Patents by Inventor Matthew D. Alexander

Matthew D. Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250188056
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Application
    Filed: July 18, 2024
    Publication date: June 12, 2025
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, III, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Patent number: 12227490
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Grant
    Filed: July 7, 2023
    Date of Patent: February 18, 2025
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, III, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Patent number: 12103920
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Grant
    Filed: March 16, 2023
    Date of Patent: October 1, 2024
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, III, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Publication number: 20240238423
    Abstract: This disclosure provides compounds of Formula (I) (e.g., (I-A) (e.g., (I-A-1), (I-A-2), or (I-A-3)), (I-B) (e.g., (I-B-1), (I-B-2), or (I-B-3)), (I-C), (I-D), (I-E) (e.g., (I-E-1), (I-E-2), or (I-E-3)), (I-Ea) (e.g., (I-Ea-1), (I-Ea-2), or (I-Ea-3)), (I-Eb) (e.g., (I-Eb-1), (I-Eb-2), or (I-Eb-3)), (I-F) (e.g., (I-F-1), (I-F-2), or (I-F-3)), (I-G), (I-Ga), (I-H) (e.g., (I-H-1), (1-H-2), or (I-H-3))) or Formula (II) (e.g., (II-a)), or a pharmaceutically acceptable salt thereof that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions containing the compounds provided herein as well as methods of using and making the same.
    Type: Application
    Filed: May 4, 2023
    Publication date: July 18, 2024
    Inventors: Evan J. Horn, Joshua D. Hansen, Matthew D. Alexander, Fei Huang, Mark A. Nagy
  • Patent number: 12029738
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: July 9, 2024
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Gerald D. Artman, Gordon L. Bray, James Carmichael, Soraya Carrancio, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Rama K. Narla, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • Publication number: 20240217955
    Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.
    Type: Application
    Filed: February 29, 2024
    Publication date: July 4, 2024
    Inventors: Matthew D. Alexander, Soraya Carrancio, Matthew D. Correa, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, Dehua Huang, Timothy S. Kercher, Antonia Lopez-Girona, Mark A. Nagy, Veronique Plantevin-Krenitsky
  • Publication number: 20240207255
    Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
    Type: Application
    Filed: January 23, 2024
    Publication date: June 27, 2024
    Inventors: Matthew D. Alexander, Gerald D. Artman, Gordon L. Bray, James Carmichael, Soraya Carranico, Brian E. Cathers, Matthew D. Correa, Joshua Hansen, Courtney G. Havens, Timothy S. Kercher, Antonia Lopez-Girona, Xiaoling Lu, Hon-Wah Man, Mark A. Nagy, Rama K. Narla, Joseph R. Piccotti, Daniel W. Pierce, Paula A. Tavares-Greco, Brandon W. Whitefield, Lilly L. Wong, Nanfei Zou
  • Patent number: 11945804
    Abstract: Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: April 2, 2024
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Soraya Carrancio, Matthew D. Correa, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, Dehua Huang, Timothy S. Kercher, Antonia Lopez-Girona, Mark A. Nagy, Veronique Plantevin-Krenitsky
  • Publication number: 20240095650
    Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.
    Type: Application
    Filed: November 28, 2023
    Publication date: March 21, 2024
    Inventors: Robert J. Taylor, Matthew D. Alexander, William M. Propes, John C. Crecelius, JR., Jason D. Bellar
  • Patent number: 11928608
    Abstract: A disclosed system for transport asset monitoring, for example monitoring truck trailer unloading progress at large retail locations, includes an artificial intelligence (AI) solution for managing operations at a facility. The AI solution analyzes current load percentage and other data to predict availability for moving the transport asset and ability to accept a new incoming transport asset. Predictions of availability can reduce response times, resulting in higher utilization rates for assets, thereby improving efficiency. An exemplary system includes a sensor configured to sense operation progress parameter data for a transport asset; and logic to receive the operation progress parameter data from the sensor; determine, using the AI solution and based at least on the operation progress parameter data, a predicted milestone parameter; and report the predicted milestone parameter to a remote node.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: March 12, 2024
    Assignee: Walmart Apollo, LLC
    Inventors: Jason Bellar, William Mark Propes, Chris Ford, Matthew D. Alexander, Amy Savaiinaea
  • Patent number: 11868947
    Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: January 9, 2024
    Assignee: WALMART APOLLO, LLC
    Inventors: Robert J. Taylor, Matthew D. Alexander, William M. Propes, John C. Crecelius, Jr., Jason D. Bellar
  • Publication number: 20230390404
    Abstract: This disclosure provides compounds of Formula (I) (e.g., (I-A) (e.g., (I-A-1), (I-A-2), or (I-A-3)), (I-B) (e.g., (I-B-1), (I-B-2), or (I-B-3)), (I-C), (I-D), (I-E) (e.g., (I-E-1), (I-E-2), or (I-E-3)), (I-Ea) (e.g., (I-Ea-1), (I-Ea-2), or (I-Ea-3)), (I-Eb) (e.g., (I-Eb-1), (I-Eb-2), or (I-Eb-3)), (I-F) (e.g., (I-F-1), (I-F-2), or (I-F-3)), (I-G), (I-Ga), (I-H) (e.g., (I-H-1), (1-H-2), or (I-H-3))) or Formula (II) (e.g., (II-a)), or a pharmaceutically acceptable salt thereof that induce degradation of a BCL-XL protein. These compounds are useful, for example, for treating a cancer in a subject (e.g., a human). This disclosure also provides compositions containing the compounds provided herein as well as methods of using and making the same.
