary emphysema and adult respiratory distress syndrome
    Patent number: 5167958
    Abstract: A method of treating pulmonary emphysema or adult respiratory distress syndrome in a subject in need thereof which comprises administering to the subject an effective amount of WS7622A, B, C and/or D, derivatives thereof, or their pharmaceutically acceptable salt.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: December 1, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Patent number: 5110811
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: May 5, 1992
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Carboxylic acid derivatives
    Patent number: 5061730
    Abstract: This invention relates to new carboxylic acid derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or aryl, and pharmaceutically acceptable salt thereof which inhibit activity of DHP-I, to a process for preparing them and to an antibacterial composition comprising them and carbapenem antibiotics.
    Type: Grant
    Filed: January 14, 1988
    Date of Patent: October 29, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Itsuo Uchida, Hiroshi Hatanaka, Kumiko Nitta, Seiji Hashimoto, Masakuni Okuhara, Hidetsugu Murai, Masashi Hashimoto
  • Pharmaceutically useful 5-hydroxy-2,3-dihydro-benzofurans and 5-hydroxy-benzofurans
    Patent number: 5043354
    Abstract: A compound of the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each lower alkyl, R.sup.4 is hydrogen or hydroxy, and a heavy solid line means a double bond when R.sup.4 is hydrogen and a single bond when R.sup.4 is hydroxy is useful in the treatment of diseases caused by reactive oxygen species and organic radicals.
    Type: Grant
    Filed: May 3, 1990
    Date of Patent: August 27, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Eisaku Tsujii, Yasuhisa Tsurumi, Masanori Okamoto, Masakuni Okuhara, Teruo Oku, Masashi Hashimoto
  • Antimicrobial agent, FR109615 and production thereof
    Patent number: 5037809
    Abstract: (1R, 2S)-2-Aminocyclopentanecarboxylic acid and its salts useful as antimicrobial agents.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: August 6, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Michiyo Miyauchi, Eisaku Tsujii, Masami Ezaki, Seiji Hashimoto, Masakuni Okuhara
  • WS7622A, B, C and D substances, derivatives thereof, processes for preparation thereof and use thereof
    Patent number: 5021240
    Abstract: The present invention relates to new WS7622A, B, C and/or D substances, derivatives thereof and pharmaceutical compositions containing the new substances as active ingredients.
    Type: Grant
    Filed: February 21, 1990
    Date of Patent: June 4, 1991
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Hiroshi Hatanaka, Masami Ezaki, Eisaku Tsujii, Masanori Okamoto, Nobuharu Shigematsu, Masakuni Okuhara, Shigehiro Takase
  • FR901228 substance and preparation thereof
    Patent number: 4977138
    Abstract: The invention relates to a compound having antimicrobial and antitumor activity, the compound being designated FR901228 substance of the following formula: ##STR1##
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: December 11, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Toshio Goto, Yasuhiro Hori, Takashi Fujita, Hirotsugu Ueda, Nobuharu Shigematsu
  • Compound, WF11605 and derivative thereof
    Patent number: 4963585
    Abstract: The invention relates to a compound of antimicrobial activity of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl,R.sup.2 is hydrogen or ##STR2## in which R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen or lower alkanoyl,R.sup.3 is carboxy or a protected carboxy, and pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 14, 1989
    Date of Patent: October 16, 1990
    Assignee: Fujisawa Pharmaceutical Company, Ltd.
    Inventors: Masanori Okamoto, Eisaku Tsujii, Tsutomu Kaizu, Hiroshi Hatanaka, Masakuni Okuhara, Kozo Sawada, Hirokazu Tanaka
  • Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
    Patent number: 4956352
    Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: ##STR1## to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: September 11, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Hirokazu Tanaka, Toshio Goto, Tohru Kino, Hiroshi Hatanaka
  • Amino acid derivatives of antitumor activity
    Patent number: 4939241
    Abstract: The invention relates to compounds of antitumor activity of the formula: ##STR1## ps in which R.sup.1 is hydrogen, lower allkyl, halo(lower)alkyl or aryl,R.sup.2 is hydrogen, hydroxy or protected hydroxy,R.sup.3 is hydrogen,R.sup.4 is aminocarboxy(lower)alkyl, protected amino(lower)alkyl or protected aminocarboxy(lower)alkyl, andR.sup.5 is hydrogen or lower alkyl, or its pharmaceutical acceptable salt.
    Type: Grant
    Filed: March 25, 1988
    Date of Patent: July 3, 1990
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Masakuni Okuhara, Toshio Goto, Masami Ezaki, Miho Tanaka, Shigehiro Takase, Hidenori Nakajima, Hideo Hirai, Akira Katayama