Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: This disclosure provides compounds of Formula (I) (e.g., (I-A) (e.g., (I-A-1), (I-A-2), or (I-A-3)), (I-B) (e.g., (I-B-1), (I-B-2), or (I-B-3)), (I-C), (I-D), (I-E) (e.g., (I-E-1), (I-E-2), or (I-E-3)), (I-Ea) (e.g., (I-Ea-1), (I-Ea-2), or (I-Ea-3)), (I-Eb) (e.g., (I-Eb-1), (I-Eb-2), or (I-Eb-3)), (I-F) (e.g., (I-F-1), (I-F-2), or (I-F-3)), (I-G), (I-Ga), (I-H) (e.g., (I-H-1), (1-H-2), or (I-H-3))) or Formula (II) (e.g., (II-a)), or a pharmaceutically acceptable salt thereof that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions containing the compounds provided herein as well as methods of using and making the same.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.

Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.

Abstract: A disclosed system for transport asset monitoring, for example monitoring truck trailer unloading progress at large retail locations, includes an artificial intelligence (AI) solution for managing operations at a facility. The AI solution analyzes current load percentage and other data to predict availability for moving the transport asset and ability to accept a new incoming transport asset. Predictions of availability can reduce response times, resulting in higher utilization rates for assets, thereby improving efficiency. An exemplary system includes a sensor configured to sense operation progress parameter data for a transport asset; and logic to receive the operation progress parameter data from the sensor; determine, using the AI solution and based at least on the operation progress parameter data, a predicted milestone parameter; and report the predicted milestone parameter to a remote node.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.

Abstract: This disclosure provides compounds of Formula (I) (e.g., (I-A) (e.g., (I-A-1), (I-A-2), or (I-A-3)), (I-B) (e.g., (I-B-1), (I-B-2), or (I-B-3)), (I-C), (I-D), (I-E) (e.g., (I-E-1), (I-E-2), or (I-E-3)), (I-Ea) (e.g., (I-Ea-1), (I-Ea-2), or (I-Ea-3)), (I-Eb) (e.g., (I-Eb-1), (I-Eb-2), or (I-Eb-3)), (I-F) (e.g., (I-F-1), (I-F-2), or (I-F-3)), (I-G), (I-Ga), (I-H) (e.g., (I-H-1), (1-H-2), or (I-H-3))) or Formula (II) (e.g., (II-a)), or a pharmaceutically acceptable salt thereof that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions containing the compounds provided herein as well as methods of using and making the same.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device, The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device. The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.

Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.

Abstract: A disclosed system for transport asset monitoring, for example monitoring truck trailer unloading progress at large retail locations, includes an artificial intelligence (AI) solution for managing operations at a facility. The AI solution analyzes current load percentage and other data to predict availability for moving the transport asset and ability to accept a new incoming transport asset. Predictions of availability can reduce response times, resulting in higher utilization rates for assets, thereby improving efficiency. An exemplary system includes a sensor configured to sense operation progress parameter data for a transport asset; and logic to receive the operation progress parameter data from the sensor; determine, using the AI solution and based at least on the operation progress parameter data, a predicted milestone parameter; and report the predicted milestone parameter to a remote node.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.