Abstract: A location database is maintained with information regarding each of a number of different geographical items in different locations. A user database is also maintained with user records for various users, each user record comprising the user's identification data. In addition, in at least one of the location database and the user database, an identification is maintained of different geographical items which each user has visited. Geographical-item-to-geographical-item similarities are defined between different geographical items based on the user database. User-to-user similarities between the users are defined based on the user database. A weighted combination of the defined geographical-item-to-geographical-item and user-to-user similarities is computed and particularly relevant geographical items in a given location are identified to a user based on the weighted combination.

Abstract: The invention provides a combination comprising a cytotoxic compound, a signalling inhibitor, an ancillary agent, or two or more further anti-cancer agents, and a compound having the formula (Ib): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4—; A is a bond, C?O, NRg(C?O) or O(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from fluorine, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g.

Abstract: An appliance having a casing with an open topped tub located within it, a lid structure including a seal for closing and sealing the tub mounted to the casing, the seal sealing with the top edge of the tub and located at or close to the perimeter of the lid structure, the lid structure including a lid centre portion and a frame which circumscribes the lid centre portion, the appliance including a gasket, connecting the frame to the lid centre portion so that at least part of the gasket forms a free body portion between the frame and the lid centre portion, the lid centre being free-floating relative to the frame, the appliance including a lid structure supporting mechanism connected to the frame to move the lid structure downwards, and if the lid centre portion is prevented from moving downwards, the frame can continue to move downwards.

Abstract: A combination comprising (a) a compound of formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NR9(C?O) or 0(C?O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1 to 3 carbon atoms; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or an optionally substituted C1-8 hydrocarbyl group wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; and (b) a compound of formul

Abstract: Disclosed herein is a device for draining a screw-on fluid filter which comprises a hollow body member movably engaged with a puncturing member. The hollow body member is dimensioned and arranged to at least partially engage a threaded attachment portion of the screw-on fluid filter. The puncturing member comprises a shaft having a puncture end movable within a conduit formed within the hollow body member wherein the puncturing member may be engaged with an inner side of a fluid filter to produce a puncture hole from inside out of the fluid filter, to produce a puncture hole from which fluid in the fluid filter may drain. A method of using the device is also disclosed.

Abstract: The invention provides a combination comprising an ancillary compound and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NR9(C?O) or 0(C?O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by

Abstract: The invention provides a combination comprising (or consisting essentially of) an ancillary compound and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein: R1 is 2,6-dichlorophenyl; R2a and R2b are both hydrogen; and R3 is a group: formula (A) where R4 is C1-4 alkyl. The combinations have activity as inhibitors of CDK kinases and inhibit the proliferation of cancer cells.

Abstract: The invention provides a combination of an ancillary agent and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein the ancillary agent is selected from: a monoclonal antibody, an alkylating agent, an anticancer agent, a further CDK inhibitor and a hormone, hormone agonist, hormone antagonist or hormone modulating agent; X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NR9(C?O) or 0(C?O) wherein R9 is hydrogen or C?hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g.

Abstract: The invention provides a combination of a cytotoxic compound or signalling inhibitor and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4- or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NRg(C?O) or 0(C?O) wherein Rg is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4alkoxy (e.g.

Abstract: The invention provides a combination of a compound having the formula (0) and two or more further anti-cancer agents: or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C?O, NR9(C?O) or 0(C?O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen (e.g. fluorine), hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy (e.g.

Abstract: A hosted system provides any Internet user with the ability to quickly set up and customize a video channel, preferably as a web page or site that can be reached from any Internet-accessible device having a web browser. The solution includes tools for use by channel site creators to customize the look, feel, and page design. A particular web page or site may be associated with a given subject. As used herein, a page or site that has such an association is sometimes referred to as “subject-specific.” Once a subject-specific channel is created, a site administrator or individual visitors can search across the web and choose to bring those search results into the channel architecture. The system also enables a multiplatform search as an integrated part of a library build; if desired, search results are automatically populated into the channel content. The system also enables the characterization of the material returned, preferably according to a user-generated taxonomy.

Abstract: The invention relates to the field of virology. The invention provides a new isolated essentially mammalian positive-sense single stranded RNA virus (EMCR-CoV) within the group of coronaviuses and components thereof.