    Type: Application
    Filed: May 4, 2023
    Publication date: December 7, 2023
    Inventors: Evan J. Horn, Joshua D. Hansen, Matthew D. Alexander, Fei Huang, Mark A. Nagy
  • Publication number: 20230348431
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Application
    Filed: July 7, 2023
    Publication date: November 2, 2023
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris III, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Patent number: 11739075
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein R1, R2, R3, R4, L, V, X, a and m are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: August 29, 2023
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, III, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Publication number: 20230267393
    Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device, The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.
    Type: Application
    Filed: May 1, 2023
    Publication date: August 24, 2023
    Inventors: Robert James Taylor, Leigh Ann Marie Scobey, Matthew D. Alexander, Jeffrey Scott Cruz, Lacrecia Lynn Billings, Joseph Wayne Hendricks
  • Publication number: 20230242509
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Application
    Filed: March 16, 2023
    Publication date: August 3, 2023
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Patent number: 11676084
    Abstract: System and methods for dynamic replenishment in a facility are disclosed. A mobile inventory processing device reads a machine readable tag affixed to a perishable item and transmits an indication of the perishable item to a stock inventory processing device. The stock inventory processing device retrieves a stock inventory value corresponding to the perishable item and a historic daily sales value for the perishable item from a database. The stock inventory processing device determines a restocking value based on whether the historic daily sales value exceeds the stock inventory value. The stock inventory processing device transmits a second indication to the mobile inventory processing device. The second indication correspond to insufficient shelf stock of the perishable item. The mobile inventory processing device receives the second indication and outputs an auditory alert in response to the second indication.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: June 13, 2023
    Assignee: Walmart Apollo, LLC
    Inventors: Robert James Taylor, Leigh Ann Marie Scobey, Matthew D. Alexander, Jeffrey Scott Cruz, Lacrecia Lynn Billings, Joseph Wayne Hendricks
  • Patent number: 11634407
    Abstract: Provided herein are piperidine dione compounds having the following structure: wherein RN, R1, R2, R3, R4, RN, L, V, X, a, m, and n are as defined herein, compositions comprising an effective amount of a piperidine dione compound, and methods for treating or preventing an androgen receptor mediated disease.
    Type: Grant
    Filed: June 23, 2021
    Date of Patent: April 25, 2023
    Assignee: Celgene Corporation
    Inventors: Matthew D. Alexander, Matthew D. Correa, Deepak Dalvie, Virginia Heather Sharron Grant, Joshua Hansen, Roy L. Harris, III, Evan J. Horn, Dehua Huang, Christopher Mayne, Stephen Norris, Veronique Plantevin-Krenitsky, John J. Sapienza, Lida Tehrani, Brandon W. Whitefield
  • Publication number: 20230103429
    Abstract: A disclosed system for transport asset monitoring, for example monitoring truck trailer unloading progress at large retail locations, includes an artificial intelligence (AI) solution for managing operations at a facility. The AI solution analyzes current load percentage and other data to predict availability for moving the transport asset and ability to accept a new incoming transport asset. Predictions of availability can reduce response times, resulting in higher utilization rates for assets, thereby improving efficiency. An exemplary system includes a sensor configured to sense operation progress parameter data for a transport asset; and logic to receive the operation progress parameter data from the sensor; determine, using the AI solution and based at least on the operation progress parameter data, a predicted milestone parameter; and report the predicted milestone parameter to a remote node.
    Type: Application
    Filed: December 8, 2022
    Publication date: April 6, 2023
    Inventors: Jason Bellar, William Mark Propes, Chris Ford, Matthew D. Alexander, Amy Savaiinaea
  • Publication number: 20230079572
    Abstract: In some embodiments, apparatuses and methods are provided herein useful to the sortation of products using a conveyor assembly.
    Type: Application
    Filed: November 16, 2022
    Publication date: March 16, 2023
    Inventors: Robert J. Taylor, Matthew D. Alexander, William M. Propes, John C. Crecelius, JR., Jason D. Bellar