Abstract: In one embodiment, an ammonium removal method can comprise: removing a multivalent cation from a stream comprising ammonium to form a treated stream; converting the ammonium in the stream to ammonia by increasing the pH of the stream; and separating the ammonia from the treated stream to form a separated stream and gaseous ammonia. In another embodiment, an ammonium removal method can comprise: a multivalent cation from a stream comprising ammonium to form a treated stream comprising a total of less than or equal to about 50 ppm by weight of multivalent cations; increasing the pH of the stream to a conversion pH; converting the ammonium to ammonia; and separating the ammonia from the treated stream to form a separated stream and gaseous ammonia.

Abstract: A method is provided for filling needleless injector capsules with liquid drug, which eliminates or reduces trapped air bubbles in the drug. A two-stage vacuum method is disclosed which enables the capsule to be evacuated rapidly to very low pressure prior to filling. The method is also suitable for filling other small containers with liquids.

Abstract: In a variable displacement type hydraulic pump/motor assembly including at least one internally movable component, such as a yoke, a swashplate, and the means for moving the swashplate, the improvement includes imparting on this component absolute location indicia markings and the addition of an optical/electronic sensor unit capable of reading such indicia markings fixedly located on a housing of the pump/motor assembly and including an optical read head extending into the housing interior and located at a spaced distance from the indicia markings for reading same, relative to a reference location, and producing a signal indicative of the absolute position of the movable component. The signal can then, in turn, be used for controlling the displacement of the pump/motor assembly. A method for determining the absolute component position is also set forth.

Abstract: Improvement, in hydraulic systems, such as for vehicle transmissions and the like, in the form of a hydraulic reservoir with integrated heat exchanger having fluid supply/return and fluid return ports, including a central section, having inner and outer shell portions with a first gap therebetween, the outer shell being provided with a plurality of radially-spaced, external cooling fins, longitudinally-directed for the length of the central section; the ends of the latter being closed off via respective bottom and top cap portions, thereby defining a central fluid cavity, the top cap portion having spaced outer and inner cap portions, with a second gap therebetween, with a fluid inlet port, in the outer cap portion, directing incoming fluid from the second gap into and through the entire length of the first gap before entering the central fluid cavity, thereby maximizing heat transfer from the fluid via the plurality of cooling fins.

Abstract: A method is provided for filling needleless injector capsules with liquid drug, which eliminates or reduces trapped air bubbles in the drug. A two-stage vacuum method is disclosed which enables the capsule to be evacuated rapidly to very low pressure prior to filling. The method is also suitable for filling other small containers with liquids.

Abstract: A pressurised gas powered actuator comprising a piston (3) operating in a cylinder (1). The stroke of the piston (3) may be reduced by uncovering one or more holes (14, 20) in the cylinder wall to permit the escape of the pressurised gas at a predetermined position along the swept wall of the cylinder. Alternatively, the piston (401) may be connected to a rod (402) which has a gas vent (406) formed therein, the position of the rod (402) with respect to the piston (401) being variable to adjust the stroke of the piston (401).

Abstract: A Bulk Mail Container (BMC) unloader uses a simple crossed four bar-linkage to move a predetermined point on a BMC unloader in a substantially straight line while the overall BMC unloader rotates about that predetermined point so as to upend the BMC container. This takes advantage of the crossed four-bar's substantially straight-line motion over a limited range of its motion, as well as the rotational motion of the particular unloader link disclosed herein. This is advantageous for unloading. In use, a BMC container is simply rolled into the BMC unloader, and the entire combination of the BMC container and BMC unloader is then actuated to produce substantially straight line motion along a suitably selected “center” point of the BMC unloader while the overall combination rotates about the center point so as to upend the BMC for unloading.

Abstract: A Bulk Mail Container (BMC) unloader uses a simple crossed four bar-linkage to move a predetermined point on a BMC unloader in a substantially straight line while the overall BMC unloader rotates about that predetermined point so as to upend the BMC container. This takes advantage of the crossed four-bar's substantially straight-line motion over a limited range of its motion, as well as the rotational motion of the particular unloader link disclosed herein. This is advantageous for unloading. In use, a BMC container is simply rolled into the BMC unloader, and the entire combination of the BMC container and BMC unloader is then actuated to produce substantially straight line motion along a suitably selected “center” point of the BMC unloader while the overall combination rotates about the center point so as to upend the BMC for unloading.